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1. The Rise and Fall of Human Oesophagostomiasis

Author

Polderman, A.M., primary, Eberhard, M., additional, Baeta, S., additional, Gasser, Robin B., additional, van Lieshout, L., additional, Magnussen, P., additional, Olsen, A., additional, Spannbrucker, N., additional, Ziem, J., additional, and Horton, J., additional

Published
2010
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5. Infections II

Author

Guillaume, C., Godard, J., Mohammedi, I., Vedrinne, J. M., Bui-Xuan, B., Reverdy, M. E., Motin, J., Bonten, M., Van Tiel, F., Gaillard, C., Stobberingh, E., Van Der Geest, S., Faurisson, F., Peytavin, G., Allaouchiche, B., Torres, A., Ferrer, M., Aznar, E., Gatell, J. M., El-Biary, M., Puig, J., Gonzalez, J., Rodriguez-Roisin, R., Gratadour, P., Mardiquian, N., Di Roio, C., Godard, J., Inglis T. J. J., Sherratt M. J., Sproat L. J., Gibson J. S., Hawkey P. M., Sirvent, J. M., Verdaguer, R., Ferrer, M. J., Carratalá, J., Armengol, J., Bonet, A., Nouira, S., Elatrous, S., Bchir, A., Jaafoura, M., Abroug, F., Bouchoucha, S., Holzapfel, L., Chastang, Cl., Blanc, P. L., Carton, M. J., Legras, A., Schoch, P., Moret, G., Boiteau, R., Timsit, J. F., Garrait, V., Misset, B., Goldstein, F. W., Dumay, M. F., Carlet, J., Seller, G., Nieto, J. M. Sánchez, Carrillo, A., Rubí, J. A. Gómez, Climent, C., Gómez, J. Ruiz, Sola, J., Vaury, F. W. G. Ph., Francoual, S., Marquette, Ch. -H., Hérengt, F., Saulnier, F., Mathieu, D., Nevierre, R., Courcol, R., Ramon, Ph., Meunier, G., Gaussorgues, P., Sab, J. M., Nageotte, A., Doré, P., Robert, R., Grollier, G., Rouffineau, J., Lanquetot, H., Charrière, J. M., Elsman, B. H. P., Legemate, D. A., van Leeuwen, M. S., Feldberg, M. A. H., Obertop, H., Carducci, P., Annetta, M. G., Mignani, V., Rumi, C., Clemente, A., Wrenger, K., Baier, J., Mortion, B., Torwesten, E., Finke, W., Neumann, H., Puchstein, C., Nys, M., Damas, P., Kleinschmidt, R., Wolf, C., Möller, H., Spannbrucker, N., Madl, C., Koppensteiner, R., Kramer, L., Kranz, A., Lenz, K., Ehringer, H., Antonelli, M., Lanore, J. J., Raponis, G. M., Dhainaut, J. F., Martino, P., Rosa, G., Mancinis, C., Segneri, M., D’Errico, R. R., Gaaparetto, A., Capellier, G., Balvay, P., Boillot, A., Tissot, M., Raccado, E., Dupont, M. J., Barale, F., Davidson, J. A. H., Zhang, P., Boom, S. J., Blyth, A., Ramsay, G., Ramsay, G., Sanchez, M., Cambronero, J. A., Lopez, J., Cerda, E., Rodriguez, J. M., Rubio, J., Rogero, S., Nunez Reiz, A., De La Fuente O’Connor, E., Talou, M. Daguerre, García, M. Sánchez, Galache, J. A. Cambronero, Marin, S. Rogero, Reiz, A. Nuñez, Alvarez, B., Muñoz, F., Alvarez, F., Lopez, M. J., Maravi, E., Alvarez-Lerma, F., Tapia, V., Masdeu, G., Garrido, S., Vázquez-Sánchez, A., Nolla, J., Solsona, J. F., Gallet, E., Cacheux, P. Le, Beck, A., Her, B., Lecoutour, X., and Charbonneau, P.

