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ABSTRACT We present Atacama Compact Array and Atacama Pathfinder Experiment observations of the [N ii] 205 μm fine-structure line in 40 sub-millimetre galaxies lying at redshifts z = 3–6, drawn from the 2500 deg2 South Pole Telescope survey. This represents the largest uniformly selected sample of high-redshift [N ii] 205 μm measurements to date. 29 sources also have [C ii] 158 μm line observations allowing a characterization of the distribution of the [C ii] to [N ii] luminosity ratio for the first time at high redshift. The sample exhibits a median L$_{{\rm{[C\,{\small II}]}}}$/L$_{{\rm{[N\,{\small II}]}}}$ ≈ 11.0 and interquartile range of 5.0 –24.7. These ratios are similar to those observed in local (Ultra)luminous infrared galaxies (LIRGs), possibly indicating similarities in their interstellar medium. At the extremes, we find individual sub-millimetre galaxies with L$_{{\rm{[C\,{\small II}]}}}$/L$_{{\rm{[N\,{\small II}]}}}$ low enough to suggest a smaller contribution from neutral gas than ionized gas to the [C ii] flux and high enough to suggest strongly photon or X-ray region dominated flux. These results highlight a large range in this line luminosity ratio for sub-millimetre galaxies, which may be caused by variations in gas density, the relative abundances of carbon and nitrogen, ionization parameter, metallicity, and a variation in the fractional abundance of ionized and neutral interstellar medium.

We probe star formation in the environments of massive (∼1013 M☉) dark matter haloes at redshifts of z ∼ 1. This star formation is linked to a submillimetre clustering signal which we detect in maps of the Planck High Frequency Instrument that are stacked at the positions of a sample of high redshift (z > 2) strongly lensed dusty star-forming galaxies (DSFGs) selected from the South Pole Telescope (SPT) 2500 deg2 survey. The clustering signal has submillimetre colours which are consistent with the mean redshift of the foreground lensing haloes (z ∼ 1). We report a mean excess of star formation rate (SFR) compared to the field, of (2700 ± 700) M☉ yr−1 from all galaxies contributing to this clustering signal within a radius of 3.5 arcmin from the SPT DSFGs. The magnitude of the Planck excess is in broad agreement with predictions of a current model of the cosmic infrared background. The model predicts that 80 per cent of the excess emission measured by Planck originates from galaxies lying in the neighbouring haloes of the lensing halo. Using Herschel maps of the same fields, we find a clear excess, relative to the field, of individual sources which contribute to the Planck excess. The mean excess SFR compared to the field is measured to be (370 ± 40) M☉ yr−1 per resolved, clustered source. Our findings suggest that the environments around these massive z ∼ 1 lensing haloes host intense star formation out to about 2 Mpc. The flux enhancement due to clustering should also be considered when measuring flux densities of galaxies in Planck data.

Galaxies grow inefficiently, with only a small percentage of the available gas converted into stars each free-fall time. Feedback processes, such as outflowing winds driven by radiation pressure, supernovae, or supermassive black hole accretion, can act to halt star formation if they heat or expel the gas supply. We report a molecular outflow launched from a dust-rich star-forming galaxy at redshift 5.3, 1 billion years after the Big Bang. The outflow reaches velocities up to 800 kilometers per second relative to the galaxy, is resolved into multiple clumps, and carries mass at a rate within a factor of 2 of the star formation rate. Our results show that molecular outflows can remove a large fraction of the gas available for star formation from galaxies at high redshift.

