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15 results on '"Spychalla, Megan"'

1. Outpatient Management of CAR-T and Teclistamab for Patients with Lymphoma and Multiple Myeloma

Author

Bansal, Radhika, primary, Paludo, Jonas, additional, Corraes, Andre De Menezes Silva, additional, Spychalla, Megan, additional, Sandahl, Tyler B., additional, Haugen, Kelsey, additional, Khurana, Arushi, additional, Hampel, Paul, additional, Durani, Urshila, additional, Dingli, David, additional, Hayman, Suzanne R, additional, Kapoor, Prashant, additional, Wang, Yucai, additional, Binder, Moritz, additional, Kenderian, Saad S., additional, Kourelis, Taxiarchis, additional, Kumar, Shaji, additional, Warsame, Rahma, additional, Bennani, Dr. N. Nora, additional, Gertz, Morie, additional, Johnston, Patrick B, additional, Ansell, Stephen, additional, and Lin, Yi, additional

Published
2024
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2. Outpatient Practice Pattern for Recently Approved CAR-T in Patients with Lymphoma and Multiple Myeloma

Author

Bansal, Radhika, primary, Paludo, Jonas, additional, Hathcock, Mr. Matthew, additional, Spychalla, Megan, additional, Khurana, Arushi, additional, Hampel, Paul, additional, Durani, Urshila, additional, Alkhateeb, Hassan B., additional, Dingli, David, additional, Hayman, Suzanne R, additional, Kapoor, Prashant, additional, Wang, Yucai, additional, Kenderian, Saad S., additional, Binder, Moritz, additional, Kourelis, Taxiarchis, additional, Kumar, Shaji, additional, Shah, Mithun V., additional, Warsame, Rahma, additional, Bennani, Dr. N. Nora, additional, Gertz, Morie, additional, Johnston, Patrick B., additional, Ansell, Stephen, additional, Siddiqui, Mustaqeem, additional, and Lin, Yi, additional

Published
2023
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3. Outpatient Practice Pattern for Recently Approved CAR-T in Patients with Lymphoma and Multiple Myeloma

Author

Bansal, Radhika, primary, Paludo, Jonas, additional, Hathcock, Matthew A., additional, Spychalla, Megan T, additional, Khurana, Arushi, additional, Hampel, Paul J., additional, Durani, Urshila, additional, Alkhateeb, Hassan B., additional, Dingli, David, additional, Hayman, Suzanne R., additional, Kapoor, Prashant, additional, Wang, Yucai, additional, Kenderian, Saad S., additional, Binder, Moritz, additional, Kourelis, Taxiarchis, additional, Kumar, Shaji K, additional, Shah, Mithun V., additional, Warsame, Rahma M, additional, Bennani, N. Nora, additional, Gertz, Morie A, additional, Johnston, Patrick B., additional, Ansell, Stephen M., additional, Siddiqui, Mustaqeem A., additional, and Lin, Yi, additional

Published
2022
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4. Metagenomic shotgun sequencing of blood to identify bacteria and viruses in leukemic febrile neutropenia

Author

Vijayvargiya, Prakhar, primary, Feri, Adeline, additional, Mairey, Mathilde, additional, Rouillon, Cécile, additional, Jeraldo, Patricio R., additional, Esquer Garrigos, Zerelda, additional, Thoendel, Matthew J., additional, Greenwood-Quaintance, Kerryl E., additional, Sohail, M. Rizwan, additional, Sampathkumar, Priya, additional, Spychalla, Megan T., additional, Stewart, A. K., additional, Patnaik, Mrinal M., additional, Tande, Aaron J., additional, Cruveiller, Stéphane, additional, Hannet, Irene, additional, Beurdeley, Pascale, additional, and Patel, Robin, additional

Published
2022
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5. Pilot Implementation of Remote Patient Monitoring Program for Outpatient Management of CAR-T Cell Therapy

