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3. Preparation of $^{87}$Rb and $^{133}$Cs in the motional ground state of a single optical tweezer

Author

Spence, S., Brooks, R. V., Ruttley, D. K., Guttridge, A., and Cornish, Simon L.

Subjects
Physics - Atomic Physics
Abstract

We report simultaneous Raman sideband cooling of a single $^{87}$Rb atom and a single $^{133}$Cs atom held in separate optical tweezers at 814\,nm and 938\,nm, respectively. Starting from outside the Lamb-Dicke regime, after 45\,ms of cooling we measure probabilities to occupy the three-dimensional motional ground state of 0.86$^{+0.03}_{-0.04}$ for Rb and 0.95$^{+0.03}_{-0.04}$ for Cs. Our setup overlaps the Raman laser beams used to cool Rb and Cs, reducing hardware requirements by sharing equipment along the same beam path. The cooling protocol is scalable, and we demonstrate cooling of single Rb atoms in an array of four tweezers. After motional ground-state cooling, a 938\,nm tweezer is translated to overlap with a 814\,nm tweezer so that a single Rb and a single Cs atom can be transferred into a common 1064\,nm trap. By minimising the heating during the merging and transfer, we prepare the atoms in the relative motional ground state with an efficiency of 0.81$^{+0.08}_{-0.08}$. This is a crucial step towards the formation of single RbCs molecules confined in optical tweezer arrays.

Published
2022
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4. Feshbach Spectroscopy of Cs Atom Pairs in Optical Tweezers

Author

Brooks, R V, Guttridge, A, Frye, Matthew D, Ruttley, D K, Spence, S, Hutson, Jeremy M, and Cornish, Simon L

Subjects
Physics - Atomic Physics
Abstract

We prepare pairs of $^{133}$Cs atoms in a single optical tweezer and perform Feshbach spectroscopy for collisions of atoms in the states $(f=3, m_f=\pm3)$. We detect enhancements in pair loss using a detection scheme where the optical tweezers are repeatedly subdivided. For atoms in the state $(3,-3)$, we identify resonant features by performing inelastic loss spectroscopy. We carry out coupled-channel scattering calculations and show that at typical experimental temperatures the loss features are mostly centred on zeroes in the scattering length, rather than resonance centres. We measure the number of atoms remaining after a collision, elucidating how the different loss processes are influenced by the tweezer depth. These measurements probe the energy released during an inelastic collision, and thus give information on the states of the collision products. We also identify resonances with atom pairs prepared in the absolute ground state $(f=3, m_f=3)$, where two-body radiative loss is engineered by an excitation laser blue-detuned from the Cs D$_2$ line. These results demonstrate optical tweezers to be a versatile tool to study two-body collisions with number-resolved detection sensitivity., Comment: 18 pages, 6 figures

Published
2022
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5. Preparation of one $^{87}$Rb and one $^{133}$Cs atom in a single optical tweezer

Author

Brooks, R V, Spence, S, Guttridge, A, Alampounti, A, Rakonjac, A, McArd, L A, Hutson, Jeremy M, and Cornish, Simon L

Subjects
Physics - Atomic Physics
Abstract

We report the preparation of exactly one $^{87}$Rb atom and one $^{133}$Cs atom in the same optical tweezer as the essential first step towards the construction of a tweezer array of individually trapped $^{87}$Rb$^{133}$Cs molecules. Through careful selection of the tweezer wavelengths, we show how to engineer species-selective trapping potentials suitable for high-fidelity preparation of Rb $+$ Cs atom pairs. Using a wavelength of 814~nm to trap Rb and 938~nm to trap Cs, we achieve loading probabilities of $0.508(6)$ for Rb and $0.547(6)$ for Cs using standard red-detuned molasses cooling. Loading the traps sequentially yields exactly one Rb and one Cs atom in $28.4(6)\,\%$ of experimental runs. Using a combination of an acousto-optic deflector and a piezo-controlled mirror to control the relative position of the tweezers, we merge the two tweezers, retaining the atom pair with a probability of $0.99^{(+0.01)}_{(-0.02)}$. We use this capability to study hyperfine-state-dependent collisions of Rb and Cs in the combined tweezer and compare the measured two-body loss rates with coupled-channel quantum scattering calculations., Comment: 22 pages, 6 figures

Published
2021
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6. Superfluid Optomechanics with Phononic Nanostructures

Author

Spence, S., Koong, Z. X., Horsley, S. A. R., and Rojas, X.

Subjects
Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract

In quantum optomechanics, finding materials and strategies to limit losses has been crucial to the progress of the field. Recently, superfluid 4He was proposed as a promising mechanical element for quantum optomechanics. This quantum fluid shows highly desirable properties (e.g. extremely low acoustic loss) for a quantum optomechanical system. In current implementations, superfluid optomechanical systems suffer from external sources of loss, which spoils the quality factor of resonators. In this work, we propose a new implementation, exploiting nanofluidic confinement. Our approach, based on acoustic resonators formed within phononic nanostructures, aims at limiting radiation losses to preserve the intrinsic properties of superfluid 4He. In this work, we estimate the optomechanical system parameters. Using recent theory, we derive the expected quality factors for acoustic resonators in different thermodynamic conditions. We calculate the sources of loss induced by the phononic nanostructures with numerical simulations. Our results indicate the feasibility of the proposed approach in a broad range of parameters, which opens new prospects for more complex geometries., Comment: 20 pages, 19 figures

Published
2020
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7. Health Equity Implications of Missing Data Among Youths With Childhood‐Onset Systemic Lupus Erythematosus: A Proof‐of‐Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry

Author

Woo, Jennifer M. P., Simmonds, Faith, Dennos, Anne, Son, Mary Beth F., Lewandowski, Laura B., Rubinstein, Tamar B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., OʼBrien, B., OʼBrien, T., Okeke, O., Oliver, M., Olson, J., OʼNeil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Marafon, D. Pires, Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2023
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8. Safety and effectiveness of abatacept in juvenile idiopathic arthritis: Results from the PRINTO/PRCSG registry