According to the current understanding of cosmic structure formation, the precursors of the most massive structures in the Universe began to form shortly after the Big Bang, in regions corresponding to the largest fluctuations in the cosmic density field. Observing these structures during their period of active growth and assembly-the first few hundred million years of the Universe-is challenging because it requires surveys that are sensitive enough to detect the distant galaxies that act as signposts for these structures and wide enough to capture the rarest objects. As a result, very few such objects have been detected so far. Here we report observations of a far-infrared-luminous object at redshift 6.900 (less than 800 million years after the Big Bang) that was discovered in a wide-field survey. High-resolution imaging shows it to be a pair of extremely massive star-forming galaxies. The larger is forming stars at a rate of 2,900 solar masses per year, contains 270 billion solar masses of gas and 2.5 billion solar masses of dust, and is more massive than any other known object at a redshift of more than 6. Its rapid star formation is probably triggered by its companion galaxy at a projected separation of 8 kiloparsecs. This merging companion hosts 35 billion solar masses of stars and has a star-formation rate of 540 solar masses per year, but has an order of magnitude less gas and dust than its neighbour and physical conditions akin to those observed in lower-metallicity galaxies in the nearby Universe. These objects suggest the presence of a dark-matter halo with a mass of more than 100 billion solar masses, making it among the rarest dark-matter haloes that should exist in the Universe at this epoch.

We report the discovery and constrain the physical conditions of the interstellar medium of the highest-redshift millimeter-selected dusty star-forming galaxy to date, SPT-S J031132-5823.4 (hereafter SPT0311-58), at z = 6.900 ± 0.002. SPT0311-58 was discovered via its 1.4 mm thermal dust continuum emission in the South Pole Telescope (SPT)-SZ survey. The spectroscopic redshift was determined through an Atacama Large Millimeter/submillimeter Array 3 mm frequency scan that detected CO(6-5), CO(7-6), and [C I](2-1), and subsequently was confirmed by detections of CO(3-2) with the Australia Telescope Compact Array and [C II] with APEX. We constrain the properties of the ISM in SPT0311-58 with a radiative transfer analysis of the dust continuum photometry and the CO and [C I] line emission. This allows us to determine the gas content without ad hoc assumptions about gas mass scaling factors. SPT0311-58 is extremely massive, with an intrinsic gas mass of Mgas 3.3±1.9×1011 M. Its large mass and intense star formation is very rare for a source well into the epoch of reionization.

We present ALMA [CI]($1-0$) (rest frequency 492 GHz) observations for asample of 13 strongly-lensed dusty star-forming galaxies originally discoveredat 1.4mm in a blank-field survey by the South Pole Telescope. We compare thesenew data with available [CI] observations from the literature, allowing a studyof the ISM properties of $\sim 30$ extreme dusty star-forming galaxies spanninga redshift range $2 < z < 5$. Using the [CI] line as a tracer of the molecularISM, we find a mean molecular gas mass for SPT-DSFGs of $6.6 \times 10^{10}$M$_{\odot}$. This is in tension with gas masses derived via low-$J$ $^{12}$COand dust masses; bringing the estimates into accordance requires either (a) anelevated CO-to-H$_2$ conversion factor for our sample of $\alpha_{\rm CO} \sim2.5$ and a gas-to-dust ratio $\sim200$, or (b) an high carbon abundance $X_{\rmCI} \sim 7\times10^{-5}$. Using observations of a range of additional atomicand molecular lines (including [CI], [CII], and multiple transitions of CO), weuse a modern Photodissociation Region code (3D-PDR) to assess the physicalconditions (including the density, UV radiation field strength, and gastemperature) within the ISM of the DSFGs in our sample. We find that the ISMwithin our DSFGs is characterised by dense gas permeated by strong UV fields.We note that previous efforts to characterise PDR regions in DSFGs may havesignificantly underestimated the density of the ISM. Combined, our analysissuggests that the ISM of extreme dusty starbursts at high redshift consists ofdense, carbon-rich gas not directly comparable to the ISM of starbursts in thelocal Universe.

