Search

Your search keyword '"Sritharan R"' showing total 193 results
Start Over Author "Sritharan R"
193 results on '"Sritharan R"'

2. Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project

Author

Zabel, M., Schlögl, S., Lubinski, A., Svendsen, J. H., Bauer, A., Arbelo, E., Brusich, S., Conen, D., Cygankiewicz, I., Dommasch, M., Flevari, P., Galuszka, J., Hansen, J., Hasenfuß, G., Hatala, R., Huikuri, H. V., Kenttä, T., Kuczejko, T., Haarmann, H., Harden, M., Iovev, S., Kääb, S., Kaliska, G., Katsimardos, A., Kasprzak, J. D., Qavoq, D., Lüthje, L., Malik, M., Novotny, T., Pavlovic, N., Perge, P., Röver, C., Schmidt, G., Shalganov, T., Sritharan, R., Svetlosak, M., Sallo, Z., Szavits-Nossan, J., Traykov, V., Vandenberk, B., Velchec, V., Vos, M. A., Willich, S. N., Friede, T., Willems, R., Merkely, B., Sticherling, C., and investigators, the EU-CERT-ICD study

Subjects
Statistics - Applications
Abstract

BACKGROUND. The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients who benefit from prophylactic ICD therapy. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) completed in 2019 will assess this issue. SUMMARY. The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicenter observational cohort study done in 44 centers across 15 European countries. A total of 2327 patients with heart failure due to ischemic heart disease or dilated cardiomyopathy indicated for primary prophylactic ICD implantation were recruited between 2014 and 2018 (>1500 patients at first ICD implantation, >750 patients non-randomized non-ICD control group). The primary endpoint was all-cause mortality, first appropriate shock was co-primary endpoint. At baseline, all patients underwent 12-lead ECG and Holter-ECG analysis using multiple advanced methods for risk stratification as well as documentation of clinical characteristics and laboratory values. The EU-CERT-ICD data will provide much needed information on the survival benefit of preventive ICD therapy and expand on previous prospective risk stratification studies which showed very good applicability of clinical parameters and advanced risk stratifiers in order to define patient subgroups with above or below average ICD benefit. CONCLUSION. The EU-CERT-ICD study will provide new and current data about effectiveness of primary prophylactic ICD implantation. The study also aims for improved risk stratification and patient selection using clinical risk markers in general, and advanced ECG risk markers in particular., Comment: 22 pages, 3 figures

Published
2019
Full Text
View/download PDF

6. Finding a sun in building-free graphs

Author

Eschen, Elaine M., Hoang, Chinh T., Spinrad, Jeremy P., and Sritharan, R.

Subjects
Computer Science - Discrete Mathematics, G.2.2
Abstract

Deciding whether an arbitrary graph contains a sun was recently shown to be NP-complete. We show that whether a building-free graph contains a sun can be decided in O(min$\{m{n^3}, m^{1.5}n^2\}$) time and, if a sun exists, it can be found in the same time bound. The class of building-free graphs contains many interesting classes of perfect graphs such as Meyniel graphs which, in turn, contains classes such as hhd-free graphs, i-triangulated graphs, and parity graphs. Moreover, there are imperfect graphs that are building-free. The class of building-free graphs generalizes several classes of graphs for which an efficient test for the presence of a sun is known. We also present a vertex elimination scheme for the class of (building, gem)-free graphs. The class of (building, gem)-free graphs is a generalization of the class of distance hereditary graphs and a restriction of the class of (building, sun)-free graphs., Comment: 3 figures

Published
2009

7. On graphs without a C4 or a diamond

Author

Eschen, Elaine M., Hoang, Chinh T., Spinrad, Jeremy P., and Sritharan, R.