Published
1992
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6. Acute/Chronic respiratory failure

Author

De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Filos, K. S., Goudas, L. C., Dougenis, D., Tassoudis, V., Patroni, O., Winkler, W. -B., Karnik, R., Seelmann, O., Havlicek, J., Stany, J., Becker, H., Peter, J. H., Pitzer, W., Schneider, H., Wichert, P. V., De Blasi R. A., Conti G., Mattia C., Mega A. M., Ferrari M., Gasparetto A., Steltzer, H., Hiesmayr, M., Krafft, P., Petcold, R., Strasser, K., Hammerle, A. F., Capellier, G., Liauw, S., Wintoh, T., Marshall, J., Demajo, W., Barale, F., Walker, P. M., Dugernier, T., Laterre, P. F., Deby-Dupont, G., Lamy, M., Reynaert, M. S., Navarrete, P., Vázquez, G., Rivera, R., Fernandez, E., Mérida, A., Boch, J. N., Eibenberger, K., Herold, C., Schlick, W., van der Heijde, R. M. J. L., Grotjohan, H. P., Versprille, A., Wagenvoort, C. A., Raijmakers, P. G. H. M., Groeneveld, A. B. J., Schneider, A. J., Rauwerda, J. A., Teule, G. J. J., Thija, L. G., Singer, M., Vermaat, J., Hall, G., Latter, G., Patel, M., Jansen, J. R. C., Bordet, F., Mercatello, A., Coronel, B., Bret, M., Tlgaud, J. D., Archimbaud, E., Moskovtchenko, J. F., Gregorakos, L., Katsanos, Ch., Michalopoulos, A., Malessios, V., Mavropanou, D., Nicolopoulos, J., Karageorgiou, K., Tognet, E., Polo, P., Devaux, Y., Fière, D., Valta, P., Takala, J., De Blasio, F., Iannuzzi, E., De Sio, A., Ferraro, F., Schiraldi, F., Mostarda, G. F., Spannbrucker, N., Kiesow, U., Kleinschmidt, R., Reper, P., Marion, E., Van Hille, F., De Neef, H., Heymans, W., Ysebaert, D., Van Hoof, R., Vanderkelen, A., Elsen, M., Gregoretti, C., Beltrame, F., Conti, G., Burbi, L., Antonaglia, V., Lucangelo, U., Biolino, P., Giugiaro, P. M., Sasso, F., Schneider H., Becker H., Cassel W., Peter J. H., von Wichert P., Ludwigs, Ulf, Klingstedt, Christer, Baehrendtz, Svante, Hedenstierna, Göran, Gomez V., De la Casa R., Anon J. M., Pascual C., Jimenez M., Yus S., Angouridakis, P., Sofianos, B., Anastasaki, M., Frantzeskos, G., Askitopoelou, B., Priem, R., Schultheiss, R., Cedzich, C., Rabbat, A., Garrouste, M. T., Nahmias, G., Le Gall, J. R., Schlemmer, B., Wegenius, Göran, Matte, P., Jacquet, L., Ceriani, R., Goenen, M., Roeseler, J., Palavecino, L., Dougnac, A., Reynaert, H., Avila, A., Oliphant, L., Ward, C., Spitzer, Sh., Fink, G., Putensen, C., Leon, M., and Putensen-Himmer, G.

Published
1992
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7. Miscellaneous III

