Search

Your search keyword '"Squires, Patrick"' showing total 38 results
Start Over Author "Squires, Patrick"
38 results on '"Squires, Patrick"'

19. A Pharmacoepidemiologic Approach to Evaluate Real-world Effectiveness of Hormonal Contraceptives in the Presence of Drug-drug Interactions.

Author

Sarayani, Amir, Brown, Joshua D., Goodin, Amie J., Squires, Patrick, Phuong Pham, Cicali, Brian, Henriksen, Carl, Schmidt, Stephan, Winterstein, Almut G., and Pham, Phuong

Subjects
ANTICONVULSANTS, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, DRUGS, ORAL contraceptives, DRUG interactions
Abstract

Background: Accurate estimation of conception is critical in the assessment of the effects of drugs used during pregnancy or to prevent pregnancy. In a novel application, we studied the effectiveness of oral contraceptives (OCs), where misclassification of conception relative to OC exposure may obscure effect estimates.Methods: We studied OC failure, in a large claims database, among women who used antiepileptic drugs with metabolizing enzyme-inducing properties (carbamazepine or oxcarbazepine), which reduce OC's effectiveness or enzyme-neutral properties (lamotrigine or levetiracetam), with no expected impact on OC effectiveness. We compared conception rates in women 12-48 years of age concomitantly using OCs and enzyme-inducing drugs with rates in concomitant users of OCs and enzyme-neutral drugs. We measured conception with a validated algorithm that estimates gestational age based on pregnancy endpoints. We estimated relative and attributable risk using generalized estimating equation models after standardized mortality ratio weighting.Results: We identified 89,777 concomitant use episodes with adjusted contraceptive failure rates of 1.6 (95% confidence interval (CI) = 1.4, 1.8) per 100 person-years among users of enzyme-neutral drugs and 18,964 episodes with a rate of 2.3 (1.9, 2.8) among users of enzyme-inducing drugs. The relative risk of conception for enzyme-inducing group was 1.4 (1.1, 1.8), and the rate difference was 0.7 (0.2, 1.2).Conclusions: OCs in combination with antiepileptic drugs that interact with metabolic enzymes were associated with increased contraceptive failure rates. Measurement of conception in claims data had adequate accuracy to uncover a strong drug-drug interaction, offering promise for broader application in comparative effectiveness studies on hormonal contraceptives to inform clinical and regulatory decisionmaking. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

33. POSSIBILITIES OF INCREASED WATER SUPPLY FROM CLOUD SEEDING.

Author

Squires, Patrick

Abstract

BSTRACT. A review of the development of weather modification to augment precipitation including the cloud-physical foundation is presented. Recent work has tended to re-emphasize the importance of physical understanding of storm systems and of the effects of cloud seeding. The Pyramid Lake Seeding Project is discussed. [ABSTRACT FROM AUTHOR]

Published
1971
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results