Subjects
Computer Science - Discrete Mathematics, G.2.2
Abstract

We consider the class of (C4, diamond)-free graphs; graphs in this class do not contain a C4 or a diamond as an induced subgraph. We provide an efficient recognition algorithm for this class. We count the number of maximal cliques in a (C4, diamond)-free graph and the number of n-vertex, labeled (C4, diamond)-free graphs. We also give an efficient algorithm for finding a largest clique in the more general class of (house, diamond)-free graphs.

Published
2009

8. On the complexity of deciding whether the distinguishing chromatic number of a graph is at most two

Author

Eschen, Elaine M., Hoang, Chinh T., Sritharan, R., and Stewart, Lorna

Subjects
Computer Science - Computational Complexity, F.2.0
Abstract

In an article [3] published recently in this journal, it was shown that when k >= 3, the problem of deciding whether the distinguishing chromatic number of a graph is at most k is NP-hard. We consider the problem when k = 2. In regards to the issue of solvability in polynomial time, we show that the problem is at least as hard as graph automorphism but no harder than graph isomorphism.

Published
2009

14. Completing Colored Graphs to Meet a Target Property

Author

Cook, Kathryn, Eschen, Elaine M., Sritharan, R., Wang, Xiaoqiang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Brandstädt, Andreas, editor, Jansen, Klaus, editor, and Reischuk, Rüdiger, editor

Published
2013
Full Text
View/download PDF

18. New Min-Max Theorems for Weakly Chordal and Dually Chordal Graphs

Author

Busch, Arthur H., Dragan, Feodor F., Sritharan, R., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Wu, Weili, editor, and Daescu, Ovidiu, editor

Published
2010
Full Text
View/download PDF

20. Strongly Chordal and Chordal Bipartite Graphs Are Sandwich Monotone

Author

Heggernes, Pinar, Mancini, Federico, Papadopoulos, Charis, Sritharan, R., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Ngo, Hung Q., editor

Published
2009
Full Text
View/download PDF

21. Leaf Powers and Their Properties: Using the Trees

Author

Fellows, Michael R., Meister, Daniel, Rosamond, Frances A., Sritharan, R., Telle, Jan Arne, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Hong, Seok-Hee, editor, Nagamochi, Hiroshi, editor, and Fukunaga, Takuro, editor

Published
2008
Full Text
View/download PDF

22. Recognition of Perfect Circular-arc Graphs

Author

Cameron, Kathie, Eschen, Elaine M., Hoàng, Chính T., Sritharan, R., Bondy, Adrian, editor, Fonlupt, Jean, editor, Fouquet, Jean-Luc, editor, Fournier, Jean-Claude, editor, and Ramírez Alfonsín, Jorge L., editor

