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2. Reduced humoral response to two doses of COVID-19 vaccine in patients with inflammatory bowel disease: Data from ESCAPE-IBD, an IG-IBD study

Author

Amato, Arnaldo, Ascolani, Marta, Calabrese, Giulio, Casà, Angelo, Comberlato, Michele, Conforti, Francesco Simone, De Bona, Manuela, Demarzo, Maria Giulia, Doldo, Patrizia, Dragoni, Gabriele, Furfaro, Federica, Mulinacci, Giacomo, Olmo, Oriana, O'Sed, Nicole Piazza, Paba, Salvatore, Radice, Simona, Renna, Sara, Ribaldone, Davide Giuseppe, Rizzuto, Giulia, Macaluso, Fabio Salvatore, Principi, Mariabeatrice, Facciotti, Federica, Contaldo, Antonella, Todeschini, Alessia, Saibeni, Simone, Bezzio, Cristina, Castiglione, Fabiana, Nardone, Olga Maria, Spagnuolo, Rocco, Fantini, Massimo Claudio, Riguccio, Gaia, Caprioli, Flavio, Viganò, Chiara, Felice, Carla, Fiorino, Gionata, Correale, Carmen, Bodini, Giorgia, Milla, Monica, Scardino, Giulia, Vernero, Marta, Desideri, Federico, Mannino, Mariella, Rizzo, Giuseppe, and Orlando, Ambrogio

Published
2023
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3. Impact of Nursing Interventions via Telephone and Email on the Quality of Life of Patients with Inflammatory Bowel Disease: Preliminary Results of a Comparative Observational Study.

Author

Mercuri, Caterina, Giordano, Vincenza, Bosco, Vincenzo, Serra, Nicola, Spagnuolo, Rocco, Nocerino, Rita, Rea, Teresa, Colaci, Carmen, Guillari, Assunta, Doldo, Patrizia, and Simeone, Silvio

Subjects
SCIENTIFIC observation, QUESTIONNAIRES, NURSING interventions, INFLAMMATORY bowel diseases, EMAIL, TELEPHONES, QUALITY of life, TELENURSING, COMPARATIVE studies
Abstract

Background: Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a heterogeneous chronic condition characterized by periods of relapse and remission. Ulcerative colitis involves inflammation of the colon and rectum mucosa, while Crohn's disease causes deeper, transmural inflammation affecting all four gut layers from the mouth to the anus and can lead to complications such as fistulation. IBD significantly impacts patients' physical and psychological well-being, thus reducing their quality of life (QoL). We aimed to evaluate the effectiveness of nursing intervention facilitated through telephone and email support in improving the quality of life (QoL) of Inflammatory Bowel Disease (IBD) patients. Methods: A pilot comparative observational design with pre-test and post-test assessments was employed, involving 50 participants assigned to either an intervention group (Group A, n = 26) or a control group (Group B, n = 24). Group A received regular telephone consultations and prompt email responses from trained nurses; Group B received standard care. Data were collected at baseline and six months post-intervention (T1) using the Patient-Reported Outcomes Measurement Information System (PROMIS®) and Pittsburgh Sleep Quality Index. Results: Group A showed significant improvements in anxiety, depression, fatigue, and sleep quality, with p-values indicating the significance of these findings. Conclusions: Tailored nursing support via remote communication significantly benefits IBD patients by alleviating psychological distress and enhancing their overall well-being, underscoring the importance of integrating such interventions into standard IBD care practices. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

Author

Bianco, Cristiana, Jamialahmadi, Oveis, Pelusi, Serena, Baselli, Guido, Dongiovanni, Paola, Zanoni, Irene, Santoro, Luigi, Maier, Silvia, Liguori, Antonio, Meroni, Marica, Borroni, Vittorio, D’Ambrosio, Roberta, Spagnuolo, Rocco, Alisi, Anna, Federico, Alessandro, Bugianesi, Elisabetta, Petta, Salvatore, Miele, Luca, Vespasiani-Gentilucci, Umberto, Anstee, Quentin M., Stickel, Felix, Hampe, Jochen, Fischer, Janett, Berg, Thomas, Fracanzani, Anna Ludovica, Soardo, Giorgio, Reeves, Helen, Prati, Daniele, Romeo, Stefano, and Valenti, Luca

Published
2021
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7. Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease

Author

Jamialahmadi, Oveis, Mancina, Rosellina Margherita, Ciociola, Ester, Tavaglione, Federica, Luukkonen, Panu K., Baselli, Guido, Malvestiti, Francesco, Thuillier, Dorothée, Raverdy, Violeta, Männistö, Ville, Pipitone, Rosaria Maria, Pennisi, Grazia, Prati, Daniele, Spagnuolo, Rocco, Petta, Salvatore, Pihlajamäki, Jussi, Pattou, François, Yki-Järvinen, Hannele, Valenti, Luca, and Romeo, Stefano

Published
2021
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8. Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study.

