88 results on '"Spatola, G"'
Search Results
2. Atypical and Anaplastic Meningiomas: Is There a Role for Stereotactic Radiosurgery?
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Franzin, A., Giudice, L., Migliorati, K., Spatola, G., Giorgi, C., Bassetti, C., D’Arrigo, C., Vivaldi, O., Bignardi, M., Longhi, Michele, editor, Motti, Enrico D. F., editor, Nicolato, Antonio, editor, and Picozzi, Piero, editor
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- 2021
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3. DOSE-RATE DEPENDENCE OF BIOLOGICALLY EFFECTIVE DOSE (BED) IN GAMMA KNIFE FUNCTIONAL RADIOSURGERY AND MANAGEMENT OF SOURCE REPLACEMENT
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Agnelli, G., primary, Chieregato, M., additional, Bassetti, C., additional, Galelli, M., additional, Maio, R., additional, Miori, G., additional, Spatola, G., additional, and Franzin, A.B., additional
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- 2023
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4. Primary sellar melanocytoma: pathological, clinical and treatment review
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Albano, L., Losa, M., Barzaghi, L. R., Spatola, G., Panni, P., Terreni, M. R., and Mortini, P.
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- 2020
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5. Long-term results of Gamma-knife stereotactic radiosurgery for vestibular schwannomas in patients with type 2 neurofibromatosis
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Spatola, G., Carron, R., Delsanti, C., Thomassin, J.-M., Roche, P.-H., and Régis, J.
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- 2018
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6. Deep brain stimulation in the treatment of obsessive-compulsive disorder: current perspectives
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Tastevin M, Spatola G, Régis J, Lançon C, and Richieri R
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deep brain stimulation ,obsessive compulsive disorder ,treatment-refractory ,Yale-Brown Obsessive-Compulsive Scale ,cortico-striato-thalamo-cortical circuitry ,Research Domain Criteria ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Maud Tastevin,1 Giorgio Spatola,2,3 Jean Régis,2,3 Christophe Lançon,1 Raphaëlle Richieri1,41Department of Psychiatry, Addictions and Psychiatry for Children, Public Assistance Marseille Hospitals, 13005 Marseille, France; 2Department of Functional and Stereotactic Neurosurgery, Public Assistance Marseille Hospitals, 13005 Marseille, France; 3Institut de Neurosciences des Systèmes, Aix Marseille University, Inserm UMR1106, France; 4Faculté des Sciences de Saint Jérôme, Aix Marseille University, Institut Fresnel - UMR 7249, Marseille, FranceAbstract: Deep brain stimulation (DBS) is a neuro-psychosurgical technique widely accepted in movement disorders, such as Parkinson’s disease. Since 1999, DBS has been explored for severe, chronic and treatment-refractory psychiatric diseases. Our review focuses on DBS in obsessive-compulsive disorder (OCD), considered as a last treatment resort by most of learned societies in psychiatry. Two main stimulation areas have been studied: the striatal region and the subthalamic nucleus. But, most of the trials are open-labeled, and the rare controlled ones have failed to highlight the most efficient target. The recent perspectives are otherwise encouraging. Indeed, clinicians are currently considering other promising targets. A case series of 2 patients reported a decrease in OCD symptoms after DBS in the medial forebrain bundle and an open-label study is exploring bilateral habenula stimulation. New response criteria are also investigating such as quality of life, or subjective and lived-experience. Moreover, first papers about cost-effectiveness which is an important criterion in decision making, have been published. The effectiveness of tractography-assisted DBS or micro-assisted DBS is studying with the aim to improve targeting precision. In addition, a trial involving rechargeable pacemakers is undergoing because this mechanism could be efficient and have a positive impact on cost-effectiveness. A recent trial has discussed the possibility of using combined cognitive behavioral therapy (CBT) and DBS as an augmentation strategy. Finally, based on RDoc Research, the latest hypotheses about the understanding of cortico-striato-thalamo-cortical circuits could offer new directions including clinical predictors and biomarkers to perform adaptive closed-loop systems in the next future.Keywords: deep brain stimulation, obsessive compulsive disorder, treatment-refractory, Yale-Brown obsessive-compulsive scale, cortico-striato-thalamo-cortical circuitry, Research Domain Criteria
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- 2019
7. PC-01.31 - DOSE-RATE DEPENDENCE OF BIOLOGICALLY EFFECTIVE DOSE (BED) IN GAMMA KNIFE FUNCTIONAL RADIOSURGERY AND MANAGEMENT OF SOURCE REPLACEMENT
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Agnelli, G., Chieregato, M., Bassetti, C., Galelli, M., Maio, R., Miori, G., Spatola, G., and Franzin, A.B.
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- 2023
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8. Primary sellar melanocytoma: pathological, clinical and treatment review
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Albano, L., Losa, M., Barzaghi, L. R., Spatola, G., Panni, P., Terreni, M. R., and Mortini, P.
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Background: Sellar melanocytomas represent a small subgroup of primary melanocytic tumors. They arise from melanocytes located in the meningeal lining of the sellar floor or in the diaphragma sellae and this location is very uncommon. Usually, sellar melanocytomas are benign and slow-growing tumors with a high likelihood of recurrence. Purpose: To our knowledge, due to the rarity of this condition, there are no guidelines regarding their diagnosis and treatment in the medical literature to date. We have developed a narrative review, analyzing the available studies regarding primary sellar melanocytomas reported in the medical literature. We have found ten papers on this topic and all of them are case reports. In all patients, tumor diagnosis was performed after the occurrence of neurological symptoms, in particular progressive visual loss or endocrinological disorders. The diagnosis is difficult, and it requires several preoperative and postoperative investigations, but histological examination is crucial. Conclusions: Transsphenoidal surgery is the first-choice treatment. In case of tumor’s recurrence or regrowth, the role of radiation therapy and chemotherapy is not entirely clear.
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- 2024
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9. Procedures performed during neurosurgery residency in Europe
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Stienen, M. N., Freyschlag, C. F., Schaller, K., Meling, T., Al-Amin, A., Al-Mahfoudh, R., Amelot, A., Arvidsson, L., Athanasiou, A., Avellan, C. I. A., Bauchet, L., Berilazic, L., Bolger, C., Bourdillon, P., Boviatsis, S., Bozinov, O., Branco, P., Braunsdorf, W., Cahill, J., Clusmann, H., Conrad, J., Cordier, D., Cristino, N., Djilvesi, D., Duerinck, J., Dumot, C., Durak, M. A., Eisenring, C. V., Esposito, G., Finiels, P. -J., Flaskas, T., Fuentes, S., Ganau, M., Georgiadis, I., Georgiopoulos, M., Giakoumettis, D., Gilis, N., Gradil, C., Grau, S. J., Grin, A., Hadjigeorgiou, G., Halatsch, M. -E., Hecht, N., Holling, M., Ilic, R., Iken, L., Santos, N. I., Jacquesson, T., Jalloh, I., Jelaca, B., Kaestner, S., Kalasauskas, D., Kaliyev, A., Kleiber, J. -C., Konczalla, J., Kothbauer, K. F., Kovacevic, V., Krajcinovic, N., Krieg, S. M., Kamarainen, O. -P., Lapcic, M., Lapras, C., Ljungqvist, J., W. B., Lo, Lubrano, V., Majovsky, M., Manet, R., Marchi, F., Medetov, Y., Meling, T. R., Melloni, I., Melot, A., Mertens, P., Metcalfe, S., Moerkve, S. H., Mora, A. R., Musabelliu, E., Naushahi, M. J., Nurzhan, A., Omerhodzic, I., Paldor, I., Pallud, J., Papanastassiou, V., Papic, V., Paschalis, T., Payer, M., Peerdeman, S. M., Peruzzi, P., Segerlind, J. P., Posti, J. P., Proust, F., Regli, L., Rinne, J., Roche, P. -H., Rocka, S., Rotermund, R., Rutherford, S. A., Ratsep, T., Ruter, A., Saarenpaa, I. M., Samanci, M. Y., Samardzic, M., Sampron, N., Sandvik, U., Scerrati, A., Schneider, M., Schul, D. B., Sengul, G., Simon, E., Sinha, S., Solheim, O., Spatola, G., Spektor, S., Sundblom, J., Syrmos, N. C., Teo, M., Thomson, S., Tonchev, N., Tosic, L., Vandertop, W. P., von der Brelie, C., Vuk, A., Walkden, J., Wendel, C., Yaqout, M., Yusupova, M., Zollino, G., University of Zurich, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, IOO, and ANS - Systems & Network Neuroscience
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Adult ,Male ,Neurosurgery/education ,medicine.medical_specialty ,Certification ,Caseload ,Europe ,Neurosurgery ,Residency ,Training program ,Working hour restriction ,610 Medicine & health ,Neurosurgical Procedures ,NO ,03 medical and health sciences ,10180 Clinic for Neurosurgery ,0302 clinical medicine ,Surveys and Questionnaires ,Germany ,Medicine ,Humans ,Child ,Greece ,business.industry ,Female sex ,Internship and Residency ,Mean age ,Surgical procedures ,Middle Aged ,Current analysis ,United Kingdom ,Original Article - Neurosurgery Training ,ddc:616.8 ,030220 oncology & carcinogenesis ,Surgery ,Female ,Neurology (clinical) ,France ,business ,030217 neurology & neurosurgery ,Switzerland ,Demography - Abstract
Background In a previous article (10.1007/s00701-019-03888-3), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries (p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.
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- 2020
10. IMMUNOIDSTOCHEMICAL LOCALIZATION OF CATHEPSIN D AND MACROPHAGES IN SOME NEOFORMATIONS OF HUMAN ORAL MUCOSA
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Gerbino, A., Leone, A., Spatola, G. F., D`Angelo, M., Giuliana, G., and Buscemi, M.
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oral mucosa ,immunohistochemical ,cathepsin D ,macrophages - Abstract
Nous avons étudié, dans notre laboratoire, la relation entre la cathepsine D et les macrophages dans plusieurs tissues normals ou pathologiques. Dans ce travail nous rapportons les résultats d'une étude himmunohistochirnique sur la distribution de la cathepsine D et des macrophages (sept cas pathologiques de neoformations) dans la muqueuse orale humaine. Nous avons observé qu'il n'y a aucune relation entre la cathepsine D et le numero des macrophages dans les differents cas que nous avons étudié
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- 2021
11. Positive clinical effects of gamma knife capsulotomy in a patient with deep brain stimulation-refractory Tourette syndrome and obsessive compulsive disorder
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Richieri, R, Blackman, G, Musil, R, Spatola, G, Cavanna, A, Lançon, C, Régis, J, Richieri R, Blackman G, Musil R, Spatola G, Cavanna A, Lançon C, Régis J, Richieri, R, Blackman, G, Musil, R, Spatola, G, Cavanna, A, Lançon, C, Régis, J, Richieri R, Blackman G, Musil R, Spatola G, Cavanna A, Lançon C, and Régis J
- Abstract
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option.