We present ALMA [CI]($1-0$) (rest frequency 492 GHz) observations for asample of 13 strongly-lensed dusty star-forming galaxies originally discoveredat 1.4mm in a blank-field survey by the South Pole Telescope. We compare thesenew data with available [CI] observations from the literature, allowing a studyof the ISM properties of $\sim 30$ extreme dusty star-forming galaxies spanninga redshift range $2 < z < 5$. Using the [CI] line as a tracer of the molecularISM, we find a mean molecular gas mass for SPT-DSFGs of $6.6 \times 10^{10}$M$_{\odot}$. This is in tension with gas masses derived via low-$J$ $^{12}$COand dust masses; bringing the estimates into accordance requires either (a) anelevated CO-to-H$_2$ conversion factor for our sample of $\alpha_{\rm CO} \sim2.5$ and a gas-to-dust ratio $\sim200$, or (b) an high carbon abundance $X_{\rmCI} \sim 7\times10^{-5}$. Using observations of a range of additional atomicand molecular lines (including [CI], [CII], and multiple transitions of CO), weuse a modern Photodissociation Region code (3D-PDR) to assess the physicalconditions (including the density, UV radiation field strength, and gastemperature) within the ISM of the DSFGs in our sample. We find that the ISMwithin our DSFGs is characterised by dense gas permeated by strong UV fields.We note that previous efforts to characterise PDR regions in DSFGs may havesignificantly underestimated the density of the ISM. Combined, our analysissuggests that the ISM of extreme dusty starbursts at high redshift consists ofdense, carbon-rich gas not directly comparable to the ISM of starbursts in thelocal Universe.

We present Chandra ACIS-S and ATCA radio continuum observations of thestrongly lensed dusty, star-forming galaxy SPT-S J034640-5204.9 (hereafterSPT0346-52) at $z$ = 5.656. This galaxy has also been observed with ALMA, HST,Spitzer, Herschel, APEX, and the VLT. Previous observations indicate that ifthe infrared (IR) emission is driven by star formation, then the inferredlensing-corrected star formation rate ($\sim$ 4500 $M_{\sun}$ yr$^{-1}$) andstar formation rate surface density $\Sigma_{\rm SFR}$ ($\sim$ 2000 $M_{\sun}{yr^{-1}} {kpc^{-2}}$) are both exceptionally high. It remained unclear fromthe previous data, however, whether a central active galactic nucleus (AGN)contributes appreciably to the IR luminosity. The {\it Chandra} upper limitshows that SPT0346-52 is consistent with being star-formation dominated in theX-ray, and any AGN contribution to the IR emission is negligible. The ATCAradio continuum upper limits are also consistent with the FIR-to-radiocorrelation for star-forming galaxies with no indication of an additional AGNcontribution. The observed prodigious intrinsic IR luminosity of (3.6 $\pm$0.3) $\times$ 10$^{13}$ $L_{\sun}$ originates almost solely from vigorous starformation activity. With an intrinsic source size of 0.61 $\pm$ 0.03 kpc,SPT0346-52 is confirmed to have one of the highest $\Sigma_{SFR}$ of any knowngalaxy. This high $\Sigma_{SFR}$, which approaches the Eddington limit for aradiation pressure supported starburst, may be explained by a combination ofvery high star formation efficiency and gas fraction.

The South Pole Telescope has discovered 100 gravitationally lensed, high-redshift, dusty, star-forming galaxies (DSFGs). We present 0 5 resolution 870μm Atacama Large Millimeter/submillimeter Array imaging of a sample of 47 DSFGs spanning z = 1.9 5.7 - , and construct gravitational lens models of these sources. Our visibility-based lens modeling incorporates several sources of residual interferometric calibration uncertainty, allowing us to properly account for noise in the observations. At least 70% of the sources are strongly lensed by foreground galaxies (m870 m m > 2), with a median magnification of m870 m m = 6.3, extending to m870 m m > 30. We compare the intrinsic size distribution of the strongly lensed sources to a similar number of unlensed DSFGs and find no significant differences in spite of a bias between the magnification and intrinsic source size. This may indicate that the true size distribution of DSFGs is relatively narrow. We use the source sizes to constrain the wavelength at which the dust optical depth is unity and find this wavelength to be correlated with the dust temperature. This correlation leads to discrepancies in dust mass estimates of a factor of two compared to estimates using a single value for this wavelength. We investigate the relationship between the [C II] line and the far-infrared luminosity and find that the same correlation between the [C II]/LFIR ratio and SFIR found for low-redshift star-forming galaxies applies to high-redshift galaxies and extends at least two orders of magnitude higher in SFIR. This lends further credence to the claim that the compactness of the IR-emitting region is the controlling parameter in establishing the [C II] deficit.