Author

Abenavoli, Ludovico, Spagnuolo, Rocco, Scarlata, Giuseppe Guido Maria, Gambardella, Maria Luisa, Boccuto, Luigi, Méndez-Sánchez, Nahum, and Luzza, Francesco

Subjects
*NON-alcoholic fatty liver disease, *CROHN'S disease, *FATTY liver, *TYPE 2 diabetes, *ULCERATIVE colitis, *INFLAMMATORY bowel diseases
Abstract

Background: Inflammatory bowel disease (IBD) is characterized by persistent inflammation and is often associated with metabolic dysfunction-associated steatotic liver disease (MASLD). IBD patients are at risk of developing MASLD due to shared risk factors such as gut dysbiosis and systemic inflammation. The new MASLD nomenclature emphasizes the link between liver steatosis and cardiometabolic comorbidities. However, the prevalence of MASLD in IBD patients remains poorly explored. The main aim of this cross-sectional study is to assess the prevalence of ultrasound (US) and the clinical features of MASLD in patients with IBDs. Materials and Methods: We conducted a retrospective study enrolling 272 Italian IBD patients attending Renato Dulbecco Teaching Hospital in a period between 1 January 2021 and 31 December 2023. MASLD was diagnosed based on the presence of liver steatosis with cardiometabolic risk factors, using established guidelines. Demographic, clinical, and laboratory data were collected and analyzed. Statistical significance was determined at a p-value < 0.05. Results: Of the 272 IBD patients, 6% had non-alcoholic fatty liver disease (NAFLD), while 18% had MASLD. Patients with IBD-MASLD were significantly older, had higher body mass index, waist circumference, and triglyceride levels, and were more likely to have type 2 diabetes mellitus and hypertension compared to those with IBD-NAFLD. IBD-MASLD patients also showed higher disease activity scores and required more frequent surgical interventions. Bivariate logistic regression revealed triglyceride levels as a significant predictor of MASLD in IBD patients. Conclusions: MASLD is more prevalent in IBD patients, highlighting the importance of early detection of liver steatosis in this at-risk population. The association between MASLD and cardiometabolic risk factors underscores the need for a multidisciplinary approach to manage these patients effectively. Further studies in larger cohorts are necessary to confirm these findings and explore the pathophysiological mechanisms involved. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study

Author

Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)

Abstract

BackgroundUstekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients with UC in a real-world setting.Research design and methodsThis is a multicenter, retrospective, observational cohort study. The primary endpoints were the clinical remission rate (partial Mayo score, PMS, <= 1) and the safety of UST. Other endpoints were corticosteroid-free remission (CSFR) rate, clinical response rate (PMS reduction of at least 2 points), and fecal calprotectin (FC) reduction at week 24.ResultsWe included 256 consecutive patients with UC (M/F 139/117, median age 52). The clinical remission and clinical response rates at eight weeks were 18.7% (44/235) and 53.2% (125/235), respectively, and 27.6% (42/152) and 61.8% (94/152) at 24 weeks, respectively. At 24 weeks, CSFR was 20.3% (31/152), and FC significantly dropped at week 12 (p = 0.0004) and 24 (p = 0.038). At eight weeks, patients naive or with one previous biologic treatment showed higher remission (p = 0.002) and clinical response rates (p = 0.018) than patients previously treated with >= 2. Adverse events occurred in six patients (2.3%), whereas four patients (1.6%) underwent colectomy.ConclusionThis real-world study shows that UST effectively and safely treats patients with UC.