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- 2018
12. Platform session
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Feigl, G., Rosmarin, W., Weninger, B., Likar, R., Hoogland, P. V., Groen, R. J. M., Vorster, W., Grobbelaar, M., Muller, C. J. F., du Toit, D. F., Moriggl, B., Greher, M., Klauser, A., Eichenberger, U., Prades, J. M., Timoshenko, A., Faye, M., Martin, C. H., Baroncini, M., Baiz, H., Ben Henda, A., Fontaine, C., Baksa, G., Toth, M., Patonay, L., Gonçalves-Ferreira, A., Gonçalves, C., Neto, L., Fonseca, T., Gaspar, H., Rino, J., Fernandes, M., Fernandes, P., Cardoso, H., Miranda, B., Rego, J., Hamel, A., Guillouche, P., Hamel, O., Garçon, M., Lager, S., Blin, Y., Armstrong, O., Robert, R., Rogez, J. M., Le Borgne, J., Kahilogulları, G., Comert, A., Esmer, A. F., Tuccar, E., Tekdemir, I., Ozdemir, M., Odabasi, A. B., Elhan, A., Anand, M. K., Singh, P. R., Verma, M., Raibagkar, C. J., Kim, H. J., Kwak, H. H., Hu, K. S., Francke, J. P., Macchi, V., Porzionato, A., Parenti, A., Metalli, P., Zanon, G. F., De Caro, R., Bernardes, A., Dionísio, J., Messias, P., Patrício, J., Apaydin, N., Uz, A., Evirgen, O., Shim, K. S., Park, H. D., Youn, K. H., Cajozzo, M., Bartolotta, T., Cappello, F., Sunseri, A., Romeo, M., Altieri, G., Modica, G., La Barbera, G., La Marca, G., Valentino, F., Valentino, B., Martino, A., Dees, G., Kleintjes, W. A., Williams, R., Herpe, B., Leborgne, J., Lagier, S., Cordova, A., Pirrello, R., Moschella, F., Mahajan, M. V., Bhat, U. B., Abhayankar, S. V., Ambiye, M. V., Kachlík, D. K., Stingl, J. S., Sosna, B. S., Fára, P. F., Lametschwandtner, A. L., Minnich, B. M., Straka, Z. S., Ifrim, M., Ifrim, C. Feng, Botea, M., Latorre, R., Sun, F., Henry, R., Crisóstomo, V., Cano, F. Gil, Usón, J., Mtez-Gomaríz, F., Climent, S., Hurmusiadis, V., Barrick, S., Barrow, J., Clifford, N., Morgan, F., Wilson, R., Wiseman, L., Fogg, O. A., Loukas, M., Tedman, R. A., Capaccioli, N., Capaccioli, L., Mannini, A., Guazzi, G., Mangoni, M., Paternostro, F., Vagnoli, P. Terrosi, Gulisano, M., Pacini, S., Grignon, B., Jankowski, R., Hennion, D., Zhu, X., Roland, J., Mutiu, G., Tessitore, V., Uzzo, M. L., Bonaventura, G., Milio, G., Spatola, G. F., Ilkan, T., Selcuk, T., Mustafa, A. M., Hamdi, C. H., Emel, T. C., Faruk, U., Hamdi, C. H., Bulent, G., Báča, V., Doubková, A., Kachlík, D., Stingl, J., Saylam, C., Kitiş, Ö., Üçerler, H., Manisahı, E., Gönül, A. S., Dashti, G. H. R., Nematbaksh, M., Mardani, M., Hami, J., Rezaian, M., Radmehr, B., Akbari, M., Paryani, M. R., Gilanpour, H., Zamfir, C., Zamfir, M., Lupusoru, C., Raileanu, C., Lupusoru, R., Bordei, P., Iliescu, D., Şapte, E., Adam, S., Baker, C., Sergi, C., Barberini, F., Ripani, M., Di Nitto, V., Zani, A., Magnosi, F., Heyn, R., Familiari, G., Elgin, U., Demiryurek, D., Berker, N., Ilhan, B., Simsek, T., Batman, A., Bayramoglu, A., Fogg, Q. A., Bartczak, A., Kamionek, M., Kiedrowski, M., Fudalej, M., Wagner, T., Artibani, W., Tiengo, C., Taglialavoro, G., Mazzoleni, F., Scapinelli, R., Ardizzone, E., Cannella, V., Peri, D., Pirrone, R., and Peri, G.
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- 2005
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13. Maintaining stereotactic radiosurgical treatments during Covid-19 outbreak: the case of the Gamma Knife Unit in Brescia – Italy
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Franzin, A., primary, Spatola, G., additional, Giudice, L., additional, Migliorati, K., additional, Vivaldi, O., additional, and Giorgi, C., additional
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- 2020
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14. Primary sellar melanocytoma: pathological, clinical and treatment review
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Albano, L., primary, Losa, M., additional, Barzaghi, L. R., additional, Spatola, G., additional, Panni, P., additional, Terreni, M. R., additional, and Mortini, P., additional
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- 2019
- Full Text
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15. Platform session
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Feigl, G., Rosmarin, W., Weninger, B., Likar, R., Hoogland, P., Groen, R., Vorster, W., Grobbelaar, M., Muller, C., du Toit, D., Moriggl, B., Greher, M., Klauser, A., Eichenberger, U., Prades, J., Timoshenko, A., Faye, M., Martin, C., Baroncini, M., Baiz, H., Ben Henda, A., Fontaine, C., Baksa, G., Toth, M., Patonay, L., Gonçalves-Ferreira, A., Gonçalves, C., Neto, L., Fonseca, T., Gaspar, H., Rino, J., Fernandes, M., Fernandes, P., Cardoso, H., Miranda, B., Rego, J., Hamel, A., Guillouche, P., Hamel, O., Garçon, M., Lager, S., Blin, Y., Armstrong, O., Robert, R., Rogez, J., Le Borgne, J., Kahilogulları, G., Comert, A., Esmer, A., Tuccar, E., Tekdemir, I., Ozdemir, M., Odabasi, A., Elhan, A., Anand, M., Singh, P., Verma, M., Raibagkar, C., Kim, H., Kwak, H., Hu, K., Francke, J., Macchi, V., Porzionato, A., Parenti, A., Metalli, P., Zanon, G., De Caro, R., Bernardes, A., Dionísio, J., Messias, P., Patrício, J., Apaydin, N., Uz, A., Evirgen, O., Shim, K., Park, H., Youn, K., Cajozzo, M., Bartolotta, T., Cappello, F., Sunseri, A., Romeo, M., Altieri, G., Modica, G., La Barbera, G., La Marca, G., Valentino, F., Valentino, B., Martino, A., Dees, G., Kleintjes, W., Williams, R., Herpe, B., Leborgne, J., Lagier, S., Cordova, A., Pirrello, R., Moschella, F., Mahajan, M., Bhat, U., Abhayankar, S., Ambiye, M., Kachlík, D., Stingl, J., Sosna, B., Fára, P., Lametschwandtner, A., Minnich, B., Straka, Z., Ifrim, M., Ifrim, C., Botea, M., Latorre, R., Sun, F., Henry, R., Crisóstomo, V., Cano, F., Usón, J., Mtez-Gomaríz, F., Climent, S., Hurmusiadis, V., Barrick, S., Barrow, J., Clifford, N., Morgan, F., Wilson, R., Wiseman, L., Fogg, O., Loukas, M., Tedman, R., Capaccioli, N., Capaccioli, L., Mannini, A., Guazzi, G., Mangoni, M., Paternostro, F., Vagnoli, P., Gulisano, M., Pacini, S., Grignon, B., Jankowski, R., Hennion, D., Zhu, X., Roland, J., Mutiu, G., Tessitore, V., Uzzo, M., Bonaventura, G., Milio, G., Spatola, G., Ilkan, T., Selcuk, T., Mustafa, A., Hamdi, C., Emel, T., Faruk, U., Bulent, G., Báča, V., Doubková, A., Saylam, C., Kitiş, Ö., Üçerler, H., Manisahı, E., Gönül, A., Dashti, G., Nematbaksh, M., Mardani, M., Hami, J., Rezaian, M., Radmehr, B., Akbari, M., Paryani, M., Gilanpour, H., Zamfir, C., Zamfir, M., Lupusoru, C., Raileanu, C., Lupusoru, R., Bordei, P., Iliescu, D., Şapte, E., Adam, S., Baker, C., Sergi, C., Barberini, F., Ripani, M., Di Nitto, V., Zani, A., Magnosi, F., Heyn, R., Familiari, G., Elgin, U., Demiryurek, D., Berker, N., Ilhan, B., Simsek, T., Batman, A., Bayramoglu, A., Fogg, Q., Bartczak, A., Kamionek, M., Kiedrowski, M., Fudalej, M., Wagner, T., Artibani, W., Tiengo, C., Taglialavoro, G., Mazzoleni, F., Scapinelli, R., Ardizzone, E., Cannella, V., Peri, D., Pirrone, R., Peri, G., Feigl, G., Rosmarin, W., Weninger, B., Likar, R., Hoogland, P., Groen, R., Vorster, W., Grobbelaar, M., Muller, C., du Toit, D., Moriggl, B., Greher, M., Klauser, A., Eichenberger, U., Prades, J., Timoshenko, A., Faye, M., Martin, C., Baroncini, M., Baiz, H., Ben Henda, A., Fontaine, C., Baksa, G., Toth, M., Patonay, L., Gonçalves-Ferreira, A., Gonçalves, C., Neto, L., Fonseca, T., Gaspar, H., Rino, J., Fernandes, M., Fernandes, P., Cardoso, H., Miranda, B., Rego, J., Hamel, A., Guillouche, P., Hamel, O., Garçon, M., Lager, S., Blin, Y., Armstrong, O., Robert, R., Rogez, J., Le Borgne, J., Kahilogulları, G., Comert, A., Esmer, A., Tuccar, E., Tekdemir, I., Ozdemir, M., Odabasi, A., Elhan, A., Anand, M., Singh, P., Verma, M., Raibagkar, C., Kim, H., Kwak, H., Hu, K., Francke, J., Macchi, V., Porzionato, A., Parenti, A., Metalli, P., Zanon, G., De Caro, R., Bernardes, A., Dionísio, J., Messias, P., Patrício, J., Apaydin, N., Uz, A., Evirgen, O., Shim, K., Park, H., Youn, K., Cajozzo, M., Bartolotta, T., Cappello, F., Sunseri, A., Romeo, M., Altieri, G., Modica, G., La Barbera, G., La Marca, G., Valentino, F., Valentino, B., Martino, A., Dees, G., Kleintjes, W., Williams, R., Herpe, B., Leborgne, J., Lagier, S., Cordova, A., Pirrello, R., Moschella, F., Mahajan, M., Bhat, U., Abhayankar, S., Ambiye, M., Kachlík, D., Stingl, J., Sosna, B., Fára, P., Lametschwandtner, A., Minnich, B., Straka, Z., Ifrim, M., Ifrim, C., Botea, M., Latorre, R., Sun, F., Henry, R., Crisóstomo, V., Cano, F., Usón, J., Mtez-Gomaríz, F., Climent, S., Hurmusiadis, V., Barrick, S., Barrow, J., Clifford, N., Morgan, F., Wilson, R., Wiseman, L., Fogg, O., Loukas, M., Tedman, R., Capaccioli, N., Capaccioli, L., Mannini, A., Guazzi, G., Mangoni, M., Paternostro, F., Vagnoli, P., Gulisano, M., Pacini, S., Grignon, B., Jankowski, R., Hennion, D., Zhu, X., Roland, J., Mutiu, G., Tessitore, V., Uzzo, M., Bonaventura, G., Milio, G., Spatola, G., Ilkan, T., Selcuk, T., Mustafa, A., Hamdi, C., Emel, T., Faruk, U., Bulent, G., Báča, V., Doubková, A., Saylam, C., Kitiş, Ö., Üçerler, H., Manisahı, E., Gönül, A., Dashti, G., Nematbaksh, M., Mardani, M., Hami, J., Rezaian, M., Radmehr, B., Akbari, M., Paryani, M., Gilanpour, H., Zamfir, C., Zamfir, M., Lupusoru, C., Raileanu, C., Lupusoru, R., Bordei, P., Iliescu, D., Şapte, E., Adam, S., Baker, C., Sergi, C., Barberini, F., Ripani, M., Di Nitto, V., Zani, A., Magnosi, F., Heyn, R., Familiari, G., Elgin, U., Demiryurek, D., Berker, N., Ilhan, B., Simsek, T., Batman, A., Bayramoglu, A., Fogg, Q., Bartczak, A., Kamionek, M., Kiedrowski, M., Fudalej, M., Wagner, T., Artibani, W., Tiengo, C., Taglialavoro, G., Mazzoleni, F., Scapinelli, R., Ardizzone, E., Cannella, V., Peri, D., Pirrone, R., and Peri, G.