Author

Lovell, D, Tzaribachev, N, Henrickson, M, Simonini, G, Griffin, T, Alexeeva, E, Bohnsack, J, Zeft, A, Horneff, G, Vehe, R, Stanevica, V, Tarvin, S, Trachana, M, Del Rio, A, Huber, A, Kietz, D, Orban, I, Dare, J, Foeldvari, I, Quartier, P, Dominique, A, Simon, T, Martini, A, Brunner, H, Ruperto, N, Brunner, J, Fernandes, T, Appenzeller, S, Oliveira, S, Terreri, M, Minden, K, Hufnagel, M, Helling-Bakki, A, Herlin, T, Moreno, E, Anton, J, Del-Castillo, P, Udaondo, C, Penades, I, Brochard, K, Ramanan, A, Hashkes, P, Olivieri, A, Zulian, F, Montin, D, Peroni, D, Stanevicha, V, Cornejo, G, Wulffraat, N, Kamphuis, S, Gastanaga, M, Miraval, T, Oliveira-Ramos, F, Lazar, C, Nikishina, I, Sarychev, A, Chasnyk, V, Grebenkina, L, Suwairi, W, Koskova, E, Ally, M, Louw, I, Breedt, J, Ting, T, Taylor, J, Huggins, J, Dewitt, E, Grom, A, Schulert, G, Rodriguez-Smith, J, Morris, P, Sukumarain, S, Gitelman, M, Miller, M, Curran, M, Alperin, R, Ardalan, K, De Ranieri, D, Hiskey, M, Nolan, B, Chalom, B, Zelf, A, Spalding, S, Costanzo, D, Rennebohm, R, Waugaman, B, Brodus, E, Robinson, A, Panupattanapong, S, Rosenkranz, M, Cassidy, E, Torok, K, Kingsbury, D, Cartwright, V, Lasky, A, Brown, D, Reiff, A, Shaham, B, Marzan, K, Wagner-Weiner, L, Onel, K, Tesher, M, Edens, C, Moore, T, Syed, R, Pepmueller, P, Tuttle, P, Dalrymple, A, Barhula, S, Feller, L, Horwitz, M, Justice, M, Nocton, J, Olson, J, Williams, C, Versbsy, J, Co, D, Roth-Wojcicki, E, Correll, C, Binstadt, B, Hobday, P, Brueck, D, Gillispie-Taylor, M, Vora, S, O'Neil, K, Ballinger, S, Blakley, M, Klausmeier, T, Oliver, M, Stevens, B, Rodriguez, M, Go, E, Inman, C, Hersh, A, Stern, S, Woodward, A, Durkee, D, Boulva, S, James, K, Treemarcki, E, Goldsmith, D, Lvovich, S, Toib, D, Patel, J, Jerath, R, Sharma, N, Newhall, L, Carrasco, R, Moorthy, N, Boneparth, A, Quintero, A, Graham, T, Spence, S, Davis, A, Gotte, A, Mehta, J, Walters, H, Mian, Z, Parkinson, E, Hui-Yen, J, Steigerwald, K, Guzman, M, Gottlieb, B, Whitaker, C, Kelly, L, Succimarri, R, Hazel, E, Chedeville, G, Compillo, S, Leblance, C, Tucker, L, Cabral, D, Houghton, K, Guzman, J, Morishita, K, Stringer, E, Ramsey, S, Lang, B, Levy, D, Silverman, E, Schmeling, H, Johnson, N, Luca, N, Dhalla, M, Lovell D. J., Tzaribachev N., Henrickson M., Simonini G., Griffin T. A., Alexeeva E., Bohnsack J. F., Zeft A., Horneff G., Vehe R. K., Stanevica V., Tarvin S., Trachana M., Del Rio A. Q., Huber A. M., Kietz D., Orban I., Dare J., Foeldvari I., Quartier P., Dominique A., Simon T. A., Martini A., Brunner H. I., Ruperto N., Brunner J., Fernandes T., Appenzeller S., Oliveira S., Terreri M. T., Minden K., Hufnagel M., Helling-Bakki A., Herlin T., Moreno E., Anton J., Del-Castillo P. M. -., Udaondo C., Penades I. C., Brochard K., Ramanan A., Hashkes P. P., Olivieri A. N., Zulian F., Montin D., Peroni D., Stanevicha V., Cornejo G. V., Wulffraat N., Kamphuis S., Gastanaga M. E. P., Miraval T., Oliveira-Ramos F., Lazar C., Nikishina I., Sarychev A., Chasnyk V., Grebenkina L., Suwairi W. M. S., Koskova E., Ally M., Louw I., Breedt J., Brunner H., Ting T., Taylor J., Huggins J., Dewitt E. M., Grom A., Lovell D., Schulert G., Rodriguez-Smith J., Morris P., Sukumarain S., Gitelman M. K., Miller M., Curran M., Alperin R., Ardalan K., De Ranieri D., Hiskey M., Nolan B., Chalom B., Zelf A., Spalding S., Costanzo D., Rennebohm R., Waugaman B., Brodus E., Robinson A., Panupattanapong S., Rosenkranz M., Cassidy E., Torok K., Kingsbury D., Cartwright V., Lasky A., Brown D., Reiff A., Shaham B., Marzan K., Wagner-Weiner L., Onel K., Tesher M., Edens C., Moore T., Syed R., Pepmueller P., Tuttle P., Dalrymple A., Barhula S., Feller L., Horwitz M., Justice M., Nocton J., Olson J., Williams C., Versbsy J., Co D., Roth-Wojcicki E., Correll C., Vehe R., Binstadt B., Hobday P., Brueck D., Griffin T., Gillispie-Taylor M., Vora S., O'Neil K., Ballinger S., Blakley M., Klausmeier T., Oliver M., Stevens B., Rodriguez M., Go E., Bohnsack J., Inman C., Hersh A., Stern S., Woodward A., Durkee D., Boulva S. F., James K., Treemarcki E., Goldsmith D., Lvovich S., Toib D., Patel J., Jerath R., Sharma N., Newhall L., Carrasco R., Moorthy N., Boneparth A., Quintero A., Graham T., Spence S., Davis A., Gotte A., Mehta J., Walters H., Mian Z., Parkinson E., Hui-Yen J., Steigerwald K., Guzman M., Gottlieb B., Whitaker C., Kelly L., Succimarri R., Hazel E., Chedeville G., Compillo S., Leblance C., Tucker L., Cabral D., Houghton K., Guzman J., Morishita K., Huber A., Stringer E., Ramsey S., Lang B., Levy D., Silverman E., Schmeling H., Johnson N., Luca N., Dhalla M., Lovell, D, Tzaribachev, N, Henrickson, M, Simonini, G, Griffin, T, Alexeeva, E, Bohnsack, J, Zeft, A, Horneff, G, Vehe, R, Stanevica, V, Tarvin, S, Trachana, M, Del Rio, A, Huber, A, Kietz, D, Orban, I, Dare, J, Foeldvari, I, Quartier, P, Dominique, A, Simon, T, Martini, A, Brunner, H, Ruperto, N, Brunner, J, Fernandes, T, Appenzeller, S, Oliveira, S, Terreri, M, Minden, K, Hufnagel, M, Helling-Bakki, A, Herlin, T, Moreno, E, Anton, J, Del-Castillo, P, Udaondo, C, Penades, I, Brochard, K, Ramanan, A, Hashkes, P, Olivieri, A, Zulian, F, Montin, D, Peroni, D, Stanevicha, V, Cornejo, G, Wulffraat, N, Kamphuis, S, Gastanaga, M, Miraval, T, Oliveira-Ramos, F, Lazar, C, Nikishina, I, Sarychev, A, Chasnyk, V, Grebenkina, L, Suwairi, W, Koskova, E, Ally, M, Louw, I, Breedt, J, Ting, T, Taylor, J, Huggins, J, Dewitt, E, Grom, A, Schulert, G, Rodriguez-Smith, J, Morris, P, Sukumarain, S, Gitelman, M, Miller, M, Curran, M, Alperin, R, Ardalan, K, De Ranieri, D, Hiskey, M, Nolan, B, Chalom, B, Zelf, A, Spalding, S, Costanzo, D, Rennebohm, R, Waugaman, B, Brodus, E, Robinson, A, Panupattanapong, S, Rosenkranz, M, Cassidy, E, Torok, K, Kingsbury, D, Cartwright, V, Lasky, A, Brown, D, Reiff, A, Shaham, B, Marzan, K, Wagner-Weiner, L, Onel, K, Tesher, M, Edens, C, Moore, T, Syed, R, Pepmueller, P, Tuttle, P, Dalrymple, A, Barhula, S, Feller, L, Horwitz, M, Justice, M, Nocton, J, Olson, J, Williams, C, Versbsy, J, Co, D, Roth-Wojcicki, E, Correll, C, Binstadt, B, Hobday, P, Brueck, D, Gillispie-Taylor, M, Vora, S, O'Neil, K, Ballinger, S, Blakley, M, Klausmeier, T, Oliver, M, Stevens, B, Rodriguez, M, Go, E, Inman, C, Hersh, A, Stern, S, Woodward, A, Durkee, D, Boulva, S, James, K, Treemarcki, E, Goldsmith, D, Lvovich, S, Toib, D, Patel, J, Jerath, R, Sharma, N, Newhall, L, Carrasco, R, Moorthy, N, Boneparth, A, Quintero, A, Graham, T, Spence, S, Davis, A, Gotte, A, Mehta, J, Walters, H, Mian, Z, Parkinson, E, Hui-Yen, J, Steigerwald, K, Guzman, M, Gottlieb, B, Whitaker, C, Kelly, L, Succimarri, R, Hazel, E, Chedeville, G, Compillo, S, Leblance, C, Tucker, L, Cabral, D, Houghton, K, Guzman, J, Morishita, K, Stringer, E, Ramsey, S, Lang, B, Levy, D, Silverman, E, Schmeling, H, Johnson, N, Luca, N, Dhalla, M, Lovell D. J., Tzaribachev N., Henrickson M., Simonini G., Griffin T. A., Alexeeva E., Bohnsack J. F., Zeft A., Horneff G., Vehe R. K., Stanevica V., Tarvin S., Trachana M., Del Rio A. Q., Huber A. M., Kietz D., Orban I., Dare J., Foeldvari I., Quartier P., Dominique A., Simon T. A., Martini A., Brunner H. I., Ruperto N., Brunner J., Fernandes T., Appenzeller S., Oliveira S., Terreri M. T., Minden K., Hufnagel M., Helling-Bakki A., Herlin T., Moreno E., Anton J., Del-Castillo P. M. -., Udaondo C., Penades I. C., Brochard K., Ramanan A., Hashkes P. P., Olivieri A. N., Zulian F., Montin D., Peroni D., Stanevicha V., Cornejo G. V., Wulffraat N., Kamphuis S., Gastanaga M. E. P., Miraval T., Oliveira-Ramos F., Lazar C., Nikishina I., Sarychev A., Chasnyk V., Grebenkina L., Suwairi W. M. S., Koskova E., Ally M., Louw I., Breedt J., Brunner H., Ting T., Taylor J., Huggins J., Dewitt E. M., Grom A., Lovell D., Schulert G., Rodriguez-Smith J., Morris P., Sukumarain S., Gitelman M. K., Miller M., Curran M., Alperin R., Ardalan K., De Ranieri D., Hiskey M., Nolan B., Chalom B., Zelf A., Spalding S., Costanzo D., Rennebohm R., Waugaman B., Brodus E., Robinson A., Panupattanapong S., Rosenkranz M., Cassidy E., Torok K., Kingsbury D., Cartwright V., Lasky A., Brown D., Reiff A., Shaham B., Marzan K., Wagner-Weiner L., Onel K., Tesher M., Edens C., Moore T., Syed R., Pepmueller P., Tuttle P., Dalrymple A., Barhula S., Feller L., Horwitz M., Justice M., Nocton J., Olson J., Williams C., Versbsy J., Co D., Roth-Wojcicki E., Correll C., Vehe R., Binstadt B., Hobday P., Brueck D., Griffin T., Gillispie-Taylor M., Vora S., O'Neil K., Ballinger S., Blakley M., Klausmeier T., Oliver M., Stevens B., Rodriguez M., Go E., Bohnsack J., Inman C., Hersh A., Stern S., Woodward A., Durkee D., Boulva S. F., James K., Treemarcki E., Goldsmith D., Lvovich S., Toib D., Patel J., Jerath R., Sharma N., Newhall L., Carrasco R., Moorthy N., Boneparth A., Quintero A., Graham T., Spence S., Davis A., Gotte A., Mehta J., Walters H., Mian Z., Parkinson E., Hui-Yen J., Steigerwald K., Guzman M., Gottlieb B., Whitaker C., Kelly L., Succimarri R., Hazel E., Chedeville G., Compillo S., Leblance C., Tucker L., Cabral D., Houghton K., Guzman J., Morishita K., Huber A., Stringer E., Ramsey S., Lang B., Levy D., Silverman E., Schmeling H., Johnson N., Luca N., and Dhalla M.