Author

Paludo, Jonas, primary, Bansal, Radhika, additional, Holland, Adam T, additional, Haugen, Kelsey L, additional, Spychalla, Megan T, additional, McClanahan, Alli L, additional, Truong, Tuan A, additional, Hathcock, Matthew A, additional, Khurana, Arushi, additional, Alkhateeb, Hassan B., additional, Dingli, David, additional, Hayman, Suzanne R., additional, Kapoor, Prashant, additional, Gertz, Morie A., additional, Wang, Yucai, additional, Kenderian, Saad S., additional, Kourelis, Taxiarchis, additional, Kumar, Shaji, additional, Shah, Mithun V., additional, Siddiqui, Mustaqeem A., additional, Warsame, Rahma M, additional, Villasboas, Jose C., additional, Bennani, Nora, additional, Johnston, Patrick B., additional, Ansell, Stephen M., additional, Haddad, Tufia C, additional, and Lin, Yi, additional

Published
2021
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6. Outpatient Management of CAR-T and Teclistamab for Patients with Lymphoma and Multiple Myeloma

Author

Bansal, Radhika, Paludo, Jonas, Corraes, Andre, Spychalla, Megan, Haugen, Kelsey, Khurana, Arushi, Hampel, Paul J., Durani, Urshila, Dingli, David, Hayman, Suzanne R., Kapoor, Prashant, Wang, Yucai, Binder, Moritz, Kenderian, Saad S., Kourelis, Taxiarchis, Kumar, Shaji Kunnathu, Warsame, Rahma M, Bennani, N. Nora, Gertz, Morie A., Johnston, Patrick B, Ansell, Stephen M, and Lin, Yi

Published
2023
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7. Outpatient Practice Pattern and Clinical Outcome for Axicabtagene Ciloleucel in Patients with Aggressive Lymphoma

Author

Bansal, Radhika, primary, Paludo, Jonas, additional, Spychalla, Megan, additional, McClanahan, Alli, additional, Holland, Adam, additional, Truong, Tuan, additional, Hathcock, Matthew, additional, Alkhateeb, Hassan B., additional, Dingli, David, additional, Hayman, Suzanne R, additional, Kapoor, Prashant, additional, Kenderian, Saad S., additional, Kourelis, Taxiarchis, additional, Kumar, Shaji, additional, Shah, Mithun V., additional, Siddiqui, Mustaqeem, additional, Warsame, Rahma, additional, Bisneto, Jose Villasboas, additional, Bennani, Nora N, additional, Johnston, Patrick B, additional, Ansell, Stephen, additional, and Lin, Yi, additional

Published
2021
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8. 47 - Outpatient Practice Pattern for Recently Approved CAR-T in Patients with Lymphoma and Multiple Myeloma

Author

Bansal, Radhika, Paludo, Jonas, Hathcock, Mr. Matthew, Spychalla, Megan, Khurana, Arushi, Hampel, Paul, Durani, Urshila, Alkhateeb, Hassan B., Dingli, David, Hayman, Suzanne R, Kapoor, Prashant, Wang, Yucai, Kenderian, Saad S., Binder, Moritz, Kourelis, Taxiarchis, Kumar, Shaji, Shah, Mithun V., Warsame, Rahma, Bennani, Dr. N. Nora, Gertz, Morie, Johnston, Patrick B., Ansell, Stephen, Siddiqui, Mustaqeem, and Lin, Yi

Published
2023
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9. Outpatient practice pattern and remote patient monitoring for axicabtagene ciloleucel CAR-T therapy in patients with aggressive lymphoma

Author

Siddiqui Mustaqeem, Matthew A. Hathcock, Spychalla Megan, Yi Lin, Jonas Paludo, Saad S. Kenderian, Mithun Vinod Shah, Adam Holland, Stephen M. Ansell, McClanahan Alli, Hassan B. Alkhateeb, Rahma Warsame, Patrick B. Johnston, N. Nora Bennani, Tufia C. Haddad, Yucai Wang, Jose C. Villasboas, Radhika Bansal, Shaji Kumar, and David Dingli

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, Remote patient monitoring, Aggressive lymphoma, medicine.disease, Chimeric antigen receptor, Cytokine release syndrome, Internal medicine, medicine, In patient, Car t cells, business, Early onset
Abstract

