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2. Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

Author

Taylor, Jacqueline, Uhl, Leonie, Moll, Iris, Hasan, Sana Safatul, Wiedmann, Lena, Morgenstern, Jakob, Giaimo, Benedetto Daniele, Friedrich, Tobias, Alsina-Sanchis, Elisenda, De Angelis Rigotti, Francesca, Mülfarth, Ronja, Kaltenbach, Sarah, Schenk, Darius, Nickel, Felix, Fleming, Thomas, Sprinzak, David, Mogler, Carolin, Korff, Thomas, Billeter, Adrian T., Müller-Stich, Beat P., Berriel Diaz, Mauricio, Borggrefe, Tilman, Herzig, Stephan, Rohm, Maria, Rodriguez-Vita, Juan, and Fischer, Andreas

Published
2023
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4. A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells

Author

Taiber, Shahar, Gozlan, Oren, Cohen, Roie, Andrade, Leonardo R, Gregory, Ellen F, Starr, Daniel A, Moran, Yehu, Hipp, Rebecca, Kelley, Matthew W, Manor, Uri, Sprinzak, David, and Avraham, Karen B

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Neurosciences, Genetics, 1.1 Normal biological development and functioning, Ear, Nesprin, LINC complex, KASH, hair cells, cochlea, Biological sciences, Biomedical and clinical sciences
Abstract

Nuclear positioning is important for the functionality of many cell types and is mediated by interactions of cytoskeletal elements and nucleoskeleton proteins. Nesprin proteins, part of the linker of nucleoskeleton and cytoskeleton (LINC) complex, have been shown to participate in nuclear positioning in multiple cell types. Outer hair cells (OHCs) in the inner ear are specialized sensory epithelial cells that utilize somatic electromotility to amplify auditory signals in the cochlea. Recently, Nesprin-4 (encoded by Syne4) was shown to play a crucial role in nuclear positioning in OHCs. Syne4 deficiency in humans and mice leads to mislocalization of the OHC nuclei and cell death resulting in deafness. However, it is unknown how Nesprin-4 mediates the position of the nucleus, and which other molecular components are involved in this process. Here, we show that the interaction of Nesprin-4 and the microtubule motor kinesin-1 is mediated by a conserved 4 amino-acid motif. Using in vivo AAV gene delivery, we show that this interaction is critical for nuclear positioning and hearing in mice. Nuclear mislocalization and cell death of OHCs coincide with the onset of hearing and electromotility and are solely restricted to outer, but not inner, hair cells. Likewise, the C. elegans functional homolog of Nesprin-4, UNC-83, uses a similar motif to mediate interactions between migrating nuclei and kinesin-1. Overall, our results suggest that OHCs require unique cellular machinery for proper nuclear positioning at the onset of electromotility. This machinery relies on the interaction between Nesprin-4 and kinesin-1 motors supporting a microtubule cargo model for nuclear positioning.

Published
2022

7. Modeling the Notch Response

Author

Binshtok, Udi, Sprinzak, David, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Borggrefe, Tilman, editor, and Giaimo, Benedetto Daniele, editor

Published
2018
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8. Mutual inactivation of Notch and Delta permits a simple mechanism for lateral inhibition patterning

Author

Lakhanpal, Amit, Sprinzak, David, and Elowitz, Michael B.

Subjects
Quantitative Biology - Molecular Networks
Abstract

Lateral inhibition patterns mediated by the Notch-Delta signaling system occur in diverse developmental contexts. These systems are based on an intercellular feedback loop in which Notch activation leads to down-regulation of Delta. However, even in relatively well-characterized systems, the pathway leading from Notch activation to Delta repression often remains elusive. Recent work has shown that cis-interactions between Notch and Delta lead to mutual inactivation of both proteins. Here we show that this type of cis-interaction enables a simpler and more direct mechanism for lateral inhibition feedback than those proposed previously. In this mechanism, Notch signaling directly up-regulates Notch expression, thereby inactivating Delta through the mutual inactivation of Notch and Delta proteins. This mechanism, which we term Simplest Lateral Inhibition by Mutual Inactivation (SLIMI), can implement patterning without requiring any additional genes or regulatory interactions. Moreover, the key interaction of Notch expression in response to Notch signaling has been observed in some systems. Stability analysis and simulation of SLIMI mathematical models show that this lateral inhibition circuit is capable of pattern formation across a broad range of parameter values. These results provide a simple and plausible explanation for lateral inhibition pattern formation during development.