Abstract

Objective: The aim of this study was to report the interim 5-year safety and effectiveness of abatacept in patients with JIA in the PRINTO/PRCSG registry. Methods: The Abatacept JIA Registry (NCT01357668) is an ongoing observational study of children with JIA receiving abatacept; enrolment started in January 2013. Clinical sites enrolled patients with JIA starting or currently receiving abatacept. Eligible patients were assessed for safety (primary end point) and effectiveness over 10 years. Effectiveness was measured by clinical 10-joint Juvenile Arthritis Disease Activity Score (cJADAS10) in patients with JIA over 5 years. As-observed analysis is presented according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Results: As of 31 March 2020, 587 patients were enrolled; 569 are included in this analysis (including 134 new users) with 1214.6 patient-years of safety data available. Over 5 years, the incidence rate (IR) per 100 patient-years of follow-up of serious adverse events was 5.52 (95% CI: 4.27, 7.01) and of events of special interest was 3.62 (95% CI: 2.63, 4.86), with 18 serious infections [IR 1.48 (95% CI: 0.88, 2.34)]. As early as month 3, 55.9% of patients achieved cJADAS10 low disease activity and inactive disease (20.3%, 72/354 and 35.6%, 126/354, respectively), sustained over 5 years. Disease activity measures improvement over 5 years across JIA categories. Conclusion: Abatacept was well tolerated in patients with JIA, with no new safety signals identified and with well-controlled disease activity, including some patients achieving inactive disease or remission.

Published
2024

9. A note concerning the modular valued von Neumann interaction operator

Author

Parks, A. D., Spence, S. E., and Farinholt, J. M.

