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8,083 results on '"Spreafico A"'

1. Combinatorial Approach on the Recurrence Sequences: An Evolutionary Historical Discussion about Numerical Sequences and the Notion of the Board

Author

Francisco Regis Vieira Alves, Paula Maria Machado Cruz Catarino, Renata Passos Machado Vieira, and Elen Viviani Pereira Spreafico

Abstract

The tradition of studies involving the combinatorial approach to recurring numerical sequences has accumulated a few decades of tradition, and several problems continue to attract the interest of mathematicians in several countries. This work specifically discusses the Fibonacci, Pell, and Jacobsthal sequences, focusing on Mersenne sequences. The often-used definition of board involves considering how to fill a specific regular surface--the board--with a limited quantity of regularly shaped tiles. On the other hand, an analogous problem can be generalized and exemplifies current research developments. Finally, the examples covered constitute unexpected ways of exploring visualization and other skills in mathematics teachers' learning, consequently inspiring them for their teaching context.

Published
2024

2. Measurement of the nucleon spin structure functions for $0.01<Q^2<1$~GeV$^2$ using CLAS

Author

Deur, A., Kuhn, S. E., Ripani, M., Zheng, X., Acar, A. G., Achenbach, P., Adhikari, K. P., Alvarado, J. S., Amaryan, M. J., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Booth, W. A., ossu, F. B, Bosted, P., Boiarinov, S., Brinkmann, K. Th., Briscoe, W. J., Bueltmann, S., Burkert, V. D., Carman, D. S., Chatagnon, P., Chen, J. P., Ciullo, G., Cole, P. L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Diehl, S., Djalali, C., Drozdov, V. A., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Eugenio, P., Faggert, J. C., Fegan, S., Fersch, R., Filippi, A., Gates, K., Gavalian, G., Gilfoyle, G. P., Gothe, R. W., Guo, L., Hakobyan, H., Hattawy, M., Hauenstein, F., Heddle, D., Hobart, A., Holtrop, M., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joosten, S., Kang, H., Keith, C., Khandaker, M., Kim, W., Klein, F. J., Klimenko, V., Konczykowski, P., Kovacs, K., Kripko, A., Kubarovsky, V., Lanza, L., Lee, S., Lenisa, P., Li, X., Long, E., MacGregor, I. J. D., Marchand, D., Mascagna, V., Matamoros, D., McKinnon, B., Meekins, D., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munoz-Camacho, C., Nadel-Turonski, P., Nagorna, T., Neupane, K., Niccolai, S., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Phillips, S. K., Pierce, J., Pilleux, N., Pokhrel, M., Price, J. W., Prok, Y., Radic, A., Reed, T., Richards, J., Rosner, G., Rossi, P., Rusova, A. A., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sirca, S., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Sulkosky, V., Tan, J. A., Tenorio, M., Trotta, N., Tyson, R., Ungaro, M., Upton, D. W., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wood, M. H., Zachariou, N., Zhang, J., and Zurek, M.

Subjects
Nuclear Experiment
Abstract

The spin structure functions of the proton and the deuteron were measured during the EG4 experiment at Jefferson Lab in 2006. Data were collected for longitudinally polarized electron scattering off longitudinally polarized NH$_3$ and ND$_3$ targets, for $Q^2$ values as small as 0.012 and 0.02 GeV$^2$, respectively, using the CEBAF Large Acceptance Spectrometer (CLAS). This is the archival paper of the EG4 experiment that summaries the previously reported results of the polarized structure functions $g_1$, $A_1F_1$, and their moments $\overline \Gamma_1$, $\overline \gamma_0$, and $\overline I_{TT}$, for both the proton and the deuteron. In addition, we report on new results on the neutron $g_1$ extracted by combining proton and deuteron data and correcting for Fermi smearing, and on the neutron moments $\overline \Gamma_1$, $\overline \gamma_0$, and $\overline I_{TT}$ formed directly from those of the proton and the deuteron. Our data are in good agreement with the Gerasimov-Drell-Hearn sum rule for the proton, deuteron, and neutron. Furthermore, the isovector combination was formed for $g_1$ and the Bjorken integral $\overline \Gamma_1^{p-n}$, and compared to available theoretical predictions. All of our results provide for the first time extensive tests of spin observable predictions from chiral effective field theory ($\chi$EFT) in a $Q^2$ range commensurate with the pion mass. They motivate further improvement in $\chi$EFT calculations from other approaches such as the lattice gauge method., Comment: 33 pages. 26 figures. Data table provided in supplementary material (30 pages)

Published
2024

3. State of the Art on the Leonardo Sequence: An Evolutionary Study of the Epistemic-Mathematical Field

Author

Milena Carolina dos Santos Mangueira, Francisco Regis Vieira Alves, Paula Maria Machado Cruz Catarino, and Elen Viviani Pereira Spreafico

Abstract

This work is a segment of an ongoing doctoral research in Brazil. The Leonardo numbers and the Leonardo sequence have gained attention from mathematicians and the academic community. Despite being a relatively new sequence within mathematical literature, its discussion has intensified over the past five years, giving rise to other branches, with contributions and associations to other topics in mathematics. Thus, the aim of this study was to construct and present the state of the art of the Leonardo sequence, considering its historical aspects and highlighting works on its evolutionary process in the epistemic-mathematical field, regarding its generalization, complexification, hyper complexification, and combinatorial model during the last five years (2019-2023). The methodology used was a bibliographic study, where the state of the art was carried out through the mapping of publications on the subject. Twenty-four research works related to the key descriptors "Leonardo sequence", "Leonardo numbers", "complexification", "generalization", "hybrids", and "combinatorial model" were found, cataloged, and discussed. From the analysis of these studies, it is noted that its development in pure mathematics has advanced to other branches and discoveries, and that, albeit timidly, research on the subject has emerged directed towards the field of education, especially in the initial teacher training and, particularly, in Brazil.

Published
2024

4. First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron

Author

CLAS Collaboration, Hobart, A., Niccolai, S., Čuić, M., Kumerički, K., Achenbach, P., Alvarado, J. S., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Boiarinov, S., Bondi, M., Booth, W. A., Bossù, F., Brinkmann, K. -Th., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Cao, T., Capobianco, R., Carman, D. S., Chatagnon, P., Ciullo, G., Cole, P. L., Contalbrigo, M., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Fogler, C., Gates, K., Gavalian, G., Gilfoyle, G. P., Glazier, D., Gothe, R. W., Gotra, Y., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Heddle, D., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joo, K., Kageya, T., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I. J. D., Marchand, D., Mascagna, V., Maynes, M., McKinnon, B., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Muñoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Rafael, S. Polcher, Poudel, J., Price, J. W., Prok, Y., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Golubenko, A. A., Salgado, C., Schadmand, S., Schmidt, A., Scott, Marshall B. C., Seroka, E. M., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Tommaso, V., Voskanyan, H., Voutier, E., Watts, D. P, Wei, X., Williams, R., Wood, M. H., Xu, L., Zachariou, N., Zhang, J., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Measuring Deeply Virtual Compton Scattering on the neutron is one of the necessary steps to understand the structure of the nucleon in terms of Generalized Parton Distributions (GPDs). Neutron targets play a complementary role to transversely polarized proton targets in the determination of the GPD $E$. This poorly known and poorly constrained GPD is essential to obtain the contribution of the quarks' angular momentum to the spin of the nucleon. DVCS on the neutron was measured for the first time selecting the exclusive final state by detecting the neutron, using the Jefferson Lab longitudinally polarized electron beam, with energies up to 10.6 GeV, and the CLAS12 detector. The extracted beam-spin asymmetries, combined with DVCS observables measured on the proton, allow a clean quark-flavor separation of the imaginary parts of the GPDs $H$ and $E$., Comment: 7 pages, 6 figures