- Published
- 2018
16. Valutazione della funzione vestibolare nei pazienti affetti da Schwannomi vestibolari: Cosa conta realmente? | [Vestibular assessment in patients with vestibular schwannomas: What really matters?]
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Teggi R, Franzin A, Spatola G, Boari N, Picozzi P, Bailo M, Piccioni L. O., Gagliardi F, MORTINI , PIETRO, Bussi M., Teggi, R, Franzin, A, Spatola, G, Boari, N, Picozzi, P, Bailo, M, Piccioni, L. O., Gagliardi, F, Mortini, Pietro, and Bussi, M.
- Subjects
Gamma-Knife ,Radiosurgery ,Hearing lo - Abstract
Vestibular function is often underdiagnosed in vestibular schwannomas (VS). To evaluate it in a selected group of patients harbouring vestibular schwannomas, 64 patients were included in this study, recruited between March 2008 and June 2011 at our institution. All patients underwent Gd-enhanced MRI and complete neurotological evaluation before gamma knife surgery. Morphological measurements included Koos Classification and quantification of internal acoustic canal filling in length and diameter. Cochlear and vestibular functions were assessed considering pure tone and speech audiometry, bedside examination and caloric test by videonystagmography. A statistical analysis was performed to find possible correlations between morphological and cochleovestibular data. Patients with a higher intracanalicular length (ICL, mean value 8.59 and median 8.8 mm) of the tumour presented a higher value of UW than the subgroup with a lower length (51.9 ± 24.3% and 38.8 ± 18.1% respectively, p = 0.04), while no difference was detected for pure tone audiometry (PTA) values (50.9 ± 22.3 db and 51.1 ± 28.9 db respectively). Patients with a higher ICL also presented a higher rate of positive HIT (88% and 60% respectively, p = 0.006). Patients with a higher value of intracanalicular diameter (ICD, mean value 5.22 and median 5.15 mm) demonstrated higher values of UW (50.2 ± 29.1% and 39.3 ± 21% respectively, p = 0.03), but not different PTA (50.2 ± 29.1 db and 51.9 ± 29.9 db respectively). Finally, patients with a positive head impulse test (HIT) demonstrated significantly higher values of unilateral weakness (UW) (p = 0.001). Vestibular disorders are probably underdiagnosed in patients with VS. ICL and ICD seem to be the main parameters that correlate with vestibular function. Also, in case of small intracanalar T1 VS a slight increase of these variables can result in significant vestibular impairment. The data reported in the present study are not inconsistent with the possibility of proactive treatment of patients with VS.
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- 2014
17. Lâespressione peptidergica immunoistochimica della leptina è associate con la recidiva del carcinoma squamoso laringeo
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Gallina, S., Sireci, F., Lorusso, F., Di Benedetto, D., Speciale, R., Marchese, D., Costantino, C., Napoli, G., Tessitore, V., Cucco, D., Leone, A., Bonaventura, G., Uzzo, M., and Spatola, G.
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Laryngeal carcinoma ,Leptin ,Malignancy recurrence ,Otorhinolaryngology2734 Pathology and Forensic Medicine - Published
- 2015
18. Long-term results of Gamma-knife stereotactic radiosurgery for vestibular schwannomas in patients with type 2 neurofibromatosis
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Spatola, G., Carron, R., Delsanti, C., Thomassin, J.-M., Roche, P.-H., and Régis, J.
- Abstract
The aim of this study was to analyze the long-term results of Gamma-knife radiosurgery treatment of vestibular schwannomas in type 2 neurofibromatosis patients.
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- 2024
- Full Text
- View/download PDF
19. MODULATION OF MMP-2 AND MMP-9 IN CHURG-STRAUSS SYNDROME RESPIRATORY MUCOSA: POTENTIAL MONITORING PARAMETERS.
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LEONE, A., UZZO, M. L., GERBINO, A., TORTORICI, S., TRALONGO, P., CAPPELLO, F., INCANDELA, S., SPATOLA, G. F., and JURJUS, A. R.
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- 2014
- Full Text
- View/download PDF
20. Lactobacillus casei and Bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice
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Bellavia, M., Rappa, F., Bello, M. L. O., Brecchia, G., Tomasello, G., Leone, A., Spatola, G., Uzzo, M. L., Bonaventura, G., David, S., Damiani, P., Hajj-Hussein, I., Zeenny, M. N., Jurjus, A., Schembri-Wismayer, P., Cocchi, M., Zummo, G., Farina, F., Gerbino, A., Francesco Cappello, Traina, G., Bellavia, M, Rappa, F, Lo Bello, M, Brecchia, G, Tomasello, G, Leone, A, Spatola, G, Uzzo, ML, Bonaventura, G, David, S, Damiani, P, Hajj Hussein, I, Zeenny, MN, Jurjus, A, Schembri-Wismayer, P, Cocchi, M, Zummo, G, Farina, F, Gerbino, A, Cappello, F, and Traina, G
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Male ,Lacticaseibacillus casei ,Mice ,Liver ,Trinitrobenzenesulfonic Acid ,Probiotics ,Dietary Supplements ,Animals ,Humans ,Bifidobacterium ,Intestinal Mucosa ,Inflammatory Bowel Diseases ,Intestinal Inflammation, intestinal cancer, microbiota,probiotic supplementation, large bowel, liver apoptosis - Abstract
Probiotics (PB) are living microorganisms that act as a commensal population in normal intestines and confer numerous beneficial effects on the host. The introduction of probiotics in the treatment of inflammatory bowel disease (IBD) prolongs remission. The aim of this study was to investigate the intestinal and hepatic effects of PB supplementation in an experimental IBD model in mice induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). In the first step of the experimental procedure, CD-1 male mice, 5 to 6 weeks old, were randomly divided into 3 groups and inoculated intrarectally with, respectively, saline, alcohol, or TNBS to assess the experimental IBD model. In the second step, mice treated, or not, with TNBS inoculation, were treated with PB (Lactobacillus Casei, Bifidobacterum Lactis) for 1, 2 or 3 weeks, on a daily basis. Large bowel (colon and rectum) and liver were processed for histological alterations, according to a scoring system. Large bowel was also assessed for apoptosis by TUNEL assay. TNBS induced, as expected, severe damage and inflammation in the large bowel, including nuclear alterations and apoptosis, and, to a lesser extent, to the liver. Administration of PB determined significant reduction of both histological alterations and apoptosis. PB administration in advance protects from inflammation. In conclusion, supplementation with Lactobacillus casei, Bifidobacterum lactis PB is able to ameliorate the colitis by reversing the histological changes caused by TNBS in mice. Experimentation in human subjects in needed to prove their efficacy in reducing histological alterations that may be present in subjects with IBD.
21. Vestibular assessment in patients with vestibular schwannomas: What really matters?,Valutazione della funzione vestibolare nei pazienti affetti da Schwannomi vestibolari: Cosa conta realmente?
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roberto teggi, Franzin, A., Spatola, G., Boari, N., Picozzi, P., Bailo, M., Piccioni, L. O., Gagliardi, F., Mortini, P., and Bussi, M.
22. Vestibular assessment in patients with vestibular schwannomas: What really matters? | Valutazione della funzione vestibolare nei pazienti affetti da Schwannomi vestibolari: Cosa conta realmente?
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Teggi, R., Franzin, A., Spatola, G., Boari, N., Picozzi, P., Bailo, M., Piccioni, L. O., Filippo Gagliardi, Mortini, P., and Bussi, M.
23. The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma,L’espressione peptidergica immunoistochimica della leptina è associate con la recidiva del carcinoma squamoso laringeo
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Salvatore GALLINA, Sireci, F., Lorusso, F., Di Benedetto, D. V., Speciale, R., Marchese, D., Costantino, C., Napoli, G., Tessitore, V., Cucco, D., Leone, A., Bonaventura, G., Uzzo, M. L., and Spatola, G. F.