Subjects
Quantum Physics
Abstract

The modular valued operator $\widehat{V}_m$ of the von Neumann interaction operator for a projector is defined. The properties of $\widehat{V}_m$ are discussed and contrasted with those of the standard modular value of a projector. The associated notion of a faux qubit is introduced and its possible utility in quantum computation is noted. An experimental implementation of $\widehat{V}_m$ is also highlighted., Comment: 6 pages, no figures

Published
2018
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11. Childhood‐Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐Term Kidney Status and Variation in Care

Author

Smitherman, Emily A., Chahine, Rouba A., Beukelman, Timothy, Lewandowski, Laura B., Rahman, A. K. M. Fazlur, Wenderfer, Scott E., Curtis, Jeffrey R., Hersh, Aimee O., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., OʼBrien, B., OʼBrien, T., Okeke, O., Oliver, M., Olson, J., OʼNeil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2023
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12. Diagnostic findings in sinonasal aspergillosis in dogs in the United Kingdom: 475 cases (2011–2021)

Author

Prior, C., primary, Swales, H., additional, Sharman, M., additional, Reed, N., additional, Bommer, N., additional, Kent, A., additional, Glanemann, B., additional, Clarke, K., additional, Kortum, A., additional, Kelly, D., additional, Lea, C., additional, Roberts, E., additional, Rutherford, L., additional, Tamborini, A., additional, Murphy, K., additional, Batchelor, D. J., additional, Calleja, S., additional, Burrow, R., additional, Jamieson, P., additional, Best, M., additional, Borgonovi, S., additional, Calvo‐saiz, I., additional, Elgueta, I., additional, Piazza, C., additional, Gil Morales, C., additional, Hrovat, A., additional, Keane, M., additional, Kennils, J., additional, Lopez, E., additional, Spence, S., additional, Izaguirre, E., additional, Hernandez‐Perello, M., additional, Lau, N., additional, Paul, A., additional, Ridyard, A., additional, Shales, C., additional, Shelton, E., additional, Farges, A., additional, Specchia, G., additional, Espada, L., additional, Fowlie, S. J., additional, Tappin, S., additional, Van den Steen, N., additional, Sparks, T. H., additional, and Allerton, F., additional

Published
2024
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14. Experimental Evidence for a Dynamical Non-Locality Induced Effect in Quantum Interference Using Weak Values

Author

Spence, S. E. and Parks, A. D.

Subjects
Quantum Physics
Abstract

The quantum theoretical concepts of modular momentum and dynamical non-locality, which were introduced four decades ago, have recently been used to explain single particle quantum interference phenomena. Although the non-local exchange of modular momentum associated with such phenomena cannot be directly observed, it has been suggested that effects induced by this exchange can be measured experimentally using weak measurements of pre- and post-selected ensembles of particles. This paper reports on such an optical experiment that yielded measured weak values that were consistent with the theoretical prediction of an effect induced by a non-local exchange of modular momentum.

Published
2010

15. Down Syndrome–Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes

Author

Jones, Jordan T., Smith, Chelsey, Becker, Mara L., Lovell, Daniel, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Akoghlanian, S., Al Ahmed, O., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Anastasopoulos, D., Anderson, E., Andrew, M., Ardalan, K., Ardoin, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Birmingham, J., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Brooks, E., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullington, A., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carpenter, S., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chiu, Y., Chundru, K., Clairman, H., Co, D., Collins, K., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Cospito, T., Costanzo, D., Cron, R., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Dionizovik‐Dimanovski, M., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Drummond, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edens, C., Edens, C., Edgerly, Y., Elder, M., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Feldman, B., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleck, D., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gergely, T., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Goh, I., Goldberg, T., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Guevara, M., Guittar, P., Gurion, R., Guzman, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hansman, E., Hanson, A., Harel, L., Haro, S., Harris, J., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hughes, R., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Iqbal, S., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Kahn, P., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khaleel, M., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lang, B., Lapidus, S., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Luca, N., Lvovich, S., Ma, M., Mackey, C., Madison, C., Madison, J., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCallum, B., McCarthy, K., McConnell, K., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McHugh, A., McKibben, K., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Morris, S., Moss, C., Moussa, T., Mruk, V., Mulvhihill, E., Muscal, E., Nahal, B., Nanda, K., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nguyen, E., Nicholas, J., Nigrovic, P., Nocton, J., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., O’Connor, M., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orlando, M., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Punaro, M., Puplava, B., Quach, J., Quinlan‐Waters, M., Quintero, A., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramsay, E., Ramsey, S., Reed, A., Reed, A., Reed, A., Reid, H., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Roberson, S., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosenwasser Raines, N., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster–Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabatino, M., Sabbagh, S., Sadun, R., Sandborg, C., Sanni, A., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shen, B., Shenoi, S., Shergill, K., Shiff, N., Shirley, J., Shishov, M., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Snider, C., Soep, J., Son, M., Soybilgic, A., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Stasek, J., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stoops, S., Strelow, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sura, A., Sutter, M., Syed, R., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Treemarcki, E., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vega‐Fernandes, P., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Wang, C., Waqar, L., Waterfield, M., Watson, M., Watts, A., Waugaman, B., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zemel, L., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2021
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16. Tripartite loss model for Mach-Zehnder interferometers with application to phase sensitivity : Complete expressions for measurement operator mean values, variances, and cross correlations

Author

Parks, A. D., Spence, S. E., and Troupe, J. E.

Subjects
Physics - Instrumentation and Detectors, Physics - Optics
Abstract

A generalized analytical tripartite loss model is posited for Mach-Zehnder interferometer (MZI) phase sensitivity which is valid for both arbitrary photon input states and arbitrary system environmental states. This model is shown to subsume the phase sensitivity models for the lossless MZI and the ground state MZI. It can be employed to develop specialized models useful for estimating phase sensitivities, as well as for performing associated design trade-off analyses, for MZIs which operate in environmental regimes that are not contained within the ground state MZI's envelope of validity. As a simple illustration of its utility, the model is used to develop phase sensitivity expessions for an MZI with "excited" internal arms and an MZI with "excited" output channels. These expressions yield a conditional relationship between the expected number of photons entering an MZI and its efficiency parameters which-when satisfied-predicts an enhanced phase sensitivity for the MZI with "excited" output channels relative to that for the MZI with "excited" internal arms., Comment: 16 pages no figures This is the model used for the research results reported in Rev. Sci. Instrum. 76 043103 (2005)

Published
2006

18. Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA–B27, and Equal Sex Representation in Sacroiliitis

Author

Rumsey, Dax G., Lougee, Aimee, Matsouaka, Roland, Collier, David H., Schanberg, Laura E., Schenfeld, Jennifer, Shiff, Natalie J., Stoll, Matthew L., Stryker, Scott, Weiss, Pamela F., Beukelman, Timothy, Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Magni Manzoni, S., Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., McCurdy Stokes, P., McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Morgan Dewitt, E., Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O’Brien, B., O’Brien, T., Okeke, O., Oliver, M., Olson, J., O’Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Pires Marafon, D., Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Sterba Rakovchik, Y., Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., von Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Wampler Muskardin, T., Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Published
2021
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19. Development and psychometric evaluation of the Diabetic Gastroparesis Symptom Severity Diary

