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3. Small pipes: preliminary experience with 3-mm or smaller pipeline flow-diverting stents for aneurysm repair prior to regulatory approval.

Author

Martin, AR, Cruz, JP, O'Kelly, C, Kelly, M, Spears, J, and Marotta, TR

Subjects
Humans, Intracranial Aneurysm, Treatment Outcome, Embolization, Therapeutic, Retrospective Studies, Equipment Design, Prosthesis Design, Device Approval, Stents, Adult, Middle Aged, Canada, Female, Male, Endovascular Procedures, Neurosciences, Hematology, Stroke, Clinical Research, Bioengineering, Assistive Technology, Cardiovascular, Clinical Sciences, Nuclear Medicine & Medical Imaging
Abstract

Flow diversion has become an established treatment option for challenging intracranial aneurysms. The use of small devices of ≤3-mm diameter remains unapproved by major regulatory bodies. A retrospective review of patients treated with Pipeline Embolization Devices of ≤3-mm diameter at 3 Canadian institutions was conducted. Clinical and radiologic follow-up data were collected and reported. Twelve cases were treated with ≥1 Pipeline Embolization Device of ≤3-mm diameter, including 2 with adjunctive coiling, with a median follow-up of 18 months (range, 4-42 months). One patient experienced a posttreatment minor complication (8%) due to an embolic infarct. No posttreatment hemorrhage or delayed complications such as in-stent stenosis/thrombosis were observed. Radiologic occlusion was seen in 9/12 cases (75%) and near-occlusion in 2/12 cases (17%). Intracranial aneurysm treatment with small-diameter flow-diverting stents provided safe and effective aneurysm closure in this small selected sample. These devices should be further studied and considered for regulatory approval.

