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Papers from four different groups were published in 1993 demonstrating the ability of functional near infrared spectroscopy (fNIRS) to non-invasively measure hemoglobin concentration responses to brain function in humans. This special issue commemorates the first 20years of fNIRS research. The 9 reviews and 49 contributed papers provide a comprehensive survey of the exciting advances driving the field forward and of the myriad of applications that will benefit from fNIRS., (Copyright © 2013 Elsevier Inc. All rights reserved.)

Dr. Mamoru Tamura (1943-2011) was the honorary president of the ISOTT 2008 meeting in Sapporo, Japan, and has made numerous contributions to biomedical optics and functional near-infrared spectrometry. This chapter briefly describes Dr. Tamura's scientific achievements and contributions to the society based on the "Memorial lecture about Mamoru Tamura's contributions to biomedical optics" in ISOTT 2012 in Bruges, Belgium.

This review is aimed at celebrating the upcoming 20th anniversary of the birth of human functional near-infrared spectroscopy (fNIRS). After the discovery in 1992 that the functional activation of the human cerebral cortex (due to oxygenation and hemodynamic changes) can be explored by NIRS, human functional brain mapping research has gained a new dimension. fNIRS or optical topography, or near-infrared imaging or diffuse optical imaging is used mainly to detect simultaneous changes in optical properties of the human cortex from multiple measurement sites and displays the results in the form of a map or image over a specific area. In order to place current fNIRS research in its proper context, this paper presents a brief historical overview of the events that have shaped the present status of fNIRS. In particular, technological progresses of fNIRS are highlighted (i.e., from single-site to multi-site functional cortical measurements (images)), introduction of the commercial multi-channel systems, recent commercial wireless instrumentation and more advanced prototypes., (Copyright © 2012 Elsevier Inc. All rights reserved.)

With poor survival and high recurrence rates, early-stage lung cancer currently appears to be understaged or undertreated, or both. Although sentinel lymph node biopsy is standard for patients with breast cancer and melanoma, its success has been unreliable in non-small cell lung cancer. Sentinel lymph node biopsy might aid in the identification of lymph nodes at the greatest risk of metastasis and allow for more detailed analysis to select for patients who might benefit from adjuvant therapy. The early results in our recent clinical trial of patients with early-stage lung cancer have suggested that near-infrared imaging might offer a platform for reliable sentinel lymph node identification in these patients., (Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.)

Optical monitoring of living tissues in the near-infrared (NIR) region of the spectrum (700 to 1300 nm) was first demonstrated some 30 years ago by Professor Frans F. Jobsis of Duke University. Jobsis had intended to study the oxidation-reduction (redox) behavior of the copper band (CuA) of cytochrome c oxidase (cyt a,a(3)) to understand certain anomalies in the behavior of the mitochondrial respiratory chain in the ultraviolet and visible regions between living tissue and isolated preparations of mitochondria. Instead, he discovered a new window into the body-for NIR light penetrates deeply into living tissues. Jobsis's pioneering studies proved it was possible to interrogate hemoglobin absorption and saturation and to assess the redox state of vital organs such as the brain directly through skin and bone. He and his collaborators had also recognized that the tissue hemoglobin signals provided valuable information about the oxygen (O(2)) content of the tissue, and cyt a,a(3) signaled the availability of cellular O(2) for oxidative phosphorylation. The ability to noninvasively monitor the O(2) delivery-uptake relationship has made NIR spectroscopy a unique tool for the assessment of tissue oxygen sufficiency in health and disease.

This review celebrates the 30th anniversary of the first in vivo near-infrared (NIR) spectroscopy (NIRS) publication, which was authored by Professor Frans Jobsis. At first, NIRS was utilized to experimentally and clinically investigate cerebral oxygenation. Later it was applied to study muscle oxidative metabolism. Since 1993, the discovery that the functional activation of the human cerebral cortex can be explored by NIRS has added a new dimension to the research. To obtain simultaneous multiple and localized information, a further major step forward was achieved by introducing NIR imaging (NIRI) and tomography. This review reports on the progress of the NIRS and NIRI instrumentation for brain and muscle clinical applications 30 years after the discovery of in vivo NIRS. The review summarizes the measurable parameters in relation to the different techniques, the main characteristics of the prototypes under development, and the present commercially available NIRS and NIRI instrumentation. Moreover, it discusses strengths and limitations and gives an outlook into the "bright" future.