Published
2007
Full Text
View/download PDF

25. Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study

Author

Zabel, Markus, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Brugada, Josep, Conen, David, Flevari, Panagiota, Hasenfuß, Gerd, Svetlosak, Martin, Huikuri, Heikki V, Malik, Marek, Pavlović, Nikola, Schmidt, Georg, Sritharan, Rajevaa, Schlögl, Simon, Szavits-Nossan, Janko, Traykov, Vassil, Tuinenburg, Anton E, Willich, Stefan N, Harden, Markus, Friede, Tim, Svendsen, Jesper Hastrup, Sticherling, Christian, Merkely, Béla, Perge, Peter, Sallo, Zoltan, Szeplaki, Gabor, Szegedi, Nandor, Nagy, Klaudia Vivien, Lüthje, Lars, Sritharan, R, Haarmann, Helge, Bergau, Leonard, Seegers, Joachim, Munoz- Exposito, Pascal, Tichelbäcker, Tobias, Kirova, Aleksandra, Hnatkova, Katerina, Vos, Marc A, Reinhold, Thomas, Vandenberk, Bert, Klinika, Magdalena, Rotkvić, L, Flevari, Panayota, Katsimardos, Andreas, Katsaras, Dimitrios, Hatala, Robert, Kuczejko, Tomasz, Hansen, Jim, Manola, Šime, Vinter, Ozren, Benko, Ivica, Tuinenburg, Anton, Sprenkeler, David, Smoczynska, A, Vos, M A, Meyer-Zürn, Christine, Eick, Christian, Arbelo, Elena, Kaliska, Gabriela, Martinek, Jozef, Dommasch, Michael, Steger, Alexander, Kääb, Stefan, Sinner, Moritz F, Rizas, Konstantinos D, Hamm, Wolfgang, Traykov, V, Cygankiewicz, Iwona, Ptaszyński, Pawel, Kaczmarek, K, Poddebska, I, Iovev, Svetoslav, Novotný, Tomáš, Kozak, Milan, Huikuri, Heikki, Kenttä, Tuomas, Pelli, Ari, Kasprzak, Jaroslaw D, Qavoq, Dariusz, Brusich, Sandro, Avdovic, Ervin, Klasan, Marina, Galuszka, Jan, Taborsky, Milos, Velchev, Vasil, Dissmann, Rüdiger, Shalganov, T, Guzik, P, Krauze, T, Bimmel, Dieter, Lieberz, Christiane, Ludwigsburg, Klinikum, Stefanow, Stefan, Rüb, Norman, Wolpert, Christian, Meier, Lars S, Behrens, Steffen, Jurisic, Zrinka, Braunschweig, Frieder, Blaschke, Florian, Pieske, Burkert, Bakotic, Zoran, Anic, Ante, Weiden, Klinikum, Schwinger, Robert H G, Platonov, Pyotr, Grönefeld, Gerian, Klingenheben, Thomas, and EU-CERT-ICD Study Investigators

Subjects
medicine.medical_specialty, medicine.medical_treatment, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, 030204 cardiovascular system & hematology, Ventricular Function, Left, Cohort Studies, EU-CERT-ICD Study Investigators, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Internal medicine, medicine, Clinical endpoint, Humans, AcademicSubjects/MED00200, Prospective Studies, 030212 general & internal medicine, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, 1102 Cardiorespiratory Medicine and Haematology, Aged, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, Heart Failure, Ejection fraction, Ischemic cardiomyopathy, business.industry, Hazard ratio, Stroke Volume, 1103 Clinical Sciences, Dilated cardiomyopathy, medicine.disease, Confidence interval, Defibrillators, Implantable, 3. Good health, Europe, Primary Prevention, Death, Sudden, Cardiac, Treatment Outcome, Cardiovascular System & Hematology, Implantable cardioverter-defibrillator, Risk factors, Mortality, Sudden cardiac death, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class Conclusion In contemporary ICM/DCM patients (LVEF ≤35%, narrow QRS), primary prophylactic ICD treatment was associated with a 27% lower mortality after adjustment. There appear to be patients with less survival advantage, such as older patients or diabetics.

Published
2020
Full Text
View/download PDF

28. Rationale and design of the EU‐CERT‐ICD prospective study:comparative effectiveness of prophylactic ICD implantation

Author

Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), Mansch, R. (R.), Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), and Mansch, R. (R.)

Abstract

Aims: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results: The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non‐randomized control group). The primary endpoint is all‐cause mortality; the co‐primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost‐effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12‐lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions: The EU‐CERT‐ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

Published
2019

34. EXAMINING CUSTOMER SATISFACTION AMONG JIO TELECOMMUNICATION SERVICE USERS

Author

Kasambu N and Sritharan R

Abstract

India’s telecommunication network, by number of telephone users and internet user base, is the second largest in the world. There are different providers of cell phone services in our country and they play an important role in meeting the needs of customers. Jio has gained a significant market share and has accomplished numbers that look to attain competitiveness over a decade. It is the only network in India that is 4G only and its USP is the free services it provides. As part of its 4G offerings, Jio released a bundle of multimedia applications on Google Play in May 2016. While the apps are available for all to download, a user would need a Jio SIM card for them. A computer network or a data network is the digital telecommunication network that enables Reliance JIO Limited a subsidiary of Reliance Industry Limited to provide resources. Reliance JIO Limited is India’s largest private sector company, which is the first telecom operator to hold a unified licence for pan India. The business offers all communications services except satellite-serviced global mobile personal contact. This research includes examining consumer satisfaction with the Jio network and gathering data from 50 respondents with the aid of a convenient sampling technique. From its research, this study suggests improving network coverage and call connectivity.