We use the Atacama Large Millimeter/submillimeter Array (ALMA) in Cycle 1 to determine spectroscopic redshifts of high-redshift dusty star-forming galaxies (DSFGs) selected by their 1.4 mm continuum emission in the South Pole Telescope (SPT) survey. We present ALMA 3 mm spectral scans between 84 and 114 GHz for 15 galaxies and targeted ALMA 1 mm observations for an additional eight sources. Our observations yield 30 new line detections from CO, [C i], [N ii], H2O and NH3. We further present Atacama Pathfinder Experiment [C ii] and CO mid-J observations for seven sources for which only a single line was detected in spectral-scan data from ALMA Cycle 0 or Cycle 1. We combine the new observations with previously published and new millimeter/submillimeter line and photometric data of the SPT-selected DSFGs to study their redshift distribution. The combined data yield 39 spectroscopic redshifts from molecular lines, a success rate of >85%. Our sample represents the largest data set of its kind today and has the highest spectroscopic completeness among all redshift surveys of high-z DSFGs. The median of the redshift distribution is z = 3.9 ±0.4, and the highest-redshift source in our sample is at z = 5.8. We discuss how the selection of our sources affects the redshift distribution, focusing on source brightness, selection wavelength, and strong gravitational lensing. We correct for the effect of gravitational lensing and find the redshift distribution for 1.4 mm selected sources with a median redshift of z = 3.1 ±0.3. Comparing to redshift distributions selected at shorter wavelengths from the literature, we show that selection wavelength affects the shape of the redshift distribution.

We present ALMA detections of the [NII] 205$\mu$m and CO(12-11) emissionlines, and the tentative detection of [CI] $^3$P$_1$ - $^3$P$_0$ for thestrongly lensed ($\mu$=5.7$\pm$0.5) dusty, star-forming galaxy SPT-SJ213242-5802.9 (hereafter SPT2132-58) at z=4.77. The [NII] and CO(12-11) linesare detected at 11.5 and 8.5 $\sigma$ level, respectively, by our band-6observations. The [CI] line is detected at 3.2 $\sigma$ after a re-analysis ofexisting band-3 data. The [CI] luminosity implies a gas mass of3.8$\pm$1.2$\times$10$^{10}$ M$_\odot$, and consequently a very short depletiontimescale of 34$\pm$13 Myr and a CO-luminosity-to-gas-mass conversion factor$\alpha_{\rm CO}$ of 1.0$\pm$0.3 M$_\odot$ (K km s$^{-1}$ pc$^{2}$)$^{-1}$.SPT2132-58 is an extreme starburst with an intrinsic star formation rate of1100$\pm$200 M$_\odot$/yr. We find a [CII]/[NII] ratio of 26$\pm$7, which isthe highest reported at z$>$4. This suggests that SPT2132-58 hosts an evolvedinterstellar medium (0.5 Z$_\odot$

We present ALMA detections of the [NII] 205$\mu$m and CO(12-11) emissionlines, and the tentative detection of [CI] $^3$P$_1$ - $^3$P$_0$ for thestrongly lensed ($\mu$=5.7$\pm$0.5) dusty, star-forming galaxy SPT-SJ213242-5802.9 (hereafter SPT2132-58) at z=4.77. The [NII] and CO(12-11) linesare detected at 11.5 and 8.5 $\sigma$ level, respectively, by our band-6observations. The [CI] line is detected at 3.2 $\sigma$ after a re-analysis ofexisting band-3 data. The [CI] luminosity implies a gas mass of3.8$\pm$1.2$\times$10$^{10}$ M$_\odot$, and consequently a very short depletiontimescale of 34$\pm$13 Myr and a CO-luminosity-to-gas-mass conversion factor$\alpha_{\rm CO}$ of 1.0$\pm$0.3 M$_\odot$ (K km s$^{-1}$ pc$^{2}$)$^{-1}$.SPT2132-58 is an extreme starburst with an intrinsic star formation rate of1100$\pm$200 M$_\odot$/yr. We find a [CII]/[NII] ratio of 26$\pm$7, which isthe highest reported at z$>$4. This suggests that SPT2132-58 hosts an evolvedinterstellar medium (0.5 Z$_\odot$

