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2. Moderni aspetti di semeiotica medica. Interpretazione clinica di segni e sintomi ed elementi di diagnosi differenziale

Author

De Luca, Pasquale De Luca, Antonio Vendemiale, Gianluigi Benvenuto, Angelo Sollazzo, Vito Addolorato, Giovanni Bruschelli, Carla Cipollone, Francesco Derosa, Giuseppe Di Stefano, Biagio Granito, Alessandro Laviano, Alessandro Mastroianni, Franco Mazzola, Paolo Meschi, Tiziana Palmieri, Vincenzo Ostilio Sperandeo, Marco Vespasiani Gentilucci, Umberto Voza, Antonio, Dioguardi, N, De Luca, P, De Luca, A, Vendemiale, G, Benvenuto, A, Sollazzo, V, Mazzola, P, Mazzola P, De Luca, Pasquale De Luca, Antonio Vendemiale, Gianluigi Benvenuto, Angelo Sollazzo, Vito Addolorato, Giovanni Bruschelli, Carla Cipollone, Francesco Derosa, Giuseppe Di Stefano, Biagio Granito, Alessandro Laviano, Alessandro Mastroianni, Franco Mazzola, Paolo Meschi, Tiziana Palmieri, Vincenzo Ostilio Sperandeo, Marco Vespasiani Gentilucci, Umberto Voza, Antonio, Dioguardi, N, De Luca, P, De Luca, A, Vendemiale, G, Benvenuto, A, Sollazzo, V, Mazzola, P, and Mazzola P

Published
2024

4. The Unveiled Triad: Clinical, Radiological and Pathological Insights into Hypersensitivity Pneumonitis

Author

Rea, Gaetano, primary, Bocchino, Marialuisa, additional, Lieto, Roberta, additional, Ledda, Roberta Eufrasia, additional, D’Alto, Michele, additional, Sperandeo, Marco, additional, Lucci, Raffaella, additional, Pasquinelli, Patrizio, additional, Sanduzzi Zamparelli, Stefano, additional, Bocchini, Giorgio, additional, Valente, Tullio, additional, and Sica, Giacomo, additional

Published
2024
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5. Low Diagnostic Accuracy of Transthoracic Ultrasound for the Assessment of Spontaneous Pneumothorax in the Emergency Setting: A Multicentric Study.

Author

Quarato, Carla Maria Irene, Mirijello, Antonio, Bocchino, Marialuisa, Feragalli, Beatrice, Lacedonia, Donato, Rea, Gaetano, Lieto, Roberta, Maggi, Michele, Hoxhallari, Anela, Scioscia, Giulia, Vicario, Aldo, Pellegrino, Giuseppe, Pazienza, Luca, Villani, Rosanna, Bellanova, Salvatore, Bracciale, Pierluigi, Notarangelo, Stefano, Morlino, Paride, De Cosmo, Salvatore, and Sperandeo, Marco

Subjects
COMPUTED tomography, CHEST pain, ULTRASONIC imaging, HOSPITAL emergency services, PNEUMOTHORAX, DYSPNEA
Abstract

