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114 results on '"Spijkerman, Annemieke M.W."'

1. Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Author

Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M. Monique, and Dollé, Martijn E.T.

Published
2019
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2. Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations1–3

Author

Zamora-Ros, Raul, Forouhi, Nita G., Sharp, Stephen J., González, Carlos A., Buijsse, Brian, Guevara, Marcela, van der Schouw, Yvonne T., Amiano, Pilar, Boeing, Heiner, Bredsdorff, Lea, Fagherazzi, Guy, Feskens, Edith J., Franks, Paul W., Grioni, Sara, Katzke, Verena, Key, Timothy J., Khaw, Kay-Tee, Kühn, Tilman, Masala, Giovanna, Mattiello, Amalia, Molina-Montes, Esther, Nilsson, Peter M., Overvad, Kim, Perquier, Florence, Redondo, M. Luisa, Ricceri, Fulvio, Rolandsson, Olov, Romieu, Isabelle, Roswall, Nina, Scalbert, Augustin, Schulze, Matthias, Slimani, Nadia, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tormo, Maria Jose, Touillaud, Marina, Tumino, Rosario, van der A, Daphne L., van Woudenbergh, Geertruida J., Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J.

Published
2014
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3. Dietary Glycemic Index, Glycemic Load, and Digestible Carbohydrate Intake Are Not Associated with Risk of Type 2 Diabetes in Eight European Countries

Author

Sluijs, Ivonne, Beulens, Joline W.J., van der Schouw, Yvonne T., van der A, Daphne L., Buckland, Genevieve, Kuijsten, Anneleen, Schulze, Matthias B., Amiano, Pilar, Ardanaz, Eva, Balkau, Beverley, Boeing, Heiner, Gavrila, Diana, Grote, Verena A., Key, Timothy J., Li, Kuanrong, Nilsson, Peter, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J.R., Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sánchez, María-José, Sieri, Sabina, Slimani, Nadia, Spijkerman, Annemieke M.W., Tjønneland, Anne, Tumino, Rosario, Sharp, Stephen J., Langenberg, Claudia, Feskens, Edith J.M., Forouhi, Nita G., Riboli, Elio, and Wareham, Nicholas J.

Published
2013
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5. DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Fraszczyk, Eliza, Thio, Chris H.L., Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Hodemaekers, Hennie, Picavet, H. Susan, Stynenbosch, Marjolein, Verschuren, W. M.Monique, Snieder, Harold, Spijkerman, Annemieke M.W., Luijten, Mirjam, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Fraszczyk, Eliza, Thio, Chris H.L., Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Hodemaekers, Hennie, Picavet, H. Susan, Stynenbosch, Marjolein, Verschuren, W. M.Monique, Snieder, Harold, Spijkerman, Annemieke M.W., and Luijten, Mirjam

Published
2022

6. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, Snieder, Harold, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, and Snieder, Harold

Published
2022

7. A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes

Author

Sluijs, Ivonne, Holmes, Michael V., van der Schouw, Yvonne T., Beulens, Joline W.J., Asselbergs, Folkert W., Huerta, José María, Palmer, Tom M., Arriola, Larraitz, Balkau, Beverley, Barricarte, Aurelio, Boeing, Heiner, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Franks, Paul W., Gavrila, Diana, Kaaks, Rudolf, Khaw, Kay Tee, Kühn, Tilman, Molina-Montes, Esther, Mortensen, Lotte Maxild, Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Sala, Núria, Schmidt, Julie A., Scott, Robert A., Sieri, Sabina, Slimani, Nadia, Spijkerman, Annemieke M.W., Tjonneland, Anne, Travis, Ruth C., Tumino, Rosario, van der A, Daphne L., Sharp, Stephen J., Forouhi, Nita G., Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J.

Published
2015
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9. Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

Author

Scott, Robert A., Fall, Tove, Pasko, Dorota, Barker, Adam, Sharp, Stephen J., Arriola, Larraitz, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Boeing, Heiner, Clavel-Chapelon, Françoise, Crowe, Francesca L., Dekker, Jacqueline M., Fagherazzi, Guy, Ferrannini, Ele, Forouhi, Nita G., Franks, Paul W., Gavrila, Diana, Giedraitis, Vilmantas, Grioni, Sara, Groop, Leif C., Kaaks, Rudolf, Key, Timothy J., Kühn, Tilman, Lotta, Luca A., Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sala, Núria, Sánchez, María-José, Schulze, Matthias B., Siddiq, Afshan, Slimani, Nadia, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., Yaghootkar, Hanieh, McCarthy, Mark I., Semple, Robert K., Riboli, Elio, Walker, Mark, Ingelsson, Erik, Frayling, Tim M., Savage, David B., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2014
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10. Smoking and Long-Term Risk of Type 2 Diabetes: The EPIC-InterAct Study in European Populations

Author

Spijkerman, Annemieke M.W., van der A, Daphne L., Nilsson, Peter M., Ardanaz, Eva, Gavrila, Diana, Agudo, Antonio, Arriola, Larraitz, Balkau, Beverley, Beulens, Joline W., Boeing, Heiner, de Lauzon-Guillain, Blandine, Fagherazzi, Guy, Feskens, Edith J.M., Franks, Paul W., Grioni, Sara, Huerta, José María, Kaaks, Rudolf, Key, Timothy J., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Redondo, M. Luisa, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sánchez, María-José, Schulze, Matthias B., Slimani, Nadia, Teucher, Birgit, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, and Wareham, Nicholas J.