Published
2024

5. Positivity violations in marginal structural survival models with time-dependent confounding: a simulation study on IPTW-estimator performance

Author

Spreafico, Marta

Subjects
Statistics - Methodology
Abstract

In longitudinal observational studies, marginal structural models (MSMs) are a class of causal models used to analyze the effect of an exposure on the (survival) outcome of interest while accounting for exposure-affected time-dependent confounding. In the applied literature, inverse probability of treatment weighting (IPTW) has been widely adopted to estimate MSMs. An essential assumption for IPTW-based MSMs is the positivity assumption, which ensures that each individual in the population has a non-zero probability of receiving each exposure level within confounder strata. Positivity, along with consistency, conditional exchangeability, and correct specification of the weighting model, is crucial for valid causal inference through IPTW-based MSMs but is often overlooked compared to confounding bias. Positivity violations can arise from subjects having a zero probability of being exposed/unexposed (strict violations) or near-zero probabilities due to sampling variability (near violations). This article discusses the effect of violations in the positivity assumption on the estimates from IPTW-based MSMs. Building on the algorithms for simulating longitudinal survival data from MSMs by Havercroft and Didelez (2012) and Keogh et al. (2021), systematic simulations under strict/near positivity violations are performed. Various scenarios are explored by varying (i) the size of the confounder interval in which positivity violations arise, (ii) the sample size, (iii) the weight truncation strategy, and (iv) the subject's propensity to follow the protocol violation rule. This study underscores the importance of assessing positivity violations in IPTW-based MSMs to ensure robust and reliable causal inference in survival analyses.

Published
2024

7. Prospective manipulation of the gut microbiome with microbial ecosystem therapeutic 4 (MET4) in HPV-related locoregionally-advanced oropharyngeal cancer squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation: ROMA2 study

Author

Oliva, Marc, Heirali, Alya, Watson, Geoffrey, Rooney, Ashley M., Cochrane, Kyla, Jennings, Sarah, Taylor, Rachel, Xu, Minge, Hosni, Ali, Hope, Andrew, Bratman, Scott V., Chepeha, Douglas, Weinreb, Ilan, Perez-Ordonez, Bayardo, Nin, Ricard Mesia, Waldron, John, Xu, Wei, Hansen, Aaron R., Siu, Lillian L., Coburn, Bryan, and Spreafico, Anna

Published
2024
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8. Secondary beams at high-intensity electron accelerator facilities

Author

Battaglieri, Marco, Bianconi, Andrea, Bondí, Mariangela, De Vita, Raffaella, Fulci, Antonino, Gosta, Giulia, Grazzi, Stefano, Jo, Hyon-Suk, Lee, Changhui, Mandaglio, Giuseppe, Mascagna, Valerio, Nagorna, Tetiana, Pilloni, Alessandro, Spreafico, Marco, Tagliapietra, Luca J, Venturelli, Luca, and Vittorini, Tommaso

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The interaction of a high-current $O$(100~\textmu A), medium energy $O$(10\,GeV) electron beam with a thick target $O$(1m) produces an overwhelming shower of standard matter particles in addition to hypothetical Light Dark Matter particles. While most of the radiation (gamma, electron/positron, and neutron) is contained in the thick target, deep penetrating particles (muons, neutrinos, and light dark matter particles) propagate over a long distance, producing high-intense secondary beams. Using sophisticated Monte Carlo simulations based on FLUKA and GEANT4, we explored the characteristics of secondary muons and neutrinos and (hypothetical) dark scalar particles produced by the interaction of Jefferson Lab 11 GeV intense electron beam with the experimental Hall-A beam dump. Considering the possible beam energy upgrade, this study was repeated for a 20 GeV CEBAF beam.

Published
2023
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9. Joint modelling of recurrent and terminal events with discretely-distributed non-parametric frailty: application on re-hospitalizations and death in heart failure patients

Author

Masci, Chiara, Spreafico, Marta, and Ieva, Francesca

Subjects
Statistics - Methodology
Abstract

In the context of clinical and biomedical studies, joint frailty models have been developed to study the joint temporal evolution of recurrent and terminal events, capturing both the heterogeneous susceptibility to experiencing a new episode and the dependence between the two processes. While discretely-distributed frailty is usually more exploitable by clinicians and healthcare providers, existing literature on joint frailty models predominantly assumes continuous distributions for the random effects. In this article, we present a novel joint frailty model that assumes bivariate discretely-distributed non-parametric frailties, with an unknown finite number of mass points. This approach facilitates the identification of latent structures among subjects, grouping them into sub-populations defined by a shared frailty value. We propose an estimation routine via Expectation-Maximization algorithm, which not only estimates the number of subgroups but also serves as an unsupervised classification tool. This work is motivated by a study of patients with Heart Failure (HF) receiving ACE inhibitors treatment in the Lombardia region of Italy. Recurrent events of interest are hospitalizations due to HF and terminal event is death for any cause.

Published
2023

10. Beam Charge Asymmetries for Deeply Virtual Compton Scattering on the Proton at CLAS12

Author

Voutier, E., Burkert, V., Niccolai, S., Paremuzyan, R., Afanasev, A., Alvarado-Galeano, J. -S., Atoui, M., Barion, L., Battaglieri, M., Bernauer, J., Bianconi, A., Bondi, M., Briscoe, W., Camsonne, A., Capobianco, R., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Cole, P., Contalbrigo, M., Costantini, G., Defurne, M., Deur, A., De Vita, R., Diehl, S., Dupré, R., Elouadrhiri, L., Fernando, I., Filippi, A., Forest, T., Girod, F. -X., Gosta, G., Grames, J., Gueye, P., Habet, S., Hattawy, M., Higinbotham, D., Hobart, A., Hyde, C., Joo, K., Kim, A., Klimenko, V., Kubarovsky, V., Leali, M., Lenisa, P., Marchand, D., Marsicano, L., Mascagna, V., Matamoros, D., McCaughan, M., McKinnon, B., Migliorati, S., Mitra, H. S., Movsisyan, A., Muñoz-Camacho, C., Osipenko, M., Ouillon, M., Pappalardo, L., Pasquini, B., Pasyuk, E., Pilleux, N., Poelker, M., Raue, B., Ripani, M., Santos, R., Schmidt, A., Singh, R., Sokhan, D., Spreafico, M., Stoler, P., Strakovsky, I., Taiuti, M., Venturelli, L., Wang, P. -K., Wei, X., Zhao, Z., Collaboration, the CLAS, and Group, the Jefferson Lab Positron Working

