18 results on '"Sposato, C."'
Search Results
2. Clay and fibers: Energy efficiency in buildings between tradition and innovation
- Author
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Cardinale, T., primary, Sposato, C., additional, Feo P, A., additional, and Fazio, De, additional
- Published
- 2018
- Full Text
- View/download PDF
3. Synthesis and characterization of Ti-silicalite-1 for the direct oxidation of benzene to phenol by hydrogen peroxide
- Author
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Aloise, A, Bonelli, Barbara, Sposato, C, Macario, A, D'Alessandro, T, Ballarini, N, Guidetti, S, Fornasari, G, Cavani, F, Piumetti, Marco, Garrone, Edoardo, Giordano, G., A. Aloise, B. Bonelli, C. Sposato, A. Macario, T. D'Alessandro, N. Ballarini, S. Guidetti, G. Fornasari, F. Cavani, M. Piumetti, E. Garrone, and G. Giordano
- Published
- 2008
4. Towards the Circular Economy of Rare Earth Elements: Lanthanum Leaching from Spent FCC Catalyst by Acids
- Author
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Massimo Migliori, Alessandro Blasi, Girolamo Giordano, Massimo Morgana, Marilena Forte, Enrico Catizzone, Giacobbe Braccio, Assunta Romanelli, Corradino Sposato, Sposato, C., Catizzone, E., Blasi, A., Forte, M., Romanelli, A., Morgana, M., Braccio, G., Giordano, G., and Migliori, M.
- Subjects
Materials science ,Process Chemistry and Technology ,Circular economy ,Chemical technology ,Extraction (chemistry) ,Rare earth ,Inorganic chemistry ,chemistry.chemical_element ,Bioengineering ,rare earth elements ,TP1-1185 ,Catalysis ,FCC catalyst ,acid leaching ,Environmental effect ,chemistry.chemical_compound ,Chemistry ,chemistry ,Nitric acid ,Lanthanum ,Chemical Engineering (miscellaneous) ,Leaching (metallurgy) ,REE recycling ,QD1-999 - Abstract
Rare earth elements (REEs) are strategic materials widely used in different applications from Information and Communication Technologies (ICT) to catalysis, which are expected to grow more in the future. In order to reduce the impact of market price and reduce the environmental effect from soil extraction, recovery/purification strategies should be exploited. This paper presents a combined acid-leaching/oxalate precipitation process to recover lanthanum from spent FCC catalyst using nitric acid. Preferred to hydrochloric and sulphuric acid (preliminary assessed), HNO3 showed a good capability to completely leach lanthanum. The combination with an oxalate precipitation step allowed demonstrating that a highly pure (>, 98% w/w) lanthanum solid can be recovered, with a neglectable amount of poisoning metals (Ni, V) contained into the spent catalyst. This could open a reliable industrial perspective to recover and purify REE in the view of a sustainable recycling strategy.
- Published
- 2021
5. Energy Performance of Construction Materials Using Waste Recycled Polymer as Fine Aggregate Replacement
- Author
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Tiziana Cardinale, Maria Bruna Alba, Corradino Sposato, P. De Fazio, Andrea Feo, Cardinale, T., Sposato, C., Alba, M. B., Feo, A., and De Fazio, P.
- Subjects
PVC compound ,Fluid Flow and Transfer Processes ,chemistry.chemical_classification ,Thermal properties ,Materials science ,Aggregate (composite) ,Mechanical Engineering ,Energy performance ,UV-aging ,Polymer ,Ecofriendly materials ,Mechanical resistance ,Condensed Matter Physics ,Ecofriendly material ,chemistry ,Composite material ,Thermal propertie - Abstract
Plastic has become an essential part of our modern lifestyle and its global diffusion has led to a significant increase in the production of related waste, with obvious repercussions on the environment and on the entire sustainability chain. Recycling this kind of materials in the field of civil and industrial engineering is considered an ecological and economical solution due to the advantages it can offer. This paper represents the results of experimental investigations of mechanical strength, hygro-thermal and durability properties of two kinds of products: urban tiles (90 % PVC powder and 10 % polyurethane resin) and cement-based mortars reinforced with PVC compound coming out of electric cable protective sheath. The manufactured mortars were obtained by the volumetric substitution of the sand with five different percentages of plastic waste, from 10 % to 50 %. Plastic aggregates reduce density, causing a decrease in flexural and compressive strength of mortars. Nevertheless, the presence of plastic aggregate leads to a significant improvement of thermal insulation and shows a greater resistance to capillary water absorption compared to the reference one. The mechanical tests after two different cycles of accelerated solar aging of urban tiles demonstrated the feasibility of its use for external flooring (green parking). These results foster future studies about the development of increasingly eco-sustainable building materials.
