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Résumé Contexte Au cours des dernières années, on s’est de plus en plus inquiété d’une baisse de la fertilité masculine. Plus précisément, certaines données indiquent que la qualité du sperme a diminué au cours des dernières années. Cependant, les rapports montrant les changements dans la qualité du sperme avec le temps sont incohérents. Une partie des contradictions entre les études est attribuée à des différences géographiques. Étonnamment, peu d’études ont inclue des données provenant de pays d’Amérique du Sud, ce qui crée un biais dans les conclusions. Cette étude vise à déterminer comment la qualité du sperme a évolué au cours des 30 dernières années en Uruguay. À cette fin, 317 dossiers médicaux de candidats donneurs de sperme prétendument en bonne santé, âgés de 18 à 36 ans, qui ont volontairement demandé à être considérés comme donneurs de sperme entre 1988 et 2019, ont été analysés. Les variables étudiées étaient les paramètres suivants du sperme: volume de sperme, concentration de cellules spermatiques, nombre total de spermatozoïdes, motilité progressive, vitalité, et morphologie des spermatozoïdes. Une analyse statistique corrélative a été effectuée entre les valeurs des paramètres séminaux et l’année de recueil des données. Résultats Nous avons trouvé une diminution statistiquement significative de la concentration de spermatozoïdes et de la morphologie normale des spermatozoïdes pendant la période étudiée. Il n’y a eu aucune diminution de la vitalité, du volume de sperme, et de la motilité progressive totale. Les paramètres du sperme n’étaient pas associés à la consommation de tabac, de drogues ou d’alcool. Conclusions Nous concluons que la qualité du sperme des candidats donneurs en Uruguay a diminué au cours de cette période. D’autres études devraient être menées pour vérifier l’apparition de ce phénomène dans la population générale et en trouver les causes possibles.

Objective: To identify the sociodemographic characteristics, motivations, and semen parameters of sperm donors in Shanghai, China. Methods: The participants were sperm donors associated with the Human Sperm Bank of Fudan University in Shanghai, China. Among the 334 sperm donors that applied for participation, 329 completed the survey process. The responses obtained in the questionnaire and face-to-face interviews were used to investigate the donor motivations and characteristics, and the semen quality was examined to identify the sperm parameter. Results: In terms of the sociodemographic characteristics, an altruistic donor in this study was aged between 26 and 30 years, was single, did not have a child, had a college or undergraduate education level, was of the Han ethnicity, and worked full time. The strongest motivation highlighted by sperm donors was a donation for altruistic (26.4%, n = 87) reasons. The second-highest rated motivation was curiosity (20.7%, n = 68), followed by a desire to procreate (17.9%, n = 59). “Complimentary body checks” (14.3%, n = 47) and “financial incentives” (14.7%, n = 47) were regarded as less important. The average semen parameters of the 329 donors were as follows: the semen volume was 3.39 ± 1.21 mL, the semen concentration was 82.75 × 106/mL, the progressive motility rate (PR%) was 63.77% ± 3.13%, the total motility rate was 66.26%, the total progressive motile count was 158.31% ± 54.43 × 106/mL, and the round cell concentration was 0.38 ± 0.51 × 106/mL. The PR% of the procreation motivation group was significantly higher than that of the other motivation groups (P < 0.05). Conclusions: Sperm donors in Shanghai, China, are altruistic about their donation, although curiosity is also a key motivator. In addition, the decisions of donors are culturally influenced, and the motivation to procreate may influence the PR%.

Background: Essential elements such as iron (Fe), cobalt (Co), copper (Cu), zinc (Zn), selenium (Se), rubidium (Rb), strontium (Sr), and molybdenum (Mo) are necessary for reproductive health. However, their associations with human semen quality remain inconclusive. Objectives: To investigate the associations of urinary Fe, Co, Cu, Zn, Se, Rb, Sr, and Mo concentrations with semen quality in healthy men screened as potential sperm donors and identify critical windows of susceptibility. Methods: 1428 healthy men provided 3766 urine and 6527 semen samples, which were measured for urinary essential element concentrations and sperm quality parameters, respectively. Linear mixed models and cubic spline curves were used to evaluate associations between urinary essential elements and semen quality. Multiple informant models were used to identify potential critical windows of susceptibility. Results: Linear mixed models and cubic spline curves showed positive dose–response relationships between urinary Zn and sperm concentration and total count and between urinary Mo and total sperm count [all False Discovery Rate (FDR) adjusted p-value for trend