24. Platform session
- Author
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Feigl, G., Rosmarin, W., Weninger, B., Likar, R., Hoogland, P., Groen, R., Vorster, W., Grobbelaar, M., Muller, C., du Toit, D., Moriggl, B., Greher, M., Klauser, A., Eichenberger, U., Prades, J., Timoshenko, A., Faye, M., Martin, C., Baroncini, M., Baiz, H., Ben Henda, A., Fontaine, C., Baksa, G., Toth, M., Patonay, L., Gonçalves-Ferreira, A., Gonçalves, C., Neto, L., Fonseca, T., Gaspar, H., Rino, J., Fernandes, M., Fernandes, P., Cardoso, H., Miranda, B., Rego, J., Hamel, A., Guillouche, P., Hamel, O., Garçon, M., Lager, S., Blin, Y., Armstrong, O., Robert, R., Rogez, J., Le Borgne, J., Kahilogulları, G., Comert, A., Esmer, A., Tuccar, E., Tekdemir, I., Ozdemir, M., Odabasi, A., Elhan, A., Anand, M., Singh, P., Verma, M., Raibagkar, C., Kim, H., Kwak, H., Hu, K., Francke, J., Macchi, V., Porzionato, A., Parenti, A., Metalli, P., Zanon, G., De Caro, R., Bernardes, A., Dionísio, J., Messias, P., Patrício, J., Apaydin, N., Uz, A., Evirgen, O., Shim, K., Park, H., Youn, K., Cajozzo, M., Bartolotta, T., Cappello, F., Sunseri, A., Romeo, M., Altieri, G., Modica, G., La Barbera, G., La Marca, G., Valentino, F., Valentino, B., Martino, A., Dees, G., Kleintjes, W., Williams, R., Herpe, B., Leborgne, J., Lagier, S., Cordova, A., Pirrello, R., Moschella, F., Mahajan, M., Bhat, U., Abhayankar, S., Ambiye, M., Kachlík, D., Stingl, J., Sosna, B., Fára, P., Lametschwandtner, A., Minnich, B., Straka, Z., Ifrim, M., Ifrim, C., Botea, M., Latorre, R., Sun, F., Henry, R., Crisóstomo, V., Cano, F., Usón, J., Mtez-Gomaríz, F., Climent, S., Hurmusiadis, V., Barrick, S., Barrow, J., Clifford, N., Morgan, F., Wilson, R., Wiseman, L., Fogg, O., Loukas, M., Tedman, R., Capaccioli, N., Capaccioli, L., Mannini, A., Guazzi, G., Mangoni, M., Paternostro, F., Vagnoli, P., Gulisano, M., Pacini, S., Grignon, B., Jankowski, R., Hennion, D., Zhu, X., Roland, J., Mutiu, G., Tessitore, V., Uzzo, M., Bonaventura, G., Milio, G., Spatola, G., Ilkan, T., Selcuk, T., Mustafa, A., Hamdi, C., Emel, T., Faruk, U., Bulent, G., Báča, V., Doubková, A., Saylam, C., Kitiş, Ö., Üçerler, H., Manisahı, E., Gönül, A., Dashti, G., Nematbaksh, M., Mardani, M., Hami, J., Rezaian, M., Radmehr, B., Akbari, M., Paryani, M., Gilanpour, H., Zamfir, C., Zamfir, M., Lupusoru, C., Raileanu, C., Lupusoru, R., Bordei, P., Iliescu, D., Şapte, E., Adam, S., Baker, C., Sergi, C., Barberini, F., Ripani, M., Di Nitto, V., Zani, A., Magnosi, F., Heyn, R., Familiari, G., Elgin, U., Demiryurek, D., Berker, N., Ilhan, B., Simsek, T., Batman, A., Bayramoglu, A., Fogg, Q., Bartczak, A., Kamionek, M., Kiedrowski, M., Fudalej, M., Wagner, T., Artibani, W., Tiengo, C., Taglialavoro, G., Mazzoleni, F., Scapinelli, R., Ardizzone, E., Cannella, V., Peri, D., Pirrone, R., Peri, G., Feigl, G., Rosmarin, W., Weninger, B., Likar, R., Hoogland, P., Groen, R., Vorster, W., Grobbelaar, M., Muller, C., du Toit, D., Moriggl, B., Greher, M., Klauser, A., Eichenberger, U., Prades, J., Timoshenko, A., Faye, M., Martin, C., Baroncini, M., Baiz, H., Ben Henda, A., Fontaine, C., Baksa, G., Toth, M., Patonay, L., Gonçalves-Ferreira, A., Gonçalves, C., Neto, L., Fonseca, T., Gaspar, H., Rino, J., Fernandes, M., Fernandes, P., Cardoso, H., Miranda, B., Rego, J., Hamel, A., Guillouche, P., Hamel, O., Garçon, M., Lager, S., Blin, Y., Armstrong, O., Robert, R., Rogez, J., Le Borgne, J., Kahilogulları, G., Comert, A., Esmer, A., Tuccar, E., Tekdemir, I., Ozdemir, M., Odabasi, A., Elhan, A., Anand, M., Singh, P., Verma, M., Raibagkar, C., Kim, H., Kwak, H., Hu, K., Francke, J., Macchi, V., Porzionato, A., Parenti, A., Metalli, P., Zanon, G., De Caro, R., Bernardes, A., Dionísio, J., Messias, P., Patrício, J., Apaydin, N., Uz, A., Evirgen, O., Shim, K., Park, H., Youn, K., Cajozzo, M., Bartolotta, T., Cappello, F., Sunseri, A., Romeo, M., Altieri, G., Modica, G., La Barbera, G., La Marca, G., Valentino, F., Valentino, B., Martino, A., Dees, G., Kleintjes, W., Williams, R., Herpe, B., Leborgne, J., Lagier, S., Cordova, A., Pirrello, R., Moschella, F., Mahajan, M., Bhat, U., Abhayankar, S., Ambiye, M., Kachlík, D., Stingl, J., Sosna, B., Fára, P., Lametschwandtner, A., Minnich, B., Straka, Z., Ifrim, M., Ifrim, C., Botea, M., Latorre, R., Sun, F., Henry, R., Crisóstomo, V., Cano, F., Usón, J., Mtez-Gomaríz, F., Climent, S., Hurmusiadis, V., Barrick, S., Barrow, J., Clifford, N., Morgan, F., Wilson, R., Wiseman, L., Fogg, O., Loukas, M., Tedman, R., Capaccioli, N., Capaccioli, L., Mannini, A., Guazzi, G., Mangoni, M., Paternostro, F., Vagnoli, P., Gulisano, M., Pacini, S., Grignon, B., Jankowski, R., Hennion, D., Zhu, X., Roland, J., Mutiu, G., Tessitore, V., Uzzo, M., Bonaventura, G., Milio, G., Spatola, G., Ilkan, T., Selcuk, T., Mustafa, A., Hamdi, C., Emel, T., Faruk, U., Bulent, G., Báča, V., Doubková, A., Saylam, C., Kitiş, Ö., Üçerler, H., Manisahı, E., Gönül, A., Dashti, G., Nematbaksh, M., Mardani, M., Hami, J., Rezaian, M., Radmehr, B., Akbari, M., Paryani, M., Gilanpour, H., Zamfir, C., Zamfir, M., Lupusoru, C., Raileanu, C., Lupusoru, R., Bordei, P., Iliescu, D., Şapte, E., Adam, S., Baker, C., Sergi, C., Barberini, F., Ripani, M., Di Nitto, V., Zani, A., Magnosi, F., Heyn, R., Familiari, G., Elgin, U., Demiryurek, D., Berker, N., Ilhan, B., Simsek, T., Batman, A., Bayramoglu, A., Fogg, Q., Bartczak, A., Kamionek, M., Kiedrowski, M., Fudalej, M., Wagner, T., Artibani, W., Tiengo, C., Taglialavoro, G., Mazzoleni, F., Scapinelli, R., Ardizzone, E., Cannella, V., Peri, D., Pirrone, R., and Peri, G.
25. Comparative analysis of Hsp10 and Hsp90 in large bowel healthy mucosa and adenocarcinomas.
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Rappa, F., Lo Bello, M., Caruso Bavisotto, C., Marino Gammazza, A., Campanella, C., David, S., Sciumè, C., Zarcone, F., Geraci, G., Modica, G., Carini, F., Tomasello, G., Bellavia, M., Uzzo, M. L., Spatola, G., Bonaventura, G., Leone, A., Damiani, P., Buccheri, F., and Gerbino, A.
- Subjects
HEAT shock proteins ,ADENOCARCINOMA ,COMPARATIVE studies - Abstract
An abstract of the article "Comparative analysis of Hsp10 and Hsp90 in large bowel healthy mucosa and adenocarcinomas," by F. Rappa and colleagues is presented.
- Published
- 2015
26. Positive clinical effects of gamma knife capsulotomy in a patient with deep brain stimulation-refractory Tourette Syndrome and Obsessive Compulsive Disorder
- Author
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Raphaëlle Richieri, Christophe Lançon, Jean Régis, Graham Blackman, Giorgio Spatola, Andrea E. Cavanna, Richard Musil, Richieri, R, Blackman, G, Musil, R, Spatola, G, Cavanna, A, Lançon, C, and Régis, J
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Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Deep brain stimulation ,Internal capsule ,Deep Brain Stimulation ,medicine.medical_treatment ,Capsulotomy ,Gamma knife ,Radiosurgery ,Tourette syndrome ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,Internal Capsule ,Obsessive compulsive ,mental disorders ,medicine ,Humans ,030212 general & internal medicine ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Obsessive compulsive disorder ,Treatment Outcome ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Tourette Syndrome - Abstract
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option.
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- 2018
27. Frequency, pattern, and outcome of recurrences after gamma knife radiosurgery for pituitary adenomas
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Antonella del Vecchio, Luigi Albano, Pietro Mortini, Marco Losa, Alessandra Gandolfi, Angelo Bolognesi, Giorgio Spatola, Losa, M, Spatola, G, Albano, L, Gandolfi, A, Del Vecchio, A, Bolognesi, A, and Mortini, Pietro
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Adenoma ,Adult ,Male ,Reoperation ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gamma knife radiosurgery ,030209 endocrinology & metabolism ,Pituitary neoplasm ,Radiosurgery ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Pituitary adenoma ,medicine ,Humans ,Pituitary Neoplasms ,Young adult ,Aged ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Middle Aged ,Pituitary surgery ,medicine.disease ,Radiation therapy ,Treatment Outcome ,Female ,Radiology ,Neoplasm Recurrence, Local ,Nuclear medicine ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Gamma Knife radiosurgery is often used in pituitary adenomas. Aim of our study is to describe the characteristics and long-term outcome of patients with adenoma recurrence after Gamma Knife radiosurgery. We conducted a retrospective analysis of patients with pituitary adenoma treated by Gamma Knife radiosurgery between 1994 and 2014. Tumor recurrence was labeled as “in field” when the tumor growth occurred adjacent or within the prescribed isodose, whereas it was classified as “out of field” when the tumor growth occurred outside the prescribed isodose. Five hundred forty-three patients were included, 272 (50.1 %) had a nonfunctioning pituitary adenoma (NFPA) and 271 (49.9 %) patients had a hormone secreting-pituitary adenoma. The median follow-up after GKRS was 78 months (IQR, 36-125 months). Thirty-nine patients (7.2 %) had recurrence of disease and it was more frequent in patients with NFPA than in patients with hormone secreting adenomas (9.6 % vs. 4.8 %). The 10-yr progression-free survival in patients with NFPA was 78.7 % (95 % CI 69.5 – 87.9 %), as compared with 93.3 % (95 % CI 89.3 – 97.3 %; p < 0.01) in hormone secreting adenomas. Tumor recurrence was “in field” in 17 cases (43.6 %) and “out of field” in 22 cases (56.4 %). Seven of the 39 patients with recurrence died despite further treatments. Six of these patients had an “in field” recurrence. Recurrence of a pituitary adenoma after GKRS may occur several years after initial treatment. Distinction between “in field” and “out of field” tumor recurrence probably reflects two different pathophysiological mechanisms and may have prognostic importance. © 2016 Springer Science+Business Media New York
- Published
- 2016
28. Evaluation of prognostic factors as predictor of AVMS obliteration after Gamma Knife radiosurgery
- Author
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Alberto Franzin, Piero Picozzi, Filippo Gagliardi, Silvia Snider, Pietro Mortini, Nicola Boari, Giorgio Spatola, Francesco Scomazzoni, Franzin, A, Snider, S, Boari, N, Scomazzoni, F, Picozzi, P, Spatola, G, Gagliardi, F, and Mortini, Pietro
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Adult ,Intracranial Arteriovenous Malformations ,Male ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Prognostic factors ,Radiosurgery ,Predictive Value of Tests ,medicine ,Humans ,Neuroradiology ,medicine.diagnostic_test ,Gamma Knife ,business.industry ,Magnetic resonance imaging ,Interventional radiology ,AVM ,Middle Aged ,Prognosis ,Magnetic Resonance Imaging ,Cerebral Angiography ,Predictive value of tests ,Female ,Surgery ,Neurology (clinical) ,Neurosurgery ,Nuclear medicine ,business ,Cerebral angiography - Abstract
"Background: The reported AVMs obliteration rate after Gamma Knife radiosurgery (GKS) ranges from 70 to 94 %. The objective of the present study was to assess prognostic factors predictive for cerebral AVMs obliteration in 127 patients who underwent GKS. Methods: The AVMs were classified according to the Spetzler-Martin classification. Twenty-one cases (16.5 %) were classified as grade I, 46 cases (36.2 %) as grade II, 51 cases (40.1 %) as grade III, and nine cases (7.1 %) as grade IV-V. The AVMs were deeply located in 16.5 % of patients. The peripheral prescription dose ranged from 16 to 30 Gy (mean 22.3 Gy). The AVMs volume ranged from 0.1 to 13 cc (mean 2.7 cc). Results: In 72 patients out of the 104 (69.2 %) with a radiological follow-up, MRI showed the AVM obliteration; in 54 cases (60 %) out of the 90 that performed a DSA, a complete AVM obliteration was achieved (average closure time 48.5 months). The volume of the nidus (p = 0.001), the prescription dose (p = 0.004), the 2002 Pollock-Flickinger classification (p = 0.031), and their 2008 revised classification (p = 0.025) were found to be statistically significant in predicting the probability of AVM closure. In the multivariate analysis, only the prescription dose was found to be an independent prognostic factor (p = 0.009) for AVM obliteration. Conclusions: The volume of the nidus and the prescription dose significantly influence the outcome of radiosurgical treatment. The Pollock-Flickinger classification was found to be a reliable scoring system in predicting the AVM closure and an important tool for selection of patients candidate for GKS. © 2013 Springer-Verlag Wien."
