388 results on '"Spicer, Timothy P."'
Search Results
2. A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
3. High throughput screening for SARS-CoV-2 helicase inhibitors
4. SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening
5. Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors
6. A high-throughput cell-based screening method for Zika virus protease inhibitor discovery
7. Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism
8. Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma
9. Neutral ceramidase-active site inhibitor chemotypes and binding modes
10. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
11. High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2
12. Time resolved imaging of the non-linear bullet mode within an injection-locked nano-contact spin Hall nano-oscillator
13. Spatial Mapping of Torques within a Spin Hall Nano-oscillator
14. Rapid deployment of inexpensive open-source orbital shakers in support of high-throughput screening
15. High throughput screening for compounds to the orphan nuclear receptor NR2F6
16. Lead identification using 3D models of pancreatic cancer
17. Screening for modulators of autism spectrum disorder using induced human neurons
18. Identification of potent small molecule inhibitors of SARS-CoV-2 entry
19. Protocol for kinetic mode potassium channel assays on common plate readers and microscopes
20. Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex
21. Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
22. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening
23. Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins
24. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
25. Stabilization of amyloidogenic immunoglobulin light chains by small molecules
26. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
27. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
28. Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening
29. Design of Microplate-Compatible Illumination Panels for a Semiautomated Benchtop Pipetting System
30. The Scripps Molecular Screening Center and Translational Research Institute
31. Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay
32. Target-based discovery of a broad spectrum flukicide
33. IoT for Real-Time Measurement of High-Throughput Liquid Dispensing in Laboratory Environments
34. A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells
35. Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
36. High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases
37. A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter β-Lactamase Resistance in Pseudomonas aeruginosa
38. In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma
39. Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease
40. A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids
41. Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology
42. Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
43. A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype
44. Protocol for 3D screening of lung cancer spheroids using natural products
45. Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus
46. Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles
47. An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors
48. A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons
49. Protocol for 3D Screening of Lung Cancer Spheroids using Natural Products
50. Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M pro /3CL pro in Living Cells
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