Published
2024

13. Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis

Author

Bossa, Fabrizio, Biscaglia, Giuseppe, Valvano, Maria Rosa, Costantino, Giuseppe, Lauria, Angelo, Clemente, Rocco, Ferracane, Concetta, Shahini, Endrit, Mendolaro, Marco, Grossi, Laurino, Mazzuoli, Silvia, Rispo, Antonio, Pranzo, Giuseppe, Sebkova, Ladislava, Tursi, Antonio, Miranda, Agnese, Patturelli, Marta, Spagnuolo, Rocco, Ricciardelli, Cristina, Sgarro, Caterina, Paese, Pietro, Inserra, Gaetano, Azzarone, Alessandro, Nardone, Olga, Fries, Walter, Buccianti, Nello, Privitera, Antonino Carlo, Principi, Maria Beatrice, Cappello, Maria, Guglielmi, Francesco William, Romano, Marco, Riegler, Gabriele, Fanigliulo, Libera, Melina, Raffaele, and Andriulli, Angelo

Published
2020
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14. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)

Author

Leone, Salvatore, Previtali, Enrica, Aloi, Marina, Alvisi, Patrizia, Antonelli, Elisabetta, Ardizzone, Sandro, Astegiano, Marco, Baldoni, Monia, Beltrami, Marina, Biancone, Livia, Bodini, Giorgia, Buda, Andrea, Bossa, Fabrizio, Bracci, Fiammetta, Calabrese, Emma, Cappello, Maria, Castiglione, Fabiana, Ciacci, Carolina, Cicala, Michele, Ciccocioppo, Rachele, Comberlato, Michele, Cortelezzi, Claudio Camillo, Cosintino, Rocco, Costa, Francesco, Costantino, Giuseppe, Cucchiara, Salvatore, Cuomo, Antonio, D’Incà, Renata, Di Paolo, Maria Carla, Di Sabatino, Antonio, Di Sario, Antonio, Frieri, Giuseppe, Fries, Walter, Gasbarrini, Antonio, Geccherle, Andrea, Gionchetti, Paolo, Graziani, Maria Giovanna, Grossi, Laurino, Guidi, Luisa, Imperiali, Gianni, Latella, Giovanni, Lionetti, Paolo, Inserra, Gaetano, Maconi, Giovanni, Manguso, Francesco, Marino, Marco, Mastronardi, Mauro, Mazzuoli, Silvia, Meucci, Gianmichele, Mendolaro, Marco, Milla, Monica, Mocci, Giammarco, Monteleone, Giovanni, Bortoluzzi, Francesco Neri, Pagnini, Cristiano, Pastorelli, Luca, Pica, Roberta, Piergallini, Simona, Privitera, Antonello, Renna, Sara, Ribaldone, Davide Giuseppe, Ricci, Chiara, Rispo, Antonio, Rocca, Rodolfo, Romano, Claudio, Romano, Marco, Russo, Giovanni, Sablich, Renato, Saibeni, Simone, Savarino, Edoardo, Scribano, Maria Lia, Spagnuolo, Rocco, Stasi, Elisa, Terpin, Maria Maddalena, Testa, Anna, Valpiani, Daniela, Variola, Angela, Vernia, Piero, Vitale, Giovanna, Zoli, Giorgio, Fiorino, Gionata, Caprioli, Flavio, Daperno, Marco, Mocciaro, Filippo, Principi, Mariabeatrice, Viscido, Angelo, Fantini, Massimo Claudio, Orlando, Ambrogio, Papi, Claudio, Annese, Vito, Danese, Silvio, Vecchi, Maurizio, Rizzello, Fernando, and Armuzzi, Alessandro

Published
2019
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15. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study