Published
2015

4. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author

Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, Amato-Marzialli, B, Boulton, M, Lopez- Ojeda, P, Sharma, M, Lownie, S, Chan, R, Swartz, R, Howard, P, Golob, D, Gladstone, D, Boyle, K, Boulos, M, Hopyan, J, Yang, V, Da Costa, L, Holmstedt, CA, Turk, AS, Navarro, R, Jauch, E, Ozark, S, Turner, R, Phillips, S, Shankar, J, Jarrett, J, Gubitz, G, Maloney, W, Vandorpe, R, Schmidt, M, Heidenreich, J, Hunter, G, Kelly, M, Whelan, R, Peeling, L, Burns, PA, Hunter, A, Wiggam, I, Kerr, E, Watt, M, Fulton, A, Gordon, P, Rennie, I, Flynn, P, Smyth, G, O'Leary, S, Gentile, N, Linares, G, McNelis, P, Erkmen, K, Katz, P, Azizi, A, Weaver, M, Jungreis, C, Faro, S, Shah, P, Reimer, H, Kalugdan, V, Saposnik, G, Bharatha, A, Li, Y, Kostyrko, P, Marotta, T, Montanera, W, Sarma, D, Selchen, D, Spears, J, Heo, JH, Jeong, K, Kim, DJ, Kim, BM, Kim, YD, Song, D, Lee, K-J, Yoo, J, Bang, OY, Rho, S, Lee, J, Jeon, P, Kim, KH, Cha, J, Kim, SJ, Ryoo, S, Lee, MJ, Sohn, S-I, Kim, C-H, Ryu, H-G, Hong, J-H, Chang, H-W, Lee, C-Y, Rha, J, Davis, Stephen M, Donnan, Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil de Rochemont, R, Singer, O, Berkefeld, J, Foerch, C, Lorenz, M, Pfeilschifer, W, Hattingen, E, Wagner, M, You, SJ, Lescher, S, Braun, H, Dehkharghani, S, Belagaje, SR, Anderson, A, Lima, A, Obideen, M, Haussen, D, Dharia, R, Frankel, M, Patel, V, Owada, K, Saad, A, Amerson, L, Horn, C, Doppelheuer, S, Schindler, K, Lopes, DK, Chen, M, Moftakhar, R, Anton, C, Smreczak, M, Carpenter, JS, Boo, S, Rai, A, Roberts, T, Tarabishy, A, Gutmann, L, Brooks, C, Brick, J, Domico, J, Reimann, G, Hinrichs, K, Becker, M, Heiss, E, Selle, C, Witteler, A, Al-Boutros, S, Danch, M-J, Ranft, A, Rohde, S, Burg, K, Weimar, C, Zegarac, V, Hartmann, C, Schlamann, M, Göricke, S, Ringlestein, A, Wanke, I, Mönninghoff, C, Dietzold, M, Budzik, R, Davis, T, Eubank, G, Hicks, WJ, Pema, P, Vora, N, Mejilla, J, Taylor, M, Clark, W, Rontal, A, Fields, J, Peterson, B, Nesbit, G, Lutsep, H, Bozorgchami, H, Priest, R, Ologuntoye, O, Barnwell, S, Dogan, A, Herrick, K, Takahasi, C, Beadell, N, Brown, B, Jamieson, S, Hussain, MS, Russman, A, Hui, F, Wisco, D, Uchino, K, Khawaja, Z, Katzan, I, Toth, G, Cheng-Ching, E, Bain, M, Man, S, Farrag, A, George, P, John, S, Shankar, L, Drofa, A, Dahlgren, R, Bauer, A, Itreat, A, Taqui, A, Cerejo, R, Richmond, A, Ringleb, P, Bendszus, M, Möhlenbruch, M, Reiff, T, Amiri, H, Purrucker, J, Herweh, C, Pham, M, Menn, O, Ludwig, I, Acosta, I, Villar, C, Morgan, W, Sombutmai, C, Hellinger, F, Allen, E, Bellew, M, Gandhi, R, Bonwit, E, Aly, J, Ecker, RD, Seder, D, Morris, J, Skaletsky, M, Belden, J, Baker, C, Connolly, LS, Papanagiotou, P, Roth, C, Kastrup, A, Politi, M, Brunner, F, Alexandrou, M, Merdivan, H, Ramsey, C, Given II, C, Renfrow, S, Deshmukh, V, Sasadeusz, K, Vincent, F, Thiesing, JT, Putnam, J, Bhatt, A, Kansara, A, Caceves, D, Lowenkopf, T, Yanase, L, Zurasky, J, Dancer, S, Freeman, B, Scheibe-Mirek, T, Robison, J, Roll, J, Clark, D, Rodriguez, M, Fitzsimmons, B-FM, Zaidat, O, Lynch, JR, Lazzaro, M, Larson, T, Padmore, L, Das, E, Farrow-Schmidt, A, Hassan, A, Tekle, W, Cate, C, Jansen, O, Cnyrim, C, Wodarg, F, Wiese, C, Binder, A, Riedel, C, Rohr, A, Lang, N, Laufs, H, Krieter, S, Remonda, L, Diepers, M, Añon, J, Nedeltchev, K, Kahles, T, Biethahn, S, Lindner, M, Chang, V, Gächter, C, Esperon, C, Guglielmetti, M, Arenillas Lara, JF, Martínez Galdámez, M, Calleja Sanz, AI, Cortijo Garcia, E, Garcia Bermejo, P, Perez, S, Mulero Carrillo, P, Crespo Vallejo, E, Ruiz Piñero, M, Lopez Mesonero, L, Reyes Muñoz, FJ, Brekenfeld, C, Buhk, J-H, Krützelmann, A, Thomalla, G, Cheng, B, Beck, C, Hoppe, J, Goebell, E, Holst, B, Grzyska, U, Wortmann, G, Starkman, S, Duckwiler, G, Jahan, R, Rao, N, Sheth, S, Ng, K, Noorian, A, Szeder, V, Nour, M, McManus, M, Huang, J, Tarpley, J, Tateshima, S, Gonzalez, N, Ali, L, Liebeskind, D, Hinman, J, Calderon-Arnulphi, M, Liang, C, Guzy, J, Koch, S, DeSousa, K, Gordon-Perue, G, Elhammady, M, Peterson, E, Pandey, V, Dharmadhikari, S, Khandelwal, P, Malik, A, Pafford, R, Gonzalez, P, Ramdas, K, Andersen, G, Damgaard, D, Von Weitzel-Mudersbach, P, Simonsen, C, Ruiz de Morales Ayudarte, N, Poulsen, M, Sørensen, L, Karabegovich, S, Hjørringgaard, M, Hjort, N, Harbo, T, Sørensen, K, Deshaies, E, Padalino, D, Swarnkar, A, Latorre, JG, Elnour, E, El-Zammar, Z, Villwock, M, Farid, H, Balgude, A, Cross, L, Hansen, K, Holtmannspötter, M, Kondziella, D, Hoejgaard, J, Taudorf, S, Soendergaard, H, Wagner, A, Cronquist, M, Stavngaard, T, Cortsen, M, Krarup, LH, Hyldal, T, Haring, H-P, Guggenberger, S, Hamberger, M, Trenkler, J, Sonnberger, M, Nussbaumer, K, Dominger, C, Bach, E, Jagadeesan, BD, Taylor, R, Kim, J, Shea, K, Tummala, R, Zacharatos, H, Sandhu, D, Ezzeddine, M, Grande, A, Hildebrandt, D, Miller, K, Scherber, J, Hendrickson, A, Jumaa, M, Zaidi, S, Hendrickson, T, Snyder, V, Killer-Oberpfalzer, M, Mutzenbach, J, Weymayr, F, Broussalis, E, Stadler, K, Jedlitschka, A, Malek, A, Mueller-Kronast, N, Beck, P, Martin, C, Summers, D, Day, J, Bettinger, I, Holloway, W, Olds, K, Arkin, S, Akhtar, N, Boutwell, C, Crandall, S, Schwartzman, M, Weinstein, C, Brion, B, Prothmann, S, Kleine, J, Kreiser, K, Boeckh-Behrens, T, Poppert, H, Wunderlich, S, Koch, ML, Biberacher, V, Huberle, A, Gora-Stahlberg, G, Knier, B, Meindl, T, Utpadel-Fischler, D, Zech, M, Kowarik, M, Seifert, C, Schwaiger, B, Puri, A, Hou, S, Wakhloo, A, Moonis, M, Henninger, N, Goddeau, R, Massari, F, Minaeian, A, Lozano, JD, Ramzan, M, Stout, C, Patel, A, Tunguturi, A, Onteddu, S, Carandang, R, Howk, M, Ribó, M, Sanjuan, E, Rubiera, M, Pagola, J, Flores, A, Muchada, M, Meler, P, Huerga, E, Gelabert, S, Coscojuela, P, Tomasello, A, Rodriguez, D, Santamarina, E, Maisterra, O, Boned, S, Seró, L, Rovira, A, Molina, CA, Millán, M, Muñoz, L, Pérez de la Ossa, N, Gomis, M, Dorado, L, López-Cancio, E, Palomeras, E, Munuera, J, García Bermejo, P, Remollo, S, Castaño, C, García-Sort, R, Cuadras, P, Puyalto, P, Hernández-Pérez, M, Jiménez, M, Martínez-Piñeiro, A, Lucente, G, Dávalos, A, Chamorro, A, Urra, X, Obach, V, Cervera, A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, Majoie, Charles B L M, Menon, Bijoy K, van Zwam, Wim H, van Oostenbrugge, Robert J, Demchuk, Andrew M, Guillemin, Francis, Dávalos, Antoni, Butcher, Kenneth S, Cherifi, Aboubaker, Marquering, Henk A, Macho Fernández, Juan M, Oppenheim, Catherine, Roos, Yvo B W E M, Shankar, Jai, Lingsma, Hester, Hernández-Pérez, María, Bharatha, Aditya, Levy, Elad I, Soudant, Marc, Aja, Lucia, Krings, Timo, Tisserand, Marie, San Román, Luis, Tomasello, Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D