7554 Background: Chimeric antigen receptor T-cell therapy (CAR-T) are commonly administered inpatient due to concern for early onset cytokine release syndrome (CRS), especially with axicabtagene ciloleucel (axi-cel). We report Mayo Clinic Rochester experience for hospital-based outpatient (HBO) management of patients (pts) receiving axi-cel and identify opportunities for improvement. HBO is closely integrated with inpatient practice and includes the same specialty trained clinical team. It is the first point of contact 24/7 for pts and triage evaluations. Lymphodepletion chemotherapy and CAR-T infusion is given on HBO followed by daily monitoring till day 8 and thereafter, as clinically needed until admission criteria is met. Methods: We retrospectively analyzed database of pts who received axi-cel between 1/2018 and 1/2021. After 06/2020, remote patient monitoring (RPM) tools were implemented to collect patient-reported neurologic symptoms and vital signs via bluetooth-enabled devices 4 times daily through month 1. Adverse data trends are addressed by the HBO team. Results: Among 72 recipients, 89% received their cells outpatient; 8% remained outpatient for the entire month. CRS and neurotoxicity incidence were comparable to those reported from CIBMTR. Median time to first admission was 2 days (Table). Use of bridging therapy, increased CRP and LDH were associated with early admission (≤3 days). Median time to tocilizumab, steroid, oxygen support, vasopressor was 4 days after admission. Half of HBO visits required intervention such as blood transfusions, IV medications through the first month. Nine pts had enrolled in RPM to date; with 8 having evaluable data. With 4 scheduled entries/day, a median of 1 entry/day was skipped and 2 entries/day were answered incompletely. An average of 57 additional unscheduled entries were generated per pt. Among a median of 373 (range 91-522) readings per pt over the first month, 4% (2%-20%) of the readings generated alerts. An average of 4 alerts were seen within 48 hours prior to admission. Data including additional subjects will be presented at ASCO meeting. Conclusions: We report a feasible outpatient care model for management of axi-cel recipients with safe outcomes. Clinical characteristics associated with more aggressive disease are associated with likelihood of early admission. Early RPM experience suggest use of digital tools could improve monitoring compliance and may predict evolution to symptoms requiring escalation of care.[Table: see text]

Published
2021

10. 230 - Outpatient Practice Pattern and Clinical Outcome for Axicabtagene Ciloleucel in Patients with Aggressive Lymphoma

Author

Bansal, Radhika, Paludo, Jonas, Spychalla, Megan, McClanahan, Alli, Holland, Adam, Truong, Tuan, Hathcock, Matthew, Alkhateeb, Hassan B., Dingli, David, Hayman, Suzanne R, Kapoor, Prashant, Kenderian, Saad S., Kourelis, Taxiarchis, Kumar, Shaji, Shah, Mithun V., Siddiqui, Mustaqeem, Warsame, Rahma, Bisneto, Jose Villasboas, Bennani, Nora N, Johnston, Patrick B, Ansell, Stephen, and Lin, Yi

Published
2021
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12. Healthcare Utilization Outcomes of Outpatient CAR-T Cell Therapy with Remote Patient Monitoring Program

Author

Paludo, Jonas, Bansal, Radhika, Hathcock, Matthew, Pritchett, Joshua C, De Menezes Silva Corraes, Andre, Oyarzabal, Beatriz A, Harmsen, William S, Lunde, Julianne J, Coffey, Jordan D, Haugen, Kelsey L, Spychalla, Megan, Khurana, Arushi, Alkhateeb, Hassan, Dingli, David, Hayman, Suzanne R., Kapoor, Prashant, Gertz, Morie A, Wang, Yucai, Binder, Moritz, Hampel, Paul J., Kenderian, Saad S., Kourelis, Taxiarchis, Kumar, Shaji Kunnathu, Shah, Mithun V, Siddiqui, Mustaqeem A, Warsame, Rahma M, Villasboas, Jose. C., Bennani, N. Nora, Johnston, Patrick B, Ansell, Stephen M, Haddad, Tufia C, and Lin, Yi

Abstract

Introduction

Published
2023
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13. Nurse Practitioners and Physician Assistants: Preparing New Providers for Hospital Medicine at the Mayo Clinic.