Published
2014
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11. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

Author

van Nielen, Monique, Feskens, Edith J.M., Mensink, Marco, Sluijs, Ivonne, Molina, Esther, Amiano, Pilar, Ardanaz, Eva, Balkau, Beverly, Beulens, Joline W.J., Boeing, Heiner, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Franks, Paul W., Halkjaer, Jytte, Huerta, José Maria, Katzke, Verena, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Menéndez, Virginia V.M., Nilsson, Peter, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Rolandsson, Olov, Romieu, Isabelle, Sacerdote, Carlotta, Sánchez, Maria-José, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L., Würtz, Anne M.L., Zamora-Ros, Raul, Langenberg, Claudia, Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, and Wareham, Nicholas J.

Published
2014
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12. Plasma Vitamin C and type 2 diabetes: Genome-wide association study and mendelian randomization analysis in European populations

Author

Zheng, Ju-Sheng, Luan, Jian’An, Sofianopoulou, Eleni, Imamura, Fumiaki, Stewart, Isobel D., Day, Felix R., Pietzner, Maik, Wheeler, Eleanor, Lotta, Luca A., Gundersen, Thomas E., Amiano, Pilar, Ardanaz, Eva, Chirlaque, María-Dolores, Fagherazzi, Guy, Franks, Paul W., Kaaks, Rudolf, Laouali, Nasser, Mancini, Francesca Romana, Nilsson, Peter M., Charlotte Onland-Moret, N., Olsen, Anja, Overvad, Kim, Panico, Salvatore, Palli, Domenico, Ricceri, Fulvio, Rolandsson, Olov, Spijkerman, Annemieke M.W., Sánchez, María-José, Schulze, Matthias B., Sala, Núria, Sieri, Sabina, Tjønneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Weiderpass, Elisabete, Riboli, Elio, Danesh, John, Butterworth, Adam S., Sharp, Stephen J., Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju-Sheng, Luan, Jian’An, Sofianopoulou, Eleni, Imamura, Fumiaki, Stewart, Isobel D., Day, Felix R., Pietzner, Maik, Wheeler, Eleanor, Lotta, Luca A., Gundersen, Thomas E., Amiano, Pilar, Ardanaz, Eva, Chirlaque, María-Dolores, Fagherazzi, Guy, Franks, Paul W., Kaaks, Rudolf, Laouali, Nasser, Mancini, Francesca Romana, Nilsson, Peter M., Charlotte Onland-Moret, N., Olsen, Anja, Overvad, Kim, Panico, Salvatore, Palli, Domenico, Ricceri, Fulvio, Rolandsson, Olov, Spijkerman, Annemieke M.W., Sánchez, María-José, Schulze, Matthias B., Sala, Núria, Sieri, Sabina, Tjønneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Weiderpass, Elisabete, Riboli, Elio, Danesh, John, Butterworth, Adam S., Sharp, Stephen J., Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Abstract

OBJECTIVE: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. RESEARCH DESIGN AND METHODS: We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. RESULTS: We identified 11 genomic regions associated with plasma vitamin C (P < 5 ☓ 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10). CONCLUSIONS: These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.

Published
2021
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13. Anti-Mullerian hormone levels and risk of type 2 diabetes in women

Author

Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Circulatory Health, Epi Kanker Team A, Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Child Health, Public Health Epidemiologie, Cardiovasculaire Epi Team 1, Cardiovasculaire Epidemiologie, Verdiesen, Renée M.G., Onland-Moret, N. Charlotte, van Gils, Carla H., Stellato, Rebecca K., Spijkerman, Annemieke M.W., Picavet, H. Susan J., Broekmans, Frank J.M., Verschuren, W. M.Monique, van der Schouw, Yvonne T., Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Circulatory Health, Epi Kanker Team A, Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Child Health, Public Health Epidemiologie, Cardiovasculaire Epi Team 1, Cardiovasculaire Epidemiologie, Verdiesen, Renée M.G., Onland-Moret, N. Charlotte, van Gils, Carla H., Stellato, Rebecca K., Spijkerman, Annemieke M.W., Picavet, H. Susan J., Broekmans, Frank J.M., Verschuren, W. M.Monique, and van der Schouw, Yvonne T.