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2019
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5. Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, Wechsler, L, Streib, S, Rangaraju, S, Campbell, D, Rocha, M, Gulati, D, Krings, T, Kalman, L, Cayley, A, Williams, J, Wiegner, R, Casaubon, LK, Jaigobin, C, del Campo, JM, Elamin, E, Schaafsma, JD, Agid, R, Farb, R, ter Brugge, K, Sapkoda, BL, Baxter, BW, Barton, K, Knox, A, Porter, A, Sirelkhatim, A, Devlin, T, Dellinger, C, Pitiyanuvath, N, Patterson, J, Nichols, J, Quarfordt, S, Calvert, J, Hawk, H, Fanale, C, Bitner, A, Novak, A, Huddle, D, Bellon, R, Loy, D, Wagner, J, Chang, I, Lampe, E, Spencer, B, Pratt, R, Bartt, R, Shine, S, Dooley, G, Nguyen, T, Whaley, M, McCarthy, K, Teitelbaum, J, Poon, W, Campbell, N, Cortes, M, Lum, C, Shamloul, R, Robert, S, Stotts, G, Shamy, M, Steffenhagen, N, Blacquiere, D, Hogan, M, AlHazzaa, M, Basir, G, Lesiuk, H, Iancu, D, Santos, M, Choe, H, Weisman, DC, Jonczak, K, Blue-Schaller, A, Shah, Q, MacKenzie, L, Klein, B, Kulandaivel, K, Kozak, O, Gzesh, DJ, Harris, LJ, Khoury, JS, Mandzia, J, Pelz, D, Crann, S, Fleming, L, Hesser, K, Beauchamp, B, 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Geoffrey A, Campbell, Bruce CV, Mitchell, Peter J, Churilov, Leonid, Yan, Bernard, Dowling, Richard, Yassi, Nawaf, Oxley, Thomas J, Wu, Teddy Y, Silver, Gabriel, McDonald, Amy, McCoy, Rachael, Kleinig, Timothy J, Scroop, Rebecca, Dewey, Helen M, Simpson, Marion, Brooks, Mark, Coulton, Bronwyn, Krause, Martin, Harrington, Timothy J, Steinfort, Brendan, Faulder, Kenneth, Priglinger, Miriam, Day, Susan, Phan, Thanh, Chong, Winston, Holt, Michael, Chandra, Ronil V, Ma, Henry, Young, Dennis, Wong, Kitty, Wijeratne, Tissa, Tu, Hans, Mackay, Elizabeth, Celestino, Sherisse, Bladin, Christopher F, Loh, Poh Sien, Gilligan, Amanda, Ross, Zofia, Coote, Skye, Frost, Tanya, Parsons, Mark W, Miteff, Ferdinand, Levi, Christopher R, Ang, Timothy, Spratt, Neil, Kaauwai, Lara, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Barber, P. Alan, McGuinness, Ben, Hope, Ayton, Moriarty, Maurice, Bennett, Patricia, Wong, Andrew, Coulthard, Alan, Lee, Andrew, Jannes, Jim, Field, Deborah, Sharma, Gagan, Salinas, Simon, Cowley, Elise, Snow, Barry, Kolbe, John, Stark, Richard, King, John, Macdonnell, Richard, Attia, John, D'Este, Cate, Saver, Jeffrey L, Goyal, Mayank, Diener, Hans-Christoph, Levy, Elad I., Bonafé, Alain, Mendes Pereira, Vitor, Jahan, Reza, Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., von Kummer, Rüdiger, Smith, Wade, Turjman, Francis, Hamilton, Scott, Chiacchierini, Richard, Amar, Arun, Sanossian, Nerses, Loh, Yince, Baxter, B, Reddy, VK, Horev, A, Star, M, Siddiqui, A, Hopkins, LN, Snyder, K, Sawyer, R, Hall, S, Costalat, V, Riquelme, C, Machi, P, Omer, E, Arquizan, C, Mourand, I, Charif, M, Ayrignac, X, Menjot de Champfleur, N, Leboucq, N, Gascou, G, Moynier, M, du Mesnil 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Ajlan, Fahad S, Reddy, Vivek, Dowlatshahi, Dar, Sourour, Nader-Antoine, Oppenheim, Catherine, Mitha, Alim P, Weimar, Christian, van Oostenbrugge, Robert J, Cobo, Erik, Demchuk, Andrew M, Boers, Anna M M, Ford, Gary A, Brown, B Scott, Jovin, Tudor, van Zwam, Wim H, Hill, Michael D, White, Phil, and Bracard, Serge

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2018
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6. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, 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A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos Medeiros, Elisabeth, Vuillier, Fabrice, Courtheoux, Patrick, Viader, Fausto, Apoil-Brissard, Marion, Bataille, Mathieu, Bonnet, Anne-Laure, Cogez, Julien, Touze, Emmanuel, Leclerc, Xavier, Leys, Didier, Aggour, Mohamed, Aguettaz, Pierre, Bodenant, Marie, Cordonnier, Charlotte, Deplanque, Dominique, Girot, Marie, Henon, Hilde, Kalsoum, Erwah, Lucas, Christian, Pruvo, Jean-Pierre, Zuniga, Paolo, Arquizan, Caroline, Costalat, Vincent, Machi, Paolo, Mourand, Isabelle, Riquelme, Carlos, Bounolleau, Pierre, Arteaga, Charles, Faivre, Anthony, Bintner, Marc, Tournebize, Patrice, Charlin, Cyril, Darcel, Françoise, Gauthier-Lasalarie, Pascale, Jeremenko, Marcia, Mouton, Servane, Zerlauth, Jean-Baptiste, Lamy, Chantal, Hervé, Deramond, Hassan, Hosseini, Gaston, André, Barral, Francis-Guy, Garnier, Pierre, Beaujeux, Rémy, Wolff, Valérie, Herbreteau, Denis, Debiais, Séverine, Murray, Alicia, Ford, Gary, Muir, Keith W, White, Philip, Brown, Martin M, Clifton, Andy, Freeman, Janet, Ford, Ian, Markus, Hugh, Wardlaw, Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, van Zwam, Wim H, Menon, Bijoy K, Dippel, Diederik W J, Demchuk, Andrew M, Bracard, Serge, Dávalos, Antoni, Majoie, Charles B L M, Ford, Gary A, de la Ossa, Natalia Pérez, Kelly, Michael, Bourcier, Romain, Roos, Yvo B W E M, Bang, Oh Young, Nogueira, Raul G, Devlin, Thomas G, Clarençon, Frédéric, Burns, Paul, Carpenter, Jeffrey, Yavagal, Dileep R, Pereira, Vitor Mendes, Quesada, Helena, Epstein, Jonathan, Rubiera, Marta, Urra, Xabier, Micard, Emilien, Brown, Scott, Guillemin, Francis, van Oostenbrugge, Robert J, Jovin, Tudor G, and Hill, Michael D