- Published
- 2019
6. Purification of Wastewater from Biomass-Derived Syngas Scrubber Using Biochar and Activated Carbons
- Author
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Giacinto Cornacchia, Daniela Cozza, Enrico Catizzone, D. Barisano, Luigi Marsico, Massimo Migliori, Corradino Sposato, Assunta Romanelli, Catizzone, E., Sposato, C., Romanelli, A., Barisano, D., Cornacchia, G., Marsico, L., Cozza, D., and Migliori, M.
- Subjects
020209 energy ,Health, Toxicology and Mutagenesis ,Biomass ,Environmental pollution ,02 engineering and technology ,010501 environmental sciences ,Wastewater ,01 natural sciences ,Article ,Adsorption ,Biochar ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,biochar ,0105 earth and related environmental sciences ,biomass ,Chemistry ,Public Health, Environmental and Occupational Health ,Pulp and paper industry ,pollutant abatement technologies ,adsorption ,Charcoal ,syngas scrubber wastewater ,Medicine ,environmental pollution ,Pyrolysis ,Syngas ,Activated carbon ,medicine.drug - Abstract
Phenol is a major component in the scrubber wastewater used for syngas purification in biomass-based gasification plants. Adsorption is a common strategy for wastewater purification, and carbon materials, such as activated carbons and biochar, may be used for its remediation. In this work, we compare the adsorption behavior towards phenol of two biochar samples, produced by pyrolysis and gasification of lignocellulose biomass, with two commercial activated carbons. Obtained data were also used to assess the effect of textural properties (i.e., surface area) on phenol removal. Continuous tests in lab-scale columns were also carried out and the obtained data were processed with literature models in order to obtain design parameters for scale-up. Results clearly indicate the superiority of activated carbons due to the higher pore volume, although biomass-derived char may be more suitable from an economic and environmental point of view. The phenol adsorption capacity increases from about 65 m/g for gasification biochar to about 270 mg/g for the commercial activated carbon. Correspondingly, service time of commercial activated carbons was found to be about six times higher than that of gasification biochar. Finally, results indicate that phenol may be used as a model for characterizing the adsorption capacity of the investigated carbon materials, but in the case of real waste water the carbon usage rate should be considered at least 1.5 times higher than that calculated for phenol.
- Published
- 2021
7. Clay and fibers: Energy efficiency in buildings between tradition and innovation
- Author
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Andrea Feo, Tiziana Cardinale, Corradino Sposato, P. De Fazio, De Fazio, P., Feo, A., Sposato, C., and Cardinale, T.
- Subjects
Materials science ,Biobased material ,Adobe brick ,Applied Mathematics ,Natural fiber ,Civil engineering ,Adobe bricks ,Thermal conductivity ,Modeling and Simulation ,Biobased materials ,Natural fibers ,Mechanical strength ,Engineering (miscellaneous) ,Efficient energy use - Abstract
Building construction technology using clay soil in various forms, already known since ancient times, presents a great potential to regulate indoor humidity, to reduce the indirect impact of construction sector on the environment and on energy consumption. Extensive studies have also been done on the effects of natural fibers on the mechanical and physical behaviour of composite materials in terms of strength, energy efficiency and impact resistance. This work is focused on some natural fiber composites made from different mixtures containing clay soil with different percentages of jute, straw and basalt fibers, in order to determine the ideal mixture between clay and fibers providing the optimum values of thermal inertia, mechanical performance and shrinkage able to improve the energy efficiency of buildings. The mechanical, physical and thermal properties of some specimens have been investigated. The obtained results show an improved mechanical strength and a better thermal conductivity of the clay composite material. © 2018, Mathematical Modelling of Engineering Problems.