We probe star formation in the environments of massive (∼1013 M☉) dark matter haloes at redshifts of z ∼ 1. This star formation is linked to a submillimetre clustering signal which we detect in maps of the Planck High Frequency Instrument that are stacked at the positions of a sample of high redshift (z > 2) strongly lensed dusty star-forming galaxies (DSFGs) selected from the South Pole Telescope (SPT) 2500 deg2 survey. The clustering signal has submillimetre colours which are consistent with the mean redshift of the foreground lensing haloes (z ∼ 1). We report a mean excess of star formation rate (SFR) compared to the field, of (2700 ± 700) M☉ yr−1 from all galaxies contributing to this clustering signal within a radius of 3.5 arcmin from the SPT DSFGs. The magnitude of the Planck excess is in broad agreement with predictions of a current model of the cosmic infrared background. The model predicts that 80 per cent of the excess emission measured by Planck originates from galaxies lying in the neighbouring haloes of the lensing halo. Using Herschel maps of the same fields, we find a clear excess, relative to the field, of individual sources which contribute to the Planck excess. The mean excess SFR compared to the field is measured to be (370 ± 40) M☉ yr−1 per resolved, clustered source. Our findings suggest that the environments around these massive z ∼ 1 lensing haloes host intense star formation out to about 2 Mpc. The flux enhancement due to clustering should also be considered when measuring flux densities of galaxies in Planck data.

To understand cosmic mass assembly in the universe at early epochs, we primarily rely on measurements of the stellar masses and star formation rates (SFRs) of distant galaxies. In this paper, we present stellar masses and SFRs of six high-redshift (2.8 ≤ z ≤ 5.7) dusty, star-forming galaxies (DSFGs) that are strongly gravitationally lensed by foreground galaxies. These sources were first discovered by the South Pole Telescope (SPT) at millimeter wavelengths and all have spectroscopic redshifts and robust lens models derived from Atacama Large Millimeter/submillimeter Array observations. We have conducted follow-up observations to obtain multi-wavelength imaging data using the Hubble Space Telescope (HST), Spitzer, Herschel, and the Atacama Pathfinder EXperiment. We use the high-resolution HST/Wide Field Camera 3 images to disentangle the background source from the foreground lens in Spitzer/IRAC data. The detections and upper limits provide important constraints on the spectral energy distributions (SEDs) for these DSFGs, yielding stellar masses, IR luminosities, and SFRs. The SED fits of six SPT sources show that the intrinsic stellar masses span a range more than one order of magnitude with a median value ∼5 ×1010 Mo. The intrinsic IR luminosities range from 4 × 1012 Lo to 4 × 1013 Lo. They all have prodigious intrinsic SFRs of 510-4800 Mo yr-1. Compared to the star-forming main sequence (MS), these six DSFGs have specific SFRs that all lie above the MS, including two galaxies that are a factor of 10 higher than the MS. Our results suggest that we are witnessing ongoing strong starburst events that may be driven by major mergers.

We present spatially resolved imaging obtained with the Australia Telescope Compact Array (ATCA) of three CO lines in two high-redshift gravitationally lensed dusty star-forming galaxies, discovered by the South Pole Telescope. Strong lensing allows us to probe the structure and dynamics of the molecular gas in these two objects, at z = 2.78 and z = 5.66, with effective source-plane resolution of less than 1 kpc. We model the lensed emission from multiple CO transitions and the dust continuum in a consistent manner, finding that the cold molecular gas as traced by low-J CO always has a larger half-light radius than the 870 μm dust continuum emission. This size difference leads to up to 50% differences in the magnification factor for the cold gas compared to dust. In the z = 2.78 galaxy, these CO observations confirm that the background source is undergoing a major merger, while the velocity field of the other source is more complex. We use the ATCA CO observations and comparable resolution Atacama Large Millimeter/submillimeter Array dust continuum imaging of the same objects to constrain the CO-H2 conversion factor with three different procedures, finding good agreement between the methods and values consistent with those found for rapidly star-forming systems. We discuss these galaxies in the context of the star formation - gas mass surface density relation, noting that the change in emitting area with observed CO transition must be accounted for when comparing high-redshift galaxies to their lower redshift counterparts.