Author

Fehnel S, Fiedorek FT, Nelson L, DiBenedetti D, Spence S, and Carson RT

Subjects
diabetes, relamorelin, patient-reported outcome, instrument, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Sheri Fehnel,1 Fred T Fiedorek,2 Lauren Nelson,1 Dana DiBenedetti,1 Sharon Spence,2 Robyn T Carson3 1Patient-Centered Outcomes Assessment, RTI Health Solutions, Research Triangle Park, NC, USA; 2Motus Therapeutics, Inc., Boston, MA, USA; 3Patient-Centered Outcomes Research, Global Evidence and Value Development, Allergan plc, Madison, NJ, USA Background: Diabetic gastroparesis (DG) is defined as delayed gastric emptying with associated gastrointestinal symptoms, without mechanical obstruction. Patient-reported symptoms are critical for diagnosis and evaluation of treatment benefit in DG. The Diabetic Gastroparesis Symptom Severity Diary (DGSSD), a new patient-reported outcome measure, was developed for use in clinical trials to support product approval and labeling claims for DG treatments. Materials and methods: Initial DGSSD development was based on a review of the existing instruments and qualitative research (focus groups and cognitive debriefing interviews) in 41 patients with DG. Psychometric evaluations (individual items and composite scores) were conducted using data from Phase IIa and IIb relamorelin clinical trials. Results: Qualitative research in patients with DG resulted in a six-item DGSSD, included in the Phase IIa trial, addressing symptom severity for nausea, vomiting, abdominal pain, early satiety, and bloating, as well as vomiting frequency. An item addressing severity of postprandial fullness (PPF) was subsequently added based on regulatory advice and included in the Phase IIb trial. Measurement properties were generally strong for weekly averages of daily item and composite scores. Item-level intraclass correlation coefficients ranged from 0.79 to 0.97 and correlations with other measures matched hypothesized patterns; the discriminating ability and responsiveness of the DGSSD were also supported. Multiple methods supported the computation of a composite score based on items addressing nausea, abdominal pain, bloating, and PPF severity. Conclusion: Qualitative and quantitative evidence support use of the DGSSD as a reliable and valid measure from which to derive endpoints to evaluate treatment benefit in future DG interventional trials. Keywords: diabetes, relamorelin, patient-reported outcome, instrument

Published
2019

25. Three-tone coherent microwave electromechanical measurement of a superfluid Helmholtz resonator

Author

Spence, S. (author), Varga, E. (author), Potts, C.A. (author), Davis, J. P. (author), Spence, S. (author), Varga, E. (author), Potts, C.A. (author), and Davis, J. P. (author)

Abstract

We demonstrate electromechanical coupling between a superfluid mechanical mode and a microwave mode formed by a patterned microfluidic chip and a 3D cavity. The electric field of the chip-cavity microwave resonator can be used to both drive and detect the motion of a pure superflow Helmholtz mode, which is dictated by geometric confinement. The coupling is characterized using a coherent measurement technique developed for measuring weak couplings deep in the sideband unresolved regime. The technique is based on two-probe optomechanically induced transparency/amplification using amplitude modulation. Instead of measuring two probe tones separately, they are interfered to retain only a signal coherent with the mechanical motion. With this method, we measure a vacuum electromechanical coupling strength of g 0 = 2 p × 23.3 µ Hz, three orders of magnitude larger than previous superfluid electromechanical experiments., Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., QN/Steele Lab

Published
2023
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26. Are we providing an effective sedation service? An evaluation of a new conscious sedation service in primary special dental care.

Author

Boynton, C., Harford, S., and Spence, S.

Subjects
CONSCIOUS sedation, FEAR of dentists, PRIMARY care, DENTAL care, EVIDENCE-based policy
Abstract

Conscious sedation using midazolam can be an effective primary care dental treatment modality for patients with both dental anxiety and additional needs. This retrospective service evaluation aims to assess the efficacy of conscious sedation with midazolam in a new special care primary dental service, by identifying whether midazolam provided operating conditions sufficient to allow planned dental treatment to be completed. Individual electronic records of patients treated with conscious sedation with midazolam by the West Dorset Special Care Primary Care Dental Service during the first nine months were examined. Efficacy of midazolam was evaluated using patient sedation scores and operating conditions. Planned treatment was successfully completed in 37 out of the 41 appointments (90%). Four patients were unable to have treatment carried out for reasons including cannulation refusal, suboptimal co-operation and vomiting. This study demonstrates that delivering dentist-led conscious sedation with midazolam in a primary care setting is a highly effective, costefficient alternative to general anaesthesia for a range of patients with anxiety and I or additional needs, and has significant potential to reduce wait times. However, the technique requires appropriately trained staff, careful patient selection together with suitable premises and equipment in line with evidence-based national policy and guidelines. [ABSTRACT FROM AUTHOR]

Published
2024

28. Small fatigue crack propagation in a near alpha titanium alloy, IMI 829

Author

Spence, S. H.

Subjects
669
Abstract

Small crack growth rates are assessed for the near alpha titanium alloy, IMI 829, with beta processed microstructures. Constant load amplitude tests were conducted using three test piece geometries which encompassed plain surfaces and stress concentrations. Two computerised crack length measurement techniques were used: A switched d.c. potential drop method and a photomicroscopic system. The p.d. system together with a clip gauge were used to assess crack closure. Crack growth is structure sensitive, characterised by crack path tortuosity, crack bifurcation and a faceted fracture surface. Colony and prior beta grain boundaries provide barriers to propagation which result in temporary arrest in many instances. Small crack growth rates were compared and contrasted with available long crack data for the same alloy and microstructure. A transition, ΔKT, was observed for the small crack growth rate data. This transition is most marked for through thickness cracks at notches and least marked for part through cracks in plain surfaces. Small crack growth behaviour was observed for values of ΔK less than ΔK_T with growth rates up to a factor of 10 greater than long crack rates. For values of ΔK greater than ΔKT the data merge, although in some instances rates for through thickness small cracks were slower. The transition from small to long crack behaviour occurs as the monotonic crack tip plastic zone approaches the widmanstatten alpha colony size. At low ΔK there was no evidence of a threshold even at 3.6 MNm^-3/2. Load ratio was not observed to affect growth rates. The results suggest that the significant difference between crack voltage signals during a load cycle, for ΔK above and below ΔKT, could be due to crack tip plasticity rather than closure in this study. Crack closure was not evident from crack opening displacements obtained using the clip gauge.