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The parameterization of the nucleon structure through Generalized Parton Distributions (GPDs) shed a new light on the nucleon internal dynamics. For its direct interpretation, Deeply Virtual Compton Scattering (DVCS) is the golden channel for GPDs investigation. The DVCS process interferes with the Bethe-Heitler (BH) mechanism to constitute the leading order amplitude of the $eN \to eN\gamma$ process. The study of the $ep\gamma$ reaction with polarized positron and electron beams gives a complete set of unique observables to unravel the different contributions to the $ep \gamma$ cross section. This separates the different reaction amplitudes, providing a direct access to their real and imaginary parts which procures crucial constraints on the model dependences and associated systematic uncertainties on GPDs extraction. The real part of the BH-DVCS interference amplitude is particularly sensitive to the $D$-term which parameterizes the Gravitational Form Factors of the nucleon. The separation of the imaginary parts of the interference and DVCS amplitudes provides insights on possible higher-twist effects. We propose to measure the unpolarized and polarized Beam Charge Asymmetries (BCAs) of the $\vec{e}^{\pm}p \to e^{\pm}p \gamma$ process on an unpolarized hydrogen target with {\tt CLAS12}, using polarized positron and electron beams at 10.6 GeV. The azimuthal and $t$-dependences of the unpolarized and polarized BCAs will be measured over a large $(x_B,Q^2)$ phase space using a 100 day run with a luminosity of 0.66$\times 10^{35}$cm$^{-2}\cdot$s$^{-1}$., Comment: Proposal to the Jefferson Lab Program Advisory Committee (PAC51)

Published
2023

11. Strong interaction physics at the luminosity frontier with 22 GeV electrons at Jefferson Lab

Author

Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avakian, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F., Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J., Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M., Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, L., Chatagnon, P., Chen, C., Chen, J.-P., Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z.-F., D’Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., de Paula, W., de Téramond, G. F., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J., Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K., Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G.-P., Girod, F.-X., Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F.-K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J.-O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Hiller Blin, A. N., Hobart, A., Hobbs, T., Holmberg, D. E., Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G., Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, D. J., Jeschonnek, S., Ji, C.-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D., Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H.-W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L., Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z.-E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, A., Mkrtchyan, H., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A., Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B., Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J.-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S.-X., Qiu, J.-W., Radici, M., Rashidi, H., Rathnayake, A. D., Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J.-M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M., Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C., Seay, D. A., Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S., Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A.-S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X.-B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S.-S., Ye, Z., Yero, C., Yuan, C.-P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Y., Zhao, Z. W., Zheng, X., Zhou, X., Ziegler, V., and Zihlmann, B.

Published
2024
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12. A Review of Existing Sources for the Design of an Archaeological Underwater Cultural Heritage Database of Puglia Region (Italy)

Author

A. Spreafico, E. Colucci, F. Chiabrando, and R. Auriemma

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Underwater cultural heritage (UCH) in Italy is under-documented despite its significance. Creating a comprehensive UCH database is essential but faces challenges, such as complex documentation processes, data interoperability, and international standard adherence. This paper examines data models, standards, and the use of webGIS and databases for underwater cultural heritage documentation in Italy and globally. International documents like the 1996 ICOMOS Charter and the 2001 UNESCO Convention emphasize in-situ preservation. However, documentation efforts remain scattered, lacking a unified database. GIS technologies are vital for managing and analyzing UCH data but are underutilized for public access and tourism. Projects like Andar per Mare and Archim3des in the Puglia region aim to promote underwater cultural heritage using webGIS platforms. However, existing sources like CartaPulia face limitations, including a lack of standardization, specialized fields for underwater cultural heritage characteristics, and language barriers. The proposed solution involves creating a new data model based on standards, resulting in a bilingual geodatabase. This geodatabase will support scientific and tourism-focused webGIS applications, enhancing accessibility and promoting Italy's underwater cultural heritage. A unified database will prevent duplication, facilitate discoveries, and promote Italy's cultural heritage.

Published
2024
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13. Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

Author

Abhinav Thakral, John JW. Lee, Tianzhichao Hou, Katrina Hueniken, Tom Dudding, Mark Gormley, Shama Virani, Andrew Olshan, Brenda Diergaarde, Andrew R. Ness, Tim Waterboer, Karl Smith-Byrne, Paul Brennan, D. Neil Hayes, Eleanor Sanderson, M. Catherine Brown, Sophie Huang, Scott V. Bratman, Anna Spreafico, John De Almeida, Joel C. Davies, Laura Bierut, Gary J. Macfarlane, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Antonio Agudo, Laia Alemany, Wolfgang Ahrens, Claire M. Healy, David I. Conway, Mari Nygard, Cristina Canova, Ivana Holcatova, Lorenzo Richiardi, Ariana Znaor, David P. Goldstein, Rayjean J. Hung, Wei Xu, Geoffrey Liu, and Osvaldo Espin-Garcia

Subjects
Science
Abstract

Abstract HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI:1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI:1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI:3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI:1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.

Published
2024
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14. Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma

Author

Spreafico, Marta, Ieva, Francesca, and Fiocco, Marta

Subjects
Statistics - Applications
Abstract

This study aims to analyse the effects of reducing Received Dose Intensity (RDI) in chemotherapy treatment for osteosarcoma patients on their survival by using a novel approach. In this scenario, toxic side effects are risk factors for mortality and predictors of future exposure levels, introducing post-assignment confounding. Chemotherapy administration data from BO03 and BO06 Randomized Clinical Trials (RCTs) in ostosarcoma are employed to emulate a target trial with three RDI-based exposure strategies: 1) standard, 2) reduced, and 3) highly-reduced RDI. Investigations are conducted between subgroups of patients characterised by poor or good Histological Responses (HRe). Inverse Probability of Treatment Weighting (IPTW) is first used to transform the original population into a pseudo-population which mimics the target randomized cohort. Then, a Marginal Structural Cox Model with effect modification is employed. Conditional Average Treatment Effects (CATEs) are ultimately measured as the difference between the Restricted Mean Survival Time of reduced/highly-reduced RDI strategy and the standard one. Confidence Intervals for CATEs are obtained using a novel IPTW-based bootstrap procedure. Significant effect modifications based on HRe were found. Increasing RDI-reductions led to contrasting trends for poor and good responders: the higher the reduction, the better (worsen) was the survival in poor (good) reponders. This study introduces a novel approach to (i) comprehensively address the challenges related to the analysis of chemotherapy data, (ii) mitigate the toxicity-treatment-adjustment bias, and (iii) repurpose existing RCT data for retrospective analyses extending beyond the original trials' intended scopes.