Author

Leal, S. R., Flores, J. M., Rivera, V., Camacho, P., Carnacho, J., Murillc, F., Ulibarrena, M. A., Pardo, N. Sainz, Ballestero, J. J., Boado, V., Vergara, J. C., Iruretagoyena, J. R., Kindlund, A., Ponte, C., Valle, J. M., Cienfuegos, F., Payo, F., Sànchez, D., Palacios, F., Polo, M., Toval, A., Latour, J., Bonastre, J., Giner, J. S., Lòpez-Camps, V., Rodrìguez-Serra, M., Rosado, L., Dobrkovic, L., Georgievska, Lj., Spiroska, V., Borozanov, V., Miletić, B., Srbinovski, L., Canovas, J., Barja, D., Perez, A., Marco, P., Caturla, J., Espasa, A., Lucas, J., Voga, C., Žuran, I., Krivec, B., Skrabl-Močnik, F., Skale, R., Marzollo, P., Sebastiano, P., Benedini, G., Marchini, A., Bianchetti, F., Picchioni, A., Pedersini, G., Paylos, J. M., de Sa, E. Lopez, Codero, B., Martinez, J. M., de la Calzada, C. Saenz, Cordero, B., Barro, S., Ruiz, R., Escudcro, J. Lopez, Sànchez, M., Hluchy, J., Wieczorek, M., Sabin, G. V., Ritz, R., Ledermann, H. P., Follath, F., Alexander, J. -P., Cambier, B., Kockx, M., Missault, L., Vandenbogaerde, J., Taeymans, Y., Van Cauwelaert, Ph., Guadagnucci, A., Vignali, G., Mondello, V., Rutili, A., Mariotti, H., Silla, A., Esteban, M., Alfayate, R., Cabello, R. J., Zhang, Haibo, Vincent, Jaan-Louis, Simeoni, U., Desprez, P., Meyer, P., Fischbach, M., Geisert, J., Sproat, L. J., Inglis, T. J. J., Weiss, M., Birkhahn, A., Mettler, S., Schneider, M., Wernet, P., Lemoine, H., Hulsebos, R. G., Beltman, F. W., Miranda, D. Reis, de Jong, I. J., Haas, J. A., Woittiez, A. J. J., Spannbrucker, N., Braun, P., Kleinschmidt, R., Schulte-Witte, H., Scheuerlen, C., Torrent, R. Lorenzo, Palacios, M. Sànchez, Cremades, J. Diaz, Feo, L. Fajardo, Padròn, P. Caballero, Arrate, D. Guerrero, Romero, D. Gonzàlez, Schneider, F., Lutun, Ph., Runge, I., Launoy, A., Hasselmann, M., Tempe, J. D., Moral, A. R., Tünbay, E., Ulusoy, B., Aksoy, N., Çevik, A., Inci, R., Demir, O., Jinènez Jimènez J., Ortiz Leyba C., Garnacho Montero J., Barros Perez M., Ramila Alarcon F., Flores Cordera J., Gonzalez Menendez E., De La Cruz, C., Criado, A., Diaz, L., Seiz, A., Vidaur, P. L., Fraile, J. R., Crespo, E., Arcalfs, L., Hernàndez-Cardona, J. L., Sempere, M. A., Martin, E., Gutierrez, A., Diez, M., de la Torre, F., Picazo, J., Damaso, D., Mazarrtsa, C. F., Noriega, A. R., Cisterna, R., de la Rosa, M., Mirow, N., Meduri, Gianfranco Umberto, Anglada, M. T., Taurà, P., Fuster, J., Bruix, J., Alvarez, L., Izquierdo, E., and Beltràn, J.

Published
1992
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10. Nierentransplantation

Author

Hammerer, P., Arndt, R., Kraemer-Hansen, A., Huland, H., Recker, F., Deutz, F.-J., Homburg, A., Bex, A., Uhlschmid, G., Heinzer, H., Huland, E., Löning, Th., Molitor, D., Miersch, W.-D., Klehr, H.-U., Spannbrucker, N., Gonnermann, D., Stenger, A., Kraemer-Hansen, H., Klosterhalfen, H., Hanke, P., Faßbinder, W., Balducci, M., Ernst, W., Hauser, I., Jonas, D., Schrott, K. M., Kramer, W., Falk, J., Keller, F., Fiedler, U., Strohmaier, W. L., Bichler, K.-H., Flüchter, St. H., Risler, T., Lauchart, W., Daniel, V., Opelz, G., Klän, R., Hirner, A., Offermann, G., Pomer, S., Hull, W., Röhl, L., Peter, H. U., Shaw, S., Weidmann, P., Studer, U. E., Pecqueux, J.-C., Dieckmann, K.-P., Bauer, H. W., Beer, M., Hofmann, S., Staehler, G., Zink, R. A., Götz, R., Heidbreder, E., Heidland, A., and Ackermann, Rolf, editor

Published
1988
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18. The Rise and Fall of Human Oesophagostomiasis

Author

Polderman, A.M., Eberhard, M., Baeta, S., Gasser, R.B., Lieshout, L. van, Magnussen, P., Olsen, A., Spannbrucker, N., Ziem, J., Horton, J., Rollinson, D., and Hay, S.I.