Background: Pneumothorax (PNX) represents a common clinical condition in emergency departments (EDs), requiring prompt recognition and treatment. The role of transthoracic ultrasounds (TUSs) in the diagnosis of PNX is still debated. We aimed to prospectively evaluate the accuracy of TUSs in the detection of spontaneous PNX in EDs. Methods: A total of 637 consecutive adult patients who presented to the EDs of four Italian hospitals complaining of acutely onset chest pain and dyspnoea were included in the study. Exclusion criteria were previous traumatic events, cardiogenic causes of pain/dyspnoea and suspected tension PNX. The absence of "lung sliding" (B-mode) and the "bar-code" sign (M-mode) were considered indicative of PNX in a TUS. Accuracy, sensitivity, specificity, and positive and negative predictive values (PPVs, NPVs) were calculated using a chest CT scan as reference. Results: Spontaneous PNX occurred in 93 patients: of those, 83 (89.2%) were correctly identified by TUSs. However, 306 patients with suspected PNX at TUS were not confirmed by chest CTs. The diagnostic accuracy of both the absence of "lung sliding" and "bar-code" sign during TUS was 50.4% (95% CI: 46.4–54.3), sensitivity was 89.2% (95% CI: 81.1–94.7), specificity was 43.8% (95% CI: 39.5–48.0), the PPV was 21.3% (95% CI: 19.7–23.1) and the NPV was 96.0% (95% CI: 92.9–97.7). Conclusions: TUS showed high sensitivity but low specificity in the identification of PNX in EDs. Relying exclusively on TUSs results for patients' management in ED settings is neither suitable nor recommendable. TUS examination can be useful to strengthen the clinical suspicion of PNX, but its results should be confirmed by a chest X-ray or CT scan. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, and Sperandeo, Marco

Abstract

Objectives: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose. Methods: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan. Results: On a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity

Published
2023

12. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, primary, Dama, Elisa, additional, Maggi, Michele, additional, Feragalli, Beatrice, additional, Borelli, Cristina, additional, Del Colle, Anna, additional, Taurchini, Marco, additional, Maiello, Evaristo, additional, De Cosmo, Salvatore, additional, Lacedonia, Donato, additional, Barbaro, Maria Pia Foschino, additional, Carpagnano, Giovanna Elisiana, additional, Scioscia, Giulia, additional, Graziano, Paolo, additional, Termine, Rosalinda, additional, Frongillo, Elisabettamaria, additional, Santamaria, Sonia, additional, Venuti, Mariapia, additional, Grimaldi, Maria Arcangela, additional, Notarangelo, Stefano, additional, Saponara, Annarita, additional, Copetti, Massimiliano, additional, Colangelo, Tommaso, additional, Cuttano, Roberto, additional, Macrodimitris, Dimitrios, additional, Mazzarelli, Francesco, additional, Talia, Michela, additional, Mirijello, Antonio, additional, Pazienza, Luca, additional, Perna, Rita, additional, Simeone, Anna, additional, Vergara, Doriana, additional, Varriale, Antonio, additional, Carella, Massimo, additional, Bianchi, Fabrizio, additional, and Sperandeo, Marco, additional

Published
2023
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13. Comparison of a Wireless Ultrasound Device with a High-End Ultrasound Machine in the Assessment of Pleuro-Pulmonary Diseases

Author

Quarato, Carla Maria Irene, primary, Fiore, Lucia Angela, additional, Lacedonia, Donato, additional, Scioscia, Giulia, additional, Salvemini, Michela, additional, Hoxhallari, Anela, additional, Villani, Rosanna, additional, D’Agostino, Federica, additional, Tuccari, Giulia, additional, Notarangelo, Stefano, additional, Mirijello, Antonio, additional, Cosmo, Salvatore De, additional, Maiello, Evaristo, additional, and Sperandeo, Marco, additional

Published
2023
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14. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, and Sperandeo, M

Subjects
ransthoracic ultrasound, high-resolution computed tomography, lung cancer, interstitial lung abnormalities, screening protocol, environmental exposure, lung cancer, interstitial lung abnormalities, high-resolution computed tomography, screening protocol, ransthoracic ultrasound, environmental exposure, transthoracic ultrasound, General Medicine, interstitial lung abnormalitie
Abstract

ObjectivesWe validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose.MethodsFrom July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan.ResultsOn a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity of 63.9% and a specificity of 69.5%, hypoechoic striae showed a sensitivity of 38.9% and a specificity of 90.1% and subpleural nodules showed a sensitivity of 58.3% and a specificity of 77.1%. Regarding to the assessment of subpleural nodules, TUS showed a sensitivity of 60.9% and a specificity of 81.0%. However, the combined employment of TUS examination and HRCT scans allowed to identify 34 patients with early subpleural ILA and to detect three suspicious pulmonary nodules (of which two were intraparenchymal and one was a large subpleural mass), which revealed to be lung cancers on further investigations.ConclusionA first-line TUS examination might aid the identification of subjects highly exposed to environmental pollution, who could benefit of a second-line low-dose HRCT scan to find early interstitial lung diseases as well as lung cancer.Protocol registration codePLEURO-SCREENING-V1.0_15 Feb, 17.