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Objective: To study the preference of sperm donors with identity disclosure (ID) versus anonymous donors (AD) and to understand if this selection affects clinical outcomes in an Israeli population., Methods: This retrospective study included patients who chose imported sperm donation during 2017-2021. Of these, 526 used their own (autologous) oocytes and 43 patients used donated oocytes (DO). The primary endpoint was the type of chosen donor with ID versus AD. We examined the tendency toward ID according to demographic parameters and the theoretical impact of donor-type selection on reproductive outcome and compared patients who performed cycles with autologous oocytes with those using DO., Results: Single women had a significantly higher probability of choosing sperm donors with ID than heterosexual couples (55.6% vs. 33.3%, OR 2.5, CI 95% 1.52-4.11, P < 0.001). Although not significant, same-sex couples were more likely to choose sperm donors with ID than heterosexual couples (49.1% vs. 33.3%, OR 1.93, CI 95% 0.97-3.85, P = 0.06). Sperm donor samples, 2501 vials, were imported. It was performed 698 intra-uterine insemination and 812 in vitro fertilization cycles were performed, respectively, resulting in 283 pregnancies without differences between patients who chose sperm donors with ID versus AD sperm. No significant differences were observed regarding the option for sperm donors with ID between patients using DO (44.2%) and those using autologous oocytes (51.3%)., Conclusion: While ID is important for a certain section (mainly single) of recipients, it is far from the only dominant factor during donor selection. Sperm donation type does not impact clinical outcomes., (Copyright © 2023 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.)

The present study aims to analyze sperm concentration trends among young and healthy Chinese adults in Wuhan, Central China, from 2010 to 2015. Semen analysis data from 9357 participants were collected and analyzed using a general linear model and the Cochran–Armitage trend test. A significant decline was observed in sperm concentration (β [standard deviation]: −1.53 [0.16]; P < 0.001). In addition, a decline in sperm density was observed by stratifying student versus nonstudent sperm donors and by analyzing the year of birth or birth year cohort of the participants. Furthermore, the percentage of participants with sperm densities of over 40 × 106 ml−1 significantly decreased with year. Notably, a dramatic decline in sperm density was recorded over the first 5 years of study. This research reported a decline in sperm concentration among young adults in Wuhan, Central China, in 2010–2015.

Comparative research on sperm donors and egg donors in the United States suggests that while men view themselves as fathers of their offspring, women do not view themselves as mothers. Comparative research suggests as well that men and women are equally interested in contact with offspring, equally curious about them, and equally likely to hold themselves responsible for those offspring. This paper re-examines these differences and similarities using data from a survey of donors who registered on a third-party website with hopes of having some contact with their genetic offspring. Our findings suggest that women and men offer similar reasons for donating and similar assessments of the experience. Yet, the two groups have developed quite different patterns of interest in their offspring. The men create a sense of “prideful lineage” rather than fatherhood. The women create a pattern of feeling that involves “concerned responsibility” rather than motherhood.

In recent decades, reproductive medicine has become a widespread global phenomenon. Within the field, donor conception, and the use of donated eggs, sperm or embryos from a third party, plays a key role. Despite the importance of those individuals who donate, there has been scant research exploring their experiences. Seeking to contribute to the growing, albeit still small, body of research on donors, this paper advocates bringing the process of donating into dialogue with a sociology of personal life. It suggests that important new insights about the donor experience can be achieved by utilising such a theoretical perspective. The paper applies a broad framework of a sociology of personal life to demonstrate that the decision to donate reverberates within donors' everyday lives and relationships, and explores, primarily theoretically, how it is that acts of donation bring such issues into play. To this end, the paper examines in detail three ways in which donating interacts with dimensions that are integral to personal life: "living" genetic connectedness, relationality and the intimate body. Ultimately, the paper suggests that a sociology of personal life shows light on new, unexplored questions for this field that demand greater scholarly attention. [ABSTRACT FROM AUTHOR]

Keywords: COVID 19; semen analysis; sperm donors; vaccination EN COVID 19 semen analysis sperm donors vaccination 8 9 2 12/19/22 20230101 NES 230101 Dear Editor, We would like to thank you for the option to correspond to Rhodes et al.[1] For the best of our knowledge, our study[2] is the longest published post-covid-19 vaccination follow-up. Response to: There is not enough evidence to support the claim that Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count Covid-19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors. [Extracted from the article]

The aim of this study was to evaluate the semen quality of university students in Wuhan, the largest city in the world in terms of the number of university students. All student sperm donors recorded in the Hubei Province Human Sperm Bank from 1 March 2010 to 31 December 2013 were screened. At last, a total of 3616 semen samples from 1808 university student sperm donors were eligible and retrospectively analyzed. Each donor's semen parameters were averaged over two samples and compared with the World Health Organization criteria, and a generalized linear regression model was used to examine several determinants of semen quality. We found that the mean and median values were 3.0 ml and 2.8 ml for semen volume, 50.2 × 10 6 ml−1 and 50.0 × 10 6 ml−1 for sperm concentration, 148.1 × 10 6 and 142.1 × 10 6 for total sperm count, and 58.6% and 60.0% for total sperm motility. About 85.0% of donors had parameters that were all normal. Season and duration of abstinence were critical factors affecting semen quality. We also found a decrease in sperm concentration during the 4 years observation; however, this may not be a strong evidence to confirm the declining trend of semen quality. In conclusion, semen quality of university students in Wuhan was not optimal and should be paid high attention, long-term observation and further study should be carried out to confirm the present situation.