Published
2023

15. Beam Spin Asymmetry Measurements of Deeply Virtual $\pi^0$ Production with CLAS12

Author

Kim, A., Diehl, S., Joo, K., Kubarovsky, V., Achenbach, P., Akbar, Z., Alvarado, J. S., Armstrong, Whitney R., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Barion, L., Battaglieri, M., Bedlinskiy, I., Benkel, B., Bianconi, A., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Brinkmann, K. T., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clary, B., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., DeVita, R., Defurne, M., Deur, A., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., ElAlaoui, A., ElFassi, L., Fegan, S., Filippi, A., Fogler, C., Gavalian, G., Gilfoyle, G. P., Gosta, G., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Hung, Yu-Chun, Ilieva, Y., Ireland, D. G., Isupov, E., Jo, H. S., Johnston, R., Joosten, S., Khachatryan, M., Khanal, A., Kim, W., Klimenko, V., Kripko, A., Kuhn, S. E., Lanza, L., Leali, M., Kabir, M. L., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., McKinnon, B., Matamoros, D., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., MunozCamacho, C., Naidoo, P., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Reed, Trevor, Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhang, J., Ziegler, V., and Zurek, M.

Subjects
Nuclear Experiment
Abstract

The new experimental measurements of beam spin asymmetry were performed for the deeply virtual exclusive $\pi^0$ production in a wide kinematic region with the photon virtualities $Q^2$ up to 8 GeV$^2$ and the Bjorken scaling variable $x_B$ in the valence regime. The data were collected by the CEBAF Large Acceptance Spectrometer (CLAS12) at Jefferson Lab with longitudinally polarized 10.6 GeV electrons scattered on an unpolarized liquid-hydrogen target. Sizable asymmetry values indicate a substantial contribution from transverse virtual photon amplitudes to the polarized structure functions.The interpretation of these measurements in terms of the Generalized Parton Distributions (GPDs) demonstrates their sensitivity to the chiral-odd GPD $\bar E_T$, which contains information on quark transverse spin densities in unpolarized and polarized nucleons and provides access to the proton's transverse anomalous magnetic moment. Additionally, the data were compared to a theoretical model based on a Regge formalism that was extended to the high photon virtualities., Comment: arXiv admin note: substantial text overlap with arXiv:2210.14557

Published
2023

16. Strong Interaction Physics at the Luminosity Frontier with 22 GeV Electrons at Jefferson Lab

Author

Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avagyan, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F, Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J, Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M, Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, Lei, Chatagnon, P., Chen, C., Chen, J-P, Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z. -F., D'Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J, Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K, Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G. -P., Girod, F-X, Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F. -K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J. -O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Blin, A. N. Hiller, Hobart, A., Hobbs, T., Holmberg, D. E, Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G, Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, DJ, Jeschonnek, S., Ji, C-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D, Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H. -W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L, Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, H., Mkrtchyan, A., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A, Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B, Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S. -X., Qiu, J. -W., Radici, M., Rashidi, H., Rathnayake, A. D, Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J. -M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M, Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C, Seay, D. A, Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S, Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P, Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. -S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X. -B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S. -S., Ye, Z., Yero, C., Yuan, C. -P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Z. W., Zhao, Y., Zheng, X., Zhou, X., Ziegler, V., Zihlmann, B., de Paula, W, and de Téramond, G. F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

This document presents the initial scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab (JLab) to 22 GeV. It is the result of a community effort, incorporating insights from a series of workshops conducted between March 2022 and April 2023. With a track record of over 25 years in delivering the world's most intense and precise multi-GeV electron beams, CEBAF's potential for a higher energy upgrade presents a unique opportunity for an innovative nuclear physics program, which seamlessly integrates a rich historical background with a promising future. The proposed physics program encompass a diverse range of investigations centered around the nonperturbative dynamics inherent in hadron structure and the exploration of strongly interacting systems. It builds upon the exceptional capabilities of CEBAF in high-luminosity operations, the availability of existing or planned Hall equipment, and recent advancements in accelerator technology. The proposed program cover various scientific topics, including Hadron Spectroscopy, Partonic Structure and Spin, Hadronization and Transverse Momentum, Spatial Structure, Mechanical Properties, Form Factors and Emergent Hadron Mass, Hadron-Quark Transition, and Nuclear Dynamics at Extreme Conditions, as well as QCD Confinement and Fundamental Symmetries. Each topic highlights the key measurements achievable at a 22 GeV CEBAF accelerator. Furthermore, this document outlines the significant physics outcomes and unique aspects of these programs that distinguish them from other existing or planned facilities. In summary, this document provides an exciting rationale for the energy upgrade of CEBAF to 22 GeV, outlining the transformative scientific potential that lies within reach, and the remarkable opportunities it offers for advancing our understanding of hadron physics and related fundamental phenomena., Comment: Updates to the list of authors; Preprint number changed from theory to experiment; Updates to sections 4 and 6, including additional figures

Published
2023

18. Prospective life cycle assessment to support eco-design of solid oxide fuel cells

Author

Christian Spreafico

Subjects
Prospective LCA, solid oxide fuel cell (SOFC), patents, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Solid oxide fuel cells (SOFCs) could have great application potential and technological development. However, there are no studies that have quantitatively and rigorously estimated the environmental impacts in the future scenario. This study fills this gap through an innovative approach consisting of patent-based technological forecasting and prospective life cycle assessment (LCA). The analysis of the 58 selected patents reveals that future SOFCs could have (on average) +53% specific power which could lead to a 56% mass reduction compared to current SOFC. The prospective LCA shows an average global warming potential (GWP) reduction of 50%. The future tubular layout is more sustainable than planar one by about 15%. GWP decreases with increasing specific power and in cells with smaller sizes and thicknesses. Finally, the ductile future SOFCs, dedicated to mobile applications and dynamic loads, have a GWP greater than future stationary SOFCs, but still equal to half of the current SOFCs. All these results therefore confirm the potential of the patented SOFC developments on environmental sustainability, arguing in favour of their industrial development and a more massive application in the future.

Published
2024
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19. Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

Author

Thakral, Abhinav, Lee, John JW., Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John, Davies, Joel C., Bierut, Laura, Macfarlane, Gary J., Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Agudo, Antonio, Alemany, Laia, Ahrens, Wolfgang, Healy, Claire M., Conway, David I., Nygard, Mari, Canova, Cristina, Holcatova, Ivana, Richiardi, Lorenzo, Znaor, Ariana, Goldstein, David P., Hung, Rayjean J., Xu, Wei, Liu, Geoffrey, and Espin-Garcia, Osvaldo

Published
2024
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21. Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study

Author

van der Beek, Justine N., Schenk, Jens-Peter, Morosi, Carlo, Watson, Tom A., Coma, Ana, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L., Spreafico, Filippo, Welter, Nils, Dzhuma, Kristina, van Tinteren, Harm, de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., and Littooij, Annemieke S.