Published
1991

32. Regulatory mechanisms to create healthier environments: planning appeals and hot food takeaways in England.

Author

O'Malley, CL, Lake, AA, Moore, HJ, Gray, N, Bradford, C, Petrokofsky, C, Papadaki, A, Spence, S, Lloyd, S, Chang, M, and Townshend, TG

Abstract

Aims: To explore existing regulatory mechanisms to restrict hot food takeaway (HFT) outlets through further understanding processes at local and national levels. Methods: The Planning Appeals Portal was utilised to identify recent HFT appeal cases across England between December 2016 and March 2020. Eight case study sites were identified using a purposive sampling technique and interviews carried out with 12 professionals involved in planning and health to explore perceptions of and including factors that may impact on the HFT appeal process. Additionally, documents applicable to each case were analysed and a survey completed by seven Local Authority (LA) health professionals. To confirm findings, interpretation meetings were conducted with participants and a wider group of planning and public health professionals, including a representative from the Planning Inspectorate. Results: Eight case study sites were identified, and 12 interviews conducted. Participants perceived that LAs would be better able to work on HFT appeal cases if professionals had a good understanding of the planning process/the application of local planning policy and supplementary planning documents; adequate time and capacity to deal with appeals cases; access to accurate, robust, and up to date information; support and commitment from elected members and senior management; good lines of communication with local groups/communities interested in the appeal; information and resources that are accessible and easy to interpret across professional groups. Conclusions: Communication across professional groups appeared to be a key factor in successfully defending decisions. Understanding the impact of takeaway outlets on health and communities in the long term was also important. To create a more robust appeals case and facilitate responsiveness, professionals involved in an appeal should know where to locate current records and statistical data. The enthusiasm of staff and support from senior management/elected officials will play a significant role in driving these agendas forward. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Three-tone coherent microwave electromechanical measurement of a superfluid Helmholtz resonator.

Author

Spence, S., Varga, E., Potts, C. A., and Davis, J. P.

Subjects
*HELMHOLTZ resonators, *MICROWAVE measurements, *SUPERFLUIDITY, *AMPLITUDE modulation, *MICROCAVITY lasers, *ELECTRIC fields
Abstract

We demonstrate electromechanical coupling between a superfluid mechanical mode and a microwave mode formed by a patterned microfluidic chip and a 3D cavity. The electric field of the chip-cavity microwave resonator can be used to both drive and detect the motion of a pure superflow Helmholtz mode, which is dictated by geometric confinement. The coupling is characterized using a coherent measurement technique developed for measuring weak couplings deep in the sideband unresolved regime. The technique is based on two-probe optomechanically induced transparency/amplification using amplitude modulation. Instead of measuring two probe tones separately, they are interfered to retain only a signal coherent with the mechanical motion. With this method, we measure a vacuum electromechanical coupling strength of g 0 = 2 π × 23.3 μ Hz, three orders of magnitude larger than previous superfluid electromechanical experiments. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Finding the missing and unknown: Novel educational approaches to warming up cold cases

Author

Bettels, K., Grimstead, D., Allsop, C., Chaussée, A., Bolton-King, R.S., Sturdy Colls, C., Chapman, B., Keatley, D., Tilley, E., Turner, J., Spence, S., Marquardt, A., Bettels, K., Grimstead, D., Allsop, C., Chaussée, A., Bolton-King, R.S., Sturdy Colls, C., Chapman, B., Keatley, D., Tilley, E., Turner, J., Spence, S., and Marquardt, A.

Abstract

In recent years, students in police academies and higher education institutions around the world have worked together to analyse cold cases including long-term missing persons cases in collaboration with investigators and prosecutors. In 2020, three European organisations, the Police Expert Network on Missing Persons (PEN-MP), AMBER Alert Europe and Locate International, succeeded in connecting these educational organisations enabling them to work collectively on cases and conduct cold case analyses (CCA) across international borders. The International Cold Case Analysis Project (ICCAP) learning objectives were to 1) collect the necessary information about the victim, 2) reconstruct the crime, and 3) investigate trace control. In a learning objective-based evaluation using Computer-Assisted Web Interviewing, 76 participating students from the German and International ICCAP teams were asked to complete a pre- and post-review questionnaire to self-assess their personal competence development. Participants reported significant increases in competence in all evaluated areas, thus demonstrating that authentic and relevant collaborations can enrich the learning environment, promote the use of professional skills, and provide significant knowledge exchange opportunities between academia and industry. Drawing on case studies of cold case missing persons' investigations and unidentified found remains, this article shares how university academics, students and community volunteers can work together nationally and internationally to find out what has happened to missing people and how we can more effectively identify the previously unidentified. In so doing, we share the expertise required to progress these cold cases and provide recommendations to support other institutions and organisations in adopting this innovative approach.

Published
2022

40. Tailoring disordered/ordered phases to revisit the degradation mechanism of high-voltage LiNi0.5Mn1.5O4 spinel cathode materials

Author

Sun, H. (Huabin), Hu, A. (Anyang), Spence, S. (Stephanie), Kuai, C. (Chunguang), Hou, D. (Dong), Mu, L. (Linqin), Liu, J. (Jue), Li, L. (Luxi), Sun, C. (Chengjun), Sainio, S. (Sami), Nordlund, D. (Dennis), Luo, W. (Wei), Huang, Y. (Yunhui), Lin, F. (Feng), Sun, H. (Huabin), Hu, A. (Anyang), Spence, S. (Stephanie), Kuai, C. (Chunguang), Hou, D. (Dong), Mu, L. (Linqin), Liu, J. (Jue), Li, L. (Luxi), Sun, C. (Chengjun), Sainio, S. (Sami), Nordlund, D. (Dennis), Luo, W. (Wei), Huang, Y. (Yunhui), and Lin, F. (Feng)

Abstract

In the spinel oxide cathode family, LiNi0.5Mn1.5O4 (LNMO) shows a high operating voltage (≈4.7 V vs Li/Li⁺) and excellent Li-ion mobility with stable 3D conducting channels. Ni/Mn cation disordered and ordered phases usually coexist in LNMO materials, and they have distinct structural and electrochemical properties, resulting in different battery performances for LNMO materials with different phase compositions. Identifying the correlation between phase compositions and electrochemical properties is of significance to the improvement of battery performance and understanding of degradation mechanisms. Herein, the disordered/ordered phase compositions in LNMO materials are tailored by post-annealing strategies and their impacts on electrochemical performance and degradation mechanisms from the surface to the bulk are systematically investigated. The ordered phase increases rapidly as Mn³⁺ is oxidized to Mn⁴⁺ through a post-annealing process. LNMO with an intermediate fraction of disordered and ordered phases gives rise to improved cycling stability. This article further reports that a high ordered phase fraction can preferentially protect Ni from dissolution during cycling. However, these results suggest that the transition metal dissolution and surface structural change of LNMO do not exhibit a direct correlation with cycling stability. These results indicate the capacity fading mainly correlates with the bulk structural distortion, leading to decreased Li-ion kinetics.