- Published
- 2013
29. The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma
- Author
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S, Gallina, F, Sireci, F, Lorusso, D V, DI Benedetto, R, Speciale, D, Marchese, C, Costantino, G, Napoli, V, Tessitore, D, Cucco, A, Leone, G, Bonaventura, M L, Uzzo, G F, Spatola, Gallina, S., Sireci, F., Lorusso, F., Di Benedetto, D., Speciale, R., Marchese, D., Costantino, C., Napoli, G., Tessitore, V., Cucco, D., Leone, A., Bonaventura, G., Uzzo, M., and Spatola, G.
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Adult ,Aged, 80 and over ,Male ,Leptin ,Settore BIO/17 - Istologia ,digestive, oral, and skin physiology ,Neuropeptides ,Otorhinolaryngology2734 Pathology and Forensic Medicine ,Middle Aged ,Prognosis ,Immunohistochemistry ,Malignancy recurrence ,Predictive Value of Tests ,Carcinoma, Squamous Cell ,Humans ,Laryngeal carcinoma ,Neoplasm Recurrence, Local ,Laryngeal Neoplasms ,Aged ,Head and Neck - Abstract
Leptin is a peptide that plays a key role in the control of satiety, energy expenditure, food intake and various reproductive processes. In the last years, the expression of leptin had been found in malignant cells of various origins. The aim of this study is to evaluate leptin expression in human laryngeal squamous cell carcinoma (SCC) and to investigate its possible role in predicting prognosis. Leptin expression was determined by immunohistochemistry in pathological and healthy tissue specimens from 24 patients with laryngeal SCC. Specimens were stained with an anti-leptin antibody. All measurements were performed using a computer-based image analysis system and scale of staining intensity was determined. All tumoural specimens showed significant immunoreactivity for leptin compared to healthy tissues (p ≤ 0.05), but showed different immunoreactivity that was related to clinicopathological features. High leptin expression was not significantly related with TNM, histological grading (HG) or advanced (III and IV) clinical stage (p0.05). Recurrence of malignancy was found to be significantly related with high expression of leptin by Spearman's rank correlation test (r = 0.59; p = 0.002), Fisher's test (p = 0.017) and Kaplan- Meier product-limit estimate (Log-rank test, p ≤ 0.05). In particular, multivariate logistic regression analysis showed that recurrences were significantly related with nodal involvement, HG and leptin expression (p ≤ 0.05). These preliminary results suggest that leptin may be a valuable parameter for predicting prognosis in laryngeal SCC.La leptina è un peptide che svolge un ruolo chiave nel controllo della sazietà, del dispendio energetico, dell'assunzione di cibo, e in vari processi riproduttivi. Negli ultimi anni, la leptina è stata trovata espressa nelle cellule maligne di varia origine. Lo scopo di questo studio è quello di valutare l'espressione di leptina nel carcinoma a cellule squamose della laringe umana (SCC) e di ricercare un suo possibile ruolo prognostico. L'espressione di leptina è stata determinata mediante immunoistochimica in campioni di tessuto patologico e sano di 24 pazienti con SCC laringea. I campioni sono stati colorati con anticorpo monoclonale anti-leptina. La valutazione dell'espressione immunoistochimica è stata eseguita da un sistema computerizzato che analizzava le immagini e stabiliva una scala di intensità di colorazione. Tutti i campioni tumorali esaminati hanno mostrato immunoreattività significativa per la leptina rispetto ai tessuti sani (p ≤ 0,05), ma è stata mostrata una diversa correlazione tra immunoreattività e caratteristiche clinico-patologiche. L'alta espressione della leptina non è correlata in modo statisticamente significativo con stadiazione TNM, grading istologico (HG) e stadio clinico avanzato (p0,05). L'insorgenza di recidive è risultata significativamente correlata con alta espressione di leptina tramite il test di correlazione di Spearman (r = 0,59, p = 0,002), test di Fisher (p = 0,017) e analisi di Kaplan-Meier (log-rank test, p ≤ 0,05). In particolare, l'analisi di regressione logistica multivariata ha dimostrato che le recidive erano significativamente correlate con il coinvolgimento linfonodale (N), HG e l'espressione di leptina (p ≤ 0,05). I nostri risultati preliminari suggeriscono che la leptina può essere un utile parametro prognostico.
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- 2015
30. Comparative analysis of Hsp10 and Hsp90 in large bowel healthy mucosa and adenocarcinomas
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francesca rappa, Lo Bello, M., Celeste Caruso Bavisotto, Antonella Marino Gammazza, Claudia Campanella, David, Sabrina, Sciume, C., Zarcone, F., Girolamo Geraci, Giuseppe Modica, francesco carini, GIOVANNI TOMASELLO, Bellavia, M., Uzzo, Maria Laura, Spatola, Giovanni Francesco, Bonaventura, Giuseppe, Leone, Angelo, Damiani, P., Buccheri, F., Gerbino, Aldo, Felicia Farina, Francesco Cappello, Rappa F., Lo Bello M., Caruso Bavisotto C., Marino Gammazza A., Campanella C., David S., Sciume C., Zarcone F., Geraci G., Modica G., Carini F., Tomasello G., Bellavia M., Uzzo M.L., Spatola G., Bonaventura G., Leone A., Damiani P., Buccheri F., Gerbino A., Farina F., Cappello F., Rappa, F, Lo Bello, M, Caruso Bavisotto, C, Marino Gammazza, A, Campanella, C, David, S, Sciumé, C, Zarcone, F, Geraci, G, Modica, G, Carini, F, Tomasello, G, Bellavia, M, Uzzo, ML, Spatola, G, Bonaventura, G, Leone, A, Damiani, P, Bucchieri, F, Gerbino, A, Farina, F, and Cappello, F
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Hsp10 ,adenocarcinomas ,Hsp90 ,large bowel mucosa - Abstract
Heat shock proteins (Hsps) are an important class of molecules with various functions. Their classic role is to assist other proteins in folding and re-folding and, when proteins are defective or irreversibly misfolded, to drive their degradation. For this reason, some Hsps are also named molecular chaperones. During evolution, this class of proteins has also acquired extrachaperoning roles such as participation in immune system regulation, cell differentiation, programmed cell death and carcinogenesis. Hsp10 is a partner of Hsp60 in the Hsp60/10 folding machine, but numerous scientific studies have shown that Hsp10 may also play other roles. In fact, Hsp10 seems to have an immunomodulatory activity and a role in tumor progression. Hsp90 regulates late-stage maturation, activation and stability of a range of client proteins, such as HER2, EGFR and BRAF, some of which are involved in signal transduction and other key pathways important for malignancy in several cancers, including large bowel carcinomas. The aim of the present study was to evaluate levels and expression of Hsp10 and Hsp90 in a series of samples of large bowel mucosa obtained from healthy controls and patients with adenocarcinomas.
31. Results of Gamma Knife Radiosurgery in Acromegaly
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Piero Picozzi, Giorgio Spatola, Pietro Mortini, Marco Losa, Alberto Franzin, Franzin, A, Spatola, G, Losa, M, Picozzi, P, and Mortini, Pietro
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medicine.medical_specialty ,lcsh:RC648-665 ,Article Subject ,Adenoma ,Endocrine and Autonomic Systems ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gamma knife radiosurgery ,Debulking ,medicine.disease ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Radiosurgery ,Surgery ,Endocrinology ,Somatostatin ,Acromegaly ,Hypoadrenalism ,medicine ,Clinical Study ,In patient ,business - Abstract
Objective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital.Methods. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009. The mean age at treatment was 42.3 years (range 22–67 yy). 103 acromegalic patients participated in the study. The median follow-up was 71 months (IQ range 43–107). All patients were treated with GK for residual or recurrent GH-secreting adenoma.Results. Sixty-three patients (61.2%) reached the main outcome of the study. The rate of remission was 58.3% at 5 years (95% CI 47.6–69.0%). Other 15 patients (14.6%) were in remission after GK while on treatment with somatostatin analogues. No serious side effects occurred after GK. Eight patients (7.8%) experienced a new deficit of pituitary function. New cases of hypogonadism, hypothyroidism, and hypoadrenalism occurred in 4 of 77 patients (5.2%), 3 of 95 patients (3.2%), and 6 of 100 patients at risk (6.0%), respectively.Conclusion. In a highly selected group of acromegalic patients, GK treatment had good efficacy and safety.
- Published
- 2012
32. Evaluation of hearing function after Gamma Knife surgery of vestibular schwannomas
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Pietro Mortini, Marzia Medone, Alberto Franzin, Giorgio Spatola, Paola Castellazzi, Carlo Serra, Piero Picozzi, Davide Milani, Franzin, A, Spatola, G, Serra, C, Picozzi, P, Medone, M, Milani, D, Castellazzi, P, and Mortini, Pietro
- Subjects
Gamma-knife surgery ,Adult ,Male ,medicine.medical_specialty ,Radiosurgery ,Postoperative Complications ,otorhinolaryngologic diseases ,medicine ,Humans ,Longitudinal Studies ,Neurofibromatosis ,Hearing Loss ,Survival rate ,Neuroradiology ,Aged ,medicine.diagnostic_test ,business.industry ,Hearing Tests ,Age Factors ,Auditory Threshold ,General Medicine ,Neuroma, Acoustic ,Middle Aged ,Neuroma ,medicine.disease ,Prognosis ,Surgery ,Tumor Burden ,Survival Rate ,Treatment Outcome ,Vestibular Schwannomas ,Audiometry, Pure-Tone ,Female ,Neurology (clinical) ,Radiology ,Audiometry ,Hearing function ,business ,Follow-Up Studies - Abstract
Object Due to technological advances in neuroradiology in recent years, incidental diagnoses of vestibular schwannomas (VSs) have increased. The aim of this study was to evaluate the hearing function after treatment with Gamma Knife surgery (GKS) for VSs in patients adequately selected with “good” or “useful” hearing before treatment and to assess the possible predictive factors for hearing function preservation. Methods Of all patients treated in the authors' hospital between 2001 and 2007, they retrospectively studied 50 patients with a unilateral VS in whom there was serviceable hearing (Gardner-Robertson [GR] Class I or II). Additional inclusion criteria were: no Type 2 neurofibromatosis, no previous treatment, and at least 6 months' follow-up of neuroradiological and audiological data. The median patient age was 54 years (range 24–78 years). The median tumor volume was 0.73 ml (range 0.03–6.6 ml), and the median radiation dose to the tumor margin was 13 Gy (range 12–16 Gy) with an isodose of 50%. Results Patient age, tumor volume, and presenting symptoms were found to correlate with hearing function. At a median of 36 months after radiosurgery, tumor growth control was 96% and no patient required any other additional treatment. Serviceable hearing was preserved in 34 patients (68%): 21 (62%) with GR Class I hearing and 13 (38%) with GR Class II hearing. The remaining 16 patients had poor hearing function:15 with GR Class III and 1 with GR Class IV hearing function. In 19 (58%) of 33 patients with GR Class I function before GKS the same class was maintained posttreatment; 29 (88%) maintained functional hearing (GR Class I or II). In all patients with an intracanalicular lesion, functional hearing was maintained. Significant prognostic factors for maintaining serviceable hearing were GR Class I function before treatment, symptoms at presentation, patient age younger than 54 years, and Koos Stage T1 disease. Conclusions The results of the study show that the probability of preserving functional hearing in patients undergoing GKS treatment for unilateral VSs is very high. Patients with GR Class I, age younger than 54 years, with presenting symptoms other than hearing loss, and a Koos Stage T1 tumor have better prognosis. The prescribed dose of 13 Gy appears to represent an excellent compromise between controlling the disease and preserving auditory function.
