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3. COVID-19 and metabolic disease: mechanisms and clinical management

Author

Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K., Tkachuk, V. A., Markov, A. G., Lehnert, H., de Angelis, M. H., Rietzsch, H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Holt, R. I. G., Skyler, J. S., Devries, J. H., Renard, E., Eckel, R. H., Alberti, K. G. M. M., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Bewick, G., Spinas, G. A., Beuschlein, F., Landgraf, R., Rubino, F., Mingrone, Geltrude, Bornstein, S. R., Mingrone G. (ORCID:0000-0003-2021-528X), Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K., Tkachuk, V. A., Markov, A. G., Lehnert, H., de Angelis, M. H., Rietzsch, H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Holt, R. I. G., Skyler, J. S., Devries, J. H., Renard, E., Eckel, R. H., Alberti, K. G. M. M., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Bewick, G., Spinas, G. A., Beuschlein, F., Landgraf, R., Rubino, F., Mingrone, Geltrude, Bornstein, S. R., and Mingrone G. (ORCID:0000-0003-2021-528X)

Abstract

Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

Published
2021

4. Consequences of the COVID-19 pandemic for patients with metabolic diseases

Author

Bornstein, S. R., Rubino, F., Ludwig, B., Rietzsch, H., Schwarz, P. E. H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. I. G., Skyler, J. S., Devries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Spinas, G. A., Beuschlein, F., Mingrone, Geltrude, Mingrone G. (ORCID:0000-0003-2021-528X), Bornstein, S. R., Rubino, F., Ludwig, B., Rietzsch, H., Schwarz, P. E. H., Rodionov, R. N., Khunti, K., Hopkins, D., Birkenfeld, A. L., Boehm, B., Amiel, S., Holt, R. I. G., Skyler, J. S., Devries, J. H., Renard, E., Eckel, R. H., Zimmet, P., Alberti, K. G., Geloneze, B., Chan, J. C., Mbanya, J. C., Onyegbutulem, H. C., Ramachandran, A., Basit, A., Hassanein, M., Spinas, G. A., Beuschlein, F., Mingrone, Geltrude, and Mingrone G. (ORCID:0000-0003-2021-528X)

Abstract

The COVID-19 pandemic has stretched healthcare resources and caused severe knock-on effects on patients with metabolic diseases worldwide. We encourage clinicians and patient-interest groups in the field of diabetes and metabolism to raise their voices to ensure adequate care and admission of patients.

Published
2021

24. Stoffwechselerkrankungen

Author

Spinas, G A, Röcken, Christoph, University of Zurich, Höfler, Gerald, Kreipe, Hans, and Moch, Holger

Subjects
10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health
Published
2019

28. Stoffwechselerkrankungen

Author

Höfler, Gerald, Kreipe, Hans, Moch, Holger; https://orcid.org/0000-0002-7986-2839, Höfler, G ( Gerald ), Kreipe, H ( Hans ), Moch, H ( Holger ), Spinas, G A, Röcken, Christoph, Höfler, Gerald, Kreipe, Hans, Moch, Holger; https://orcid.org/0000-0002-7986-2839, Höfler, G ( Gerald ), Kreipe, H ( Hans ), Moch, H ( Holger ), Spinas, G A, and Röcken, Christoph

Published
2019

33. Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5year single centre follow-up

Author

Gerber, P., Pavlicek, V., Demartines, N., Zuellig, R., Pfammatter, T., Wüthrich, R., Weber, M., Spinas, G., and Lehmann, R.

Abstract

Aims/hypothesis: The aim of this study was to compare the long-term outcomes—in terms of glucose control, renal function and procedure-related complications—of simultaneous islet-kidney (SIK) transplantation with those of simultaneous pancreas-kidney (SPK) transplantation in patients with type 1 diabetes mellitus. Methods: HbA1c, need for insulin, GFR and complication rate were compared between 13 recipients of SIK and 25 recipients of SPK transplants at the same institution. The mean follow-up was 41months. Results: Two primary organ non-functions occurred in the SIK group. HbA1c did not differ at any time point during follow-up in the SIK group compared with the SPK group (mean during follow-up 6.3 vs 5.9%). Similarly, kidney function over time was not different between the two groups. A higher rate of insulin independence following SPK transplantation (after 1year 96 vs 31% in the SIK group) was counterbalanced by a higher rate of serious adverse events (40% relaparotomies vs 0% in the SIK group). Conclusions/interpretation: The endogenous insulin production achieved by islet transplantation, combined with optimal insulin therapy, was sufficient for maintaining near-normal glucose levels. In terms of glucose control, islet transplantation provides results comparable to those achieved with pancreas transplantation. However, SPK results in a higher rate of insulin independence, albeit at the cost of more surgical complications. These results have led to a new paradigm in islet transplantation at our institution, where the primary goal is not insulin independence, but good glucose control and avoidance of severe hypoglycaemia

Published
2018

42. Ovar

Author

Spinas, G A, Fischli, S, Spinas, G A ( G A ), Fischli, S ( S ), Imthurn, B, Spinas, G A, Fischli, S, Spinas, G A ( G A ), Fischli, S ( S ), and Imthurn, B

Abstract

Das Ovar ist ein zentrales Organ der Fertilität und der endokrinen Aktivität der Frau. Nur die intakte Interaktion zwischen Ovar und Hypothalamus/Hypophyse einerseits und Uterus anderseits resultiert in einer funktionierenden Fertilität. Darüber hinaus haben die ovariellen Hormone, in erster Linie Östradiol, eine ubiquitäre Bedeutung für den weiblichen Organismus. So kann ein Östrogenmangel neben Hitzewallungen zu Osteoporose und kardiovaskulären Erkrankungen führen.

Published
2011

46. Insulintherapie

Author

Spinas, G A, University of Zurich, and Spinas, G A

Subjects
2712 Endocrinology, Diabetes and Metabolism, 610 Medicine & health, 142-005 142-005
Published
2006

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