Published
2022

41. Health Equity Implications of Missing Data Among Youths With Childhood‐OnsetSystemic Lupus Erythematosus: A Proof‐of‐ConceptStudy in the Childhood Arthritis and Rheumatology Research Alliance Registry

Author

Woo, Jennifer M. P., Simmonds, Faith, Dennos, Anne, Son, Mary Beth F., Lewandowski, Laura B., Rubinstein, Tamar B., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Phillippi, K., Marafon, D. Pires, Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Abstract

Health disparities in childhood‐onset systemic lupus erythematosus (SLE) disproportionately impact marginalized populations. Socioeconomically patterned missing data can magnify existing health inequities by supporting inferences that may misrepresent populations of interest. Our objective was to assess missing data and subsequent health equity implications among participants with childhood‐onset SLE enrolled in a large pediatric rheumatology registry. We evaluated co‐missingness of 12 variables representing demographics, socioeconomic position, and clinical factors (e.g., disease‐related indices) using Childhood Arthritis and Rheumatology Research Alliance Registry childhood‐onset SLE enrollment data (2015–2022; n = 766). We performed logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for missing disease‐related indices at enrollment (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI‐2K] and/or Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) associated with data missingness. We used linear regression to assess the association between socioeconomic factors and SLEDAI‐2K at enrollment using 3 analytic methods for missing data: complete case analysis, multiple imputation, and nonprobabilistic bias analyses, with missing values imputed to represent extreme low or high disadvantage. On average, participants were missing 6.2% of data, with over 50% of participants missing at least 1 variable. Missing data correlated most closely with variables within data categories (i.e., demographic). Government‐assisted health insurance was associated with missing SLEDAI‐2K and/or SDI scores compared to private health insurance (OR 2.04 [95% CI 1.22, 3.41]). The different analytic approaches resulted in varying analytic sample sizes and fundamentally conflicting estimated associations. Our results support intentional evaluation of missing data to inform effect estimate interpretation and critical assessment of causal statements that might otherwise misrepresent health inequities.

Published
2023
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42. UK National DCD Heart Transplant Program - First Year Experience

Author

Berman, M., primary, Ali, A., additional, Macklam, D., additional, Garcia Saez, D., additional, Jothidasan, A., additional, Husain, M., additional, Stock, U., additional, Mehta, V., additional, Venkateswaran, R., additional, Curry, P., additional, Messer, S., additional, Mukadam, M., additional, Mascaro, J., additional, Clarke, S., additional, Baxter, J., additional, Tsui, S., additional, Large, S., additional, Osman, M., additional, Kaul, P., additional, Boda, G., additional, Jenkins, D., additional, Simmonds, J., additional, Quigley, R., additional, Whitney, J., additional, Gardiner, D., additional, Watson, C., additional, Rubino, A., additional, Currie, I., additional, Foley, J., additional, Macleod, A., additional, Slater, C., additional, Marley, F., additional, Downward, L., additional, Rushton, S., additional, Armstrong, L., additional, Ayton, L., additional, Ryan, M., additional, Parker, M., additional, Gibson, S., additional, Spence, S., additional, Quinn, K., additional, Watson, S., additional, and Forsythe, J., additional

Published
2022
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43. beyondblue.

Author

Sheffield, J., Holland,-Thomson K., Davis, A., Anderson, R., Spence, S., Kennedy, L., Krelle, A., Kay, D., Boucher, S., Burns, J., Hodges, C., Glover, S., Patton, G., Graetz, B., and Sawyer, M.