- Published
- 2018
8. Study of a Synergistic Solvent Extracting System to Separate Yttrium and Heavy Rare Earths: A Deep Investigation on System Behavior
- Author
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Massimo Morgana, Giacobbe Braccio, Alessandro Blasi, Corradino Sposato, Assunta Romanelli, Blasi, A., Morgana, M., Braccio, G., Romanelli, A., and Sposato, C.
- Subjects
musculoskeletal diseases ,International research ,Solvent extraction ,Inorganic chemistry ,CA-12 ,Synergistic extraction ,P-507 ,Rare earths ,Mineralogy ,chemistry.chemical_element ,Yttrium ,Phosphate ,Chloride ,Solvent ,Acetic acid ,chemistry.chemical_compound ,chemistry ,Phase (matter) ,medicine ,Scientific activity ,medicine.drug - Abstract
Yttrium is a strategical material for its several usages in a wide range of industrial production. For this reason, improving the recovery of Yttrium has become a crucial focus for international research. In this scientific activity, the utilization of two extractants, 2-ethylhexyl-mono 2-ethylhexyl ester phosphonic acid (P-507) and sec-octylphenoxy acetic acid (CA-12), working in a synergistic extracting system, has been tested. A series of trials have been carried out to optimize the experimental conditions in order to separate yttrium from a mix of heavy rare earths in chloride media. Tests with different relative concentrations of extractants and a phase modifier (TPB, trybutyl phosphate), with different presaponification rate, have been performed to evaluate the behavior of the synergistic system. Results are very promising to recover and separate yttrium with a high purity. © 2017, The Minerals, Metals & Materials Society.
- Published
- 2017
9. Behavior of sec-octylphenoxy acetic acid (CA-12) in yttrium recovery from high concentrated heavy rare earths mixture
- Author
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Giacobbe Braccio, Corradino Sposato, Alessandro Blasi, Massimo Morgana, Assunta Romanelli, Morgana, M., Braccio, G., Romanelli, A., Blasi, A., and Sposato, C.
- Subjects
Liquid-liquid extraction ,Rare earths ,Solvent extraction ,CA-12 ,Extraction (chemistry) ,Inorganic chemistry ,Aqueous two-phase system ,chemistry.chemical_element ,Yttrium ,chemistry.chemical_compound ,Acetic acid ,chemistry ,Liquid–liquid extraction ,Sodium hydroxide ,Phase (matter) ,Rare earth ,Tributyl phosphate ,Nuclear chemistry - Abstract
The solvent extraction technique is the only industrial way used to separate and purificate yttrium from other rare earths. In order to improve this process several extractants have been tested during last years. In this work, the behavior of sec-octylphenoxy acetic acid (CA-12) in Yttrium recovery from high concentrated heavy rare earth mixture was investigated. Sodium hydroxide solution was used in order to presaponify organic phase composed by CA-12 and Tributyl phosphate (TBP) diluted in kerosene. In the investigated condition, TBP confirmed its role of phase modifier not significantly altering the extraction behavior of CA-12. The CA-12-TBP system showed a high affinity in extraction for lighter rare earths such as Sm, Eu, and Gd, leaving yttrium in aqueous phase. Using a feed concentration (∑ [RE]) of 1M, organic mixture is capable to extract around the 70% of metals in a single extraction test showing this extraction sequence Y < Lu < Yb < Tm < Er < Ho < Dy < Tb < Gd < Eu < Sm. Moreover for [CA-12] = 1.79 M and [RE] = 2M the instability of extraction system occurs. © 2017, The Minerals, Metals & Materials Society.
- Published
- 2017
10. Comparison among different extractants, AS (2-ethylhexyl)-mono (2-ethylhexyl) ester phosphonic acid (p507), secondary-octyl phenoxy acetic acid (CA-12) and BIS(2, 4, 4-trimethylpentyl)phosphinic acid (CYANEX272), in the separation of heavy rare earths via hydrometallurgical processes
- Author
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Alessandro Blasi, Giuseppe Devincenzis, Pietro Garzone, Massimo Morgana, Corradino Sposato, Morgana, M., Garzone, P., Devincenzis, G., Blasi, A., and Sposato, C.
