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The most important information still missing in the field of the low-energy antikaon-nucleon inter actions studies is the experimental determination of the hadronic energy shift and width of kaonic deuterium. This measurement will be performed by the SIDDHARTA-2 experiment, installed at the DAΦNE collider and presently in data taking campaign. The precise measurement of the shift and width of the 1s level with respect to the purely electromagnetic calculated values, generated by the presence of the strong interaction, through the measurement of the X-ray transitions to this level, in kaonic hydrogen, was performed by the SIDDHARTA collaboration, the kaonic deuterium is underway by SIDDHARTA-2. These measurement will allow the first precise experimental extraction of the isospin dependent antikaon-nucleon scattering lengths, funda mental quantities for understanding low-energy QCD in the strangeness sector. The experimental challenge of the kaonic deuterium measurement is the very small X-rays yield, the even larger width (compared to kaonic hy drogen), and the difficulty to perform X-rays spectroscopy with weak signals in the high radiation environment of DAΦNE. It was, therefore, crucial to develop a new apparatus involving large-area X-rays detector system, to optimize the signal and to control and by improve the signal-to-background ratio by gaining in solid angle, increasing the timing capability, and as well implementing additional charge particle tracking veto systems.

KAMEO (Kaonic Atoms Measuring Nuclear Resonance Effects Ob-servables) is a proposal for an experiment aiming to perform the first consistent measurement of the E2 nuclear resonance effects in kaonic molybdenum A=94,96,98,100 isotopes. The E2 nuclear resonance mixes atomic states, due to the electrical quadrupole excitation of nuclear rotational states. It occurs in atoms having the energy of a nuclear excitation state closely matching an atomic de-excitation state energy, and affects the rates of X-ray atomic transitions matching the energy of the resonance. The measurement E2 nuclear resonance effect in KMO isotopes allows the study of the strong kaon-nucleus interaction in a rotational excited nuclear state. Moreover, the effect enables the K- to access an inner atomic level not easily reachable by the kaon normal cascade, due to the nuclear absorption. The KAMEO proposed apparatus consists of 4 enriched Mo A=94,96,98,100 isotope strips, exposed to the kaons produced by the DAφNE collider, for kaonic atoms formation, with a high-purity germanium detector, cooled with liquid nitrogen, used to measure the X-ray atomic transitions. The DAφNE collider is located at the National Laboratories of Frascati (LNF-INFN), in Italy. It is already suited for kaonic atoms measurement by the SIDDHARTA-2 collaboration.

The E2 nuclear resonance effect in kaonic atoms occurs when the energy of atomic de-excitation closely matches the energy of nuclear excitation, leading to the attenuation of some X-ray lines in the resonant isotope target. This phenomenon provides crucial information on the strong interaction between kaons and nuclei. The only nuclear E2 resonance effect observed so far was in the K− −9842Mo isotope, measured by G. L. Goldfrey, G-K. Lum, and C. E. Wiegand at Lawrence Berkeley Laboratory in 1975. However, the 25 hours of data taking were not sufficient to yield conclusive results. In four kaonic Molybdenum isotopes (9442Mo, 9642Mo, 9842and Mo, and 10042Mo), the nuclear E2 resonance effect is expected to occur at the same transition with similar energy values. To investigate this, the KAMEO (Kaonic Atoms Measuring Nuclear Resonance Effects Observables) experiment plans to conduct research on kaonic Molybdenum isotopes at the DAΦNE e+e− collider during the SIDDHARTA-2 experiment. The experimental strategy involves exposing four solid strip targets, each enriched with one Molybdenum isotope, to negatively charged kaons and using a germanium detector to measure X-ray transitions. In addition, a non-resonant 9242Mo isotope solid strip target will be used as a reference for standard non-resonant transitions.

Light kaonic atoms spectroscopy provides a unique approach to study the low-energy strong interaction in the strangeness sector. Precise measurements of X-ray emission from light kaonic atoms provide valuable information on kaon-nucleus interaction at threshold without the need for extrapolation as required in scattering experiments. The SIDDHARTA-2 experiment at the DAΦNE collider of INFN-LNF is now poised to perform the challenging measurements of the K−- d 2p → 1s transition to extract the isospin-dependent antikaonnucleon scattering lengths. To achieve this goal, the background reduction is a crucial factor. This paper provides an overview of the SIDDHARTA-2 Veto-1 system, which uses scintillators outside the vacuum chamber to detect charged particles produced by K− absorption by the nucleus. The arrival time of these particles is correlated with the position where the kaonic atom has been created inside the setup, allowing for the rejection of kaons stopped outside the target cell, which is a critical component for reducing the background and improve the accuracy of the measurement.

The AMADEUS Collaboration aims to provide unique experimental constraints to the antikaon-nucleon strong interaction in the regime of nonperturbative QCD. The K− nuclear captures, both at-rest and in-flight, are studied using the monochromatic low-momentum kaon beam (pK ∼ 120 MeV/c) produced at the DAΦNE collider, interacting with the KLOE detector materials. The studies are performed by reconstructing the hyperon-pion and hyperonnucleon final states. In this work a brief description of AMADEUS results for Λπ− and Λp final states is presented.