Published
2018
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8. Learning Curve for Flow Diversion of Posterior Circulation Aneurysms: A Long-Term International Multicenter Cohort Study

Author

Adeeb, N., primary, Dibas, M., additional, Griessenauer, C.J., additional, Cuellar, H.H., additional, Salem, M.M., additional, Xiang, S., additional, Enriquez-Marulanda, A., additional, Hong, T., additional, Zhang, H., additional, Taussky, P., additional, Grandhi, R., additional, Waqas, M., additional, Aldine, A.S., additional, Tutino, V.M., additional, Aslan, A., additional, Siddiqui, A.H., additional, Levy, E.I., additional, Ogilvy, C.S., additional, Thomas, A.J., additional, Ulfert, C., additional, Möhlenbruch, M.A., additional, Renieri, L., additional, Bengzon Diestro, J.D., additional, Lanzino, G., additional, Brinjikji, W., additional, Spears, J., additional, Vranic, J.E., additional, Regenhardt, R.W., additional, Rabinov, J.D., additional, Harker, P., additional, Müller-Thies-Broussalis, E., additional, Killer-Oberpfalzer, M., additional, Islak, C., additional, Kocer, N., additional, Sonnberger, M., additional, Engelhorn, T., additional, Kapadia, A., additional, Yang, V.X.D, additional, Salehani, A., additional, Harrigan, M.R., additional, Krings, T., additional, Matouk, C.C., additional, Mirshahi, S., additional, Chen, K.S., additional, Aziz-Sultan, M.A., additional, Ghorbani, M., additional, Schirmer, C.M., additional, Goren, O., additional, Dalal, S.S., additional, Finkenzeller, T., additional, Holtmannspötter, M., additional, Buhk, J.-H., additional, Foreman, P.M., additional, Cress, M.C., additional, Hirschl, R.A., additional, Reith, W., additional, Simgen, A., additional, Janssen, H., additional, Marotta, T.R., additional, Stapleton, C.J., additional, Patel, A.B., additional, and Dmytriw, A.A., additional

Published
2022
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10. P15 Evaluation of effectiveness and safety of the CorPath® GRX System in endovascular embolization procedures of cerebral aneurysms

Author

Piotin, M, primary, Blanc, R, additional, Turner, R, additional, Tomasello, A, additional, Ribo, M, additional, Galdámez, M, additional, Costalat, V, additional, Sourour, N, additional, Mordasini, P, additional, Killer-Oberpfalzer, M, additional, Rice, H, additional, Spears, J, additional, and Pereira, VM, additional

Published
2022
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14. LB007 Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study

Author

Diestro, J, primary, Dibas, M, additional, Adeeb, N, additional, Regenhardt, R, additional, Vranic, J, additional, Guenego, A, additional, Lay, S, additional, Renieri, L, additional, Sundararajan, S, additional, Premat, K, additional, El Namaani, K, additional, Saliou, G, additional, Möhlenbruch, M, additional, Lylyk, I, additional, Foreman, P, additional, Vachhani, J, additional, Župančić, V, additional, Hafeez, M, additional, Rutledge, C, additional, Rai, H, additional, Tutino, V, additional, Mirshahi, S, additional, Ghozy, S, additional, Harker, P, additional, Alotaibi, N, additional, Rabinov, J, additional, Spears, J, additional, Parra-Farinas, C, additional, Patel, A, additional, and Dmytriw, A, additional

Published
2022
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20. Infrared Scene Projector Digital Model Mathematical Description

Author

Manzardo, Mark A., Gossage, Brett, Spears, J. Brent, LeSueur, Kenneth G., Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Alexandrov, Vassil N., editor, Dongarra, Jack J., editor, Juliano, Benjoe A., editor, Renner, René S., editor, and Tan, C. J. Kenneth, editor

Published
2001
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21. Infrared Scene Projector Digital Model Development

Author

Manzardo, Mark A., Gossage, Brett, Spears, J. Brent, LeSueur, Kenneth G., Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Alexandrov, Vassil N., editor, Dongarra, Jack J., editor, Juliano, Benjoe A., editor, Renner, René S., editor, and Tan, C. J. Kenneth, editor

Published
2001
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24. Molecular and translational advances in meningiomas

Author

Suppiah S., Nassiri F., Bi W. L., Dunn I. F., Hanemann C. O., Horbinski C. M., Hashizume R., James C. D., Mawrin C., Noushmehr H., Perry A., Sahm F., Sloan A., Von Deimling A., Wen P. Y., Aldape K., Zadeh G., Au K., Barnhartz-Sloan J., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Griffith B., Herold-Mende C., Huang R. Y., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., McDermott M., Munoz D., Ng H. -K., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Deimling A. V., Walbert T., Westphal M., Workewych A. M., Suppiah S., Nassiri F., Bi W.L., Dunn I.F., Hanemann C.O., Horbinski C.M., Hashizume R., James C.D., Mawrin C., Noushmehr H., Perry A., Sahm F., Sloan A., Von Deimling A., Wen P.Y., Aldape K., Zadeh G., Au K., Barnhartz-Sloan J., Brastianos P.K., Butowski N., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Griffith B., Herold-Mende C., Huang R.Y., James D., Jenkinson M.D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mansouri A., McDermott M., Munoz D., Ng H.-K., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Deimling A.V., Walbert T., Westphal M., and Workewych A.M.