Published
2021

14. The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations: The EPIC-InterAct study

Author

Zamora-Ros, Raul, Forouhi, Nita G., Sharp, Stephen J., González, Carlos A., Buijsse, Brian, Guevara, Marcela, van der Schouw, Yvonne T., Amiano, Pilar, Boeing, Heiner, Bredsdorff, Lea, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Feskens, Edith J., Franks, Paul W., Grioni, Sara, Katzke, Verena, Key, Timothy J., Khaw, Kay-Tee, Kühn, Tilman, Masala, Giovanna, Mattiello, Amalia, Molina-Montes, Esther, Nilsson, Peter M., Overvad, Kim, Perquier, Florence, Quirós, J. Ramón, Romieu, Isabelle, Sacerdote, Carlotta, Scalbert, Augustin, Schulze, Matthias, Slimani, Nadia, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tormo, Maria Jose, Tumino, Rosario, van der A, Daphne L., Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J.

Published
2013
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15. Age at Menarche and Type 2 Diabetes Risk: The EPIC-InterAct study

Author

Elks, Cathy E., Ong, Ken K., Scott, Robert A., van der Schouw, Yvonne T., Brand, Judith S., Wark, Petra A., Amiano, Pilar, Balkau, Beverley, Barricarte, Aurelio, Boeing, Heiner, Fonseca-Nunes, Ana, Franks, Paul W., Grioni, Sara, Halkjaer, Jytte, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Mattiello, Amalia, Nilsson, Peter M., Overvad, Kim, Palli, Domenico, Quirós, J. Ramón, Rinaldi, Sabina, Rolandsson, Olov, Romieu, Isabelle, Sacerdote, Carlotta, Sánchez, María-José, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tormo, Maria-Jose, Tumino, Rosario, van der A, Daphne L., Forouhi, Nita G., Sharp, Stephen J., Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J.

Published
2013
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18. Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

Author

Zheng, Ju-Sheng, primary, Luan, Jian’an, additional, Sofianopoulou, Eleni, additional, Imamura, Fumiaki, additional, Stewart, Isobel D., additional, Day, Felix R., additional, Pietzner, Maik, additional, Wheeler, Eleanor, additional, Lotta, Luca A., additional, Gundersen, Thomas E., additional, Amiano, Pilar, additional, Ardanaz, Eva, additional, Chirlaque, María-Dolores, additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Kaaks, Rudolf, additional, Laouali, Nasser, additional, Mancini, Francesca Romana, additional, Nilsson, Peter M., additional, Onland-Moret, N. Charlotte, additional, Olsen, Anja, additional, Overvad, Kim, additional, Panico, Salvatore, additional, Palli, Domenico, additional, Ricceri, Fulvio, additional, Rolandsson, Olov, additional, Spijkerman, Annemieke M.W., additional, Sánchez, María-José, additional, Schulze, Matthias B., additional, Sala, Núria, additional, Sieri, Sabina, additional, Tjønneland, Anne, additional, Tumino, Rosario, additional, van der Schouw, Yvonne T., additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Danesh, John, additional, Butterworth, Adam S., additional, Sharp, Stephen J., additional, Langenberg, Claudia, additional, Forouhi, Nita G., additional, and Wareham, Nicholas J., additional

Published
2020
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19. Replacement of red and processed meat with other food sources of protein and the risk of type 2 diabetes in European populations; the EPIC-InterAct study

Author

Ibsen, Daniel B., primary, Steur, Marinka, primary, Imamura, Fumiaki, primary, Overvad, Kim, primary, Schulze, Matthias B., primary, Bendinelli, Benedetta, primary, Guevara, Marcela, primary, Agudo, Antonio, primary, Amiano, Pilar, primary, Aune, Dagfinn, primary, Barricarte, Aurelio, primary, Ericson, Ulrika, primary, Fagherazzi, Guy, primary, Franks, Paul W., primary, Freisling, Heinz, primary, Quiros, Jose R., primary, Grioni, Sara, primary, Heath, Alicia K., primary, Huybrechts, Inge, primary, Katze, Verena, primary, Laouali, Nasser, primary, Mancini, Francesca, primary, Masala, Giovanna, primary, Olsen, Anja, primary, Papier, Keren, primary, Ramne, Stina, primary, Rolandsson, Olov, primary, Sacerdote, Carlotta, primary, Sánchez, Maria-José, primary, Santiuste, Carmen, primary, Simeon, Vittorio, primary, Spijkerman, Annemieke M.W., primary, Srour, Bernard, primary, Tjønneland, Anne, primary, Tong, Tammy Y.N., primary, Tumino, Rosario, primary, Schouw, Yvonne T. van der, primary, Weiderpass, Elisabete, primary, Wittenbecher, Clemens, primary, Sharp, Stephen J., primary, Riboli, Elio, primary, Forouhi, Nita G., primary, and Wareham, Nick J., primary

Published
2020
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24. Effect of change in physical activity on body fatness over a 10-y period in the Doetinchem Cohort Study