We present [C II] observations of 20 strongly lensed dusty star-forming galaxies at 2.1 < z < 5.7 using Atacama Pathfinder EXperiment and Herschel. The sources were selected on their 1.4 mm flux (S1.4mm > 20 mJy) from the South Pole Telescope (SPT) survey, with far-infrared (FIR) luminosities determined from extensive photometric data. The [CII] line is robustly detected in 17 sources, all but one being spectrally resolved. 11 out of 20 sources observed in [C II] also have low-J CO detections from Australia Telescope Compact Array. A comparison with mid- and high-J CO lines from Atacama Large Millimeter/submillimeter Array reveals consistent [C II] and CO velocity profiles, suggesting that there is little differential lensing between these species. The [C II], low-J CO and FIR data allow us to constrain the properties of the interstellar medium. We find [C II] to CO(1-0) luminosity ratios in the SPT sample of 5200 ± 1800, with significantly less scatter than in other samples. This line ratio can be best described by a medium of [C II] and CO emitting gas with a higher [C II] than CO excitation temperature, high CO optical depth τ CO(1-0) ≫ 1, and low to moderate [CII] optical depth τ[C II]≲ 1. The geometric structure of photodissociation regions allows for such conditions.

We present the average rest-frame spectrum of high-redshift dusty, star-forming galaxies from 250 to 770 GHz. This spectrum was constructed by stacking Atacama Large Millimeter/submillimeter Array (ALMA) 3 mm spectra of 22 such sources discovered by the South Pole Telescope and spanning z = 2.0-5.7. In addition to multiple bright spectral features of 12CO, [C I], and H 2O, we also detect several faint transitions of 13CO, HCN, HNC, HCO+, and CN, and use the observed line strengths to characterize the typical properties of the interstellar medium of these high-redshift starburst galaxies. We find that the 13CO brightness in these objects is comparable to that of the only other z > 2 star-forming galaxy in which 13CO has been observed. We show that the emission from the high-critical density molecules HCN, HNC, HCO+, and CN is consistent with a warm, dense medium with T kin 55 K and cm-3. High molecular hydrogen densities are required to reproduce the observed line ratios, and we demonstrate that alternatives to purely collisional excitation are unlikely to be significant for the bulk of these systems. We quantify the average emission from several species with no individually detected transitions, and find emission from the hydride CH and the linear molecule CCH for the first time at high redshift, indicating that these molecules may be powerful probes of interstellar chemistry in high-redshift systems. These observations represent the first constraints on many molecular species with rest-frame transitions from 0.4 to 1.2 mm in star-forming systems at high redshift, and will be invaluable in making effective use of ALMA in full science operations. © 2014. The American Astronomical Society. All rights reserved..

We present observations of SPT-S J053816-5030.8, a gravitationally lensed dusty star-forming galaxy (DSFG) at z = 2.7817 that was first discovered at millimeter wavelengths by the South Pole Telescope. SPT 0538-50 is typical of the brightest sources found by wide-field millimeter-wavelength surveys, being lensed by an intervening galaxy at moderate redshift (in this instance, at z = 0.441). We present a wide array of multi-wavelength spectroscopic and photometric data on SPT 0538-50, including data from ALMA, Herschel PACS and SPIRE, Hubble, Spitzer, the Very Large Telescope, ATCA, APEX, and the Submillimeter Array. We use high-resolution imaging from the Hubble Space Telescope to de-blend SPT 0538-50, separating DSFG emission from that of the foreground lens. Combined with a source model derived from ALMA imaging (which suggests a magnification factor of 21 ± 4), we derive the intrinsic properties of SPT 0538-50, including the stellar mass, far-IR luminosity, star formation rate, molecular gas mass, and - using molecular line fluxes - the excitation conditions within the interstellar medium. The derived physical properties argue that we are witnessing compact, merger-driven star formation in SPT 0538-50 similar to local starburst galaxies and unlike that seen in some other DSFGs at this epoch. © 2013. The American Astronomical Society. All rights reserved..