- Subjects
Heavy Rare Earth ,P507 ,Cyanex 272 ,Chemistry ,Organic chemistry ,Phenoxy acetic acid ,CA-12 ,Heavy Rare Earths ,Separation - Abstract
A comparison among (2-ethylhexyl)-mono (2-ethylhexyl) ester Phosphonic acid (P507), Secondary-octyl phenoxy acetic acid (CA-12) and Bis(2, 4, 4-trimethylpentyl) phosphinic acid (Cyanex272), in heavy rare earths separation via hydrometallurgical processes has been investigated. The separation coefficients, β, were obtained and the extraction selectivity has been evaluated using a mixture of heavy rare earths from Samarium to Ytterbium. The experimental results indicated that P507 and Cyanex 272 display a greater affinity for heavier rare earths while CA12 proved to be more effective for the lighter rare earth metals.
11. Definition of the process to separate light rare earths by working with (2-Ethylexyl)-Mono(2-Ethylexyl)ester phosphonic acid (P507) in a mixer settler battery
- Author
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Blasi, A., Corradino Sposato, Devincenzis, G., Garzone, P., Morgana, M., Morgana, M., Garzone, P., Devincenzis, G., Sposato, C., and Blasi, A.
- Subjects
P507 ,Light Rare Earths ,Light Rare Earth ,Mixer settler battery ,Separation - Abstract
The rare earth elements are essential for a diverse and expanding array of high-technology applications, which constitute an important part of the industrial economy of the 21st century. As a matter of fact, rare earth has been listed in the category of strategic elements in many countries becoming a core business for international research. Experimental tests have been carried out on a bench scale battery of mixer settler composed of 24 stages, each one with a volume of 150 ml. These trials have been performed at room temperature checked by a micro-climatic control system. The battery was setted in two sections: extraction and scrubbing section. Rare earths concentrations were obtained by ICP-OES analysis made on aqueous phase and on the stripped from organic phase. We obtained a complete separation of light rare earth (La, Ce, Pr, Nd) in two sub-groups: La/Ce and Pr/Nd.
12. Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation.
- Author
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Del Giovane A, Russo M, Tirou L, Faure H, Ruat M, Balestri S, Sposato C, Basoli F, Rainer A, Kassoussi A, Traiffort E, and Ragnini-Wilson A
- Abstract
The regeneration of myelin is known to restore axonal conduction velocity after a demyelinating event. Remyelination failure in the central nervous system contributes to the severity and progression of demyelinating diseases such as multiple sclerosis. Remyelination is controlled by many signaling pathways, such as the Sonic hedgehog (Shh) pathway, as shown by the canonical activation of its key effector Smoothened (Smo), which increases the proliferation of oligodendrocyte precursor cells via the upregulation of the transcription factor Gli1. On the other hand, the inhibition of Gli1 was also found to promote the recruitment of a subset of adult neural stem cells and their subsequent differentiation into oligodendrocytes. Since Smo is also able to transduce Shh signals via various non-canonical pathways such as the blockade of Gli1, we addressed the potential of non-canonical Smo signaling to contribute to oligodendroglial cell maturation in myelinating cells using the non-canonical Smo agonist GSA-10, which downregulates Gli1. Using the Oli-neuM cell line, we show that GSA-10 promotes Gli2 upregulation, MBP and MAL/OPALIN expression via Smo/AMP-activated Protein Kinase (AMPK) signaling, and efficiently increases the number of axonal contact/ensheathment for each oligodendroglial cell. Moreover, GSA-10 promotes the recruitment and differentiation of oligodendroglial progenitors into the demyelinated corpus callosum in vivo . Altogether, our data indicate that non-canonical signaling involving Smo/AMPK modulation and Gli1 downregulation promotes oligodendroglia maturation until axon engagement. Thus, GSA-10, by activation of this signaling pathway, represents a novel potential remyelinating agent., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Del Giovane, Russo, Tirou, Faure, Ruat, Balestri, Sposato, Basoli, Rainer, Kassoussi, Traiffort and Ragnini-Wilson.)