Author

May, Anne M., Bueno-de-Mesquita, H. Bas, Boshuizen, Hendriek, Spijkerman, Annemieke M.W., Peeters, Petra H.M., and Verschuren, W.M. Monique

Subjects
Exercise -- Health aspects, Exercise -- Research, Obesity -- Complications and side effects, Obesity -- Care and treatment, Obesity -- Research, Food/cooking/nutrition, Health
Abstract

Background: Obesity is related to many adverse health-related outcomes. Objective: We investigated whether changes in physical activity were related to less gain in either body weight or waist circumference (WC). Design: The association between prospectively assessed physical activity and either body weight or WC was examined in 4944 participants of the Doetinchem Study (men and women aged between 26 and 66 y at baseline). Information on physical activity (derived from a validated physical activity index), body weight, and WC, measured according to standardized procedures, was collected at baseline and at the 5- and 10-y follow-ups. Results: Random mixed-effects models showed that a single measurement of physical activity was not clearly related to change in body weight and WC over a 5-y period. However, analyses of repeated measures showed that compared with those who maintained their activity level, those who increased their physical activity over a 5-y period had less gain in WC (-0.35 cm; 95% CI: -0.65, -0.05 cm) and possibly in body weight (-280 g; 95% CI: -620, 5 g). Most importantly, these effects were sustained (although not significantly) in the consecutive 5 y for WC (-0.56 cm; 95% CI: - 108, 0.04 cm) and for body weight (-590 g; 95% CI: -1005, -130 g), which indicated that physical activity was truly a determinant of body size changes. Conclusions: An increase in physical activity was associated with a statistically significant lower gain in body weight and in WC, which was maintained during the following 5 y. These findings support the need for public health programs that promote physical activity. doi: 10.3945/ajcn.2010.29404

Published
2010

26. Replacement of red and processed meat with other food sources of protein and the risk of type 2 diabetes in European populations:The epic-interact study

Author

Ibsen, Daniel B., Steur, Marinka, Imamura, Fumiaki, Overvad, Kim, Schulze, Matthias B., Bendinelli, Benedetta, Guevara, Marcela, Agudo, Antonio, Amiano, Pilar, Aune, Dagfinn, Barricarte, Aurelio, Ericson, Ulrika, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Quiros, Jose R., Grioni, Sara, Heath, Alicia K., Huybrechts, Inge, Katze, Verena, Laouali, Nasser, Mancini, Francesca, Masala, Giovanna, Olsen, Anja, Papier, Keren, Ramne, Stina, Rolandsson, Olov, Sacerdote, Carlotta, Sánchez, Maria José, Santiuste, Carmen, Simeon, Vittorio, Spijkerman, Annemieke M.W., Srour, Bernard, Tjønneland, Anne, Tong, Tammy Y.N., Tumino, Rosario, van der Schouw, Yvonne T., Weiderpass, Elisabete, Wittenbecher, Clemens, Sharp, Stephen J., Riboli, Elio, Forouhi, Nita G., Wareham, Nick J., Ibsen, Daniel B., Steur, Marinka, Imamura, Fumiaki, Overvad, Kim, Schulze, Matthias B., Bendinelli, Benedetta, Guevara, Marcela, Agudo, Antonio, Amiano, Pilar, Aune, Dagfinn, Barricarte, Aurelio, Ericson, Ulrika, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Quiros, Jose R., Grioni, Sara, Heath, Alicia K., Huybrechts, Inge, Katze, Verena, Laouali, Nasser, Mancini, Francesca, Masala, Giovanna, Olsen, Anja, Papier, Keren, Ramne, Stina, Rolandsson, Olov, Sacerdote, Carlotta, Sánchez, Maria José, Santiuste, Carmen, Simeon, Vittorio, Spijkerman, Annemieke M.W., Srour, Bernard, Tjønneland, Anne, Tong, Tammy Y.N., Tumino, Rosario, van der Schouw, Yvonne T., Weiderpass, Elisabete, Wittenbecher, Clemens, Sharp, Stephen J., Riboli, Elio, Forouhi, Nita G., and Wareham, Nick J.

Abstract

OBJECTIVE There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH DESIGN AND METHODS The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were estimated by Prentice-weighted Cox regression and pooled using random-effects meta-analysis. RESULTS There was a lower hazard for type 2 diabetes for the modeled replacement of red and processed meat (50 g/day) with cheese (HR 0.90, 95% CI 0.83–0.97) (30 g/day), yogurt (0.90, 0.86–0.95) (70 g/day), nuts (0.90, 0.84–0.96) (10 g/day), or cereals (0.92, 0.88–0.96) (30 g/day) but not for replacements with poultry, fish, eggs, legumes, or milk. If a causal association is assumed, replacing red and processed meat with cheese, yogurt, or nuts could prevent 8.8%, 8.3%, or 7.5%, respectively, of new cases of type 2 diabetes. CONCLUSIONS Replacement of red and processed meat with cheese, yogurt, nuts, or cereals was associated with a lower rate of type 2 diabetes. Substituting red and processed meat by other protein sources may contribute to the prevention of incident type 2 diabetes in European populations.