- Published
- 2009
33. Il controllo nitrossidergico e peptidergico della secrezione salivare nella parotide di alcuni mammiferi
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BONAVENTURA, Giuseppe, SPATOLA, Giovanni Francesco, UZZO, Maria Laura, MANDRACCHIA R, BONAVENTURA G, MANDRACCHIA R, SPATOLA G, and UZZO, ML
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nitrossidergico e peptidergico - Published
- 2006
34. Immunhistochemical studies on leptin, ghrelin, orexin and orphanin fq expression in the stomach of obese (fa/fa)zucker rats
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TESSITORE, Vincenzo, UZZO, Maria Laura, SPATOLA, Giovanni Francesco, BONAVENTURA, Giuseppe, CUCCO D, TESSITORE V, UZZO, ML, SPATOLA G, CUCCO D, and BONAVENTURA G
- Published
- 2006
35. White matter changes after Gamma Knife Capsulotomy in patients with intractable obsessive-compulsive disorder.
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Spatola G, Triebkorn P, Richieri R, Baunez C, Farisse J, Cretol A, Guedj E, Jirsa V, and Regis J
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Background: Anterior capsulotomy is one of the therapeutic options for refractory obsessive-compulsive disorder (OCD). Safety and efficacy of Gamma Knife Capsulotomy (GKC) have been demonstrated in the past., Objective: To characterize changes induced by GKC using a fixel-based analysis (FBA) and possible predictors of efficacy., Methods: Patients with OCD refractory to other therapies underwent bilateral GKC with 120 Gy as a maximum dose on the anterior limb of the internal capsule (ALIC). The clinical outcome was percent reduction in Yale- Brown Obsessive-Compulsive Scale (Y-BOCS). White Matter changes were analyzed using fixel-based analysis (FBA) for fibre density (FD), fibre-bundle cross-section (FC) and the combination of the two (FDC)., Results: Seven patients underwent GKC. Median follow-up was 13 months (range 12-58 months). Mean (±SD) decrease in Y-BOCS score at last follow-up was 61 % ± 35 % with five patients considered as responders. FBA showed a symmetric FD reduction in the ALIC with extension to the anterior fronto-thalamic radiation; a reduction of FC along the superior longitudinal fasciculus (SLF) in both hemispheres with a predominance in the left one. Reductions in FDC were detected predominantly in the right hemisphere, with a similar pattern to FD reductions and associated with a positive correlation (p < 0.05) between Y-BOCS reduction and fibres passing in the ventral part., Conclusions: GKC is safe and efficient in reducing OCD severity in selected patients. Changes induced in white matter by GKC extend over the ALIC. Reduction of fibres passing the ventral part of the right sided ALIC correlates with better results., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Jirsa Viktor reports financial support was provided by 10.13039/100007586Aix-Marseille University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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36. The "Dry-Lab" Side of Food Authentication: Benchmark of Bioinformatic Pipelines for the Analysis of Metabarcoding Data.
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Spatola G, Giusti A, and Armani A
- Abstract
Next Generation Sequencing Technologies (NGS), particularly metabarcoding, are valuable tools for authenticating foodstuffs and detecting eventual fraudulent practices such as species substitution. This technique, mostly used for the analysis of prokaryotes in several environments (including food), is in fact increasingly applied to identify eukaryotes (e.g., fish, mammals, avian, etc.) in multispecies food products. Besides the "wet-lab" procedures (e.g., DNA extraction, PCR, amplicon purification, etc.), the metabarcoding workflow includes a final "dry-lab" phase in which sequencing data are analyzed using a bioinformatic pipeline (BP). BPs play a crucial role in the accuracy, reliability, and interpretability of the metabarcoding results. Choosing the most suitable BP for the analysis of metabarcoding data could be challenging because it might require greater informatics skills than those needed in standard molecular analysis. To date, studies comparing BPs for metabarcoding data analysis in foodstuff authentication are scarce. In this study, we compared the data obtained from two previous studies in which fish burgers and insect-based products were authenticated using a customizable, ASV-based, and command-line interface BP (BP1) by analyzing the same data with a customizable but OTU-based and graphical user interface BP (BP2). The final sample compositions were compared statistically. No significant difference in sample compositions was highlighted by applying BP1 and BP2. However, BP1 was considered as more user-friendly than BP2 with respect to data analysis streamlining, cost of analysis, and computational time consumption. This study can provide useful information for researchers approaching the bioinformatic analysis of metabarcoding data for the first time. In the field of food authentication, an effective and efficient use of BPs could be especially useful in the context of official controls performed by the Competent Authorities and companies' self-control in order to detect species substitution and counterfeit frauds.
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- 2024
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37. Novel foods, old issues: Metabarcoding revealed mislabeling in insect-based products sold by e-commerce on the EU market.
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Giusti A, Spatola G, Mancini S, Nuvoloni R, and Armani A
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- Humans, Animals, RNA, Ribosomal, 16S genetics, Commerce, Insecta, Snacks, Agammaglobulinemia
- Abstract
Insects intended for human consumption are considered Novel Foods according to EU legislation. marketed in form of powders, bars, snacks are increasingly available on the EU market, especially on e-commerce. The commercial form and the way of distribution make IBPs particularly prone to mislabeling. Literature concerning the mislabeling occurrence in IBPs is extremely scarce. In this study, 46 processed IBPs were collected on nine EU e-commerce platforms (e-CO) to be authenticated by metabarcoding. A 200 bp region from 16S rRNA gene was used as molecular target. Sequencing data were processed using DADA2 R package, and sequences were taxonomically assigned through BLAST analysis against GenBank. Procedural blanks and positive controls were included in the analysis, and threshold values were established to filter the final data. The mislabeling rate (i. e. the mismatch between the species declared on the IBP label and the species identified by metabarcoding) was calculated. Overall, a high mislabeling rate (33.3 %) was observed, although this percentage is influenced by the e-CO platform and the insect species, with A. domesticus particularly involved. The use of species not listed in authorized Novel Food (e. g. Gryllus locorojo), and/or the partial replacement of high value species with lower value species was highlighted for the first time in processed IBPs. The presence of insect pests was also detected. Metabarcoding was confirmed as an effective tool for IBPs authentication. Also, outcomes from this study can provide useful data on the main issues involving the EU IBPs' market, that can represent an incentive to reinforce both official controls and FBO's self-controls on these poorly investigated products., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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38. Effects of the COVID-19 Pandemic on Everyday Neurosurgical Practice in Alsace, France: Lessons Learned, Current Perspectives, and Future Challenges-Preliminary Results of a Longitudinal Multicentric Study Registry.
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Dannhoff G, Mallereau CH, Ganau M, Carangelo BR, Spatola G, Todeschi J, Prisco L, Maduri R, Santin MDN, Woelffel S, Mastrobuono I, Voirin J, Moruzzi F, Nannavecchia B, Muzii VF, Zalaffi A, Bruno C, and Chibbaro S
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- Humans, SARS-CoV-2, Pandemics, Longitudinal Studies, Prospective Studies, Neurosurgical Procedures methods, Communicable Disease Control, France epidemiology, COVID-19 epidemiology
- Abstract
Background and Objectives : The global outbreak caused by the SARS-CoV-2 pandemic disrupted healthcare worldwide, impacting the organization of intensive care units and surgical care units. This study aimed to document the daily neurosurgical activity in Alsace, France, one of the European epicenters of the pandemic, and provide evidence of the adaptive strategies deployed during such a critical time for healthcare services. Materials and Methods : The multicentric longitudinal study was based on a prospective cohort of patients requiring neurosurgical care in the Neurosurgical Departments of Alsace, France, between March 2020 and March 2022. Surgical activity was compared with pre-pandemic performances through data obtained from electronic patient records. Results : A total of 3842 patients benefited from care in a neurosurgical unit during the period of interest; 2352 of them underwent surgeries with a wide range of pathologies treated. Surgeries were initially limited to neurosurgical emergencies only, then urgent cases were slowly reinstated; however, a significant drop in surgical volume and case mix was noticed during lockdown (March-May 2020). The crisis continued to impact surgical activity until March 2022; functional procedures were postponed, though some spine surgeries could progressively be performed starting in October 2021. Various social factors, such as increased alcohol consumption during the pandemic, influenced the severity of traumatic pathologies. The progressive return to the usual profile of surgical activity was characterized by a rebound of oncological interventions. Deferrable procedures for elective spinal and functional pathologies were the most affected, with unexpected medical and social impacts. Conclusions : The task shifting and task sharing approaches implemented during the first wave of the pandemic supported the reorganization of neurosurgical care in its aftermath and enabled the safe and timely execution of a broad spectrum of surgeries. Despite the substantial disruption to routine practices, marked by a significant reduction in elective surgical volumes, comprehensive records demonstrate the successful management of the full range of neurosurgical pathologies. This underscores the efficacy of adaptive strategies in navigating the challenges imposed by the largest healthcare crisis in recent history. Those lessons will continue to provide valuable insights and guidance for health and care managers to prepare for future unpredictable scenarios.
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- 2024
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39. The Effect of Titanium Anodization on the Bond Strength of 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) Resin Cement.
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Bömicke W, Rammelsberg P, Spatola G, and Rues S
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- Titanium, Surface Properties, Methacrylates chemistry, Water chemistry, Materials Testing, Zirconium chemistry, Dental Stress Analysis, Tensile Strength, Resin Cements chemistry, Dental Bonding
- Abstract
Purpose: To examine the effects of anodization and different surface modifications of titanium on bond strength to 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) resin cement., Materials and Methods: Grade 5 titanium alloy disks (n = 160) were assigned to one of five prebonding surface treatment study groups (polished; polished and anodized; polished, etched, and anodized; sandblasted; sandblasted and anodized). Disks were adhesively bonded with 10-MDP resin cement (Panavia 21; bonding area: 3.3 mm in diameter) to composite resin cylinders. In each study group, tensile bond strength tests were conducted after 24 ± 1 hours and after 6 months (180 ± 2 days) of water storage (n = 16 specimens per water storage subgroup). Debonded specimens were stereomicroscopically analyzed to determine their fracture mode. Statistics included one-way and multifactorial ANOVA and Tukey post hoc tests (α = .05)., Results: Anodization and water storage did not significantly (P ≥ .389) affect tensile bond strength. Although subgroups of polished samples had significantly (P ≤ .031) lower bond strengths (subgroup mean values: 20 to 26 MPa) than etched or sandblasted samples (subgroup mean values: 29 to 33 MPa), they nonetheless exceeded the empirical threshold of 10 MPa used as a criterion for clinical recommendation. The fracture mode of all test specimens was predominantly cohesive., Conclusions: Anodization of titanium surfaces can be performed without weakening the adhesion of 10-MDP-based resin cement to titanium.
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- 2023
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40. Second Cancer Affecting the Central Nervous System: Systematic Literature Review Exploring the Link Between Malignant Melanoma and Glioblastoma.