Author

Tursi, Antonio, primary, Mocci, Giammarco, additional, Scaldaferri, Franco, additional, Napolitano, Daniele, additional, Maresca, Rossella, additional, Pugliese, Daniela, additional, Semprucci, Gianluca, additional, Savarino, Edoardo, additional, Cuomo, Antonio, additional, Donnarumma, Laura, additional, Bodini, Giorgia, additional, Pasta, Andrea, additional, Maconi, Giovanni, additional, Cataletti, Giovanni, additional, Pranzo, Giuseppe, additional, Rodinò, Stefano, additional, Sebkova, Ladislava, additional, Costa, Francesco, additional, Ferronato, Antonio, additional, Gaiani, Federica, additional, Marzo, Manuela, additional, Luppino, Ileana, additional, Fabiano, Giulia, additional, Paese, Pietro, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Grossi, Laurino, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Chiri, Stefania, additional, Grasso, Giuseppina, additional, Antonelli, Elisabetta, additional, Bassotti, Gabrio, additional, Spagnuolo, Rocco, additional, Luzza, Francesco, additional, Fanigliulo, Libera, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Rocchi, Chiara, additional, Bolognini, Laura, additional, Bendia, Emanuele, additional, Bianco, Maria Antonia, additional, Capone, Pietro, additional, Meucci, Costantino, additional, Colucci, Raffaele, additional, Tonti, Paolo, additional, Neve, Viviana, additional, Della Valle, Nicola, additional, Felice, Carla, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Forti, Giacomo, additional, Onidi, Francesca Maria, additional, Usai Satta, Paolo, additional, Checchin, Davide, additional, Gravina, Antonietta Gerarda, additional, Pellegrino, Raffaele, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional

Published
2024
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17. Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.

Author

De Caro, Carmen, Spagnuolo, Rocco, Quirino, Angela, Mazza, Elisa, Carrabetta, Federico, Maurotti, Samantha, Cosco, Cristina, Bennardo, Francesco, Roberti, Roberta, Russo, Emilio, Giudice, Amerigo, Pujia, Arturo, Doldo, Patrizia, Matera, Giovanni, and Marascio, Nadia

Subjects
*NON-alcoholic fatty liver disease, *INFLAMMATORY bowel diseases, *GUT microbiome, *METAGENOMICS
Abstract

Gut microbiota imbalances have a significant role in the pathogenesis of Inflammatory Bowel Disease (IBD) and Non-Alcoholic Fatty Liver Disease (NAFLD). Herein, we compared gut microbial composition in patients diagnosed with either IBD or NAFLD or a combination of both. Seventy-four participants were stratified into four groups: IBD-NAFLD, IBD-only, NAFLD-only patients, and healthy controls (CTRLs). The 16S rRNA was sequenced by Next-Generation Sequencing. Bioinformatics and statistical analysis were performed. Bacterial α-diversity showed a significant lower value when the IBD-only group was compared to the other groups and particularly against the IBD-NAFLD group. β-diversity also showed a significant difference among groups. The higher Bacteroidetes/Firmicutes ratio was found only when comparing IBD groups and CTRLs. Comparing the IBD-only group with the IBD-NAFLD group, a decrease in differential abundance of Subdoligranulum, Parabacteroides, and Fusicatenibacter was found. Comparing the NAFLD-only with the IBD-NAFLD groups, there was a higher abundance of Alistipes, Odoribacter, Sutterella, and Lachnospira. An inverse relationship in the comparison between the IBD-only group and the other groups was shown. For the first time, the singularity of the gut microbial composition in IBD and NAFLD patients has been shown, implying a potential microbial signature mainly influenced by gut inflammation. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Lack of Seroconversion Following COVID-19 Vaccination Is an Independent Risk Factor for SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: Data from ESCAPE-IBD, an IG-IBD Study.

Author

Macaluso, Fabio Salvatore, Principi, Mariabeatrice, Facciotti, Federica, Contaldo, Antonella, Todeschini, Alessia, Saibeni, Simone, Bezzio, Cristina, Castiglione, Fabiana, Nardone, Olga Maria, Spagnuolo, Rocco, Fantini, Massimo Claudio, Riguccio, Gaia, Conforti, Simone, Caprioli, Flavio, Viganò, Chiara, Felice, Carla, Fiorino, Gionata, Correale, Carmen, Bodini, Giorgia, and Milla, Monica

Published
2024
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21. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Author

Mancina, Rosellina Margherita, Dongiovanni, Paola, Petta, Salvatore, Pingitore, Piero, Meroni, Marica, Rametta, Raffaela, Borén, Jan, Montalcini, Tiziana, Pujia, Arturo, Wiklund, Olov, Hindy, George, Spagnuolo, Rocco, Motta, Benedetta Maria, Pipitone, Rosaria Maria, Craxì, Antonio, Fargion, Silvia, Nobili, Valerio, Käkelä, Pirjo, Kärjä, Vesa, Männistö, Ville, Pihlajamäki, Jussi, Reilly, Dermot F., Castro-Perez, Jose, Kozlitina, Julia, Valenti, Luca, and Romeo, Stefano