Published
2020

27. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Sharp, Stephen J., Day, Felix R., Imamura, Fumiaki, Gundersen, Thomas E., Lotta, Luca A., Sluijs, Ivonne, Stewart, Isobel D., Shah, Rupal L., Van Der Schouw, Yvonne T., Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C., Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K., Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Olsen, Anja, Panico, Salvatore, Ramón Quirós, J., Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tong, Tammy Y.N., Tumino, Rosario, Tsilidis, Konstantinos K., Danesh, John, Riboli, Elio, Butterworth, Adam S., Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Sharp, Stephen J., Day, Felix R., Imamura, Fumiaki, Gundersen, Thomas E., Lotta, Luca A., Sluijs, Ivonne, Stewart, Isobel D., Shah, Rupal L., Van Der Schouw, Yvonne T., Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C., Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K., Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Olsen, Anja, Panico, Salvatore, Ramón Quirós, J., Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tong, Tammy Y.N., Tumino, Rosario, Tsilidis, Konstantinos K., Danesh, John, Riboli, Elio, Butterworth, Adam S., Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Published
2020

28. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, Wareham, Nicholas J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, and Wareham, Nicholas J.

Published
2020

29. Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Sharp, Stephen J., Imamura, Fumiaki, Chowdhury, Rajiv, Gundersen, Thomas E., Steur, Marinka, Sluijs, Ivonne, Van Der Schouw, Yvonne T., Agudo, Antonio, Aune, Dagfinn, Barricarte, Aurelio, Boeing, Heiner, Chirlaque, María Dolores, Dorronsoro, Miren, Freisling, Heinz, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Kyrø, Cecilie, Katzke, Verena, Kühn, Tilman, Khaw, Kay Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Papier, Keren, Quirós, J. Ramón, Rolandsson, Olov, Redondo-Sánchez, Daniel, Ricceri, Fulvio, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjønneland, Anne, Tong, Tammy Y.N., Tumino, Rosario, Weiderpass, Elisabete, Danesh, John, Butterworth, Adam S., Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Sharp, Stephen J., Imamura, Fumiaki, Chowdhury, Rajiv, Gundersen, Thomas E., Steur, Marinka, Sluijs, Ivonne, Van Der Schouw, Yvonne T., Agudo, Antonio, Aune, Dagfinn, Barricarte, Aurelio, Boeing, Heiner, Chirlaque, María Dolores, Dorronsoro, Miren, Freisling, Heinz, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Kyrø, Cecilie, Katzke, Verena, Kühn, Tilman, Khaw, Kay Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Papier, Keren, Quirós, J. Ramón, Rolandsson, Olov, Redondo-Sánchez, Daniel, Ricceri, Fulvio, Schulze, Matthias B., Spijkerman, Annemieke M.W., Tjønneland, Anne, Tong, Tammy Y.N., Tumino, Rosario, Weiderpass, Elisabete, Danesh, John, Butterworth, Adam S., Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.

Published
2020

34. PS8 - 37. Physical Activity and Mortality in Individuals With Diabetes Mellitus: A Prospective Study and Meta-analysis

Author

Sluik, Diewertje, Buijsse, Brian, Muckelbauer, Rebecca, Kaaks, Rudolf, Teucher, Birgit, Føns Johnsen, Nina, Tjønneland, Anne, Overvad, Kim, Nautrup Østergaard, Jane, Amiano, Pilar, Ardanaz, Eva, Bendinelli, Benedetta, Pala, Valeria, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Spijkerman, Annemieke M.W., Monninkhof, Evelyn M., May, Anne M., Franks, Paul W., Nilsson, Peter M., Wennberg, Patrik, Rolandsson, Olov, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Huerta Castaño, José María, Gallo, Valentina, Boeing, Heiner, and Nöthlings, Ute

Published
2012
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35. Autoimmunity plays a role in the onset of diabetes after 40 years of age

Author

Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria José, Severi, Gianluca, Spijkerman, Annemieke M.W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, Wareham, Nicholas J., Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria José, Severi, Gianluca, Spijkerman, Annemieke M.W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2019

36. Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct : A Mendelian Randomization Study