Subjects
Cancer Research, Supplement Articles, Genomics, Intracranial Neoplasm, sporadic meningioma, Bioinformatics, World health, Translational Research, Biomedical, Meningioma, 03 medical and health sciences, biomolecular, 0302 clinical medicine, Meningeal Neoplasms, otorhinolaryngologic diseases, medicine, Recurrent disease, Humans, Meningeal Neoplasm, Molecular Targeted Therapy, xenograft, Stage (cooking), neoplasms, MENINGIOMA, business.industry, cell line, Prognosis, medicine.disease, Combined Modality Therapy, nervous system diseases, 3. Good health, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Neurology (clinical), genetic, business, epigenetic, 030217 neurology & neurosurgery
Abstract

Meningiomas are the most common primary intracranial neoplasm. The current World Health Organization (WHO) classification categorizes meningiomas based on histopathological features, but emerging molecular data demonstrate the importance of genomic and epigenomic factors in the clinical behavior of these tumors. Treatment options for symptomatic meningiomas are limited to surgical resection where possible and adjuvant radiation therapy for tumors with concerning histopathological features or recurrent disease. At present, alternative adjuvant treatment options are not available in part due to limited historical biological analysis and clinical trial investigation on meningiomas. With advances in molecular and genomic techniques in the last decade, we have witnessed a surge of interest in understanding the genomic and epigenomic landscape of meningiomas. The field is now at the stage to adopt this molecular knowledge to refine meningioma classification and introduce molecular algorithms that can guide prediction and therapeutics for this tumor type. Animal models that recapitulate meningiomas faithfully are in critical need to test new therapeutics to facilitate rapid-cycle translation to clinical trials. Here we review the most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation, and highlight the landscape of available preclinical models in meningiomas.

Published
2019
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25. Life after surgical resection of a meningioma: a prospective cross-sectional study evaluating health-related quality of life

Author

Nassiri F., Price B., Shehab A., Au K., Cusimano M. D., Jenkinson M. D., Jungk C., Mansouri A., Santarius T., Suppiah S., Teng K. X., Toor G. S., Zadeh G., Walbert T., Drummond K. J., Aldape K., Barnhartz-Sloan J., Bi W. L., Brastianos P. K., Butowski N., Carlotti C., Dimeco F., Dunn I. F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C. O., Herold-Mende C., Horbinski C., Huang R. Y., James D., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H. -K., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Sahm F., Saladino A., Schichor C., Schultz D., Schmidt N. O., Selman W., Sloan A., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Deimling A. V., Wen P. Y., Westphal M., Workewych A. M., Nassiri F., Price B., Shehab A., Au K., Cusimano M.D., Jenkinson M.D., Jungk C., Mansouri A., Santarius T., Suppiah S., Teng K.X., Toor G.S., Zadeh G., Walbert T., Drummond K.J., Aldape K., Barnhartz-Sloan J., Bi W.L., Brastianos P.K., Butowski N., Carlotti C., Dimeco F., Dunn I.F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C.O., Herold-Mende C., Horbinski C., Huang R.Y., James D., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H.-K., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Sahm F., Saladino A., Schichor C., Schultz D., Schmidt N.O., Selman W., Sloan A., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Deimling A.V., Wen P.Y., Westphal M., and Workewych A.M.

Subjects
Male, cognition, Cancer Research, medicine.medical_specialty, Cross-sectional study, insomnia, Population, Neurosurgery, Supplement Articles, meningioma, surgery, Meningioma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Surveys and Questionnaires, Internal medicine, Meningeal Neoplasms, otorhinolaryngologic diseases, medicine, Humans, Longitudinal Studies, Prospective Studies, Prospective cohort study, education, education.field_of_study, business.industry, COGNIÇÃO, Cognition, Middle Aged, Prognosis, medicine.disease, humanities, 3. Good health, health-related quality of life, Cross-Sectional Studies, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, fatigue, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies, Cohort study
Abstract

Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.

Published
2019
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27. Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment

Author

Abu-Shawareb, H, Acree, R, Adams, P, Adams, J, Addis, B, Aden, R, Adrian, P, Afeyan, BB, Aggleton, M, Aghaian, L, Aguirre, A, Aikens, D, Akre, J, Albert, F, Albrecht, M, Albright, BJ, Albritton, J, Alcala, J, Alday, C, Alessi, DA, Alexander, N, Alfonso, J, Alfonso, N, Alger, E, Ali, SJ, Ali, ZA, Alley, WE, Amala, P, Amendt, PA, Amick, P, Ammula, S, Amorin, C, Ampleford, DJ, Anderson, RW, Anklam, T, Antipa, N, Appelbe, B, Aracne-Ruddle, C, Araya, E, Arend, M, Arnold, P, Arnold, T, Asay, J, Atherton, LJ, Atkinson, D, Atkinson, R, Auerbach, JM, Austin, B, Auyang, L, Awwal, AS, Ayers, J, Ayers, S, Ayers, T, Azevedo, S, Bachmann, B, Back, CA, Bae, J, Bailey, DS, Bailey, J, Baisden, T, Baker, KL, Baldis, H, Barber, D, Barberis, M, Barker, D, Barnes, A, Barnes, CW, Barrios, MA, Barty, C, Bass, I, Batha, SH, Baxamusa, SH, Bazan, G, Beagle, JK, Beale, R, Beck, BR, Beck, JB, Bedzyk, M, Beeler, RG, Behrendt, W, Belk, L, Bell, P, Belyaev, M, Benage, JF, Bennett, G, Benedetti, LR, Benedict, LX, Berger, R, Bernat, T, Bernstein, LA, Berry, B, Bertolini, L, Besenbruch, G, Betcher, J, Bettenhausen, R, Betti, R, Bezzerides, B, Bhandarkar, SD, Bickel, R, Biener, J, Biesiada, T, Bigelow, K, Bigelow-Granillo, J, Bigman, V, Bionta, RM, Birge, NW, Bitter, M, Black, AC, Bleile, R, Bleuel, DL, Bliss, E, Blue, B, Boehly, T, Boehm, K, Boley, CD, Bonanno, R, Bond, EJ, Bond, T, Bonino, MJ, Borden, M, Bourgade, J-L, Bousquet, J, Bowers, J, Bowers, M, Boyd, R, Bozek, A, Bradley, DK, Bradley, KS, Bradley, PA, Bradley, L, Brannon, L, Brantley, PS, Braun, D, Braun, T, Brienza-Larsen, K, Briggs, TM, Britten, J, Brooks, ED, Browning, D, Bruhn, MW, Brunner, TA, Bruns, H, Brunton, G, Bryant, B, Buczek, T, Bude, J, Buitano, L, Burkhart, S, Burmark, J, Burnham, A, Burr, R, Busby, LE, Butlin, B, Cabeltis, R, Cable, M, Cabot, WH, Cagadas, B, Caggiano, J, Cahayag, R, Caldwell, SE, Calkins, S, Callahan, DA, Calleja-Aguirre, J, Camara, L, Camp, D, Campbell, EM, Campbell, JH, Carey, B, Carey, R, Carlisle, K, Carlson, L, Carman, L, Carmichael, J, Carpenter, A, Carr, C, Carrera, JA, Casavant, D, Casey, A, Casey, DT, Castillo, A, Castillo, E, Castor, JI, Castro, C, Caughey, W, Cavitt, R, Celeste, J, Celliers, PM, Cerjan, C, Chandler, G, Chang, B, Chang, C, Chang, J, Chang, L, Chapman, R, Chapman, T, Chase, L, Chen, H, Chen, K, Chen, L-Y, Cheng, B, Chittenden, J, Choate, C, Chou, J, Chrien, RE, Chrisp, M, Christensen, K, Christensen, M, Christopherson, AR, Chung, M, Church, JA, Clark, A, Clark, DS, Clark, K, Clark, R, Claus, L, Cline, B, Cline, JA, Cobble, JA, Cochrane, K, Cohen, B, Cohen, S, Collette, MR, Collins, G, Collins, LA, Collins, TJB, Conder, A, Conrad, B, Conyers, M, Cook, AW, Cook, D, Cook, R, Cooley, JC, Cooper, G, Cope, T, Copeland, SR, Coppari, F, Cortez, J, Cox, J, Crandall, DH, Crane, J, Craxton, RS, Cray, M, Crilly, A, Crippen, JW, Cross, D, Cuneo, M, Cuotts, G, Czajka, CE, Czechowicz, D, Daly, T, Danforth, P, Darbee, R, Darlington, B, Datte, P, Dauffy, L, Davalos, G, 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TJ, Munteanu, FM, Nafziger, J, Nagayama, T, Nagel, SR, Nast, R, Negres, RA, Nelson, A, Nelson, D, Nelson, J, Nelson, S, Nemethy, S, Neumayer, P, Newman, K, Newton, M, Nguyen, H, Di Nicola, J-MG, Di Nicola, P, Niemann, C, Nikroo, A, Nilson, PM, Nobile, A, Noorai, V, Nora, R, Norton, M, Nostrand, M, Note, V, Novell, S, Nowak, PF, Nunez, A, Nyholm, RA, O'Brien, M, Oceguera, A, Oertel, JA, Okui, J, Olejniczak, B, Oliveira, J, Olsen, P, Olson, B, Olson, K, Olson, RE, Opachich, YP, Orsi, N, Orth, CD, Owen, M, Padalino, S, Padilla, E, Paguio, R, Paguio, S, Paisner, J, Pajoom, S, Pak, A, Palaniyappan, S, Palma, K, Pannell, T, Papp, F, Paras, D, Parham, T, Park, H-S, Pasternak, A, Patankar, S, Patel, MV, Patel, PK, Patterson, R, Patterson, S, Paul, B, Paul, M, Pauli, E, Pearce, OT, Pearcy, J, Pedrotti, B, Peer, A, Pelz, LJ, Penetrante, B, Penner, J, Perez, A, Perkins, LJ, Pernice, E, Perry, TS, Person, S, Petersen, D, Petersen, T, Peterson, DL, Peterson, EB, Peterson, JE, Peterson, JL, Peterson, K, Peterson, RR, Petrasso, RD, Philippe, F, Phipps, TJ, Piceno, E, Ping, Y, Pickworth, L, Pino, J, Plummer, R, Pollack, GD, Pollaine, SM, Pollock, BB, Ponce, D, Ponce, J, Pontelandolfo, J, Porter, JL, Post, J, Poujade, O, Powell, C, Powell, H, Power, G, Pozulp, M, Prantil, M, Prasad, M, Pratuch, S, Price, S, Primdahl, K, Prisbrey, S, Procassini, R, Pruyne, A, Pudliner, B, Qiu, SR, Quan, K, Quinn, M, Quintenz, J, Radha, PB, Rainer, F, Ralph, JE, Raman, KS, Raman, R, Rambo, P, Rana, S, Randewich, A, Rardin, D, Ratledge, M, Ravelo, N, Ravizza, F, Rayce, M, Raymond, A, Raymond, B, Reed, B, Reed, C, Regan, S, Reichelt, B, Reis, V, Reisdorf, S, Rekow, V, Remington, BA, Rendon, A, Requieron, W, Rever, M, Reynolds, H, Reynolds, J, Rhodes, J, Rhodes, M, Richardson, MC, Rice, B, Rice, NG, Rieben, R, Rigatti, A, Riggs, S, Rinderknecht, HG, Ring, K, Riordan, B, Riquier, R, Rivers, C, Roberts, D, Roberts, V, Robertson, G, Robey, HF, Robles, J, Rocha, P, Rochau, G, Rodriguez, J, Rodriguez, S, Rosen, M, Rosenberg, M, Ross, G, Ross, JS, Ross, P, Rouse, J, Rovang, D, Rubenchik, AM, Rubery, MS, Ruiz, CL, Rushford, M, Russ, B, Rygg, JR, Ryujin, BS, Sacks, RA, Sacks, RF, Saito, K, Salmon, T, Salmonson, JD, Sanchez, J, Samuelson, S, Sanchez, M, Sangster, C, Saroyan, A, Sater, J, Satsangi, A, Sauers, S, Saunders, R, Sauppe, JP, Sawicki, R, Sayre, D, Scanlan, M, Schaffers, K, Schappert, GT, Schiaffino, S, Schlossberg, DJ, Schmidt, DW, Schmitt, MJ, Schneider, DHG, Schneider, MB, Schneider, R, Schoff, M, Schollmeier, M, Schölmerich, M, Schroeder, CR, Schrauth, SE, Scott, HA, Scott, I, Scott, JM, Scott, RHH, Scullard, CR, Sedillo, T, Seguin, FH, Seka, W, Senecal, J, Sepke, SM, Seppala, L, Sequoia, K, Severyn, J, Sevier, JM, Sewell, N, Seznec, S, Shah, RC, Shamlian, J, Shaughnessy, D, Shaw, M, Shaw, R, Shearer, C, Shelton, R, Shen, N, Sherlock, MW, Shestakov, AI, Shi, EL, Shin, SJ, Shingleton, N, Shmayda, W, Shor, M, Shoup, M, Shuldberg, C, Siegel, L, Silva, FJ, Simakov, AN, Sims, BT, Sinars, D, Singh, P, Sio, H, Skulina, K, Skupsky, S, Slutz, S, Sluyter, M, Smalyuk, VA, Smauley, D, Smeltser, RM, Smith, C, Smith, I, Smith, J, Smith, L, Smith, R, Sohn, R, Sommer, S, Sorce, C, Sorem, M, Soures, JM, Spaeth, ML, Spears, BK, Speas, S, Speck, D, Speck, R, Spears, J, Spinka, T, Springer, PT, Stadermann, M, Stahl, B, Stahoviak, J, Stanton, LG, Steele, R, Steele, W, Steinman, D, Stemke, R, Stephens, R, Sterbenz, S, Sterne, P, Stevens, D, Stevers, J, Still, CB, Stoeckl, C, Stoeffl, W, Stolken, JS, Stolz, C, Storm, E, Stone, G, Stoupin, S, Stout, E, Stowers, I, Strauser, R, Streckart, H, Streit, J, Strozzi, DJ, Suratwala, T, Sutcliffe, G, Suter, LJ, Sutton, SB, Svidzinski, V, Swadling, G, Sweet, W, Szoke, A, Tabak, M, Takagi, M, Tambazidis, A, Tang, V, Taranowski, M, Taylor, LA, Telford, S, Theobald, W, Thi, M, Thomas, A, Thomas, CA, Thomas, I, Thomas, R, Thompson, IJ, Thongstisubskul, A, Thorsness, CB, Tietbohl, G, Tipton, RE, Tobin, M, Tomlin, N, Tommasini, R, Toreja, AJ, Torres, J, Town, RPJ, Townsend, S, Trenholme, J, Trivelpiece, A, Trosseille, C, Truax, H, Trummer, D, Trummer, S, Truong, T, Tubbs, D, Tubman, ER, Tunnell, T, Turnbull, D, Turner, RE, Ulitsky, M, Upadhye, R, Vaher, JL, VanArsdall, P, VanBlarcom, D, Vandenboomgaerde, M, VanQuinlan, R, Van Wonterghem, BM, Varnum, WS, Velikovich, AL, Vella, A, Verdon, CP, Vermillion, B, Vernon, S, Vesey, R, Vickers, J, Vignes, RM, Visosky, M, Vocke, J, Volegov, PL, Vonhof, S, Von Rotz, R, Vu, HX, Vu, M, Wall, D, Wall, J, Wallace, R, Wallin, B, Walmer, D, Walsh, CA, Walters, CF, Waltz, C, Wan, A, Wang, A, Wang, Y, Wark, JS, Warner, BE, Watson, J, Watt, RG, Watts, P, Weaver, J, Weaver, RP, Weaver, S, Weber, CR, Weber, P, Weber, SV, Wegner, P, Welday, B, Welser-Sherrill, L, Weiss, K, Widmann, K, Wheeler, GF, Whistler, W, White, RK, Whitley, HD, Whitman, P, Wickett, ME, Widmayer, C, Wiedwald, J, Wilcox, R, Wilcox, S, Wild, C, Wilde, BH, Wilde, CH, Wilhelmsen, K, Wilke, MD, Wilkens, H, Wilkins, P, Wilks, SC, Williams, EA, Williams, GJ, Williams, W, Williams, WH, Wilson, DC, Wilson, B, Wilson, E, Wilson, R, Winters, S, Wisoff, J, Wittman, M, Wolfe, J, Wong, A, Wong, KW, Wong, L, Wong, N, Wood, R, Woodhouse, D, Woodruff, J, Woods, DT, Woods, S, Woodworth, BN, Wooten, E, Wootton, A, Work, K, Workman, JB, Wright, J, Wu, M, Wuest, C, Wysocki, FJ, Xu, H, Yamaguchi, M, Yang, B, Yang, ST, Yatabe, J, Yeamans, CB, Yee, BC, Yi, SA, Yin, L, Young, B, Young, CS, Young, CV, Young, P, Youngblood, K, Zacharias, R, Zagaris, G, Zaitseva, N, Zaka, F, Ze, F, Zeiger, B, Zika, M, Zimmerman, GB, Zobrist, T, Zuegel, JD, Zylstra, AB, Indirect Drive ICF Collaboration, Collaboration, Indirect Drive ICF, AWE Plc, Lawrence Livermore National Laboratory, and U.S Department of Energy