Summary: Static assessment of sperm DNA Fragmentation (SDF at the time of ejaculation or sperm thawing when cryopreserved) and the dynamic assessment of SDF (SDF assessed after T2 hr, T6 hr and T24 hr of sperm thawing) were used to establish cut‐off values associated with sperm donors when compared with closely related normozoospermic patients. Cryopreserved samples from donors revealed SDF levels two times lower in comparison with the patients. Donor sperm DNA exhibited a 2.5 times higher longevity when compared with the patients. Static values of SDF after thawing of approximately 11% identify the donors with a 71% of sensitivity and 84% specificity. With respect to the dynamic assessment, SDF increases of 2.3 per hr during the first 2 hr of incubation identify the donors with 70% of sensitivity and 66% of specificity. Creating the Rate of Combined Damage (RCD) defined as the product of SDF‐T0 by the increase in the damage registered during the first 2 hr of incubation (r‐SDF‐T0–2), an index of RCD = 22.2 units has an identification capacity of donors with a 78% sensitivity and 77% specificity. Such cut‐off values could be used to characterise donors with high chromatin resistance to damage when meeting the above‐established criteria. [ABSTRACT FROM AUTHOR]

Comparative research on sperm donors and egg donors in the United States suggests that while men view themselves as fathers of their offspring, women do not view themselves as mothers. Comparative research suggests as well that men and women are equally interested in contact with offspring, equally curious about them, and equally likely to hold themselves responsible for those offspring. This paper re-examines these differences and similarities using data from a survey of donors who registered on a third-party website with hopes of having some contact with their genetic offspring. Our findings suggest that women and men offer similar reasons for donating and similar assessments of the experience. Yet, the two groups have developed quite different patterns of interest in their offspring. The men create a sense of “prideful lineage” rather than fatherhood. The women create a pattern of feeling that involves “concerned responsibility” rather than motherhood. [ABSTRACT FROM PUBLISHER]

Objective: To report findings from 10 years of requests from adults eligible to obtain their open-identity sperm donor's information.Design: Analysis of archived family and donor data. Semistructured interviews at information releases.Setting: Not applicable.Patient(s): A total of 85 DI adults requesting 43 donor identities; program data on 256 DI families.Intervention(s): None.Main Outcome Measure(s): We identified [1] demographic predictors of requesting donor identities, [2] information release timing and length, and [3] request motives.Result(s): Just >35% of eligible DI adults requested their donor's identity. Adults ranged from 18-27 years, requesting at median age 18 years. More women than men requested. Proportionally fewer adults requested when they had heterosexual-couple parents, and proportionally more when they had one rather than two parents. In interviews, the common theme was wanting to know more about the donor, especially about shared characteristics. Most adults planned to contact their donor. More than 94% of adults had donors who were open to contact; adults expressed modest expectations about this contact.Conclusion(s): In 2001, the first adults became eligible to obtain their open-identity sperm donor's information. Ten years of identity requests at one program indicates that information about one's donor is important to a significant proportion of these DI adults. Most requested their donor's identity soon after becoming eligible, suggesting some urgency to wanting the information. Interview data highlighted the role of donor information in helping adults better understand themselves and their ancestry. Findings hold important implications for practice and policy. [ABSTRACT FROM AUTHOR]

In animal and human studies, exposure to trihalomethanes (THMs) has been associated with reduced semen quality. However, the underlying mechanisms remain poorly understood. To investigate the associations of blood THM concentrations with sperm mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) among healthy men. We recruited 958 men who volunteered as potential sperm donors. A single blood sample was collected from each participant at recruitment and measured for chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM) concentrations. Within a 90-day follow-up, the last semen sample provided by each participant was quantified for sperm mtDNAcn and TL. We used multivariable linear regression models to assess the associations between blood THM concentrations and sperm mtDNAcn and TL. We also performed stratified analyses according to the time intervals between baseline blood THM determinations and semen collection (i.e., 0–9, 10–14, 15–69, or >69 days) to explore potential windows of susceptibility. After adjusting for potential confounders, we found inverse associations between quartiles (or categories) of blood TBM, brominated THM (Br-THM, the sum of BDCM, DBCM, and TBM), and total THM (TTHM, the sum of all four THMs) concentrations and sperm mtDNAcn (all P for trend≤0.03). Besides, we found inverse associations between quartiles of blood TCM, Br-THM, chlorinated THM (Cl-THM, the sum of TCM, BDCM, and DBCM), and TTHM concentrations and sperm TL (all P for trend<0.10). Stratified analyses showed stronger associations between Br-THM concentrations and sperm mtDNAcn determined 15–69 days since baseline exposure determinations, and between blood TCM and TTHM concentrations and sperm TL determined >69 days since baseline exposure determinations. Exposure to THMs may be associated with sperm mitochondrial and telomeric dysfunction. [Display omitted] • Blood THMs and sperm mtDNAcn and TL were determined among 958 healthy men. • Blood TBM, Br-THMs, and TTHM were inversely associated with sperm mtDNAcn. • Blood TCM, Br-THMs, Cl-THMs, and TTHMs were inversely associated with sperm TL. • Part of these associations differed across the duration of spermatogenesis. [ABSTRACT FROM AUTHOR]