Published
2024
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22. Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck

Author

Sanz-Garcia, Enrique, Zou, Jinfeng, Avery, Lisa, Spreafico, Anna, Waldron, John, Goldstein, David, Hansen, Aaron, Cho, B. C. John, de Almeida, John, Hope, Andrew, Hosni, Ali, Hahn, Ezra, Perez-Ordonez, Bayardo, Zhao, Zhen, Smith, Christopher, Zheng, Yangqiao, Singaravelan, Nitthusha, Bratman, Scott V., and Siu, Lillian L.

Published
2024
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24. Hodge de Rham theory and analytic torsion for spaces with horn type singularities

Author

Spreafico, Mauro

Subjects
Mathematics - Functional Analysis
Abstract

We study the global analytic properties of a space $X$ with a horn type singularity. In particular, we introduce some de Rham complex of square integrable forms and we describe its homology and the spectral properties of the associated Hodge Laplace operator. All this is applied to produce a suitable description of the analytic torsion of $X$ and to prove an extension of the Cheeger M\"{u}ller theorem.

Published
2023

25. Localised analytic torsion and relative analytic torsion for non compact Lie groups of type I

Author

Della Vedova, A. and Spreafico, M.

Subjects
Mathematics - Functional Analysis, Mathematics - Differential Geometry, Mathematics - Representation Theory
Abstract

Let $G$ be a (non compact) connected simply connected locally compact second countable Lie group, either abelian or unimodular of type I, and $\rho$ an irreducible unitary representation of $G$. Then, we define the analytic torsion of $G$ localised at the representation $\rho$. Next, let $\Gamma$ a discrete cocompact subgroup of $G$. We use the localised analytic torsion to define the relative analytic torsion of the pair $(G,\Gamma)$, and we prove that it coincides with the Lott $L^2$ analytic torsion of a covering space. We illustrate these constructions analysing in some details two examples: the abelian case, and the case $G=H$, the Heisenberg group.

Published
2023

26. First measurement of hard exclusive $\pi^- \Delta^{++}$ electroproduction beam-spin asymmetries off the proton

Author

Diehl, S., Trotta, N., Joo, K., Achenbach, P., Akbar, Z., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bossu, F., Brinkmann, K. -T., Briscoe, W. J., Bulumulla, D., Burkert, V., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Djalali, C., Dupre, R., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gavalian, G., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Illari, I., Ireland, D. G., Isupov, E. L., Jo, H. S., Johnston, R., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., Camacho, C. Munoz, Naidoo, P., Neupane, K., Niccolai, S., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatie, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I., Strauch, S., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment
Abstract

The polarized cross section ratio $\sigma_{LT'}/\sigma_{0}$ from hard exclusive $\pi^{-} \Delta^{++}$ electroproduction off an unpolarized hydrogen target has been extracted based on beam-spin asymmetry measurements using a 10.2 GeV / 10.6 GeV incident electron beam and the CLAS12 spectrometer at Jefferson Lab. The study, which provides the first observation of this channel in the deep-inelastic regime, focuses on very forward-pion kinematics in the valence regime, and photon virtualities ranging from 1.5 GeV$^{2}$ up to 7 GeV$^{2}$. The reaction provides a novel access to the $d$-quark content of the nucleon and to $p \rightarrow \Delta^{++}$ transition generalized parton distributions. A comparison to existing results for hard exclusive $\pi^{+} n$ and $\pi^{0} p$ electroproduction is provided, which shows a clear impact of the excitation mechanism, encoded in transition generalized parton distributions, on the asymmetry.

Published
2023
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27. Baseline biomarkers of efficacy and on-treatment immune-profile changes associated with bempegaldesleukin plus nivolumab

Author

Helen Gogas, Shruthi Ravimohan, Antara Datta, Aparna Chhibber, Eva Muñoz Couselo, Adi Diab, Caio Pereira, Gaëlle Quéreux, Shahneen Sandhu, Brendan Curti, Nikhil I. Khushalani, Matthew H. Taylor, Gregory A. Daniels, Anna Spreafico, Tarek Meniawy, Alfons J. M. Van Den Eertwegh, Yongliang Sun, Yull Arriaga, Ming Zhou, Georgina V. Long, and Céleste Lebbé

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract In PIVOT IO 001 (NCT03635983), the combination of the investigational interleukin-2 agonist bempegaldesleukin (BEMPEG) with nivolumab (NIVO) had no added clinical benefit over NIVO monotherapy in unresectable/metastatic melanoma. Pre-defined baseline and on-treatment changes in selected biomarkers were analyzed to explore the potential mechanisms underlying the clinical observations. In each treatment arm, higher baseline tumor mutational burden or immune infiltration/inflammation was associated with improved efficacy compared with lower levels. On-treatment peripheral biomarker changes showed that BEMPEG + NIVO increased all immune cell subset counts interrogated, including regulatory T cells. This was followed by attenuation of the increase in CD8 + T cells, conventional CD4 + T cells, and systemic interferon gamma levels at later treatment cycles in the combination arm. Changes in tumor biomarkers were comparable between arms. These biomarker results help provide a better understanding of the mechanism of action of BEMPEG + NIVO and may help contextualize the clinical observations from PIVOT IO 001.

Published
2024
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28. Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data

Author

Marta Spreafico, Audinga-Dea Hazewinkel, Hans Gelderblom, and Marta Fiocco

Subjects
dynamic prediction, osteosarcoma, clinical trial, landmark analysis, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Current prediction models for patients with ostosarcoma are restricted to predictions from a single, static point in time, such as diagnosis or surgery. These approaches discard information which becomes available during follow-up and may have an impact on patient’s prognosis. This study aims at developing a dynamic prediction model providing 5-year overall survival (OS) predictions from different time points during follow-up. The developed model considers relevant baseline prognostic factors, accounting for where appropriate time-varying effects and time-varying intermediate events such as local recurrence (LR) and new metastatic disease (NM). A landmarking approach is applied to 1965 patients with high-grade resectable osteosarcoma from the EURAMOS-1 trial (NCT00143030). Results show that LR and NM negatively affected 5-year OS (HRs: 2.634, 95% CI 1.845–3.761; 8.558, 95% CI 7.367–9.942, respectively). Baseline factors with strong prognostic value (HRs > 2) included poor histological response (≥10% viable tumor), axial tumor location, and the presence of lung metastases. The effect of poor versus good histological response changed over time, becoming non-significant from 3.25 years post-surgery onwards. This time-varying effect, as well as the strong impact of disease-related time-varying variables, show the importance of including updated information collected during follow-up in the model to provide more accurate survival predictions.