Author

Vissers, Linda E.T., Sluijs, Ivonne, van der Schouw, Yvonne T., Forouhi, Nita G., Imamura, Fumiaki, Burgess, Stephen, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Chirlaque, Maria Dolores, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Ramón Quirós, J., Ibsen, Daniel B., Kaaks, Rudolf, Key, Timothy, Khaw, Kay T., Kühn, Tilman, Mokoroa, Olatz, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Rodríguez-Barranco, Miguel, Rolandsson, Olov, Riboli, Elio, Sharp, Stephen J., Langenberg, Claudia, Wareham, Nicholas J., Vissers, Linda E.T., Sluijs, Ivonne, van der Schouw, Yvonne T., Forouhi, Nita G., Imamura, Fumiaki, Burgess, Stephen, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Chirlaque, Maria Dolores, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Ramón Quirós, J., Ibsen, Daniel B., Kaaks, Rudolf, Key, Timothy, Khaw, Kay T., Kühn, Tilman, Mokoroa, Olatz, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Rodríguez-Barranco, Miguel, Rolandsson, Olov, Riboli, Elio, Sharp, Stephen J., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2019

37. Association of plasma Vitamin D metabolites with incident type 2 diabetes : EPIC-InterAct case-cohort study

Author

Zheng, Ju Sheng, Imamura, Fumiaki, Sharp, Stephen J., Van Der Schouw, Yvonne T., Sluijs, Ivonne, Gundersen, Thomas E., Ardanaz, Eva, Boeing, Heiner, Bonet, Catalina, Gómez, Jesus Humberto, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Jenab, Mazda, Kuhn, Tilman, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Lasheras, Cristina, Mokoroa, Olatz, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Palli, Domenico, Rolandsson, Olov, Sieri, Sabina, Salamanca-Fernández, Elena, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Stepien, Magdalena, Tjonneland, Anne, Tumino, Rosario, Butterworth, Adam S., Riboli, Elio, Danesh, John, Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju Sheng, Imamura, Fumiaki, Sharp, Stephen J., Van Der Schouw, Yvonne T., Sluijs, Ivonne, Gundersen, Thomas E., Ardanaz, Eva, Boeing, Heiner, Bonet, Catalina, Gómez, Jesus Humberto, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Jenab, Mazda, Kuhn, Tilman, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Lasheras, Cristina, Mokoroa, Olatz, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Palli, Domenico, Rolandsson, Olov, Sieri, Sabina, Salamanca-Fernández, Elena, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Stepien, Magdalena, Tjonneland, Anne, Tumino, Rosario, Butterworth, Adam S., Riboli, Elio, Danesh, John, Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Published
2019

38. Autoimmunity plays a role in the onset of diabetes after 40 years of age

Author

Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria José, Severi, Gianluca, Spijkerman, Annemieke M.W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, Wareham, Nicholas J., Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rolandsson, Olov, Hampe, Christiane S., Sharp, Stephen J., Ardanaz, Eva, Boeing, Heiner, Fagherazzi, Guy, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Chirlaque, Maria Dolores, Dorronsoro, Miren, Gunter, Marc J., Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Krogh, Vittorio, Kühn, Tilman, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Sánchez, Maria José, Severi, Gianluca, Spijkerman, Annemieke M.W., Tumino, Rosario, van der Schouw, Yvonne T., Riboli, Elio, Forouhi, Nita G., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2019

39. Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Author

Public Health Epidemiologie, Other research (not in main researchprogram), Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, Dollé, Martijn E.T., Public Health Epidemiologie, Other research (not in main researchprogram), Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Rietman, M. Liset, Spijkerman, Annemieke M.W., Wong, Albert, van Steeg, Harry, Bürkle, Alexander, Moreno-Villanueva, María, Sindlinger, Thilo, Franceschi, Claudio, Grubeck-Loebenstein, Beatrix, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Debacq-Chainiaux, Florence, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Basso, Andrea, Piacenza, Francesco, Malavolta, Marco, Collino, Sebastiano, Jansen, Eugene H.J.M., Verschuren, W. M.Monique, and Dollé, Martijn E.T.

Published
2019

40. Association of plasma Vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study

Author

UMC Utrecht, Julius Centrum, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Imamura, Fumiaki, Sharp, Stephen J., Van Der Schouw, Yvonne T., Sluijs, Ivonne, Gundersen, Thomas E., Ardanaz, Eva, Boeing, Heiner, Bonet, Catalina, Gómez, Jesus Humberto, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Jenab, Mazda, Kuhn, Tilman, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Lasheras, Cristina, Mokoroa, Olatz, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Palli, Domenico, Rolandsson, Olov, Sieri, Sabina, Salamanca-Fernández, Elena, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Stepien, Magdalena, Tjonneland, Anne, Tumino, Rosario, Butterworth, Adam S., Riboli, Elio, Danesh, John, Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J., UMC Utrecht, Julius Centrum, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Zheng, Ju Sheng, Imamura, Fumiaki, Sharp, Stephen J., Van Der Schouw, Yvonne T., Sluijs, Ivonne, Gundersen, Thomas E., Ardanaz, Eva, Boeing, Heiner, Bonet, Catalina, Gómez, Jesus Humberto, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Jenab, Mazda, Kuhn, Tilman, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Lasheras, Cristina, Mokoroa, Olatz, Mancini, Francesca Romana, Nilsson, Peter M., Overvad, Kim, Panico, Salvatore, Palli, Domenico, Rolandsson, Olov, Sieri, Sabina, Salamanca-Fernández, Elena, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Stepien, Magdalena, Tjonneland, Anne, Tumino, Rosario, Butterworth, Adam S., Riboli, Elio, Danesh, John, Langenberg, Claudia, Forouhi, Nita G., and Wareham, Nicholas J.