The SIDDHARTA-2 experiment aims to perform the first measurement of the kaonic deuterium 2p → 1s x-ray transition energy. Such measurement, together with the measurement of kaonic hydrogen 2p → 1s x-ray energy transition performed by the SIDDHARTA experiment in 2011, allows the determination of kaon proton and kaon neutron scattering lengths and represents a fundamental input for the low energies QCD in the strangeness sector theory. The SIDDHARTA-2 experiment is presently installed at the DAΦNE electronpositron collider at the National Laboratories of Frascati, in Italy. In May 2022, the kaonic 4He x-ray transitions measurement was performed by the complete SIDDHARTA-2 setup, by using a gaseous target. The result of this measurement is presented in this paper, with a specific focus on the background rejection performed by the kaon trigger system.

The low-energy, non-perturbative regime of QCD can be studied directly by X-ray spectroscopy of light kaonic atoms. The SIDDHARTA-2 experiment, located at the DAΦNE collider, aims to measure the 2p → 1s transition in kaonic deuterium for the first time to extract the antikaon-nucleon scattering lengths. This measurement is impeded, inter alia, by the low K−d X-ray yield. Hence, several updates have been implemented on the apparatus to increase the signal-to-background ratio, which are discussed in detail in this paper: a lightweight gas target cell, novel Silicon Drift Detectors for the X-ray detection with excellent performance, and a veto system for active background suppression. The experiment has undergone a first preparatory run during DAΦNE’s commissioning phase in 2021, concluding with a successful kaonic helium measurement.

The X-ray spectroscopy measurements of light kaonic atoms’ deexcitation towards the fundamental level provide unique information on the low-energy Quantum ChromoDynamics (QCD) in the strangeness sector, being a direct probe of the kaon/nucleon interaction at threshold, unobtainable through the scattering experiments. In this framework, the SIDDHARTA-2 collaboration is going to perform the first kaonic deuterium 2p → 1s transition measurement at the DAΦNE collider of Istituto Nazionale di Fisica Nucleare – Laboratori Nazionali di Frascati. Combining this measurement with the kaonic hydrogen one performed by SIDDHARTA in 2009 it will be possible to obtain, in a model-independent way, the isospin-dependent antikaon-nucleon scattering lengths. The paper introduces the SIDDHARTA-2 setup, an upgraded version with respect to the one used for the kaonic hydrogen measurement, dedicated to the ambitious kaonic deuterium measurement, together with the preliminary results obtained during the kaonic helium run, preparatory for the SIDDHARTA-2 data taking campaign.

Background The aim was to investigate if autonomic symptoms questionnaire Composite Autonomic Symptom Score (COMPASS) 31 has different association with cardiovascular autonomic neuropathy (CAN) and diagnostic performance between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Methods Seventy-nine participants with T1DM and 140 with T2DM completed COMPASS 31 before cardiovascular reflex tests (CARTs) for CAN, and assessment of symptoms, signs, vibration, and thermal perception thresholds for diabetic polyneuropathy (DPN) diagnosis. Results COMPASS 31 total weighted score (TWS) was similar in the two groups, but significantly associated with confirmed CAN only in T1DM (P=0.0056) and not T2DM group (P=0.1768) and correlated with CARTs score more strongly in T1DM (rho=0.356, P=0.0016) than in T2DM group (rho=0.084, P=0.3218) (P=0.016). Only in T1DM and not T2DM group, the area under the receiver operating characteristic curve (AUC) reached a fair diagnostic accuracy (>0.7) for confirmed CAN (0.73±0.07 vs. 0.61±0.08) and DPN (0.75±0.06 vs. 0.68±0.05), although without a significant difference. COMPASS 31 TWS (cut-off 16.44) reached acceptable diagnostic performance in T1DM, with sensitivity for confirmed CAN 81.2% and sensitivity and specificity for DPN 76.3% and 78%, compared to T2DM group (all

The AMADEUS experiment at the DAΦNE collider of LNF-INFN deals with the investigation of the at-rest, or low-momentum, K− interactions in light nuclear targets, with the aim to constrain the low energy QCD models in the strangeness sector. The 0 step of the experiment consisted in the reanalysis of the 2004/2005 KLOE data, exploiting K− absorptions in H, 4He, 9Be and 12C, leading to the first invariant mass spectroscopic study with very low momentum (about 100 MeV) in-flight K− captures. With AMADEUS step 1 a dedicated pure Carbon target was implemented in the central region of the KLOE detector, providing a high statistic sample of pure at-rest K− nuclear interaction. The first measurement of the non-resonant transition amplitude | AK−n→Λπ− |$\left| {{A_{{K^ - }n \to \Lambda {\pi ^ - }}}} \right|$ at s=33 MeV$\sqrt s = 33\,MeV$ below the K̄N threshold is presented, in relation with the Λ(1405) properties studies. The analysis procedure adopted in the serarch for K− multi-nucleon absorption cross sections and Branching Ratios will be also described.