Published
2024
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29. An Archival Framework for Sharing of Cultural Heritage 3D Survey Data: OpenHeritage3D.org

Author

S. McAvoy, B. Tanduo, A. Spreafico, F. Chiabrando, D. Rissolo, J. Ristevski, and F. Kuester

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Photogrammetry and LiDAR have become increasingly accessible methods for documentation of Cultural Heritage sites. Academic and government agencies recognize the utility of high-resolution 3D models supporting long-term asset management through visualization, conservation planning, and change detection. Though detailed models can be created with increasing ease, their potential for future use can be constrained by a lack of accompanying topographic data, data collector skill level, and incomplete recording of the key metadata and paradata which make such survey data useful to future endeavors. In this paper, informed by various international survey organizations and data archives, we present a framework to record and communicate Cultural Heritage - focusing on architectures based on 3D metric survey - to first describe the data and metadata which should be included by surveyors to enable data usage and to communicate the expected utility of this data.

Published
2024
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30. Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses

Author

Luecke, Stefanie, Adelaja, Adewunmi, Guo, Xiaolu, Sen, Supriya, Spreafico, Roberto, Singh, Apeksha, Liu, Yi, Taylor, Brooks, Diaz, Jessica, Cheng, Quen, and Hoffmann, Alexander

Subjects
Genetics, Aetiology, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Inflammatory and immune system, Pathogen-Associated Molecular Pattern Molecules, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Macrophages, epigenome integrity, immune sentinel cells, inflammation, NF kappa B dynamics, tonic TNF, NFκB dynamics, Biochemistry and Cell Biology, Developmental Biology
Abstract

Tumor necrosis factor (TNF) is a key inflammatory cytokine that warns recipient cells of a nearby infection or tissue damage. Acute exposure to TNF activates characteristic oscillatory dynamics of the transcription factor NFκB and induces a characteristic gene expression program; these are distinct from the responses of cells directly exposed to pathogen-associated molecular patterns (PAMPs). Here, we report that tonic TNF exposure is critical for safeguarding TNF's specific functions. In the absence of tonic TNF conditioning, acute exposure to TNF causes (i) NFκB signaling dynamics that are less oscillatory and more like PAMP-responsive NFκB dynamics, (ii) immune gene expression that is more similar to the Pam3CSK4 response program, and (iii) broader epigenomic reprogramming that is characteristic of PAMP-responsive changes. We show that the absence of tonic TNF signaling effects subtle changes to TNF receptor availability and dynamics such that enhanced pathway activity results in non-oscillatory NFκB. Our results reveal tonic TNF as a key tissue determinant of the specific cellular responses to acute paracrine TNF exposure, and their distinction from responses to direct exposure to PAMPs.

Published
2023

31. Topological phases of graphene-Kagome systems

Author

de Souza, A. B. Felix, Spreafico, L., Faria, D., and Latgé, A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The growing skill in the synthesis processes of new materials has intensified the interest in exploring the properties of systems modeled by more complex lattices. Two-dimensional super-honeycomb lattices, have been investigated in metallic organic frameworks. They turned out as a significant route to the emergence of localized electronic responses, manifested as flat bands in their structure with topological isolating behavior. A natural inquiry is a complete analysis of their topological phases in the presence of electronic correlation effects. Here we analyse of the electron-electron correlation effects via Hubbard mean-field approximation on the topological phases of 2D and quasi-1D graphene-Kagome lattices. The 2D spin conductivity phase's diagrams describe metallic, trivial and topological insulating behaviors, considering different energy coupling and electronic occupations. Our results pave the way to smart-engineered nanostructured devices with relevant applications in spintronics and transport responses., Comment: Article submitted to Physical Review B, 6 pages, 8 figures

Published
2023

32. Widening the spectrum of players affected by genetic changes in Wilms tumor relapse

Author

Sara Ciceri, Alessia Bertolotti, Annalisa Serra, Giovanna Gattuso, Luna Boschetti, Maria Capasso, Cecilia Cecchi, Stefania Sorrentino, Paola Quarello, Chiara Maura Ciniselli, Paolo Verderio, Loris De Cecco, Giacomo Manenti, Francesca Diomedi Camassei, Paola Collini, Filippo Spreafico, and Daniela Perotti

Subjects
Cancer, Clinical genetics, Genomics, Human genetics, Science
Abstract

Summary: Few studies investigated the genetics of relapsed Wilms tumor (WT), suggesting the SIX1 gene, the microRNA processing genes, and the MYCN network as possibly involved in a relevant percentage of relapses. We investigated 28 relapsing WT patients (10 new cases and 18 cases in which the involvement of SIX and miRNAPG had been excluded) with a panel of ∼5000 genes. We identified variants affecting genes involved in DNA damage prevention and repair in 12/28 relapsing patients (42.9%), and affecting genes involved in chromatin modification and regulation in 6/28 relapsing patients (21.4%), widening the spectrum of anomalies detected in relapsed tumors. The disclosure of molecular pathways possibly underlying tumor progression might allow to use molecularly targeted therapies at relapse. Surprisingly, germline anomalies, mostly affecting DNA damage prevention and repair genes, were identified in 13/28 patients (46.4%), raising the issue of performing a genetic testing to all children presenting with a WT.

Published
2024
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34. On Leonardo Numbers and Fibonacci Fundamental System

Author

Spreafico, Elen Viviani Pereira, Catarino, Paula Maria Machado Cruz, Gayoso Martínez, Víctor, editor, Yilmaz, Fatih, editor, Queiruga-Dios, Araceli, editor, Rasteiro, Deolinda M.L.D., editor, Martín-Vaquero, Jesús, editor, and Mierluş-Mazilu, Ion, editor

Published
2024
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35. Prospective Life Cycle Assessment Based on Patent Analysis to Support Eco-design

Author

Spreafico, Christian, Landi, Daniele, Russo, Davide, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Carfagni, Monica, editor, Furferi, Rocco, editor, Di Stefano, Paolo, editor, and Governi, Lapo, editor

Published
2024
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36. First CLAS12 measurement of DVCS beam-spin asymmetries in the extended valence region

Author

CLAS Collaboration, Christiaens, G., Defurne, M., Sokhan, D., Achenbach, P., Akbar, Z., Amaryan, M. J., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossù, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bueltmann, S., Bulumulla, D., Burkert, V. D., Cao, T., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gates, K., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holmberg, D. E., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Kabir, M. L., Keller, D., Khachatryan, M., Khanal, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Molina, E., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Scott, M. B. C., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhang, J., Zhao, Z. W., Ziegler, V., and Zurek, M.

Subjects
High Energy Physics - Experiment
Abstract

Deeply virtual Compton scattering (DVCS) allows one to probe Generalized Parton Distributions (GPDs) describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.6 GeV electron beam scattering from unpolarised protons. The results greatly extend the $Q^2$ and Bjorken-$x$ phase space beyond the existing data in the valence region and provide over 2000 new data points measured with unprecedented statistical uncertainty, setting new, tight constraints for future phenomenological studies., Comment: Revised Figure 4 and discussion around the number of effective ANNs after Bayesian reweighting

Published
2022

37. On the anomaly terms in Cheeger-M\'uller theorem on spaces with conical singularities

Author

Hartmann, Luiz and Spreafico, Mauro

Subjects
Mathematics - Differential Geometry, Mathematics - Algebraic Topology, Mathematics - Spectral Theory, 58J52, 11M36, 57Q10
Abstract

We prove that the anomaly term appearing in the ratio between Reidemeister torsion and analytic torsion for a space with a conical singularity vanishes in the smooth case. Moreover, we show that such anomaly term is non trivial for the cone over a torus.