Published
2019

41. Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study

Author

UMC Utrecht, Julius Centrum, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Circulatory Health, Vissers, Linda E.T., Sluijs, Ivonne, van der Schouw, Yvonne T., Forouhi, Nita G., Imamura, Fumiaki, Burgess, Stephen, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Chirlaque, Maria Dolores, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Ramón Quirós, J., Ibsen, Daniel B., Kaaks, Rudolf, Key, Timothy, Khaw, Kay T., Kühn, Tilman, Mokoroa, Olatz, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Rodríguez-Barranco, Miguel, Rolandsson, Olov, Riboli, Elio, Sharp, Stephen J., Langenberg, Claudia, Wareham, Nicholas J., UMC Utrecht, Julius Centrum, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Circulatory Health, Vissers, Linda E.T., Sluijs, Ivonne, van der Schouw, Yvonne T., Forouhi, Nita G., Imamura, Fumiaki, Burgess, Stephen, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Chirlaque, Maria Dolores, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., Ramón Quirós, J., Ibsen, Daniel B., Kaaks, Rudolf, Key, Timothy, Khaw, Kay T., Kühn, Tilman, Mokoroa, Olatz, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Rodríguez-Barranco, Miguel, Rolandsson, Olov, Riboli, Elio, Sharp, Stephen J., Langenberg, Claudia, and Wareham, Nicholas J.

Published
2019

42. Intake of dietary saturated fatty acids and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort : associations by types, sources of fatty acids and substitution by macronutrients

Author

Liu, Shengxin, van der Schouw, Yvonne T., Soedamah-Muthu, Sabita S., Spijkerman, Annemieke M.W., Sluijs, Ivonne, Liu, Shengxin, van der Schouw, Yvonne T., Soedamah-Muthu, Sabita S., Spijkerman, Annemieke M.W., and Sluijs, Ivonne

Abstract

Purpose: The association between dietary saturated fatty acids (SFA) intake and type 2 diabetes (T2D) remains unclear. This study aimed at investigating the association between SFA intake and T2D risk based on (1) individual SFA (differing in carbon chain length), (2) food sources of SFA and (3) the substituting macronutrients. Methods: 37,421 participants from the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) cohort were included in this study. Baseline dietary intake was assessed by a validated food frequency questionnaire. T2D risks were estimated by Cox regression models adjusted for non-dietary and dietary covariates. Results: 893 incident T2D cases were documented during 10.1-year follow-up. We observed no association between total SFA and T2D risk. Marginally inverse associations were found for lauric acid (HR per 1 SD of energy%, 95% CI 0.92, 0.85–0.99), myristic acid (0.89, 0.79–0.99), margaric acid (0.84, 0.73–0.97), odd-chain SFA (pentadecylic plus margaric acids; 0.88, 0.79–0.99), and cheese derived SFA (0.90, 0.83–0.98). Soft and liquid fats derived SFA was found related to higher T2D risk (1.08, 1.01–1.17). When substituting SFA by proteins, carbohydrates and polyunsaturated fatty acids, significantly higher risks of T2D were observed (HRs per 1 energy% ranging from 1.05 to 1.15). Conclusion: In this Dutch population, total SFA does not relate to T2D risk. Rather, the association may depend on the types and food sources of SFA. Cheese-derived SFA and individual SFA that are commonly found in cheese, were significantly related to lower T2D risks. We cannot exclude the higher T2D risks found for soft and liquid fats derived SFA and for substituting SFA with other macronutrients are influenced by residual confounding by trans fatty acids or limited intake variation in polyunsaturated fatty acids and vegetable protein.

Published
2019

43. Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study

Author

Vissers, Linda E.T., primary, Sluijs, Ivonne, additional, van der Schouw, Yvonne T., additional, Forouhi, Nita G., additional, Imamura, Fumiaki, additional, Burgess, Stephen, additional, Barricarte, Aurelio, additional, Boeing, Heiner, additional, Bonet, Catalina, additional, Chirlaque, Maria-Dolores, additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Freisling, Heinz, additional, Gunter, Marc J., additional, Quirós, J. Ramón, additional, Ibsen, Daniel B., additional, Kaaks, Rudolf, additional, Key, Timothy, additional, Khaw, Kay T., additional, Kühn, Tilman, additional, Mokoroa, Olatz, additional, Nilsson, Peter M., additional, Overvad, Kim, additional, Pala, Valeria, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Sacerdote, Carlotta, additional, Spijkerman, Annemieke M.W., additional, Tjonneland, Anne, additional, Tumino, Rosario, additional, Rodríguez-Barranco, Miguel, additional, Rolandsson, Olov, additional, Riboli, Elio, additional, Sharp, Stephen J., additional, Langenberg, Claudia, additional, and Wareham, Nicholas J., additional