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Todeschi J, Dannhoff G, Chibbaro S, Segbedji F, Spatola G, Mallereau CH, Noel G, Schott R, Lhermitte B, Cebula H, and Ganau M
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- Humans, Aged, Central Nervous System, Skin pathology, Glioblastoma diagnostic imaging, Glioblastoma surgery, Glioblastoma pathology, Melanoma complications, Melanoma surgery, Neoplasms, Second Primary, Brain Neoplasms diagnostic imaging, Brain Neoplasms surgery, Brain Neoplasms pathology
- Abstract
Background: Glioblastoma (GBM) is a malignant primary brain cancer, among the most devastating and lethal diseases of the central nervous system. Similarly, malignant melanoma (MM) is responsible for most skin cancer-related deaths. A link between those 2 aggressive cancers has not yet been established. We present here a systematic review of the literature and an exemplificative case., Methods: A systematic review of the literature was conducted to assess possible commonalities between MM and GBM. An exemplificative surgical vignette of a 73-year-old patient with the occurrence of a frontobasal GBM after surgical removal of a metastasis of MM in the same location was then detailed., Results: Fifteen studies published in the English international literature support a link between MM and GBM, both based on epidemiologic and pathophysiologic/genetic aspects. This theory is reinforced by our surgical vignette of a collision tumor with the occurrence of both tumors in the same location several years apart., Conclusions: The evidence reported in the literature, as well as our surgical vignette, support a likely link between the pathogenesis of GBM and MM., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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41. Approaching Intradural Lesions of the Anterior Foramen Magnum and Craniocervical Junction: Anatomical Comparison of the Open Posterolateral and Anterior Extended Endonasal Endoscopic Approaches.
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Dannhoff G, Gallinaro P, Todeschi J, Ganau M, Spatola G, Ollivier I, Cebula H, Mallereau CH, Baloglu S, Pop R, Proust F, and Chibbaro S
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Background: Lesions of the foramen magnum (FM) and craniocervical junction area are traditionally managed surgically through anterior, anterolateral, and posterolateral skull-base approaches. This anatomical study aimed to compare the usefulness of a modified extended endoscopic approach, the so-called far-medial endonasal approach (FMEA), versus the traditional posterolateral far-lateral approach (FLA)., Methods: Ten fixed silicon-injected heads specimens were used in the Skull Base ENT-Neurosurgery Laboratory of the University Hospital of Strasbourg, France. A total of 20 FLAs and 10 FMEAs were realized. A high-resolution computed tomography scan was performed for quantitative analysis of the different approaches. The analysis aimed to estimate the extent of surgical exposure and freedom of movement (maneuverability) through the operating channel using a polygonal surface model to obtain a morphometric estimation of the area of interest (surface and volume) on postdissection computed tomography scans using Slicer 3D software., Results: FMEA allows for a more direct route to the anterior FM, with wider brainstem exposure compared with the FLA and an excellent visualization of all anterior midline structures. The limitations of the FMEA include the deep and narrow surgical corridor and difficulty in reaching lesions located laterally over the jugular foramen and hypoglossal canal., Conclusions: The FMEA and FLA are both effective surgical routes to reach FM and craniocervical junction lesions. Modern skull base surgeons should have a good command of both because they appear complementary. This anatomical study provides the tools for comprehensive preoperative evaluations and selection of the most appropriate surgical approach., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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42. Primary sellar melanocytoma: report of two cases treated at the same institution and their long-term outcome.
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Albano L, Losa M, Spatola G, Panni P, Terreni MR, Barzaghi LR, and Mortini P
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- Adult, Female, Humans, Male, Middle Aged, Combined Modality Therapy, Magnetic Resonance Imaging, Skull, Adenoma surgery, Pituitary Neoplasms diagnostic imaging, Pituitary Neoplasms surgery
- Abstract
Sellar melanocytomas represent a small subgroup of primary melanocytic tumors arising from leptomeningeal melanocytes. They are benign, slow-growing tumors with a high risk of recurrence. We report two cases of sellar melanocytoma treated at the same institute. A 35-year-old woman presented with amenorrhea and an intrasellar mass with suprasellar extension simulating a hemorrhagic pituitary adenoma. The second case is a 51-year-old man with progressive visual loss and a recurrence of primary sellar and suprasellar melanocytoma. The first patient underwent gross total resection and the second patient underwent subtotal resection. Neither of them was treated with postoperative adjuvant therapies. The second patient had tumor regrowth 75 months after surgery; he therefore underwent gamma knife radiosurgery. Both patients are alive and well at the last follow-up (140 and 93 months, respectively).
- Published
- 2023
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43. Radioactive contamination in feral dogs in the Chernobyl exclusion zone: Population body-burden survey and implications for human radiation exposure.
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Hecla J, Kambarian E, Tubbs R, McKinley C, Berliner AJ, Russell K, Spatola G, Chertok J, Braun W, Hank N, Marquette C, Betz J, Paik T, Chenery M, Cagan A, Willis C, and Mousseau T
- Subjects
- Humans, Dogs, Animals, Body Burden, Cesium Radioisotopes adverse effects, Cesium Radioisotopes analysis, Nuclear Power Plants, Ukraine, Chernobyl Nuclear Accident, Radioactive Hazard Release, Radiation Exposure adverse effects, Food Contamination, Radioactive analysis, Radiation Monitoring methods
- Abstract
This report describes a two-year effort to survey the internal 137Cs and external β-emitter contamination present in the feral dog population near the Chernobyl nuclear power plant (ChNPP) site, and to understand the potential for human radiation exposure from this contamination. This work was performed as an integral part of the radiation safety and control procedures of an animal welfare oriented trap-neuter-release (TNR) program. The measurement program focused on external contamination surveys using handheld β-sensitive probes, and internal contamination studies using a simple whole-body counter. Internal 137Cs burden was measured non-invasively during post-surgical observation and recovery. External β contamination surveys performed during intake showed that 21/288 animals had significant, removable external contamination, though not enough to pose a large hazard for incidental contact. Measurements with the whole-body counter indicated internal 137Cs body burdens ranging from undetectable (minimum detection level ∼100 Bq/kg in 2017, ∼30 Bq/kg in 2018) to approximately 30,000 Bq/kg. A total of 33 animals had 137Cs body-burdens above 1 kBq/kg, though none posed an external exposure hazard. The large variation in the 137Cs concentration in these animals is not well-understood, could be due to prey selection, access to human food scraps, or extended residence in highly contaminated areas. The small minority of animals with external contamination may pose a contamination risk allowing exposures in excess of regulatory standards., Competing Interests: RT was employed by the company Tubbs Nuclear Consulting (and likewise volunteered his time). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2023 Hecla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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44. Pituitary Abscess: A Challenging Preoperative Diagnosis-A Multicenter Study.
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Mallereau CH, Todeschi J, Ganau M, Cebula H, Bozzi MT, Romano A, Le Van T, Ollivier I, Zaed I, Spatola G, Nannavecchia B, Mahoudeau P, Djennaoui I, Debry C, Signorelli F, Ligarotti GKI, Pop R, Baloglu S, Fasciglione E, Goichot B, Bund C, Gaudias J, Proust F, and Chibbaro S
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- Humans, Abscess, Pituitary Gland pathology, Headache, Magnetic Resonance Imaging, Pituitary Diseases complications, Pituitary Diseases diagnosis, Pituitary Diseases surgery, Pituitary Neoplasms complications, Pituitary Neoplasms diagnosis, Pituitary Neoplasms surgery
- Abstract
Background and Objectives: Pituitary abscess (PA) is a rare occurrence, representing less than 1% of pituitary lesions, and is defined by the presence of an infected purulent collection within the sella turcica. Pas can be classified as either primary, when the underlying pituitary is normal prior to infection, or secondary, when there is associated a pre-existing sellar pathology (i.e., pituitary adenoma, Rathke's cleft cysts, or craniopharyngioma), with or without a recent history of surgery. Preoperative diagnosis, owing to both non-specific symptoms and imaging features, remains challenging. Treatment options include endonasal trans-sphenoidal pus evacuation, as well as culture and tailored antibiotic therapy. Methods: A retrospective multicenter study, conducted on a prospectively built database over a 20-year period, identified a large series of 84 patients harboring primary sellar abscess. The study aimed to identify crucial clinical and imaging features in order to accelerate appropriate management. Results : The most common clinical presentation was a symptom triad consisting of various degrees of asthenia (75%), visual impairment (71%), and headache (50%). Diagnosis was achieved in 95% of cases peri- or postoperatively. Functional recovery was good for visual disturbances and headache. Pituitary function recovery remained very poor (23%), whereas the preoperative diagnosis represented a protective factor. Conclusions : In light of the high prevalence of pituitary dysfunction following the management of PAs, early diagnosis and treatment might represent a crucial issue. Currently, there are no standard investigations to establish a conclusive preoperative diagnosis; however, new, emerging imaging methods, in particular nuclear imaging modalities, represent a very promising tool, whose potential warrants further investigations.
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- 2023
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45. Post Surgical Management of WHO Grade II Meningiomas: Our Experience, the Role of Gamma Knife and a Literature Review.
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Migliorati K, Spatola G, Giudice L, de Graaf N, Bassetti C, Giorgi C, Fontanella M, Vivaldi O, Bignardi M, and Franzin A
- Abstract
Purpose: Grade II meningiomas are rarer than Grade I, and when operated on, bear a higher risk of local recurrence, with a 5-year progression free survival (PFS) ranging from 59 to 90%. Radiotherapy (RT) or radiosurgery, such as Gamma Knife radiosurgery (GKRS) can reduce the risk of relapse in patients with residual disease, even if their role, particularly after gross total resection (GTR), is still under debate. Main goal of this study was to compare the outcomes of different post-surgical management of grade II meningiomas, grouped by degree of surgical removal (Simpson Grade); next in order we wanted to define the role of GKRS for the treatment of residual disease or relapse. Methods: from November 2016 to November 2020 all patients harboring grade II meningiomas, were divided into three groups, based on post-surgical management: (1) wait and see, (2) conventional adjuvant radiotherapy and (3) stereotactic GKRS radiosurgery. Relapse rate and PFS were registered at the time of last follow up and results were classified as stable, recurrence next to or distant from the surgical cavity. In the second part of the study we collected data of all patients who underwent GKRS in our Centers from November 2017 to November 2020. Results: A total of 37 patients were recruited, including seven patients with multiple meningiomas. Out of 47 meningiomas, 33 (70.2%) were followed with a wait and see strategy, six (12.7%) were treated with adjuvant radiotherapy, and 8 patients (17.0%) with adjuvant GKRS. Follow up data were available for 43 (91.4%) meningiomas. Within the wait and see group, recurrence rates differed based on Simpson grades, lower recurrence rates being observed in three Simpson I cases (30%) compared to twelve relapses (60%) in patients with Simpson grade II/III. Finally, out of the 24 meningiomas undergoing GKRS (8 residual and 16 recurrence), 21 remained stable at follow up. Conclusions : Gross total resection (GTR) Simpson II and III have a significantly worse outcome as compared to Simpson I. The absence of adjuvant treatment leads to significant worsening of the disease progression curve. Adjuvant radiotherapy, especially GKRS, provides good local control of the disease and should be considered as an adjuvant treatment in all cases where Simpson I resection is not possible.
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- 2022
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46. Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review.