Published
2023

15. A Review on Biological Effects of Ultrasounds: Key Messages for Clinicians

Author

Quarato, Carla Maria Irene, primary, Lacedonia, Donato, additional, Salvemini, Michela, additional, Tuccari, Giulia, additional, Mastrodonato, Grazia, additional, Villani, Rosanna, additional, Fiore, Lucia Angela, additional, Scioscia, Giulia, additional, Mirijello, Antonio, additional, Saponara, Annarita, additional, and Sperandeo, Marco, additional

Published
2023
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16. Contrast-Enhanced Ultrasound in Distinguishing between Malignant and Benign Peripheral Pulmonary Consolidations: The Debated Utility of the Contrast Enhancement Arrival Time

Author

Quarato, Carla Maria Irene, primary, Feragalli, Beatrice, additional, Lacedonia, Donato, additional, Rea, Gaetano, additional, Scioscia, Giulia, additional, Maiello, Evaristo, additional, Di Micco, Concetta, additional, Borelli, Cristina, additional, Mirijello, Antonio, additional, Graziano, Paolo, additional, Dimitri, Lucia, additional, Villani, Rosanna, additional, and Sperandeo, Marco, additional

Published
2023
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17. A Large Idiopathic Arteriovenous Malformation of the Right Lung, Which Was Mistaken for Lung Cancer.

Author

Quarato, Carla Maria Irene, Taurchini, Marco, Ferretti, Gianmaria, Simeone, Anna, Ciccarese, Giovanni, Dimitri, Lucia, Fuso, Paolo, and Sperandeo, Marco

Abstract

A 53-year-old male was admitted to the hospital because of retrosternal and epigastric pain radiating to the back. Radiologic images showed a homogeneous soft tissue mass in the right upper lobe that was initially misdiagnosed as a lung cancer. Fortunately, a careful Doppler examination identified two vascular structures within the lesion. This diagnostic study suggested the execution of a more appropriate computed tomography angiography (CTA). The examination confirmed the diagnosis of a simple pulmonary arteriovenous malformation (AVM). The patient underwent embolization of the arterial side of the AVM and finally a posterolateral mini-thoracotomy to remove the lesion. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Transthoracic ultrasound shear wave elastography for the study of subpleural lung lesions

Author

Quarato, Carla Maria Irene, primary, Venuti, Mariapia, additional, Dimitri, Lucia, additional, Lacedonia, Donato, additional, Simeone, Anna, additional, Mirijello, Antonio, additional, De Cosmo, Salvatore, additional, Maiello, Evaristo, additional, Taurchini, Marco, additional, Scioscia, Giulia, additional, Barbaro, Maria Pia Foschino, additional, Copetti, Massimiliano, additional, and Sperandeo, Marco, additional

Published
2022
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30. Chest Imaging in the Diagnosis and Management of Pulmonary Tuberculosis: The Complementary Role of Thoraci Ultrasound

Author

Rea, Gaetano, primary, Sperandeo, Marco, additional, Lieto, Roberta, additional, Bocchino, Marialuisa, additional, Quarato, Carla Maria Irene, additional, Feragalli, Beatrice, additional, Valente, Tullio, additional, Scioscia, Giulia, additional, Giuffreda, Ernesto, additional, Foschino Barbaro, Maria Pia, additional, and Lacedonia, Donato, additional

Published
2021
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37. A Transthoracic Ultrasound-Guided Needle Biopsy Provided the Diagnosis for a Synovial Sarcoma of the Pleura.