Published
2019
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44. Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

Author

Kröger, Janine, primary, Meidtner, Karina, additional, Stefan, Norbert, additional, Guevara, Marcela, additional, Kerrison, Nicola D., additional, Ardanaz, Eva, additional, Aune, Dagfinn, additional, Boeing, Heiner, additional, Dorronsoro, Miren, additional, Dow, Courtney, additional, Fagherazzi, Guy, additional, Franks, Paul W., additional, Freisling, Heinz, additional, Gunter, Marc J., additional, Huerta, José María, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Khaw, Kay Tee, additional, Krogh, Vittorio, additional, Kühn, Tilman, additional, Mancini, Francesca Romana, additional, Mattiello, Amalia, additional, Nilsson, Peter M., additional, Olsen, Anja, additional, Overvad, Kim, additional, Palli, Domenico, additional, Quirós, J. Ramón, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Sala, Núria, additional, Salamanca-Fernández, Elena, additional, Sluijs, Ivonne, additional, Spijkerman, Annemieke M.W., additional, Tjonneland, Anne, additional, Tsilidis, Konstantinos K., additional, Tumino, Rosario, additional, van der Schouw, Yvonne T., additional, Forouhi, Nita G., additional, Sharp, Stephen J., additional, Langenberg, Claudia, additional, Riboli, Elio, additional, Schulze, Matthias B., additional, and Wareham, Nicholas J., additional

Published
2018
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47. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence : analysis within EPIC-InterAct across eight European countries

Author

Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., Wareham, Nicholas J., Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., and Wareham, Nicholas J.

Published
2018

48. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

Author

Cardiovasculaire Epi Team 3, Brain, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 1, Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., Wareham, Nicholas J., Cardiovasculaire Epi Team 3, Brain, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 1, Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Quirós, J. Ramón, Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M.W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., and Wareham, Nicholas J.

Published
2018

49. Association of dietary protein and dairy intakes and change in renal function : Results from the population-based longitudinal Doetinchem cohort study1,2

Author

Herber-Gast, Gerrie Cor M., Biesbroek, Sander, Verschuren, W.M.M., Stehouwer, Coen D.A., Gansevoort, Ron T., Bakker, Stephan J.L., and Spijkerman, Annemieke M.W.

Subjects
Dairy, Dietary proteins, General population, Longitudinal study, Renal function
Abstract

Background: Evidence has suggested that protein from dairy may be less detrimental to renal health than protein from nondairy products. However, to our knowledge, no previous studies have used cystatin C-based measures of the estimated glomerular filtration rate (EGFR). Objective: We investigated the associations of sources of protein and dairy with the change in the EGFR in persons with a normal or mildly decreased EGFR. Design: We included 3798 participants, aged 26-65 y, from the Doetinchem Cohort study who were examined 3 times 5 y apart. Intakes of protein and dairy and subtypes of protein and dairy were assessed at each round. With the use of the Chronic Kidney Disease Epidemiology Collaboration equation, the EGFR was estimated from cystatin C with all available samples per participant examined in one assay run. Generalized estimating equation models, which were adjusted for lifestyle, biological, and other dietary factors (monounsaturated fat, polyunsaturated fat, phosphorus, magnesium, calcium, and Vitamin D) were performed. Results: The mean baseline EGFR in the total cohort and in subjects with a mildly decreased EGFR (1 EGFR of 60-90 mL min21 1.73 m22 during follow-up; n = 1326) was 108.6 and 95.2 mL min21 1.73 m22, and the mean annual decline in both groups was 1.01 and 1.34 mL min21 1.73 m22, respectively. Intakes of total, vegetable, animal, and nondairy protein, dairy protein, cheese, total dairy, highfat dairy, and fermented dairy were not associated with EGFR changes. In individuals with a mildly decreased EGFR, higher consumption of milk, milk products, and low-fat dairy was associated with less annual decline in the EGFR (P-trend = 0.003). These associations were partially explained by dietary components of dairy (monounsaturated fat, polyunsaturated fat, phosphorus, magnesium, calcium, and Vitamin D; P-trend , 0.04). Conclusions: Higher low-fat dairy consumption, but not sources of protein, is associated with less annual decline in the EGFR, particularly in individuals with a mildly decreased EGFR. These associations are partly attributable to other major components of dairy. Confirmation of these results will improve our ability to understand the role of dairy consumption in the prevention of renal dysfunction.

Published
2016

50. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study

Author

Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J.M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, De Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M.W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, Van Der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J.M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, De Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M.W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, Van Der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.

Abstract

BackgroundAccumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways.MethodsWe measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested.ResultsHigher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption.ConclusionsSubtypes of SFAs ar

Published
2017

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