Subjects
strand conformation polymorphism necator-americanus infections induced colonic pathology induced nodular pathology northern ghana hookworm infections nonhuman-primates bifurcum nematoda mass treatment ancylostoma-duodenale
Abstract

Until recently, the infections of humans with representatives of the genus Oesophagostomum were thought to be rare and of zoonotic origin. In the 19805, it was recognised that intense transmission associated with the disease was taking place in northern Togo and Ghana. Pathology can be severe and two clinical presentations, called 'Dapaong Tumour' and Multinodular disease', have been described. Lesions can now be efficiently and specifically visualised by ultrasound. The prevalence of infection appeared to be high in many villages, although its distribution was limited and focal. Parasitological diagnosis has been based on the demonstration of third-stage larvae in stool cultures and more recently on PCR. Molecular and epidemiological evidence supports the proposal that Oesophagostomum bifurcum infections of humans in Ghana and Togo represent a distinct genotype from that of non-human primates in the area. Mass treatment, using repeated doses of albendazole rapidly resulted in the effective elimination of human oesophagostomiasis in the affected areas. This review takes a historic perspective on oesophagostomiasis of humans. This chapter discusses how the unexpected success of mass treatment together with aberrant pathogenesis, the severity of pathology in humans and the limited geographic distribution of the parasite all reflect a poor adaptation of the parasite to the human host.

Published
2010

19. Nierentransplantation

Author

Hammerer, P., primary, Arndt, R., additional, Kraemer-Hansen, A., additional, Huland, H., additional, Recker, F., additional, Deutz, F.-J., additional, Homburg, A., additional, Bex, A., additional, Uhlschmid, G., additional, Heinzer, H., additional, Huland, E., additional, Löning, Th., additional, Molitor, D., additional, Miersch, W.-D., additional, Klehr, H.-U., additional, Spannbrucker, N., additional, Gonnermann, D., additional, Stenger, A., additional, Kraemer-Hansen, H., additional, Klosterhalfen, H., additional, Hanke, P., additional, Faßbinder, W., additional, Balducci, M., additional, Ernst, W., additional, Hauser, I., additional, Jonas, D., additional, Schrott, K. M., additional, Kramer, W., additional, Falk, J., additional, Keller, F., additional, Fiedler, U., additional, Strohmaier, W. L., additional, Bichler, K.-H., additional, Flüchter, St. H., additional, Risler, T., additional, Lauchart, W., additional, Daniel, V., additional, Opelz, G., additional, Klän, R., additional, Hirner, A., additional, Offermann, G., additional, Pomer, S., additional, Hull, W., additional, Röhl, L., additional, Peter, H. U., additional, Shaw, S., additional, Weidmann, P., additional, Studer, U. E., additional, Pecqueux, J.-C., additional, Dieckmann, K.-P., additional, Bauer, H. W., additional, Beer, M., additional, Hofmann, S., additional, Staehler, G., additional, Zink, R. A., additional, Götz, R., additional, Heidbreder, E., additional, and Heidland, A., additional

Published
1988
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22. Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana

Author

Ziem, J. B., Spannbrucker, N., Magnussen, P., Olsen, A., Amon-Kotey, D. Nii, Frenzel, K., Nang-beifubah, A., Westendorp, R. G.J., Polderman, A. M., Ziem, J. B., Spannbrucker, N., Magnussen, P., Olsen, A., Amon-Kotey, D. Nii, Frenzel, K., Nang-beifubah, A., Westendorp, R. G.J., and Polderman, A. M.

Abstract

Human infection with Oesophagostomum bifurcum is rare globally, but focally endemic and common in Ghana and Togo. Two clinical presentations are identified: uni-nodular disease, which may be recognized as a 'Dapaong Tumour', and multi-nodular disease. Here, we describe the prevalence of O. bifurcum infection and the association with nodular pathology in northern Ghana. The study was performed in October 2002. Out of a well-defined population of approximately 18 000, 928 subjects of all ages were randomly selected for parasitological and ultrasound examination. In stool cultures, 44% had detectable third-stage O. bifurcum larvae present. Females were more often infected than males (P < 0.05). In 34% of the samples, nodules were detected along the colon wall, with the ascending and the transverse colon being the most affected regions. Significant correlations existed between the intensity of infection and the presence of nodules, both at the village and the individual level (P < 0.001 for both). Patients with multi-nodular pathology had significantly higher larval counts than patients with uni-nodular pathology. The present data suggest that nodular pathology, and probably the severity of the disease, are directly related to intensity of the infection.