We present observations of SPT-S J053816-5030.8, a gravitationally lensed dusty star-forming galaxy (DSFG) at z = 2.7817 that was first discovered at millimeter wavelengths by the South Pole Telescope. SPT 0538-50 is typical of the brightest sources found by wide-field millimeter-wavelength surveys, being lensed by an intervening galaxy at moderate redshift (in this instance, at z = 0.441). We present a wide array of multi-wavelength spectroscopic and photometric data on SPT 0538-50, including data from ALMA, Herschel PACS and SPIRE, Hubble, Spitzer, the Very Large Telescope, ATCA, APEX, and the Submillimeter Array. We use high-resolution imaging from the Hubble Space Telescope to de-blend SPT 0538-50, separating DSFG emission from that of the foreground lens. Combined with a source model derived from ALMA imaging (which suggests a magnification factor of 21 ± 4), we derive the intrinsic properties of SPT 0538-50, including the stellar mass, far-IR luminosity, star formation rate, molecular gas mass, and - using molecular line fluxes - the excitation conditions within the interstellar medium. The derived physical properties argue that we are witnessing compact, merger-driven star formation in SPT 0538-50 similar to local starburst galaxies and unlike that seen in some other DSFGs at this epoch. © 2013. The American Astronomical Society. All rights reserved..

Dust grains absorb half of the radiation emitted by stars throughout the history of the universe, re-emitting this energy at infrared wavelengths 1-3 . Polycyclic aromatic hydrocarbons (PAHs) are large organic molecules that trace millimetre-size dust grains and regulate the cooling of interstellar gas within galaxies 4,5 . Observations of PAH features in very distant galaxies have been difficult owing to the limited sensitivity and wavelength coverage of previous infrared telescopes 6,7 . Here we present James Webb Space Telescope observations that detect the 3.3 μm PAH feature in a galaxy observed less than 1.5 billion years after the Big Bang. The high equivalent width of the PAH feature indicates that star formation, rather than black hole accretion, dominates infrared emission throughout the galaxy. The light from PAH molecules, hot dust and large dust grains and stars are spatially distinct from one another, leading to order-of-magnitude variations in PAH equivalent width and ratio of PAH to total infrared luminosity across the galaxy. The spatial variations we observe suggest either a physical offset between PAHs and large dust grains or wide variations in the local ultraviolet radiation field. Our observations demonstrate that differences in emission from PAH molecules and large dust grains are a complex result of localized processes within early galaxies., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Star formation in half of massive galaxies was quenched by the time the Universe was 3 billion years old 1 . Very low amounts of molecular gas seem to be responsible for this, at least in some cases 2-7 , although morphological gas stabilization, shock heating or activity associated with accretion onto a central supermassive black hole are invoked in other cases 8-11 . Recent studies of quenching by gas depletion have been based on upper limits that are insufficiently sensitive to determine this robustly 2-7 , or stacked emission with its problems of averaging 8,9 . Here we report 1.3 mm observations of dust emission from 6 strongly lensed galaxies where star formation has been quenched, with magnifications of up to a factor of 30. Four of the six galaxies are undetected in dust emission, with an estimated upper limit on the dust mass of 0.0001 times the stellar mass, and by proxy (assuming a Milky Way molecular gas-to-dust ratio) 0.01 times the stellar mass in molecular gas. This is two orders of magnitude less molecular gas per unit stellar mass than seen in star forming galaxies at similar redshifts 12-14 . It remains difficult to extrapolate from these small samples, but these observations establish that gas depletion is responsible for a cessation of star formation in some fraction of high-redshift galaxies., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

Change history: In this Letter, the Acknowledgements section should have included the following sentence: "The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.". This omission has been corrected online.