- Published
- 2022
- Full Text
- View/download PDF
13. Synthesis, Characterization and Mechanical Properties of Novel Bio-Based Polyurethane Foams Using Cellulose-Derived Polyol for Chain Extension and Cellulose Citrate as a Thickener Additive.
- Author
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Maiuolo L, Olivito F, Algieri V, Costanzo P, Jiritano A, Tallarida MA, Tursi A, Sposato C, Feo A, and De Nino A
- Abstract
A novel series of bio-based polyurethane composite foams was prepared, employing a cellulose-derived polyol for chain extension and cellulose-citrate as a thickener additive. The utilized polyol was obtained from the reduction reaction of cellulose-derived bio-oil through the use of sodium borohydride and iodine. Primarily, we produced both rigid and flexible polyurethane foams through chain extension of the prepolymers. Secondly, we investigated the role of cellulose citrate as a polyurethane additive to improve the mechanical properties of the realized composite materials. The products were characterized by FT-IR spectroscopy and their morphologies were analysed by SEM. Mechanical tests were evaluated to open new perspectives towards different applications.
- Published
- 2021
- Full Text
- View/download PDF
14. Purification of Wastewater from Biomass-Derived Syngas Scrubber Using Biochar and Activated Carbons.
- Author
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Catizzone E, Sposato C, Romanelli A, Barisano D, Cornacchia G, Marsico L, Cozza D, and Migliori M
- Subjects
- Adsorption, Biomass, Charcoal, Wastewater
- Abstract
Phenol is a major component in the scrubber wastewater used for syngas purification in biomass-based gasification plants. Adsorption is a common strategy for wastewater purification, and carbon materials, such as activated carbons and biochar, may be used for its remediation. In this work, we compare the adsorption behavior towards phenol of two biochar samples, produced by pyrolysis and gasification of lignocellulose biomass, with two commercial activated carbons. Obtained data were also used to assess the effect of textural properties (i.e., surface area) on phenol removal. Continuous tests in lab-scale columns were also carried out and the obtained data were processed with literature models in order to obtain design parameters for scale-up. Results clearly indicate the superiority of activated carbons due to the higher pore volume, although biomass-derived char may be more suitable from an economic and environmental point of view. The phenol adsorption capacity increases from about 65 m/g for gasification biochar to about 270 mg/g for the commercial activated carbon. Correspondingly, service time of commercial activated carbons was found to be about six times higher than that of gasification biochar. Finally, results indicate that phenol may be used as a model for characterizing the adsorption capacity of the investigated carbon materials, but in the case of real waste water the carbon usage rate should be considered at least 1.5 times higher than that calculated for phenol.
- Published
- 2021
- Full Text
- View/download PDF
15. The Current Challenges for Drug Discovery in CNS Remyelination.
- Author
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Balestri S, Del Giovane A, Sposato C, Ferrarelli M, and Ragnini-Wilson A
- Subjects
- Animals, Axons drug effects, Axons pathology, Brain drug effects, Brain pathology, Central Nervous System pathology, Demyelinating Diseases pathology, Humans, Myelin Sheath drug effects, Myelin Sheath pathology, Nerve Regeneration drug effects, Oligodendroglia drug effects, Oligodendroglia pathology, Central Nervous System drug effects, Demyelinating Diseases drug therapy, Drug Discovery, Remyelination drug effects
- Abstract
The myelin sheath wraps around axons, allowing saltatory currents to be transmitted along neurons. Several genetic, viral, or environmental factors can damage the central nervous system (CNS) myelin sheath during life. Unless the myelin sheath is repaired, these insults will lead to neurodegeneration. Remyelination occurs spontaneously upon myelin injury in healthy individuals but can fail in several demyelination pathologies or as a consequence of aging. Thus, pharmacological intervention that promotes CNS remyelination could have a major impact on patient's lives by delaying or even preventing neurodegeneration. Drugs promoting CNS remyelination in animal models have been identified recently, mostly as a result of repurposing phenotypical screening campaigns that used novel oligodendrocyte cellular models. Although none of these have as yet arrived in the clinic, promising candidates are on the way. Many questions remain. Among the most relevant is the question if there is a time window when remyelination drugs should be administrated and why adult remyelination fails in many neurodegenerative pathologies. Moreover, a significant challenge in the field is how to reconstitute the oligodendrocyte/axon interaction environment representative of healthy as well as disease microenvironments in drug screening campaigns, so that drugs can be screened in the most appropriate disease-relevant conditions. Here we will provide an overview of how the field of in vitro models developed over recent years and recent biological findings about how oligodendrocytes mature after reactivation of their staminal niche. These data have posed novel questions and opened new views about how the adult brain is repaired after myelin injury and we will discuss how these new findings might change future drug screening campaigns for CNS regenerative drugs.