Subjects
General Physics, 02 Physical Sciences, General Physics and Astronomy, Indirect Drive ICF Collaboration, 01 Mathematical Sciences, 09 Engineering
Abstract

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.

Published
2022

29. Laser Balloon Angioplasty

Author

Cheong, Wai-Fung, Crilly, R. J., Spears, J. R., Kogelnik, H., editor, Welch, Ashley J., editor, and Van Gemert, Martin J. C., editor

Published
1995
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38. Introduction

Author

Spears, J. Richard, Serruys, Patrick W., editor, Strauss, Bradley H., editor, and King, Spencer B., III, editor

Published
1992
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46. Fully automated derivation of coronary artery calcium scores and cardiovascular risk assessment from contrast medium-enhanced coronary CT angiography studies

Author

Ebersberger, Ullrich, Eilot, Dov, Goldenberg, Roman, Lev, Alon, Spears, J. Reid, Rowe, Garrett W., Gallagher, Nicholas Y., Halligan, William T., Blanke, Philipp, Makowski, Marcus R., Krazinski, Aleksander W., Silverman, Justin R., Bamberg, Fabian, Leber, Alexander W., Hoffmann, Ellen, and Schoepf, U. Joseph

Published
2013
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48. P-003 Association between baseline serology and symptomatic intracranial hemorrhage after endovascular thrombectomy for acute ischemic stroke

Author

Diestro, J, primary, Parra-Farinas, C, additional, Balas, M, additional, Zador, Z, additional, Almusalam, N, additional, Dmytriw, A, additional, Rajendram, P, additional, Phillips, R, additional, Alqabbani, A, additional, Qazi, E, additional, Li, Y, additional, Montanera, W, additional, Sarma, D, additional, Marotta, T, additional, Bharatha, A, additional, and Spears, J, additional

