625 results on '"Spalluto, Giampiero"'
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2. 7-Amino-[1,2,4]triazolo[1,5-a][1,3,5]triazines as CK1δ inhibitors: Exploring substitutions at the 2 and 5-positions
3. Adenosine Receptor Ligands, Probes, and Functional Conjugates: A 20-Year History of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidines (PTP)
4. Adenosine Receptor Ligands, Probes, and Functional Conjugates: A 20-Year History of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidines (PTP)
5. Gaucher Disease: A Glance from a Medicinal Chemistry Perspective
6. Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems
7. Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes
8. The current status of pharmacotherapy for the treatment of Parkinson’s disease: transition from single-target to multitarget therapy
9. Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.
10. Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors
11. [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype
12. Front Cover: Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors (ChemMedChem 14/2023)
13. Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA
14. Are two riboses better than one? The case of the recognition and activation of adenosine receptors
15. 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors
16. [1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines.
17. “Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
18. Discovery of simplified N2-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: Efficient synthetic approaches, biological evaluations and molecular docking studies
19. 8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands
20. Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases
21. Riluzole–Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
22. Fluorescent ligands for adenosine receptors
23. The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
24. Does the combination of optimal substitutions at the C 2-, N 5- and N 8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A 3 adenosine receptors?
25. "Dual Anta-Inhibitors" of the A 2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies.
26. Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand–receptor recognition process
27. A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ
28. Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A 2A and A 3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
29. 6-Amino-2-mercapto-3 H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y 12 receptors
30. Biomedical Applications I: Delivery of Drugs
31. Mixed-reversible and covalent kinase inhibition as a possible new strategy to treat neuro-inflammatory/degenerative diseases
32. Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes
33. New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile
34. Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
35. Targeting G protein-coupled receptors with magnetic carbon nanotubes: The A3 adenosine receptor case
36. Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties
37. Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine [A.sub.3] receptor as an example
38. Potent and Selective A2A Adenosine Receptor Antagonists: Recent Improvement
39. Recent Developments in the Field of Non Peptidic α vβ 3 Antagonists
40. Biomedical Applications I
41. Receptor-Driven Identification of Novel Human A3 Adenosine Receptor Antagonists as Potential Therapeutic Agents
42. The application of a 3D-QSAR ( autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A 3 adenosine receptor antagonist
43. Novel fluorescent antagonist as a molecular probe in A3 adenosine receptor binding assays using flow cytometry
44. Novel versatile fullerene synthons
45. Targeting G Protein‐Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A 3 Adenosine Receptor
46. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro
47. Mastering beta-keto esters
48. A new approach to kainoids through tandem Michael reaction methodology: application to the enantioselective synthesis of (+)- and (-)-alpha-allokainic acid and to the formal synthesis of (-)-kainic acid
49. Fullerene derivatives: an attractive tool for biological applications
50. Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors
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