1. A Combination of Gamma-Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine, and Cyanocobalamin vs Ginger Extract in the Management of Chronic Motion Sickness: A Clinical Evaluation
- Author
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Carlos P. Nunes, MD, Claudio Rodrigues, MD, Mendel Suchmacher, MD, Claudia Regina Esteves, MD, Karin Gonçalves, PhD, Hélio Rzetelna, MD, Rafael V. Rodrigues, MD, Luciana Regina de Vasconcelos, MD, Spyros G.E. Mezitis, MD, PhD, Heros Rabelo, MSc, Renato Kaufmann, MD, PhD, Fernanda Schwarz, MChem, Henrique Goldberg, (In Memoriam), MD, Aline Sintoveter, MD, and Mauro Geller, MD, PhD
- Subjects
Gamma-aminobutyric acid tartrate and associations ,Ginger ,Motion sickness ,Therapeutics. Pharmacology ,RM1-950 - Abstract
ABSTRACT: Background: Motion sickness (kinetosis) is a common and temporarily incapacitant ailment, manageable with behavioral as well as pharmacological measures. Objective: To assess the effectiveness and safety of a combination of gamma-aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine, and cyanocobalamin (Group A) (n = 170) and extract of Zingiber officinale (ginger) (Group B) (n = 165) in the management of chronic complaints consistent with motion sickness. Methods: Both groups were tested according to the following end points, under self-paired as well as comparative study designs: reduction of ≥20 score points in the total motion sickness assessment questionnaire (MSAQ) score, percentage of patients presenting a reduction of the total MSAQ score, absolute MSAQ score reduction, physician's assessment scores, final overall assessment of study medication, and willingness to continue treatment. Safety was also evaluated. Results: There was a statistically significant better performance under both study designs for Group A (P = 0.05 using different statistical tests) in all end points. Both regimens were safe, with different neurological and gastrointestinal tolerability outcomes. Conclusions: Group A and Group B regimens were effective and safe in the management of chronic complaints consistent with motion sickness and the Group A regimen was more effective than Group B.
- Published
- 2023
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