Published
2020
Full Text
View/download PDF

35. Clinical effectiveness of primary prevention implantable cardioverter-defibrillators:results of the EU-CERT-ICD controlled multicentre cohort study

Author

Zabel, M. (Markus), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Brugada, J. (Josep), Conen, D. (David), Flevari, P. (Panagiota), Hasenfuß, G. (Gerd), Svetlosak, M. (Martin), Huikuri, H. V. (Heikki V.), Malik, M. (Marek), Pavlović, N. (Nikola), Schmidt, G. (Georg), Sritharan, R. (Rajevaa), Schlögl, S. (Simon), Szavits-Nossan, J. (Janko), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Willich, S. N. (Stefan N.), Harden, M. (Markus), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Sticherling, C. (Christian), Merkely, B. (Béla), and EU-CERT-ICD Study Investigators

Subjects
Sudden cardiac death, Risk factors, Mortality, Implantable cardioverter-defibrillator
Abstract

Aims: The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results: We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class

Published
2020

43. Present criteria for prophylactic ICD implantation:insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project

Author

Zabel, M. (Markus), Schloegl, S. (Simon), Lubinski, A. (Andrzej), Svendsen, J. H. (Jesper Hastrup), Bauer, A. (Axel), Arbelo, E. (Elena), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Dommasch, M. (Michael), Flevari, P. (Panagiota), Galuszka, J. (Jan), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Kentta, T. (Tuomas), Kucejko, T. (Tomasz), Haarmann, H. (Helge), Harden, M. (Markus), Iovev, S. (Svetoslav), Kaab, S. (Stefan), Kaliska, G. (Gabriela), Katsimardos, A. (Andreas), Kasprzak, J. D. (Jaroslaw D.), Qavoq, D. (Dariusz), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Perge, P. (Peter), Roever, C. (Christian), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Svetlosak, M. (Martin), Sallo, Z. (Zoltan), Szavits-Nossan, J. (Janko), Traykov, V. (Vassil), Vandenberk, B. (Bert), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Willems, R. (Rik), Merkely, B. (Bela), and Sticherling, C. (Christian)

Subjects
Sudden cardiac death, Risk factors, Implantable cardioverter defibrillator, Mortality
Abstract

Background: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients who benefit from prophylactic ICD therapy. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) completed in 2019 will assess this issue. Summary: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicenter observational cohort study done in 44 centers across 15 European countries. A total of 2327 patients with heart failure due to ischemic heart disease or dilated cardiomyopathy indicated for primary prophylactic ICD implantation were recruited between 2014 and 2018 (>1500 patients at first ICD implantation, >750 patients non-randomized non-ICD control group). The primary endpoint was all-cause mortality, and first appropriate shock was co-primary endpoint. At baseline, all patients underwent 12‑lead ECG and Holter-ECG analysis using multiple advanced methods for risk stratification as well as documentation of clinical characteristics and laboratory values. The EU-CERT-ICD data will provide much needed information on the survival benefit of preventive ICD therapy and expand on previous prospective risk stratification studies which showed very good applicability of clinical parameters and advanced risk stratifiers in order to define patient subgroups with above or below average ICD benefit. Conclusion: The EU-CERT-ICD study will provide new and current data about effectiveness of primary prophylactic ICD implantation. The study also aims for improved risk stratification and patient selection using clinical risk markers in general, and advanced ECG risk markers in particular.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results