Published
2021
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49. DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management

Author

Nassiri F., Mamatjan Y., Suppiah S., Badhiwala J. H., Mansouri S., Karimi S., Saarela O., Poisson L., Gepfner-Tuma I., Schittenhelm J., Ng H. -K., Noushmehr H., Harter P., Baumgarten P., Weller M., Preusser M., Herold-Mende C., Tatagiba M., Tabatabai G., Sahm F., Von Deimling A., Aldape K., Au K., Barnhartz-Sloan J., Bi W. L., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Dunn I. F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C. O., Horbinski C., Huang R. Y., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Malta T. M., Mawrin C., McDermott M., Munoz D., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Sloan A., Spears J., Snyder J., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Wen P. Y., Walbert T., Westphal M., Workewych A. M., Zadeh G., Aldape K. D., Nassiri F., Mamatjan Y., Suppiah S., Badhiwala J.H., Mansouri S., Karimi S., Saarela O., Poisson L., Gepfner-Tuma I., Schittenhelm J., Ng H.-K., Noushmehr H., Harter P., Baumgarten P., Weller M., Preusser M., Herold-Mende C., Tatagiba M., Tabatabai G., Sahm F., Von Deimling A., Aldape K., Au K., Barnhartz-Sloan J., Bi W.L., Brastianos P.K., Butowski N., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Dunn I.F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C.O., Horbinski C., Huang R.Y., James D., Jenkinson M.D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Malta T.M., Mawrin C., McDermott M., Munoz D., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Sloan A., Spears J., Snyder J., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Wen P.Y., Walbert T., Westphal M., Workewych A.M., Zadeh G., and Aldape K.D.

Subjects
Oncology, Cancer Research, medicine.medical_specialty, recurrence, predictor, ESTUDOS DE VALIDAÇÃO, Meningioma, nomogram, Internal medicine, medicine, Biomarkers, Tumor, Meningeal Neoplasms, Humans, Survival rate, Retrospective Studies, Oncotype DX Breast Cancer Assay, business.industry, Hazard ratio, Cancer, Disease Management, Retrospective cohort study, Nomogram, DNA Methylation, medicine.disease, Prognosis, Gene Expression Regulation, Neoplastic, Survival Rate, Clinical research, Basic and Translational Investigations, Neurology (clinical), methylation, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both models was evaluated and compared with standard-of-care models using multiple independent cohorts. Results The methylome-based predictor of 5-year RFS performed favorably compared with a grade-based predictor when tested using the 3 validation cohorts (ΔAUC = 0.10, 95% CI: 0.03–0.018) and was independently associated with RFS after adjusting for histopathologic grade, extent of resection, and burden of copy number alterations (hazard ratio 3.6, 95% CI: 1.8–7.2, P < 0.001). A nomogram combining the methylome predictor with clinical factors demonstrated greater discrimination than a nomogram using clinical factors alone in 2 independent validation cohorts (ΔAUC = 0.25, 95% CI: 0.22–0.27) and resulted in 2 groups with distinct recurrence patterns (hazard ratio 7.7, 95% CI: 5.3–11.1, P < 0.001) with clinical implications. Conclusions The models developed and validated in this study provide important prognostic information not captured by previously established clinical and molecular factors which could be used to individualize decisions regarding postoperative therapeutic interventions, in particular whether to treat patients with adjuvant radiotherapy versus observation alone.

Published
2019

50. Advances in multidisciplinary therapy for meningiomas

Author

Brastianos P. K., Galanis E., Butowski N., Chan J. W., Dunn I. F., Goldbrunner R., Herold-Mende C., Ippen F. M., Mawrin C., McDermott M. W., Sloan A., Snyder J., Tabatabai G., Tatagiba M., Tonn J. C., Wen P. Y., Aldape K., Nassiri F., Zadeh G., Jenkinson M. D., Raleigh D. R., Au K., Barnhartz-Sloan J., Bi W. L., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Giannini C., Griffith B., Hashizume R., Hanemann C. O., Horbinski C., Huang R. Y., James D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., Munoz D., Noushmehr H., Ng H. -K., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Spears J., Suppiah S., Tirapelli D., Tsang D., Vogelbaum M. A., Deimling A. V., Walbert T., Westphal M., Workewych A. M., Brastianos P.K., Galanis E., Butowski N., Chan J.W., Dunn I.F., Goldbrunner R., Herold-Mende C., Ippen F.M., Mawrin C., McDermott M.W., Sloan A., Snyder J., Tabatabai G., Tatagiba M., Tonn J.C., Wen P.Y., Aldape K., Nassiri F., Zadeh G., Jenkinson M.D., Raleigh D.R., Au K., Barnhartz-Sloan J., Bi W.L., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Giannini C., Griffith B., Hashizume R., Hanemann C.O., Horbinski C., Huang R.Y., James D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mansouri A., Munoz D., Noushmehr H., Ng H.-K., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Spears J., Suppiah S., Tirapelli D., Tsang D., Vogelbaum M.A., Deimling A.V., Walbert T., Westphal M., and Workewych A.M.

Subjects
Oncology, Cancer Research, medicine.medical_treatment, Supplement Articles, meningioma, Systemic therapy, surgery, 0302 clinical medicine, Meningeal Neoplasms, Trabectedin, Cancer, clinical trial, targeted therapy, Prognosis, Combined Modality Therapy, 3. Good health, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, International Consortium on Meningiomas, Patient Safety, Meningioma, medicine.drug, medicine.medical_specialty, Oncology and Carcinogenesis, Antineoplastic Agents, Radiosurgery, 03 medical and health sciences, Internal medicine, medicine, otorhinolaryngologic diseases, Humans, Meningeal Neoplasm, Oncology & Carcinogenesis, neoplasms, business.industry, Neurosciences, Evaluation of treatments and therapeutic interventions, medicine.disease, RADIOTERAPIA, Brain Disorders, nervous system diseases, Clinical trial, Radiation therapy, radiation, Neurology (clinical), Cranial Irradiation, business, 030217 neurology & neurosurgery
Abstract

Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.

Published
2019

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