Published
2005

31. Serum erythropoietin levels in patients with sepsis and septic shock.

Author

Abel J, Spannbrucker N, Fandrey J, and Jelkmann W

Subjects
Adult, Aged, Biomarkers, Female, Humans, Interleukin-1 blood, Interleukin-6 blood, Male, Middle Aged, Prognosis, Tumor Necrosis Factor-alpha metabolism, Erythropoietin blood, Sepsis blood, Shock, Septic blood
Abstract

The role of the immune system in the control of the production of erythropoietin is still poorly understood. Herein, the levels of circulating immunoreactive erythropoietin, tumour necrosis factor alpha, interleukin-1 beta and interleukin-6 were determined in 10 septic patients for up to 4 d following the admission to an internal intensive care unit. The data show that the production of erythropoietin was not suppressed despite an increase in the levels of proinflammatory cytokines. Circulating erythropoietin and interleukin-6 greatly increased in the 6 nonsurviving patients. The pattern of the serum erythropoietin level in the nonsurvivors resembled that of acute phase proteins and was independent of the blood haemoglobin concentration. Similar to interleukin 6, abnormally high serum erythropoietin levels appear to be a negative prognostic indicator in patients suffering from septic shock.

Published
1996
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32. Amanita phalloides intoxications in a family of russian immigrants. Case reports and review of the literature with a focus on orthotopic liver transplantation.

Author

Scheurlen C, Spannbrucker N, Spengler U, Zachoval R, Schulte-Witte H, Brensing KA, and Sauerbruch T

Subjects
Adult, Aged, Child, Preschool, Critical Care, Female, Germany, Hepatic Encephalopathy diagnosis, Hepatic Encephalopathy etiology, Humans, Liver Function Tests, Male, Mushroom Poisoning complications, Russia ethnology, Amanita, Amanitins poisoning, Emigration and Immigration, Hepatic Encephalopathy surgery, Liver Transplantation, Mushroom Poisoning diagnosis, Mushroom Poisoning surgery
Abstract

Alpha-amanitin, the main toxin of the death cap fungus (Amanita phalloides) is one of the most dangerous natural poison. This toxin damages eukaryotic cells by inhibiting their transcription. Lesions are seen in cells with rapid protein synthesis, particular in liver and renal cells, even at low toxin concentrations. Without adequate intensive therapy, the outcome of alpha-amanitin poisoning is very poor. This article reports various courses of amanitin intoxication in a family. In 3/4 patients, severe hepatic failure developed as assessed by a decrease of all coagulation factors, mainly Quick's test and factor V (< 10%-15%). Despite vigorous replacement of coagulation factors, in 1 of the patients orthotopic liver transplantation had to be performed on day 4, whereas in all other patients liver function improved spontaneously. All patients survived their intoxication. Both the pharmacological basis and clinical manifestations of Amanita intoxication are discussed. On this basis a treatment scheme is presented which the authors believe may be useful to clinicians.

Published
1994

33. [Pregnancy, labor and postpartum development after kidney transplantation and triple therapy with cyclosporin A--follow-up in relation to literature review].

Author

Bung P, Molitor D, and Spannbrucker N

Subjects
Adult, Cyclosporins adverse effects, Eclampsia therapy, Female, Humans, Infant, Newborn, Kidney Function Tests, Pregnancy, Respiratory Distress Syndrome, Newborn etiology, Cesarean Section, Cyclosporins administration & dosage, Eclampsia etiology, Kidney Failure, Chronic surgery, Kidney Transplantation immunology, Postoperative Complications etiology
Abstract

This report pertains to a 26-year old primigravida three years after kidney transplantation and still on immunotherapy. Her pregnancy progressed without severe complications until the 33rd week of gestation. Then a sudden and rapidly worsening pre-eclampsia led to admission and delivery. The postoperative period was complicated by an episode of severe septic shock. Reported is a review of the literature. Problems following pregnancy after kidney transplantation and triple therapy including Cyclosporin A are pointed out.

Published
1991

34. [Combination of dopamine and dobutamine in the differential therapy of acute and chronic myocardial failure].