Published
2010

11. Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve

Author

Tessler, Idit, primary, Albuisson, Juliette, additional, Piñeiro-Sabarís, Rebeca, additional, Verstraeten, Aline, additional, Kamber Kaya, Hatem Elif, additional, Siguero-Álvarez, Marcos, additional, Goudot, Guillaume, additional, MacGrogan, Donal, additional, Luyckx, Ilse, additional, Shpitzen, Shoshana, additional, Levin, Galina, additional, Kelman, Guy, additional, Reshef, Noga, additional, Mananet, Hugo, additional, Holdcraft, Jake, additional, Muehlschlegel, Jochen D., additional, Peloso, Gina M., additional, Oppenheim, Olya, additional, Cheng, Charles, additional, Mazzella, Jean-Michael, additional, Andelfinger, Gregor, additional, Mital, Seema, additional, Eriksson, Per, additional, Billon, Clarisse, additional, Heydarpour, Mahyar, additional, Dietz, Harry C., additional, Jeunemaitre, Xavier, additional, Leitersdorf, Eran, additional, Sprinzak, David, additional, Blacklow, Stephen C., additional, Body, Simon C., additional, Carmi, Shai, additional, Loeys, Bart, additional, de la Pompa, José Luis, additional, Gilon, Dan, additional, Messas, Emmanuel, additional, and Durst, Ronen, additional

Published
2023
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13. Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

Author

Porcheri, Cristina, Golan, Ohad, Calero‐Nieto, Fernando J, Thambyrajah, Roshana, Ruiz‐Herguido, Cristina, Wang, Xiaonan, Catto, Francesca, Guillén, Yolanda, Sinha, Roshani, González, Jessica, Kinston, Sarah J, Mariani, Samanta A, Maglitto, Antonio, Vink, Chris S, Dzierzak, Elaine, Charbord, Pierre, Göttgens, Bertie, Espinosa, Lluis, Sprinzak, David, and Bigas, Anna

Published
2020
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21. The GPSM2/LGN GoLoco motifs are essential for hearing

Author

Bhonker, Yoni, Abu-Rayyan, Amal, Ushakov, Kathy, Amir-Zilberstein, Liat, Shivatzki, Shaked, Yizhar-Barnea, Ofer, Elkan-Miller, Tal, Tayeb-Fligelman, Einav, Kim, Sun Myoung, Landau, Meytal, Kanaan, Moien, Chen, Ping, Matsuzaki, Fumio, Sprinzak, David, and Avraham, Karen B.

Published
2016
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30. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

Author

Kuang, Yi, primary, Pyo, Anna, additional, Eafergan, Natanel, additional, Cain, Brittany, additional, Gutzwiller, Lisa M., additional, Axelrod, Ofri, additional, Gagliani, Ellen K., additional, Weirauch, Matthew T., additional, Kopan, Raphael, additional, Kovall, Rhett A., additional, Sprinzak, David, additional, and Gebelein, Brian, additional

Published
2021
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32. Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain

Author

Dray, Nicolas, Mancini, Laure, Binshtok, Udi, Cheysson, Felix, Supatto, Willy, Mahou, Pierre, Bedu, Sébastien, Ortica, Sara, Than-Trong, Emmanuel, Krecsmarik, Monika, Herbert, Sébastien, Masson, Jean-Baptiste, Tinevez, Jean-Yves, Lang, Gabriel, Beaurepaire, Emmanuel, Sprinzak, David, Bally-Cuif, Laure, Neurogénétique du Poisson zébré / Zebrafish Neurogenetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège Doctoral, Sorbonne Université (SU), Tel Aviv University (TAU), Mathématiques et Informatique Appliquées (MIA Paris-Saclay), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Biologie du Développement et Cellules souches - Department of Developmental and Stem Cell Biology, Institut Pasteur [Paris] (IP), Hub d'analyse d'images - Image Analysis Hub (Platform) (IAH), Département de Neuroscience - Department of Neuroscience, Département de Biologie Computationnelle - Department of Computational Biology, Work in the L.B.-C. laboratory was funded by the ANR (Labex Revive), La Ligue Nationale Contre le Cancer, CNRS, Institut Pasteur, DIM ELICIT (with E.B.), and the European Research Council (ERC) (AdG 322936). L.M. was recipient of a Ph.D. student fellowship from Labex Revive and the Fondation pour la Recherche Médicale (FRM). D.S. and U.B. acknowledge the support of the ERC under the EU Horizon 2020 research and innovation program (GA No. 682161). U.B. is the recipient of a fellowship from The Marian Gertner Institute for Medical Nanosystems at Tel Aviv University. Multiphoton equipment in E.B.’s laboratory was partly supported by the ANR (ANR-11-EQPX-0029 Morphoscope2, ANR-10-INSB-04 France BioImaging)., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), ANR-11-EQPX-0029,MORPHOSCOPE 2,Imagerie et reconstruction multiéchelles de la morphogenèse. (Plateforme d'innovation technologique et méthodologique pour l'imagerie in vivo et la reconstruction des dynamiques multiéchelles de la morphogenèse)(2011), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), European Project: 322936,EC:FP7:ERC,ERC-2012-ADG_20120314,SYSTEMATICS(2013), European Project: 682161,ERC-2015-CoG ,MorphoNotch(2016), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Collège doctoral [Sorbonne universités], Tel Aviv University [Tel Aviv], Mathématiques et Informatique Appliquées (MIA-Paris), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], Beaurepaire, Emmanuel, Laboratoires d'excellence - Stem Cells in Regenerative Biology and Medicine - - REVIVE2010 - ANR-10-LABX-0073 - LABX - VALID, Equipements d'excellence - Imagerie et reconstruction multiéchelles de la morphogenèse. (Plateforme d'innovation technologique et méthodologique pour l'imagerie in vivo et la reconstruction des dynamiques multiéchelles de la morphogenèse) - - MORPHOSCOPE 22011 - ANR-11-EQPX-0029 - EQPX - VALID, Développment d'une infrastructure française distribuée coordonnée - - France-BioImaging2010 - ANR-10-INBS-0004 - INBS - VALID, Dynamics and Homeostasis of Germinal Zones in the Adult Vertebrate Brain - SYSTEMATICS - - EC:FP7:ERC2013-09-01 - 2018-08-31 - 322936 - VALID, and Multi-scale analysis of the interplay between cell morphology and cell-cell signaling - MorphoNotch - - ERC-2015-CoG 2016-06-01 - 2021-05-31 - 682161 - VALID

Subjects
Multiphoton microscopy MPM, [SDV]Life Sciences [q-bio], zebrafish, analytical modeling, population behavior, intrinsic niche, spatial statistics, [SDV] Life Sciences [q-bio], pallium, nervous system, Adult neural stem cell, In vivo imaging, quiescence, spatiotemporal homeostasis, reproductive and urinary physiology, Notch signaling
Abstract

International audience; Neural stem cell (NSC) populations persist in the adult vertebrate brain over a lifetime, and their homeostasis is controlled at the population level through unknown mechanisms. Here, we combine dynamic imaging of entire NSC populations in their in vivo niche over several weeks with pharmacological manipulations, mathematical modeling, and spatial statistics and demonstrate that NSCs use spatiotemporally resolved local feedback signals to coordinate their decision to divide in adult zebrafish brains. These involve Notch-mediated short-range inhibition from transient neural progenitors and a dispersion effect from the dividing NSCs themselves exerted with a delay of 9–12 days. Simulations from a stochastic NSC lattice model capturing these interactions demonstrate that these signals are linked by lineage progression and control the spatiotemporal distribution of output neurons. These results highlight how local and temporally delayed interactions occurring between brain germinal cells generate self-propagating dynamics that maintain NSC population homeostasis and coordinate specific spatiotemporal correlations.

Published
2021

34. Cis-interactions between Notch and Delta generate mutually exclusive signalling states

Author

Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Santat, Leah A., Fontes, Michelle E., Anderson, Graham A., Garcia-Ojalvo, Jordi, and Elowitz, Michael B.

Subjects
Cell lines -- Research -- Physiological aspects, Gene expression -- Research -- Physiological aspects, T cells -- Research -- Physiological aspects, Cellular signal transduction -- Research -- Physiological aspects, Cell interaction -- Research -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The Notch-Delta signalling pathway allows communication between neighbouring cells during development (1).It has a critical role in the formation of 'fine-grained' patterns, generating distinct cell fates among groups of initially equivalent neighbouring cells and sharply delineating neighbouring regions in developing tissues (2-5).The Delta ligand has been shown to have two activities: it transactivates Notch in neighbouring cells and cis-inhibits Notch in its own cell. However, it remains unclear how Notch integrates these two activities and how the resulting system facilitates pattern formation. Here we report the development of a quantitative time-lapse microscopy platform for analysing Notch-Delta signalling dynamics in individual mammalian cells, with the aim of addressing these issues. By controlling both cis-and trans-Delta concentrations, and monitoring the dynamics of a Notch reporter, we measured the combined cis--trans input--output relationship in the Notch--Delta system. The data revealed a striking difference between the responses of Notch to trans-and cis-Delta: whereas the response to trans-Delta is graded, the response to cis-Delta is sharp and occurs at a fixed threshold, independent of trans-Delta. We developed a simple mathematical model that shows how these behaviours emerge from the mutual inactivation of Notch and Delta proteins in the same cell. This interaction generates an ultrasensitive switch between mutually exclusive sending (high Delta/low Notch) and receiving (high Notch/low Delta) signalling states. At the multicellular level, this switch can amplify small differences between neighbouring cells even without transcription-mediated feedback. This Notch-Delta signalling switch facilitates the formation of sharp boundaries and lateral-inhibition patterns in models of development, and provides insight into previously unexplained mutant behaviours., Notch and Delta are single-pass transmembrane protein families found in metazoan species. Delta in one cell can bind to, and transactivate, Notch in a neighbouring cell. This interaction results in [...]