Author

Palumbo, Maria Giovanna, Quarato, Carla Maria Irene, Lacedonia, Donato, Lucia, Dimitri, Simeone, Anna, Di Micco, Concetta, De Cosmo, Salvatore, Scioscia, Giulia, Foschino Barbaro, Maria Pia, and Sperandeo, Marco

Abstract

A case report is presented of a 72-year-old woman with monophasic synovial sarcoma of the buttocks, diagnosed four years before. The tumor was treated with surgical removal followed by radiotherapy. The patient regularly underwent follow-up examinations and the last chest computed tomogram (CT) showed a left-sided pleural mass and ipsilateral effusion. The patient was admitted in hospital to obtain a specific histological diagnosis before treatment of chest pathology was initiated. An ultrasound (US)-guided fine needle aspiration biopsy (FNAB) of the pleural lesion and US-guided thoracentesis with drainage of blood serum pleural fluid were performed. The pathological examination of the lesion revealed a definitive diagnosis of synovial sarcoma of the pleura. For pleural-based lesions, the diagnostic accuracy of US-guided biopsy is similar to that of CT-guided biopsy, with a lower complication rate, the absence of radiation exposure to patients, and a significantly reduced procedural time. The presence of pleural effusion creates a favorable acoustic window for US-guided biopsy of pleural lesion, which is useful for the diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Intraoperative Lung Ultrasound (ILU) for the Assessment of Pulmonary Nodules

Author

Taurchini, Marco, primary, Quarato, Carla Maria Irene, additional, Frongillo, Elisabetta Maria, additional, Ferretti, Gian Maria, additional, Cipriani, Cristiana, additional, Bizzarri, Marco, additional, Foschino Barbaro, Maria Pia, additional, Lacedonia, Donato, additional, Simeone, Annalisa, additional, Graziano, Paolo, additional, Dimitri, Lucia, additional, Maiello, Evaristo, additional, Cavaliere, Lucio, additional, De Cosmo, Salvatore, additional, and Sperandeo, Marco, additional

Published
2021
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39. Effectiveness and Safety of Transthoracic Ultrasound in Guiding Percutaneous Needle Biopsy in the Lung and Comparison vs. CT Scan in Assessing Morphology of Subpleural Consolidations

Author

Sperandeo, Marco, primary, Maiello, Evaristo, additional, Graziano, Paolo, additional, Simeone, Annalisa, additional, De Cosmo, Salvatore, additional, Dimitri, Lucia, additional, Di Micco, Concetta, additional, Perrone, Elio, additional, Taurchini, Marco, additional, Ferretti, Gianmaria, additional, Mirijello, Antonio, additional, Varriale, Antonio, additional, Grimaldi, Maria Arcangela, additional, Lacedonia, Donato, additional, and Quarato, Carla Maria Irene, additional

Published
2021
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49. COVID-19 Pneumonia: The Great Ultrasonography Mimicker

Author

Lacedonia, Donato, primary, Quarato, Carla Maria Irene, additional, Mirijello, Antonio, additional, Trovato, Guglielmo M., additional, Del Colle, Anna, additional, Rea, Gaetano, additional, Scioscia, Giulia, additional, Foschino Barbaro, Maria Pia, additional, and Sperandeo, Marco, additional

Published
2021
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50. Lung Ultrasound in the Diagnosis of COVID-19 Pneumonia: Not Always and Not Only What Is COVID-19 “Glitters”

Author

Quarato, Carla Maria Irene, primary, Mirijello, Antonio, additional, Maggi, Michele Maria, additional, Borelli, Cristina, additional, Russo, Raffaele, additional, Lacedonia, Donato, additional, Foschino Barbaro, Maria Pia, additional, Scioscia, Giulia, additional, Tondo, Pasquale, additional, Rea, Gaetano, additional, Simeone, Annalisa, additional, Feragalli, Beatrice, additional, Massa, Valentina, additional, Greco, Antonio, additional, De Cosmo, Salvatore, additional, and Sperandeo, Marco, additional

Published
2021
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