Author

Kleinschmidt R, Spannbrucker N, and Vogel F

Subjects
Clinical Trials as Topic, Dose-Response Relationship, Drug, Drug Therapy, Combination, Heart drug effects, Heart Failure physiopathology, Hemodynamics drug effects, Humans, Myocardial Contraction drug effects, Receptors, Adrenergic, beta drug effects, Renal Circulation drug effects, Shock, Cardiogenic drug therapy, Vascular Resistance drug effects, Vasodilation drug effects, Catecholamines therapeutic use, Dobutamine therapeutic use, Dopamine therapeutic use, Heart Failure drug therapy
Published
1985
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38. Magnetic resonance imaging in renal transplants.

Author

Klehr HU, Spannbrucker N, Molitor D, Miersch W, and Steudel A

Subjects
Adult, Female, Graft Rejection, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Kidney Diseases diagnosis, Kidney Transplantation
Published
1987

39. [MR tomography following kidney transplantation].

Author

Steudel A, Nicolas V, Klehr HU, Spannbrucker N, Molitor D, and Harder T

Subjects
Adult, Female, Graft Rejection, Humans, Kidney Cortex pathology, Kidney Medulla pathology, Kidney Tubular Necrosis, Acute diagnosis, Male, Middle Aged, Kidney Transplantation, Magnetic Resonance Imaging
Abstract

The results obtained by MR tomography in 30 patients after renal grafting are compared with the clinical and histological data in respect of corticomedullary contrast (CMC). In 22 patients with regular functioning of the transplant the CMC was normal at 19.4%. Eight MR examinations yielded a clearly reduced CMC below 14%. In 7 of these 8 patients it was possible to prove histologically the existence of an acute tubular necrosis or of a transplant rejection. Noninvasive MR tomography yielded an early indication for treating the acute renal transplant rejection without being able to differentiate between such a rejection and acute renal failure.

Published
1987
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40. [Sympathomimetics in intensive medicine].

Author

Vogel F, Spannbrucker N, and Bodem G

Subjects
Anaphylaxis drug therapy, Dobutamine therapeutic use, Dopamine therapeutic use, Epinephrine therapeutic use, Heart Failure drug therapy, Humans, Isoproterenol therapeutic use, Metaproterenol therapeutic use, Norepinephrine therapeutic use, Resuscitation, Critical Care, Sympathomimetics therapeutic use
Published
1981
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41. Comparative study on the antihypertensive efficacy of torasemide and indapamide in patients with essential hypertension.

Author

Spannbrucker N, Achhammer I, Metz P, and Glocke M

Subjects
Adult, Aged, Blood Glucose metabolism, Blood Pressure drug effects, Clinical Trials as Topic, Creatinine urine, Diuretics adverse effects, Double-Blind Method, Electrolytes blood, Female, Humans, Hypertension physiopathology, Indapamide adverse effects, Male, Middle Aged, Random Allocation, Sulfonamides adverse effects, Torsemide, Uric Acid urine, Diuretics therapeutic use, Hypertension drug therapy, Indapamide therapeutic use, Sulfonamides therapeutic use
Abstract

In a double-blind randomized multicenter study the antihypertensive efficacy of 2.5 mg torasemide (1- isopropyl-3-([4-(3-methyl-phenylamino)pyridine]-3-sulfony)urea) and 2.5 mg indapamide was compared in patients with essential hypertension, known as responders to diuretic therapy. After a wash-out period of 4 weeks patients with a sitting diastolic blood pressure of 100-115 mmHg were included in the 12-weeks active treatment period. After 4 weeks of treatment with a once daily 2.5 mg dose of each drug, doses could once be doubled if blood-pressure decrease was considered to be insufficient. 66 patients qualified for the statistical evaluation, 32 in the torasemide group and 34 in the indapamide group. In these patients both drugs caused a similar fall in blood pressure leading to a normalization of blood pressure in most of the patients. Serum parameters remained within normal limits. Only serum potassium was significantly lower with 2.5 mg indapamide compared to 2.5 mg torasemide at the end of the study. No side effects were reported for both drugs. As the lowest effective dose of a diuretic should be used for the treatment of hypertensive patients, 2.5 mg torasemide, which is below the threshold dose for significantly enhanced diuresis, seems to be the recommended dose for antihypertensive treatment.

Published
1988

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