The interaction of antikaons (K−) with nucleons and nuclei in the low-energy regime represents a very active research field in hadron physics. A unique and rather direct experimental access to the antikaon-nucleon scattering lengths is provided by precision X-ray spectroscopy of transitions in low-lying states in the lightest kaonic atoms (i.e. kaonic hydrogen and deuterium). In the SIDDHARTA experiment at the electron-positron collider DAFNE of LNFINFN we measured the most precise values of the strong interaction observables in conic hydrogen. The strong interaction on the 1s ground state of the electromagnetically bound K-p atom causes an energy shift and broadening of the 1s state. SIDDHARTA will extend the spectroscopy to kaonic deuterium to get access to the antikaon-neutron interaction and thus the isospin dependent scattering lengths. At J-PARC a kaon beam is used in a complementary experiment with a different setup for spectroscopy of kaonic deuterium atoms. The talk will give an overview of the of the upcoming experiments SIDDHARTA and the complementary experiment at J-PARC.Furthermore, the implications of the experiments for the theory of low-energy strong interaction with strangeness will be discussed.

The main steps for the analysis of the Λp correlated production in low-energy K− captures on Carbon nuclei, performed by the AMADEUS collaboration, are presented. The goal is to perform the first comprehensive study of the K− absorption on two, three and four nucleons, exploiting the lowmomentum K−s (pK ~ 127 MeV/c) produced at the DAΦNE collider, and to measure the low-energy cross sections and branching ratios of the K− multinucleon absorption processes in both the Λp and Σ0p channels. An integrated luminosity of 1.74 fb−1 collected during the KLOE 2004/2005 data campaign is analysed by reconstructing the Λp final state.

The interaction of antikaons with nucleons and nuclei in the low-energy regime represents an active research field in hadron physics with still many important open questions. The investigation of light kaonic atoms, in which one electron is replaced by a negatively charged kaon, is a unique tool to provide precise information on this interaction; the energy shift and the broadening of the low-lying states of such atoms, induced by the kaon-nucleus hadronic interaction, can be determined with high precision from the atomic X-ray spectroscopy, and this experimental method provides unique information to understand the low energy kaon-nucleus interaction at the production threshold. The lightest atomic systems, like the kaonic hydrogen and the kaonic deuterium deliver, in a model-independent way, the isospin-dependent kaon-nucleon scattering lengths. The most precise kaonic hydrogen measurement to-date, together with an exploratory measurement of kaonic deuterium, were carried out in 2009 by the SIDDHARTA collaboration at the DAΦNE electron-positron collider of LNF-INFN, combining the excellent quality kaon beam delivered by the collider with new experimental techniques, as fast and very precise X-ray detectors, like the Silicon Drift Detectors. The SIDDHARTA results triggered new theoretical work, which achieved major progress in the understanding of the low-energy strong interaction with strangeness reflected by the antikaon-nucleon scattering lengths calculated with the antikaon-proton amplitudes constrained by the SIDDHARTA data. The most important open question is the experimental determination of the hadronic energy shift and width of kaonic deuterium; presently, a major upgrade of the setup, SIDDHARTA-2, is being realized to reach this goal. In this paper, the results obtained in 2009 and the proposed SIDDHARTA-2 upgrades are presented.

The AMADEUS collaboration is performing experimental investigations in the sector of the low energy strangeness hadron physics by taking advantage of the DAΦNE collider, which provides a unique source of monochromatic low-momentum kaons and exploiting the KLOE detector as an active target. The K− single and multi-nuclear absorption on H, 4He, 9Be and 12C, both at-rest and in-flight, are studied with the aim to determine the nature of the controversial Λ(1405), the non-resonant hyperon pion formation amplitude below the K̅N threshold, the yield and cross sections of K− multi-nucleon absorptions intimately connected to the antikaon multi-nucleon clusters properties and the K− scattering cross sections on light nuclear targets. These studies have a strong impact on the non-perturbative strangeness QCD with implications ranging from nuclear physics to the equation of state of neutron stars.

The goal of the AMADEUS experiment is to shed light on unsolved fundamental issues in the non-perturbative strangeness QCD sector through the study of lowenergy K- hadronic interactions with light nuclear targets. The main open questions are the controversial nature of the Δ(1405) state, which is investigated in hyperon-pion correlation studies, and the possible existence of exotic antikaon multi-nucleon clusters, whose search in K- induced reactions is intimately related to the studies of the K- multi-nucleon absorption processes in hyperon-nucleon/nucleus channels. The DAΦNE collider at the INFN-LNF provides unique monochromatic low-momentum kaons from the φ meson decay almost at-rest, suitable for the AMADEUS studies. The KLOE detector is exploited as an active target, in order to obtain excellent acceptance and resolution data for K- nuclear capture on H, 4He, 9Be and 12C, both at-rest and in-flight.