Published
2005

49. Childhood‐OnsetLupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short‐TermKidney Status and Variation in Care

Author

Smitherman, Emily A., Chahine, Rouba A., Beukelman, Timothy, Lewandowski, Laura B., Rahman, A. K. M. Fazlur, Wenderfer, Scott E., Curtis, Jeffrey R., Hersh, Aimee O., Abel, N., Abulaban, K., Adams, A., Adams, M., Agbayani, R., Aiello, J., Akoghlanian, S., Alejandro, C., Allenspach, E., Alperin, R., Alpizar, M., Amarilyo, G., Ambler, W., Anderson, E., Ardoin, S., Armendariz, S., Baker, E., Balboni, I., Balevic, S., Ballenger, L., Ballinger, S., Balmuri, N., Barbar‐Smiley, F., Barillas‐Arias, L., Basiaga, M., Baszis, K., Becker, M., Bell‐Brunson, H., Beltz, E., Benham, H., Benseler, S., Bernal, W., Beukelman, T., Bigley, T., Binstadt, B., Black, C., Blakley, M., Bohnsack, J., Boland, J., Boneparth, A., Bowman, S., Bracaglia, C., Brooks, E., Brothers, M., Brown, A., Brunner, H., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Cameron, B., Canna, S., Cannon, L., Carper, P., Cartwright, V., Cassidy, E., Cerracchio, L., Chalom, E., Chang, J., Chang‐Hoftman, A., Chauhan, V., Chira, P., Chinn, T., Chundru, K., Clairman, H., Co, D., Confair, A., Conlon, H., Connor, R., Cooper, A., Cooper, J., Cooper, S., Correll, C., Corvalan, R., Costanzo, D., Cron, R., Curiel‐Duran, L., Curington, T., Curry, M., Dalrymple, A., Davis, A., Davis, C., Davis, C., Davis, T., De Benedetti, F., De Ranieri, D., Dean, J., Dedeoglu, F., DeGuzman, M., Delnay, N., Dempsey, V., DeSantis, E., Dickson, T., Dingle, J., Donaldson, B., Dorsey, E., Dover, S., Dowling, J., Drew, J., Driest, K., Du, Q., Duarte, K., Durkee, D., Duverger, E., Dvergsten, J., Eberhard, A., Eckert, M., Ede, K., Edelheit, B., Edens, C., Edens, C., Edgerly, Y., Elder, M., Ervin, B., Fadrhonc, S., Failing, C., Fair, D., Falcon, M., Favier, L., Federici, S., Feldman, B., Fennell, J., Ferguson, I., Ferguson, P., Ferreira, B., Ferrucho, R., Fields, K., Finkel, T., Fitzgerald, M., Fleming, C., Flynn, O., Fogel, L., Fox, E., Fox, M., Franco, L., Freeman, M., Fritz, K., Froese, S., Fuhlbrigge, R., Fuller, J., George, N., Gerhold, K., Gerstbacher, D., Gilbert, M., Gillispie‐Taylor, M., Giverc, E., Godiwala, C., Goh, I., Goheer, H., Goldsmith, D., Gotschlich, E., Gotte, A., Gottlieb, B., Gracia, C., Graham, T., Grevich, S., Griffin, T., Griswold, J., Grom, A., Guevara, M., Guittar, P., Guzman, M., Hager, M., Hahn, T., Halyabar, O., Hammelev, E., Hance, M., Hanson, A., Harel, L., Haro, S., Harris, J., Harry, O., Hartigan, E., Hausmann, J., Hay, A., Hayward, K., Heiart, J., Hekl, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hill, P., Hillyer, S., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horwitz, M., Hsu, J., Huber, A., Huggins, J., Hui‐Yuen, J., Hung, C., Huntington, J., Huttenlocher, A., Ibarra, M., Imundo, L., Inman, C., Insalaco, A., Jackson, A., Jackson, S., James, K., Janow, G., Jaquith, J., Jared, S., Johnson, N., Jones, J., Jones, J., Jones, J., Jones, K., Jones, S., Joshi, S., Jung, L., Justice, C., Justiniano, A., Karan, N., Kaufman, K., Kemp, A., Kessler, E., Khalsa, U., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Kompelien, B., Kosikowski, A., Kovalick, L., Kracker, J., Kramer, S., Kremer, C., Lai, J., Lam, J., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Latham, D., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lentini, L., Lerman, M., Levy, D., Li, S., Lieberman, S., Lim, L., Lin, C., Ling, N., Lingis, M., Lo, M., Lovell, D., Lowman, D., Luca, N., Lvovich, S., Madison, C., Madison, J., Manzoni, S. Magni, Malla, B., Maller, J., Malloy, M., Mannion, M., Manos, C., Marques, L., Martyniuk, A., Mason, T., Mathus, S., McAllister, L., McCarthy, K., McConnell, K., McCormick, E., McCurdy, D., Stokes, P. McCurdy, McGuire, S., McHale, I., McMonagle, A., McMullen‐Jackson, C., Meidan, E., Mellins, E., Mendoza, E., Mercado, R., Merritt, A., Michalowski, L., Miettunen, P., Miller, M., Milojevic, D., Mirizio, E., Misajon, E., Mitchell, M., Modica, R., Mohan, S., Moore, K., Moorthy, L., Morgan, S., Dewitt, E. Morgan, Moss, C., Moussa, T., Mruk, V., Murphy, A., Muscal, E., Nadler, R., Nahal, B., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Neely, J., Nelson, B., Newhall, L., Ng, L., Nicholas, J., Nicolai, R., Nigrovic, P., Nocton, J., Nolan, B., Oberle, E., Obispo, B., O'Brien, B., O'Brien, T., Okeke, O., Oliver, M., Olson, J., O'Neil, K., Onel, K., Orandi, A., Orlando, M., Osei‐Onomah, S., Oz, R., Pagano, E., Paller, A., Pan, N., Panupattanapong, S., Pardeo, M., Paredes, J., Parsons, A., Patel, J., Pentakota, K., Pepmueller, P., Pfeiffer, T., Phillippi, K., Marafon, D. Pires, Phillippi, K., Ponder, L., Pooni, R., Prahalad, S., Pratt, S., Protopapas, S., Puplava, B., Quach, J., Quinlan‐Waters, M., Rabinovich, C., Radhakrishna, S., Rafko, J., Raisian, J., Rakestraw, A., Ramirez, C., Ramsay, E., Ramsey, S., Randell, R., Reed, A., Reed, A., Reed, A., Reid, H., Remmel, K., Repp, A., Reyes, A., Richmond, A., Riebschleger, M., Ringold, S., Riordan, M., Riskalla, M., Ritter, M., Rivas‐Chacon, R., Robinson, A., Rodela, E., Rodriquez, M., Rojas, K., Ronis, T., Rosenkranz, M., Rosolowski, B., Rothermel, H., Rothman, D., Roth‐Wojcicki, E., Rouster – Stevens, K., Rubinstein, T., Ruth, N., Saad, N., Sabbagh, S., Sacco, E., Sadun, R., Sandborg, C., Sanni, A., Santiago, L., Sarkissian, A., Savani, S., Scalzi, L., Schanberg, L., Scharnhorst, S., Schikler, K., Schlefman, A., Schmeling, H., Schmidt, K., Schmitt, E., Schneider, R., Schollaert‐Fitch, K., Schulert, G., Seay, T., Seper, C., Shalen, J., Sheets, R., Shelly, A., Shenoi, S., Shergill, K., Shirley, J., Shishov, M., Shivers, C., Silverman, E., Singer, N., Sivaraman, V., Sletten, J., Smith, A., Smith, C., Smith, J., Smith, J., Smitherman, E., Soep, J., Son, M., Spence, S., Spiegel, L., Spitznagle, J., Sran, R., Srinivasalu, H., Stapp, H., Steigerwald, K., Rakovchik, Y. Sterba, Stern, S., Stevens, A., Stevens, B., Stevenson, R., Stewart, K., Stingl, C., Stokes, J., Stoll, M., Stringer, E., Sule, S., Sumner, J., Sundel, R., Sutter, M., Syed, R., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tapani, S., Tarshish, G., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Terry, M., Tesher, M., Thatayatikom, A., Thomas, B., Tiffany, K., Ting, T., Tipp, A., Toib, D., Torok, K., Toruner, C., Tory, H., Toth, M., Tse, S., Tubwell, V., Twilt, M., Uriguen, S., Valcarcel, T., Van Mater, H., Vannoy, L., Varghese, C., Vasquez, N., Vazzana, K., Vehe, R., Veiga, K., Velez, J., Verbsky, J., Vilar, G., Volpe, N., Scheven, E., Vora, S., Wagner, J., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, J., Walters, H., Muskardin, T. Wampler, Waqar, L., Waterfield, M., Watson, M., Watts, A., Weiser, P., Weiss, J., Weiss, P., Wershba, E., White, A., Williams, C., Wise, A., Woo, J., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yee, M., Yen, E., Yeung, R., Yomogida, K., Yu, Q., Zapata, R., Zartoshti, A., Zeft, A., Zeft, R., Zhang, Y., Zhao, Y., Zhu, A., and Zic, C.

Abstract

The goal was to characterize short‐term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood‐onset systemic lupus erythematosus (cSLE) and nephritis. We analyzed previously collected prospective data from North American patients with cSLE with kidney biopsy‐proven nephritis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry from March 2017 through December 2019. We determined the proportion of patients with abnormal kidney status at the most recent registry visit and applied generalized linear mixed models to identify associated factors. We also calculated frequency of medication use, both during induction and ever recorded. We identified 222 patients with kidney biopsy–proven nephritis, with 64% class III/IV nephritis on initial biopsy. At the most recent registry visit at median (interquartile range) of 17 (8–29) months from initial kidney biopsy, 58 of 106 patients (55%) with available data had abnormal kidney status. This finding was associated with male sex (odds ratio [OR] 3.88, 95% confidence interval [95% CI] 1.21–12.46) and age at cSLE diagnosis (OR 1.23, 95% CI 1.01–1.49). Patients with class IV nephritis were more likely than class III to receive cyclophosphamide and rituximab during induction. There was substantial variation in mycophenolate, cyclophosphamide, and rituximab ever use patterns across rheumatology centers. In this cohort with predominately class III/IV nephritis, male sex and older age at cSLE diagnosis were associated with abnormal short‐term kidney status. We also observed substantial variation in contemporary medication use for pediatric lupus nephritis between pediatric rheumatology centers. Additional studies are needed to better understand the impact of this variation on long‐term kidney outcomes.

Published
2023
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