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Ganau M, Zaed I, Todeschi J, Prisco L, Cebula H, Bruno C, Spatola G, Ligarotti GKI, Alessandrello R, Fricia M, Romano A, Pop R, Baloglu S, Savarese L, Scibilia A, Nannavecchia B, Proust F, and Chibbaro S
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- Aged, Cerebral Ventricles, Female, Humans, Male, Multicenter Studies as Topic, Retrospective Studies, Treatment Outcome, Hydrocephalus, Lymphoma, Neuroendoscopy
- Abstract
Introduction: To date, confined intra-ventricular localization of primary central nervous system lymphoma (PCNSL) has been usually managed with open surgical resection and/or stereotactic biopsy; nonetheless, the endoscopic approach to such localization can provide many advantages over standard microsurgery and/or stereotactic biopsy. Here we present our experience in managing such a rare pathology through the endoscopic approach., Method: In order to gather more information about such a rare pathology, a retrospective multicentric study on a prospectively built database has been performed during a 5 year period. Ten different European centers have been involved., Results: A total of 60 patients, 25 women and 35 men, have been enrolled in the study. The mean age was 65.3 years. The mean lesion size was 40.3 mm. Among all selected patients, 40 (66.6%) had superficial lesions within the ventricle, whereas the remaining 20 (33.4%) had lesions involving/extending to deeper structures. All surgical procedures were uneventful and ETV was deemed necessary only in 20/60 cases., Conclusion: In our experience, endoscopic management of intraventricular PCNSL is an effective option. It should be considered after a careful examination of neurological and immunological status, alternative options for diagnostic sampling, location of the lesion, and presence or absence of hydrocephalus. Endoscopic management could be considered as a safe and minimally invasive option to obtain: (a) a biopsy sample of the lesion for further diagnostic workup, (b) CSF diversion through third ventriculostomy or VP shunt for the management of hydrocephalus, and (c) insertion of ventricular access devices for long term medical management and whenever necessary as a rescue option for ventricular tap., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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47. Upfront and Repeated Gamma-Knife Radiosurgery for Small (≤5 mL) Unruptured Brain Arteriovenous Malformation: A Cohort of 249 Consecutive Patients.
- Author
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Hak JF, Borius PY, Spatola G, Chopinet S, Testud B, Girard N, Brunel H, and Regis J
- Subjects
- Adult, Brain, Follow-Up Studies, Hemorrhage surgery, Humans, Retrospective Studies, Treatment Outcome, Intracranial Arteriovenous Malformations radiotherapy, Intracranial Arteriovenous Malformations surgery, Nervous System Malformations surgery, Radiosurgery adverse effects
- Abstract
Objective: According to A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA), conservative treatment seems to be superior to any intervention for unruptured brain arteriovenous malformations (AVMs). This study aims to evaluate safety and efficacy of upfront and repeated Gamma-Knife Radiosurgery (GKRS) in patients harboring small AVMs fulfilling the inclusion criteria of ARUBA., Methods: A retrospective study was conducted to evaluate outcomes of unruptured naive brain AVM with a volume ⩽ 5 mL eligible to ARUBA treated by GKRS with at least 3 years of follow-up., Results: From 1992 to 2014, 249 patients fulfilled the inclusion criteria of this study. The median age was 36 years (range: 18-78 years). The median treated volume of the nidus was 1.3 mL (range: 0.4-5 mL) and 63% of the AVM were in eloquent areas. Radiosurgery-based AVM score was 1-1.8 (76%), the Spetzler-Martin grade was II-III (73%), and the Virginia Radiosurgery AVM scale was ≤1 point (75%). The overall AVM obliteration rate was 77.1% after up to 3 GKRS sessions. The median dose at the margin was 24 Gy (15-25 Gy) and the median follow-up was 45 months (range: 36-205 months). Eight patients (3.2%) experienced hemorrhage after GKRS, corresponding to a post-GKRS hemorrhage annual rate of 1.03%. Permanent symptomatic radio-induced changes rate was 2% (4 increased seizures, 1 neurologic deficit)., Conclusions: The very low toxicity rate and the high occlusion rate suggest in favor of upfront and repeated GKRS for unruptured small AVMs (⩽5 mL)., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2022
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48. Odontoid Type II fractures in elderly: what are the real management goals and how to best achieve them? A multicenter European study on functional outcome.
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Chibbaro S, Mallereau CH, Ganau M, Zaed I, Teresa Bozzi M, Scibilia A, Cebula H, Ollivier I, Loit MP, Chaussemy D, Coca HA, Dannhoff G, Romano A, Nannavecchia B, Gubian A, Spatola G, Signorelli F, Iaccarino C, Pop R, Proust F, Baloglu S, and Todeschi J
- Subjects
- Aged, Aged, 80 and over, Female, Goals, Humans, Male, Quality of Life, Retrospective Studies, Treatment Outcome, Odontoid Process diagnostic imaging, Odontoid Process injuries, Odontoid Process surgery, Spinal Fractures diagnostic imaging, Spinal Fractures surgery
- Abstract
Odontoid fractures constitute the most common cervical fractures in elderly. External immobilization is the treatment of choice for Type I and III; there is still no wide consensus about the best management of Type II fractures. Observational multicenter study was conducted on a prospectively built database on elderly patients (> 75 years) with Type II odontoid fracture managed conservatively during the last 10 years. All patients underwent CT scan on admission and at 3 months; if indicated, selected patient had CT scan at 6 and 12 months. All patients were clinically evaluated by Neck Disability Index (NDI), Charlson Comorbidity Index (CCI), and American Society of Anaesthesiologists classification (ASA) on admission; NDI was assessed also at 6 weeks, 3, 6, 12, and 24 months; furthermore, a quality of life (QoL) assessment with the SF-12 form was performed at 3 and 12 months. Among the 260 patients enrolled, 177 (68%) were women and 83 (32%) men, with a median age of 83 years. Patients were followed up for a minimum of 24 months: 247 (95%) showed an excellent functional outcome within 6 weeks, among them 117 (45%) showed a good bony healing, whereas 130 (50%) healed in pseudo-arthrosis. The residual 5% were still variably symptomatic at 12 weeks; however, only 5 out of 13 (2% of the total cohort) required delayed surgery. This study showed that a conservative approach to odontoid Type II fracture in elderly is an effective and valid option, resulting in an excellent functional outcome (regardless of bony fusion) in the majority of cases. Failure of conservative treatment can be safely addressed with surgical fixation at a later stage., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2022
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49. Is Real-Time Inverse Planning Optimizing Dose to the Normal Brain? A Prospective Comparative Trial in a Series of Brain Metastases Treated by Stereotactic Radiosurgery.
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Beltaifa Y, Hamdi H, Spatola G, Balossier A, Merly L, Castillo L, Cretol A, and Regis J
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- Adult, Aged, Aged, 80 and over, Brain pathology, Humans, Middle Aged, Prospective Studies, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted methods, Young Adult, Brain Neoplasms radiotherapy, Brain Neoplasms surgery, Percutaneous Coronary Intervention, Radiosurgery methods
- Abstract
Background: Radiosurgery has demonstrated good safety and efficacy in the treatment of multiple brain metastases (BMs). However, multi-target dose planning can be challenging and time-consuming. A recently developed real-time inverse treatment planning (IP) by convex optimization has been demonstrated to produce high-quality treatment plans with good conformity and selectivity in single-target plans. We intended to test the capacity of this IP to rapidly generate efficient plans while optimizing the preservation of normal tissue in multiple BM., Methods: Seventy-nine patients (mean age 62.4, age range 22-85) with a total of 272 BMs were treated by Gamma Knife Radiosurgery. All subjects were treated using a forward planning (FP) technique by an expert neurosurgeon. The new Intuitive Plan was applied and able to automatically generate an alternative plan for each patient. All planning variables were collected from the IP to be compared with the corresponding measurements obtained from the FP. A paired sample t test was applied to compare the 2 plans for the following variables: brain volumes receiving 10 Gy (V10) (primary endpoint), and 12 Gy (V12), planning indices (selectivity, coverage, gradient, and Paddick Conformity Index [PCI]), beam-on time (BOT), and integral doses. Additionally, the noninferiority margin for each item was calculated, and the 2 plans were compared for noninferiority using a paired t test., Results: The mean age of patients was 62.4 years old (age range 22-85), with a sex ratio of 1.02. The average number of lesions per patient was 3.4 (range 1-12). The mean prescription dose was 21.46 Gy (range 14-24 Gy). Noninferiority of the IP was concluded for V10, V12, prescription isodose volume, BOT, PCI, and selectivity. The V10 (and V12) was significantly lower with the IP (p < 0.001). These volumes were 8.69 cm3 ± 11.39 and 5.47 cm3 ± 7.03, respectively, for the FP and 7.57 cm3 ± 9.44 and 4.78 cm3 ± 5.86 for the IP. Only the coverage was significantly lower with the IP (-2.3%, p < 0.001), but both selectivity (+17%) and PCI (+15%) were significantly higher with the IP than FP (p < 0.001)., Conclusion: This IP demonstrated its capacity to generate multi-target plans rapidly, with a dose to the brain (V10) and BOT noninferior to the one of a human expert planner. These results would benefit from confirmation in a larger prospective series., (© 2021 S. Karger AG, Basel.)
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- 2022
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50. Epileptic hypothalamic hamartomas impact of topography on clinical presentation and radiosurgical outcome.
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Hamdi H, Ferrante P, Spatola G, Clawson W, McGonigal A, Daquin G, Villeneuve N, Laguitton V, Bartolomei F, and Regis J
- Subjects
- Humans, Magnetic Resonance Imaging, Treatment Outcome, Epilepsy diagnostic imaging, Epilepsy etiology, Epilepsy surgery, Hamartoma complications, Hamartoma diagnostic imaging, Hamartoma surgery, Hypothalamic Diseases complications, Hypothalamic Diseases diagnostic imaging, Hypothalamic Diseases surgery, Radiosurgery methods
- Abstract
Introduction: Evidence exists for the role of the hypothalamic hamartoma's topography as a determinant for the clinical presentation. How the hamartoma relation to the hypothalamic structures can make clinical presentations, severity and surgery outcomes different from patient to patient is largely unknown. Our aim was to analyze the effect of fine anatomical topography on clinical spectrum and radiosurgery outcome., Methods: Forty-eight epileptic patients with hypothalamic hamartoma were treated by Gamma Knife Surgery and were reviewed for fine topography and morphology using magnetic resonance neuroimaging. We evaluated different topographic patterns; contact to prominent structures (the mammillary body, tuber cinereum and pituitary stalk), the degree of involvement within sagittally-oriented regions, (mammillary, tuberal, and supra optic) coronally-oriented zones (periventricular, medial, and lateral), lesion dimensions (length, width, and height),and volumes (total, intra-hypothalamic, and extra-hypothalamic volumes). This data were statistically analysed for correlation with all clinical variables and epilepsy surgery outcome. We reviewed all the classification protocols in the literature., Results: Focal onset impaired awareness seizures started at an earlier age of onset with larger hypothalamic hamartoma volume and dimensions. Lateral extension within the hypothalamus was associated with more severe epilepsy, higher seizure frequency, more severe psychiatric comorbidity, hetero-aggression, hyperkinesia, and school difficulties. Presence of precocious puberty was positively correlated to anterior-posterior extension; tuberal region involvement, hypothalamic hamartoma volume, and type III-VI. Larger hypothalamic hamartoma presented precocious puberty at an earlier age of onset. After Gamma Knife Surgery, epilepsy outcome was better and rapid when lesion is smaller. Post-radiosurgical transient increased seizures were present when the mammillary region was more involved., Conclusion: Clinical presentation of epileptic hypothalamic hamartoma is significantly affected by fine topography patterns and invaded hypothalamic areas. Gamma Knife Radiosurgery effect is better and rapid in smaller hamartoma (Type I-III) and seizure outcome was not affected by the invaded hypothalamic areas., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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