Published
2010
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36. Roadmap for the multiscale coupling of biochemical and mechanical signals during development

Author

Lenne, Pierre-François, primary, Munro, Edwin, additional, Heemskerk, Idse, additional, Warmflash, Aryeh, additional, Bocanegra-Moreno, Laura, additional, Kishi, Kasumi, additional, Kicheva, Anna, additional, Long, Yuchen, additional, Fruleux, Antoine, additional, Boudaoud, Arezki, additional, Saunders, Timothy E, additional, Caldarelli, Paolo, additional, Michaut, Arthur, additional, Gros, Jerome, additional, Maroudas-Sacks, Yonit, additional, Keren, Kinneret, additional, Hannezo, Edouard, additional, Gartner, Zev J, additional, Stormo, Benjamin, additional, Gladfelter, Amy, additional, Rodrigues, Alan, additional, Shyer, Amy, additional, Minc, Nicolas, additional, Maître, Jean-Léon, additional, Di Talia, Stefano, additional, Khamaisi, Bassma, additional, Sprinzak, David, additional, and Tlili, Sham, additional

Published
2021
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37. Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

Author

Porcheri, Cristina; https://orcid.org/0000-0002-0057-1757, Golan, Ohad, Calero‐Nieto, Fernando J, Thambyrajah, Roshana, Ruiz‐Herguido, Cristina, Wang, Xiaonan, Catto, Francesca; https://orcid.org/0000-0002-0429-2552, Guillén, Yolanda, Sinha, Roshani, González, Jessica, Kinston, Sarah J, Mariani, Samanta A, Maglitto, Antonio, Vink, Chris S, Dzierzak, Elaine, Charbord, Pierre; https://orcid.org/0000-0002-8400-8581, Göttgens, Bertie; https://orcid.org/0000-0001-6302-5705, Espinosa, Lluis; https://orcid.org/0000-0002-2897-4099, Sprinzak, David; https://orcid.org/0000-0001-6776-6957, Bigas, Anna; https://orcid.org/0000-0003-4801-6899, Porcheri, Cristina; https://orcid.org/0000-0002-0057-1757, Golan, Ohad, Calero‐Nieto, Fernando J, Thambyrajah, Roshana, Ruiz‐Herguido, Cristina, Wang, Xiaonan, Catto, Francesca; https://orcid.org/0000-0002-0429-2552, Guillén, Yolanda, Sinha, Roshani, González, Jessica, Kinston, Sarah J, Mariani, Samanta A, Maglitto, Antonio, Vink, Chris S, Dzierzak, Elaine, Charbord, Pierre; https://orcid.org/0000-0002-8400-8581, Göttgens, Bertie; https://orcid.org/0000-0001-6302-5705, Espinosa, Lluis; https://orcid.org/0000-0002-2897-4099, Sprinzak, David; https://orcid.org/0000-0001-6776-6957, and Bigas, Anna; https://orcid.org/0000-0003-4801-6899

Abstract

Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is known about the molecular characteristics of the developing hematopoietic cells, we lack a complete understanding of their origin and the three-dimensional organization of the niche. Here, we use advanced live imaging techniques of organotypic slice cultures, clonal analysis, and mathematical modeling to show the two-step process of intra-aortic hematopoietic cluster (IACH) formation. First, a hemogenic progenitor buds up from the endothelium and undergoes division forming the monoclonal core of the IAHC. Next, surrounding hemogenic cells are recruited into the IAHC, increasing their size and heterogeneity. We identified the Notch ligand Dll4 as a negative regulator of the recruitment phase of IAHC. Blocking of Dll4 promotes the entrance of new hemogenic Gfi1+ cells into the IAHC and increases the number of cells that acquire HSC activity. Mathematical modeling based on our data provides estimation of the cluster lifetime and the average recruitment time of hemogenic cells to the cluster under physiologic and Dll4-inhibited conditions.

