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13 results on '"Sreeranganathan,Maya"'

7. Porous polysaccharide scaffolds: Proof of concept study on wound healing and stem cell differentiation

Author

Gopalakrishnan Usha, Preethi, primary, Jalajakumari, Sreekutty, additional, Babukuttan Sheela, Unnikrishnan, additional, Mohan, Deepa, additional, Meena Gopalakrishnan, Archana, additional, Sreeranganathan, Maya, additional, Kuttan Pillai, Raveendran, additional, Berry, Catherine, additional, Maiti, Kaustabh Kumar, additional, and Therakathinal Thankappan, Sreelekha, additional

Published
2022
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11. In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts [Corrigendum]

Author

Sreeranganathan,Maya, Uthaman,Saji, Sarmento,Bruno, Mohan,Chethampadi Gopi, Park,In-Kyu, and Jayakumar,Rangasamy

Subjects
International Journal of Nanomedicine
Abstract

Sreeranganathan M, Uthaman S, Sarmento B, et al. Int JNanomedicine. 2017;12:7165–7182. When reviewing the paper, the authors noted some errorsin Figure 2E (page 7171) and Figure 6 (page 7176). Theyconfirm that the corrections to Figures 2 and 6 do not alterthe inferences or conclusion of the respective figures, northe overall conclusion of the article, and apologize for thisinadvertent error. In the original manuscript, Figure 2 represents the cellularinternalization of the nanoparticles and Figure 2E representsthe uptake of targeted nanoparticles by MKN-28 cells at ahigher magnification. In Figure 2E, the fluorescence imagewas wrongly merged with the incorrect brightfield image ofthe cell. The authors have rectified this mistake by replacingFigure 2E with the confocal microscope image using thecorrect phase contrast, fluorescent, and merged images. Thecorrected version of Figure 2 is included as follows. Read the original article &nbsp

Published
2019

13. In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts

Author

Sreeranganathan,Maya, Uthaman,Saji, Sarmento,Bruno, Mohan,Chethampadi Gopi, Park,In-Kyu, Jayakumar,Rangasamy, Sreeranganathan,Maya, Uthaman,Saji, Sarmento,Bruno, Mohan,Chethampadi Gopi, Park,In-Kyu, and Jayakumar,Rangasamy

Abstract

Maya Sreeranganathan,1 Saji Uthaman,2 Bruno Sarmento,3–5 Chethampadi Gopi Mohan,1 In-Kyu Park,1 Rangasamy Jayakumar2 1Centre for Nanosciences and Molecular Medicine, Amrita University, Kochi, India; 2Department of Biomedical Science, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju, Republic of Korea; 3I3S – Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal, 4INEB – Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal, 5CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Universitário de Ciências da Saúde, Gandra, Portugal Abstract: Epidermal growth factor receptor (EGFR), upregulated in gastric cancer patients, is an oncogene of interest in the development of targeted cancer nanomedicines. This study demonstrates in silico modeling of monoclonal antibody cetuximab (CET MAb)-conjugated docetaxel (DOCT)-loaded poly(γ-glutamic acid) (γ-PGA) nanoparticles (Nps) and evaluates the in vitro/in vivo effects on EGFR-overexpressing gastric cancer cells (MKN-28). Nontargeted DOCT-γ-PGA Nps (NT Nps: 110±40 nm) and targeted CET MAb-DOCT-γ-PGA Nps (T Nps: 200±20 nm) were prepared using ionic gelation followed by 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide­– N-Hydoxysuccinimide (EDC­– NSH) chemistry. Increased uptake correlated with enhanced cytotoxicity induced by targeted Nps to EGFR +ve MKN-28 compared with nontargeted Nps as evident from MTT and flow cytometric assays. Nanoformulated DOCT showed a superior pharmacokinetic profile to that of free DOCT in Swiss albino mice, indicating the possibility of improved therapeutic e

Published
2017

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