Published
2022

39. Robotics for Heritage Surveying: preliminary test on Leica BLK ARC & Spot® toward autonomous 3D mapping

Author

G. Sammartano, A. Spreafico, B. Tanduo, and F. Chiabrando

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Today, robotics technologies are revolutionizing surveying and construction in AEC fields, enhancing precision, safety, and efficiency and also in the realm of Cultural Heritage knowledge and protection, the integration of cutting-edge technologies is reshaping consolidated surveying methods for documentation, especially in risk scenarios. One such innovation making waves is the use of mobile mapping systems, where automation and expediency are the determining factors in technological development, both in the direction of in indoor positioning (visual/LiDAR SLAM, UWB, etc.) and 3D mapping of known and unknown spaces. The BLK ARC by Leica, equipping the Agile Mobile Robot Spot® by Boston Dynamics, as a dynamic sensing platform, is here presented and discussed. BLK ARC is part of a diverse landscape of mobile mapping systems, each offering unique features and specifications tailored to different surveying needs, from handheld devices and wearable systems, to vehicle-mounted systems, the options vary in dimension, weight, price, and technical capabilities and the recent companies and research are largely focusing on them. A preliminary evaluation takes into consideration the dual dynamic-static 3D data-types, considering local and global accuracy of the 3D data delivered from the first experimental tests in a case study. Different metrics have been considered including acquisition time, precision, resolution, density, accuracy, roughness, and completeness of the acquired data.

Published
2024
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40. Alignment of the CLAS12 central hybrid tracker with a Kalman Filter

Author

Paul, S. J., Peck, A., Arratia, M., Gotra, Y., Ziegler, V., De Vita, R., Bossu, F., Defurne, M., Atac, H., Gayoso, C. Ayerbe, Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biondo, L., Biselli, A. S., Bondi, M., Boiarinov, S., Brinkmann, K. Th., Briscoe, W. J., Brooks, W. K., Bulumulla, D., Burkert, V. D., Capobianco, R., Carman, D. S., Carvajal, J. C., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Cole, P. L., Costantini, G., Angelo, A. D, Dashyan, N., Deur, A., Diehl, S., Djalali, C., Dupre, R., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Filippi, A., Gates, K., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Golubenko, A. A., Gosta, G., Gothe, R. W., Griffioen, K., Guidal, M., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Johnston, R., Joo, K., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Klimenko, V., Kripko, A., Lanza, L., Leali, M., Lenisa, P., Li, X., MacGregor, I. J. D., Marchand, D., Marsicano, L., Mascagna, V., McKinnon, B., McLauchlin, C., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Nguyen, D., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Paremuzyan, R., Pilleux, N., Pogorelko, O., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Reed, T., Ripani, M., Ritman, J., Sabatie, F., Schadmand, S., Schmidt, A., Shirokov, E. V., Shrestha, U., Simmerling, P., Spreafico, M., Sokhan, D., Sparveris, N., Strakovsky, I. I., Strauch, S., Tan, J. A., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wishart, R., Wood, M. H., and Zachariou, N.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Several factors can contribute to the difficulty of aligning the sensors of tracking detectors, including a large number of modules, multiple types of detector technologies, and non-linear strip patterns on the sensors. All three of these factors apply to the CLAS12 CVT, which is a hybrid detector consisting of planar silicon sensors with non-parallel strips, and cylindrical micromegas sensors with longitudinal and arc-shaped strips located within a 5~T superconducting solenoid. To align this detector, we used the Kalman Alignment Algorithm, which accounts for correlations between the alignment parameters without requiring the time-consuming inversion of large matrices. This is the first time that this algorithm has been adapted for use with hybrid technologies, non-parallel strips, and curved sensors. We present the results for the first alignment of the CLAS12 CVT using straight tracks from cosmic rays and from a target with the magnetic field turned off. After running this procedure, we achieved alignment at the level of 10~$\mu$m, and the widths of the residual spectra were greatly reduced. These results attest to the flexibility of this algorithm and its applicability to future use in the CLAS12 CVT and other hybrid or curved trackers, such as those proposed for the future Electron-Ion Collider.

Published
2022
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41. Dark matter search with the BDX-MINI experiment

Author

Battaglieri, M., Bondì, M., Celentano, A., Cole, P. L., De Napoli, M., De Vita, R., Marsicano, L., Randazzo, N., Smith, E. S., Snowden-Ifft, D., Spreafico, M., and Wood, M. H.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

BDX-MINI is a beam dump experiment optimized to search for Light Dark Matter produced in the interaction of the intense CEBAF 2.176 GeV electron beam with the Hall A beam dump at Jefferson Lab. The BDX-MINI detector consists of a PbWO$_4$ electromagnetic calorimeter surrounded by a hermetic veto system for background rejection. The experiment accumulated $2.56 \times 10^{21}$ EOT in six months of running. Simulations of fermionic and scalar Dark Matter interactions with electrons of the active volume of the BDX-MINI detector were used to estimate the expected signal. Data collected during the beam-off time allowed us to characterize the background dominated by cosmic rays. A blind data analysis based on a maximum-likelihood approach was used to optimize the experiment sensitivity. An upper limit on the production of light dark matter was set using the combined event samples collected during beam-on and beam-off configurations. In some kinematics, this pilot experiment is sensitive to the parameter space covered by some of the most sensitive experiments to date, which demonstrates the discovery potential of the next generation beam dump experiment planned at intense electron beam facilities., Comment: (13 pages, 11 figures)

Published
2022
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42. Experiments and Facilities for Accelerator-Based Dark Sector Searches

Author

Ilten, Philip, Tran, Nhan, Achenbach, Patrick, Ariga, Akitaka, Ariga, Tomoko, Battaglieri, Marco, Bian, Jianming, Bisio, Pietro, Celentano, Andrea, Citron, Matthew, Crivelli, Paolo, de Lellis, Giovanni, Di Crescenzo, Antonia, Diwan, Milind, Feng, Jonathan L., Gatto, Corrado, Gori, Stefania, Kling, Felix, Marsicano, Luca, Mazza, Simone M., McFayden, Josh, Molina-Bueno, Laura, Spreafico, Marco, Toro, Natalia, Toups, Matthew, Trojanowski, Sebastian, Tsai, Yu-Dai, Williams, Mike, Zettlemoyer, Jacob, and Zhong, Yiming

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

This paper provides an overview of experiments and facilities for accelerator-based dark matter searches as part of the US Community Study on the Future of Particle Physics (Snowmass 2021). Companion white papers to this paper present the physics drivers: thermal dark matter, visible dark portals, and new flavors and rich dark sectors., Comment: contribution to Snowmass 2021