Author

Spychalla, Megan T., Heathman, Joanne H., Pearson, Katherine A., Herber, Andrew J., and Newman, James S.

Subjects
*NURSE practitioners, *MEDICAL personnel, *INTERNAL medicine, *CONTINUING medical education, *PHYSICIANS' assistants, *TRAINING
Abstract

Background: Hospital medicine is a growing field with an increasing demand for additional healthcare providers, especially in the face of an aging population. Reductions in resident duty hours, coupled with a continued deficit of medical school graduates to appropriately meet the demand, require an additional workforce to counter the shortage. A major dilemma of incorporating nonphysician providers such as nurse practitioners and physician assistants (NPPAs) into a hospital medicine practice is their varying academic backgrounds and inpatient care experiences. Medical institutions seeking to add NPPAs to their hospital medicine practice need a structured orientation program and ongoing NPPA educational support. Methods: This article outlines an NPPA orientation and training program within the Division of Hospital Internal Medicine (HIM) at the Mayo Clinic in Rochester, MN. Results: In addition to a practical orientation program that other institutions can model and implement, the division of HIM also developed supplemental learning modalities to maintain ongoing NPPA competencies and fill learning gaps, including a formal NPPA hospital medicine continuing medical education (CME) course, an NPPA simulation-based boot camp, and the first hospital-based NPPA grand rounds offering CME credit. Since the NPPA orientation and training program was implemented, NPPAs within the division of HIM have gained a reputation for possessing a strong clinical skill set coupled with a depth of knowledge in hospital medicine. Conclusion: The NPPA-physician model serves as an alternative care practice, and we believe that with the institution of modalities, including a structured orientation program, didactic support, hands-on learning, and professional growth opportunities, NPPAs are capable of fulfilling the gap created by provider shortages and resident duty hour restrictions. Additionally, the use of NPPAs in hospital medicine allows for patient care continuity that is otherwise missing with resident practice models. [ABSTRACT FROM AUTHOR]

Published
2014

14. New Frontiers: The Role of CAR T-Cell Therapy in Multiple Myeloma.

Author

McClanahan A and Spychalla M

Abstract

Multiple myeloma remains the second most common hematologic malignancy, and relapse rates are high, with refractory disease common with each relapse. Chimeric antigen receptor (CAR)-modified T cells are a promising new treatment, and at JADPRO Live Virtual 2021, presenters compared pivotal trials in CAR T-cell therapy for multiple myeloma, discussed how to recognize and manage common toxicities after CAR T-cell infusion, and reviewed pre-CAR-T consultation and post-CAR-T management., Competing Interests: The presenters had no conflicts of interest to disclose., (© 2022 Harborside™.)

Published
2022
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15. Mayo Clinic Hematology Fellowship for Advanced Practice Providers.

Author

Hwa YL, Shelly JL, Zblewski DL, Spychalla MT, Udenberg DM, Cieslak KR, Nowakowski GS, Lacy MQ, and Marshall AL

Abstract

Advanced practice providers (APPs), including nurse practitioners (NPs) and physician assistants (PAs), are part of a growing cancer care workforce. Current hematology-specific education provided by most graduate NP and PA school educations is limited. Mayo Clinic School of Health Sciences launched a hematology-specific fellowship in 2018 to provide APPs with the skills and knowledge required to deliver high-quality specialty care in hematology and blood and marrow transplant (BMT). The fellowship curriculum was developed based on a needs-based assessment study as well as the qualitative reported experiences of current hematology-specific APPs. The curriculum contains didactic in-class education, research opportunities, and mentored clinical rotations in both inpatient and outpatient practice in hematology and BMT. This 12-month fellowship, one of the only postgraduate training programs dedicated to benign and malignant hematology practice, provides structured training for highly qualified graduate APPs interested in developing a rewarding career in hematology., Competing Interests: The authors have no conflicts of interest to disclose., (© 2020 Harborside™.)

Published
2020
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