Published
2020

40. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation

Author

Kobia, Francis M., primary, Preusse, Kristina, additional, Dai, Quanhui, additional, Weaver, Nicholas, additional, Hass, Matthew R., additional, Chaturvedi, Praneet, additional, Stein, Sarah J., additional, Pear, Warren S., additional, Yuan, Zhenyu, additional, Kovall, Rhett A., additional, Kuang, Yi, additional, Eafergen, Natanel, additional, Sprinzak, David, additional, Gebelein, Brian, additional, Brunskill, Eric W., additional, and Kopan, Raphael, additional

Published
2020
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42. Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

Author

Dray, Nicolas, primary, Mancini, Laure, additional, Binshtok, Udi, additional, Cheysson, Felix, additional, Supatto, Willy, additional, Mahou, Pierre, additional, Bedu, Sébastien, additional, Ortica, Sara, additional, Krecsmarik, Monika, additional, Herbert, Sébastien, additional, Masson, Jean-Baptiste, additional, Tinevez, Jean-Yves, additional, Lang, Gabriel, additional, Beaurepaire, Emmanuel, additional, Sprinzak, David, additional, and Bally-Cuif, Laure, additional

Published
2020
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43. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

Author

Kuang, Yi, primary, Pyo, Anna, additional, Eafergan, Natanel, additional, Cain, Brittany, additional, Gutzwiller, Lisa M., additional, Axelrod, Ofri, additional, Gagliani, Ellen K., additional, Weirauch, Matthew T., additional, Kopan, Raphael, additional, Kovall, Rhett A., additional, Sprinzak, David, additional, and Gebelein, Brian, additional

Published
2020
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44. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Author

Kuang, Yi, primary, Golan, Ohad, additional, Preusse, Kristina, additional, Cain, Brittany, additional, Christensen, Collin J, additional, Salomone, Joseph, additional, Campbell, Ian, additional, Okwubido-Williams, FearGod V, additional, Hass, Matthew R, additional, Yuan, Zhenyu, additional, Eafergan, Nathanel, additional, Moberg, Kenneth H, additional, Kovall, Rhett A, additional, Kopan, Raphael, additional, Sprinzak, David, additional, and Gebelein, Brian, additional

Published
2020
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45. Author response: Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Author

Kuang, Yi, primary, Golan, Ohad, additional, Preusse, Kristina, additional, Cain, Brittany, additional, Christensen, Collin J, additional, Salomone, Joseph, additional, Campbell, Ian, additional, Okwubido-Williams, FearGod V, additional, Hass, Matthew R, additional, Yuan, Zhenyu, additional, Eafergan, Nathanel, additional, Moberg, Kenneth H, additional, Kovall, Rhett A, additional, Kopan, Raphael, additional, Sprinzak, David, additional, and Gebelein, Brian, additional

Published
2020
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46. Exposure to Mites Sensitizes Intestinal Stem Cell Maintenance, Splenic Marginal Zone B Cell Homeostasis, And Heart Development to Notch Dosage and Cooperativity

Author

Kobia, Francis M., primary, Preusse, Kristina, additional, Dai, Quanhui, additional, Weaver, Nicholas, additional, Chaturvedi, Praneet, additional, Stein, Sarah J., additional, Pear, Warren S., additional, Yuan, Zhenyu, additional, Kovall, Rhett A., additional, Kuang, Yi, additional, Eafergen, Natanel, additional, Sprinzak, David, additional, Gebelein, Brian, additional, Brunskill, Eric, additional, and Kopan, Raphael, additional

Published
2020
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47. Notch ligand Dll4 impairs cell recruitment into aortic clusters and limits hematopoietic stem cells

Author

Porcheri, Cristina, primary, Golan, Ohad, additional, Calero-Nieto, Fernando J., additional, Thambyrajah, Roshana, additional, Ruiz-Herguido, Cristina, additional, Wang, Xiaonan, additional, Catto, Francesca, additional, Guillen, Yolanda, additional, Sinha, Roshani, additional, González, Jessica, additional, Kinston, Sarah J., additional, Mariani, Samanta A., additional, Maglitto, Antonio, additional, Vink, Chris, additional, Dzierzak, Elaine, additional, Charbord, Pierre, additional, Göttgens, Bertie, additional, Espinosa, Lluis, additional, Sprinzak, David, additional, and Bigas, Anna, additional

Published
2019
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