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Observational prospective population-based incidence study. The main objective of this study was to assess the incidence of traumatic spinal cord injuries (TSCIs) and incidence rates, in order to provide estimates by age, gender, characteristics and cause. This study was conducted at acute-care spinal cord injury (SCI) hospitals and SCI centers from 11 Italian regions, between 1 October 2013 and 30 September 2014. Data of all consecutive patients with acute TSCI who met the inclusion criteria were obtained through case reporting by clinicians. The data were collected into a web database. Incidence rates and incidence rate ratios were calculated and stratified by age, gender, cause, level and completeness. From 50% of the entire population of Italy, 445 new cases of TSCI were included. The crude incidence rate of TSCI was 14.7 cases per million per year (95% CI: 13.4–16.4); the overall male to female ratio was 4:1 and the mean age was 54. Complete information was available in 85% of the sample and revealed tetraplegia in 58% and incomplete lesion in 67% of cases. The leading cause of TSCI was falls (40.9%) followed by road traffic accidents (33.5%). The leading cause was falls for patients over 55 and road traffic accidents for patients under 55. The changing trend of TSCI epidemiology concerns the increase in the average age of TSCI people and the increase of both cervical and incomplete lesions. The etiology shows the primacy of falls over road traffic accidents and suggests the need for a change in prevention policies.

A photoredox catalytic synthesis of functionalized 2-aminofurans is proposed starting from α-halo carbonyl substrates and N-allenamides. The protocol proves to be efficient and sustainable thanks to: i) the use of visible light as green energy source, ii) the redox-neutral nature of the transformation, allowing to avoid additives and strong oxidants, iii) the mild reaction conditions and the functional groups tolerance, iv) the low photocatalyst loading and the absence of excess reagents, v) the one-pot formation of three new bonds in a domino sequence. According to our mechanistic hypothesis, the transformation is configured as a double radical-polar crossover reaction, in which the photocatalyst is excited, oxidized and reduced twice for each molecule of 2-aminofuran produced. The novelty of the designed synthetic approach also lies in the use of N-allenamides as substrates, which, after the addition of the first electrophilic radical, preserve a further reactive π-system, making possible the addition of a second α-keto radical and enabling the installation of a keto functionality at a remote position. The good yields, the broad scope, and the possibility to further synthetically elaborate the obtained furans make this protocol particularly promising for the construction of useful products. (Figure presented.).