Published
2022

43. Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery

Author

Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau, and Konrad Krawczyk

Subjects
CDR-H3, database, repertoire, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607
Abstract

The naïve human antibody repertoire has theoretical access to an estimated > 1015 antibodies. Identifying subsets of this prohibitively large space where therapeutically relevant antibodies may be found is useful for development of these agents. It was previously demonstrated that, despite the immense sequence space, different individuals can produce the same antibodies. It was also shown that therapeutic antibodies, which typically follow seemingly unnatural development processes, can arise independently naturally. To check for biases in how the sequence space is explored, we data mined public repositories to identify 220 bioprojects with a combined seven billion reads. Of these, we created a subset of human bioprojects that we make available as the AbNGS database (https://naturalantibody.com/ngs/). AbNGS contains 135 bioprojects with four billion productive human heavy variable region sequences and 385 million unique complementarity-determining region (CDR)-H3s. We find that 270,000 (0.07% of 385 million) unique CDR-H3s are highly public in that they occur in at least five of 135 bioprojects. Of 700 unique therapeutic CDR-H3, a total of 6% has direct matches in the small set of 270,000. This observation extends to a match between CDR-H3 and V-gene call as well. Thus, the subspace of shared (‘public’) CDR-H3s shows utility for serving as a starting point for therapeutic antibody design.

Published
2024
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44. Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala

Author

Daniel C. Moreira, Claudia Garrido, Roy Rosado, Verónica Girón, Tomás Letona, Gerson Morales, Patricia Valverde, Thelma Velásquez, Jeanine Alfaro, Elizabeth Orellana, Miguel Angel Ortega, Paola Salguero, Leeanna Fox Irwin, Allyson Andujar, Pedro A. de Alarcón, Sandra Luna-Fineman, Marilyn Manco-Johnson, Valentino Conter, Marta Verna, Marta Canesi, Maura Massimino, Filippo Spreafico, Andrea Ferrari, Pascale Y. Gassant, Roberto Vásquez, Paola Friedrich, Ricardo Mack, Raul Ribeiro, Monika L. Metzger, Carlos Rodriguez-Galindo, and Federico Antillón-Klussmann

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PURPOSEThis study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala.METHODSThe Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is the only hospital in Central America dedicated exclusively to childhood and adolescent cancer. To address the regional need for specialists, a fellowship program in pediatric hematology/oncology was launched in 2003. The UNOP fellowship program comprises 3 years of training. Although the program is based at UNOP, it also includes rotations locally and internationally to enhance clinical exposure. The curriculum is based on international standards to cover clinical expertise, research, professionalism, communication, and health advocacy. Trainees are selected according to country or facility-level need for pediatric hematologists/oncologists, with a plan for them to be hired immediately after completing their training.RESULTSForty physicians from 10 countries in Latin America have completed training. In addition, there are currently 13 fellows from five countries in training. Of the graduates, 39 (98%) are now practicing in pediatric hematology/oncology in Latin America. Moreover, many of them have leadership positions within their institutions and participate in research, advocacy, and policy making. Graduates from the UNOP program contribute to institutions by providing care for an increasing number of patients with pediatric cancer. The UNOP program is the first pediatric hematology/oncology fellowship program in the world to be accredited by Accreditation Council for Graduate Medical Education-International, an international body accrediting clinical training programs.CONCLUSIONThe UNOP program has trained specialists to increase the available care for children with cancer in Latin America. This regional approach to specialist training can maximize resources and serve as a model for other programs and regions.

Published
2024
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45. General support of physical exercise programs in pediatric oncology but differences in perception by childhood cancer care professionals at European and North-African/Arab centers

Author

Moatasem El-Ayadi, Kyra Druivenga, Thomas Perwein, Gunther Nussbaumer, Filippo Spreafico, Maura Massimino, Shady Fadel, Nisreen Amayiri, Nisrine Khoubila, Laila Hessissen, Omar Chamdine, Natàlia Rodríguez, Gemma Calaf Valls, Andres Morales la Madrid, Christine Dahl, Darren Hargrave, Elwira Szychot, Simon Bailey, Dannis G. van Vuurden, Martin Benesch, Ina Hunger, Ingrid Kühnle, Simone Mascher, Albane Bertha Rosa Maggio, André O. von Bueren, and Christof M. Kramm

Subjects
Childhood cancer, Cancer, Child, Physical exercise, Psychomotor, Sports, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: To explore the perception of physical exercise programs for pediatric oncology patients among childhood cancer care professionals. We also aimed at comparing such perceptions between cultures. Healthcare professionals’ endorsement may be essential for initiating and promoting such programs. Methods: An anonymous survey was designed and administered voluntarily to childhood cancer care professionals (including pediatric oncologists, nurses, and physiotherapists) in European, North-African and Arab pediatric oncology centers. Results: Five-hundred-and twenty-eight professionals from 14 sites answered the survey. Most respondents considered physical exercise programs as a suitable therapeutic approach for pediatric cancer patients with a potential positive contribution to survival (81%), wellbeing (82%), quality of life (80%), and self-esteem (75%). 91% of respondents would also support the future introduction of physical exercise programs into standard pediatric oncological care. There was a comparatively higher appreciation of physical exercise programs among European centers compared to North-African / Arab centers. Conclusion: We registered a broad acceptance of physical exercise programs among all European and North-African / Arab childhood cancer care professionals. The positive perception was independent of any pre-existing experience with such programs and seems therefore representative. This finding may encourage the further promotion of physical exercise programs in pediatric oncology.

Published
2024
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46. The prognostic value of image-identified extranodal extension in laryngeal and hypopharyngeal carcinoma following definitive (chemo-)radiotherapy

Author

Alsheikh, Sulaiman, Su, Jie, O’Sullivan, Brian, Ringash, Jolie, Waldron, John N, V Bratman, Scott, Cho, John, Sanz Garcia, Enrique, Spreafico, Anna, de Almeida, John, Hahn, Ezra, Hope, Andrew, Hosni, Ali, Kim, John, McPartlin, Andrew, Tsai, Jillian, Li, Tong, Xu, Wei, Yu, Eugene, and Huang, Shao Hui

Published
2024
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48. A Phase II, Open-Label, Randomized Trial of Durvalumab With Olaparib or Cediranib in Patients With Mismatch Repair—Proficient Colorectal or Pancreatic Cancer

Author

Hernando-Calvo, Alberto, Han, Ming, Ayodele, Olubukola, Wang, Ben X., Bruce, Jeffrey P., Abbas-Aghababazadeh, Farnoosh, Vila-Casadesús, Maria, Sanz-Garcia, Enrique, Yang, S.Y. Cindy, Berman, Hal K., Vivancos, Ana, Lam, Bernard, Lungu, Ilinca, Salawu, Abdulazeez, Stayner, Lee-Anne, Haibe-Kains, Benjamin, Bedard, Philippe L., Avery, Lisa, Razak, Albiruni R.A., Pugh, Trevor J., Spreafico, Anna, Siu, Lillian L., and Hansen, Aaron R.

Published
2024
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