Massive galaxy clusters have been found that date to times as early as three billion years after the Big Bang, containing stars that formed at even earlier epochs 1-3 . The high-redshift progenitors of these galaxy clusters-termed 'protoclusters'-can be identified in cosmological simulations that have the highest overdensities (greater-than-average densities) of dark matter 4-6 . Protoclusters are expected to contain extremely massive galaxies that can be observed as luminous starbursts 7 . However, recent detections of possible protoclusters hosting such starbursts 8-11 do not support the kind of rapid cluster-core formation expected from simulations 12 : the structures observed contain only a handful of starbursting galaxies spread throughout a broad region, with poor evidence for eventual collapse into a protocluster. Here we report observations of carbon monoxide and ionized carbon emission from the source SPT2349-56. We find that this source consists of at least 14 gas-rich galaxies, all lying at redshifts of 4.31. We demonstrate that each of these galaxies is forming stars between 50 and 1,000 times more quickly than our own Milky Way, and that all are located within a projected region that is only around 130 kiloparsecs in diameter. This galaxy surface density is more than ten times the average blank-field value (integrated over all redshifts), and more than 1,000 times the average field volume density. The velocity dispersion (approximately 410 kilometres per second) of these galaxies and the enormous gas and star-formation densities suggest that this system represents the core of a cluster of galaxies that was already at an advanced stage of formation when the Universe was only 1.4 billion years old. A comparison with other known protoclusters at high redshifts shows that SPT2349-56 could be building one of the most massive structures in the Universe today.

In the past decade, our understanding of galaxy evolution has been revolutionized by the discovery that luminous, dusty starburst galaxies were 1,000 times more abundant in the early Universe than at present. It has, however, been difficult to measure the complete redshift distribution of these objects, especially at the highest redshifts (z > 4). Here we report a redshift survey at a wavelength of three millimetres, targeting carbon monoxide line emission from the star-forming molecular gas in the direction of extraordinarily bright millimetre-wave-selected sources. High-resolution imaging demonstrates that these sources are strongly gravitationally lensed by foreground galaxies. We detect spectral lines in 23 out of 26 sources and multiple lines in 12 of those 23 sources, from which we obtain robust, unambiguous redshifts. At least 10 of the sources are found to lie at z > 4, indicating that the fraction of dusty starburst galaxies at high redshifts is greater than previously thought. Models of lens geometries in the sample indicate that the background objects are ultra-luminous infrared galaxies, powered by extreme bursts of star formation.

Rationale: Stroke is a common and costly condition where an effective early treatment may be expected to affect patients' future quality of life, the cost of acute medical treatment, and the cost of rehabilitation and any supportive care needed for their remaining lifetime. To assist in informing discussions on early adoption of potential treatments, economic analyses should accompany investigations that seek to improve outcomes for stroke patients., Aims: The primary aim is to assess whether i.v./i.a. rt-PA therapy is cost-effective at 3 months compared with i.v. rt-PA, and provides cost-savings or is cost-neutral by 12 months. Design Cost-effectiveness of the two treatment arms will be measured at months 3, 6, 9, and 12. Cost-effectiveness will be calculated using 1.standard cost-effectiveness methodology (incremental cost-effectiveness ratios), and 2.an econometric model to assess multiple outcome measures while controlling for multiple subject and treatment-related factors that are known to affect both outcomes and costs., Study Outcomes: Total cost for the initial hospitalization of treating stroke subjects randomized to either i.v./i.a. or i.v. rt-PA treatment arms will be measured, as will differences in types of resource utilization over 12 months between the two arms of the trial. Quality-of-life data (EuroQol EQ-5D) will be collected over a 12-month period and quality-adjusted life years will be used as a morbidity-adjusted measure of effectiveness. Subgroup analyses will include dichotomized NIH Stroke Scale (<20, >or=20), country, time between onset and randomization, and i.a. devices.