- Published
- 2021
- Full Text
- View/download PDF
16. EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP.
- Author
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Nocita E, Del Giovane A, Tiberi M, Boccuni L, Fiorelli D, Sposato C, Romano E, Basoli F, Trombetta M, Rainer A, Traversa E, and Ragnini-Wilson A
- Subjects
- Animals, Cell Differentiation, Cell Line, Remyelination, Clobetasol pharmacology, ErbB Receptors metabolism, Gefitinib pharmacology, Myelin Basic Protein metabolism, Oligodendrocyte Precursor Cells cytology, Oligodendrocyte Precursor Cells metabolism, Oligodendroglia cytology, Oligodendroglia metabolism, Retinoid X Receptor gamma metabolism
- Abstract
Remyelination in the adult brain relies on the reactivation of the Neuronal Precursor Cell (NPC) niche and differentiation into Oligodendrocyte Precursor Cells (OPCs) as well as on OPC maturation into myelinating oligodendrocytes (OLs). These two distinct phases in OL development are defined by transcriptional and morphological changes. How this differentiation program is controlled remains unclear. We used two drugs that stimulate myelin basic protein (MBP) expression (Clobetasol and Gefitinib) alone or combined with epidermal growth factor receptor (EGFR) or Retinoid X Receptor gamma (RXRγ) gene silencing to decode the receptor signaling required for OPC differentiation in myelinating OLs. Electrospun polystyrene (PS) microfibers were used as synthetic axons to study drug efficacy on fiber engagement. We show that EGFR inhibition per se stimulates MBP expression and increases Clobetasol efficacy in OPC differentiation. Consistent with this, Clobetasol and Gefitinib co-treatment, by co-regulating RXRγ, MBP and phosphatidylinositol 4,5-bisphosphate (PIP2) levels, maximizes synthetic axon engagement. Conversely, RXRγ gene silencing reduces the ability of the drugs to promote MBP expression. This work provides a view of how EGFR/ErbB inhibition controls OPC differentiation and indicates the combination of Clobetasol and Gefitinib as a potent remyelination-enhancing treatment.
- Published
- 2019
- Full Text
- View/download PDF
17. Guidelines for a curriculum in healthcare quality and resource management.
- Author
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Sposato CF
- Subjects
- Forms and Records Control, Guidelines as Topic, Program Development, United States, Curriculum, Health Personnel education, Health Resources organization & administration, Quality Assurance, Health Care organization & administration
- Abstract
Issues of quality pervade American society. Demands for accountability for the quality of and the resources utilized in delivering healthcare services are coming from consumer advocacy groups, regulatory agencies, third-party payers, and corporate purchasers of healthcare. To date, institutions of higher education do not consistently offer either adequate or coordinated programs to prepare healthcare professionals to assume the regulator role. Promoting quality is both a mandate and a legacy, and each professional will need to be involved to ensure continuing quality care for consumers. Active collaboration between academic, service, and professional organizations, as well as a strong commitment to the development and timely implementation of a suitable curriculum, are imperative.
- Published
- 1994
- Full Text
- View/download PDF
18. Needed: a curriculum in health care quality and resource management for the health professions.
- Author
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Sposato CF
- Subjects
- Competency-Based Education, Curriculum, Socialization, United States, Health Occupations education, Health Resources organization & administration, Quality of Health Care
- Published
- 1993
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