Published
2016
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23. SARS-CoV-2 infection in patients with inflammatory bowel disease: comparison between the first and second pandemic waves

Author

Bezzio, Cristina, Vernero, Marta, Costa, Stefania, Armuzzi, Alessandro, Fiorino, Gionata, Ardizzone, Sandro, Roselli, Jenny, Carparelli, Sonia, Orlando, Ambrogio, Caprioli, Flavio Andrea, Castiglione, Fabiana, Viganò, Chiara, Ribaldone, Davide G., Zingone, Fabiana, Monterubbianesi, Rita, Imperatore, Nicola, Festa, Stefano, Daperno, Marco, Scucchi, Ludovica, Ferronato, Antonio, Pastorelli, Luca, Alimenti, Eleonora, Balestrieri, Paola, Ricci, Chiara, Cappello, Maria, Felice, Carla, Coppini, Francesca, Alvisi, Patrizia, Di Luna, Imma, Gerardi, Viviana, Variola, Angela, Mazzuoli, Silvia, Lenti, Marco Vincenzo, Saibeni, Simone, Pugliese, Daniela, Furfaro, Federica, Maconi, Giovanni, Milla, Monica, Bossa, Fabrizio, Giuliano, Alessandra, Piazza, Nicole, Manes, Gianpiero, Sartini, Alessandro, Buda, Andrea, Micheli, Federica, Ciardo, Valeria, Casella, Giovanni, Viscido, Angelo, Bodini, Giorgia, Casini, Valentina, Soriano, Alessandra, Amato, Arnaldo, Grossi, Laurino, Onali, Sara, Rottoli, Matteo, Spagnuolo, Rocco, Baroni, Stefania, Cortelezzi, Claudio, Baldoni, Monia, Scaldaferri, Franco, Guarino, Alessia, Palermo, Andrea, D’Incà, Renata, Scribano, Maria Lia, Biancone, Livia, Carrozza, Lucio, Ascolani, Marta, Costa, Francesco, Di Sabatino, Antonio, Zammarchi, Irene, Gottin, Matteo, Conforti, Francesco Simone, Null, Null, Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Bezzio, Cristina, Vernero, Marta, Costa, Stefania, Armuzzi, Alessandro, Fiorino, Gionata, Ardizzone, Sandro, Roselli, Jenny, Carparelli, Sonia, Orlando, Ambrogio, Caprioli, Flavio Andrea, Castiglione, Fabiana, Viganò, Chiara, Ribaldone, Davide G., Zingone, Fabiana, Monterubbianesi, Rita, Imperatore, Nicola, Festa, Stefano, Daperno, Marco, Scucchi, Ludovica, Ferronato, Antonio, Pastorelli, Luca, Alimenti, Eleonora, Balestrieri, Paola, Ricci, Chiara, Cappello, Maria, Felice, Carla, Coppini, Francesca, Alvisi, Patrizia, Di Luna, Imma, Gerardi, Viviana, Variola, Angela, Mazzuoli, Silvia, Lenti, Marco Vincenzo, Saibeni, Simone, Pugliese, Daniela, Furfaro, Federica, Maconi, Giovanni, Milla, Monica, Bossa, Fabrizio, Giuliano, Alessandra, Piazza, Nicole, Manes, Gianpiero, Sartini, Alessandro, Buda, Andrea, Micheli, Federica, Ciardo, Valeria, Casella, Giovanni, Viscido, Angelo, Bodini, Giorgia, Casini, Valentina, Soriano, Alessandra, Amato, Arnaldo, Grossi, Laurino, Onali, Sara, Rottoli, Matteo, Spagnuolo, Rocco, Baroni, Stefania, Cortelezzi, Claudio, Baldoni, Monia, Scaldaferri, Franco, Guarino, Alessia, Palermo, Andrea, D’Incà, Renata, Scribano, Maria Lia, Biancone, Livia, Carrozza, Lucio, Ascolani, Marta, Costa, Francesco, Di Sabatino, Antonio, Zammarchi, Irene, Gottin, Matteo, Conforti, Francesco Simone, Null, Null, Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), and Scaldaferri, Franco (ORCID:0000-0001-8334-7541)

Abstract

BackgroundIn Italy, the incidence of SARS-CoV-2 infection peaked in April and November 2020, defining two pandemic waves of coronavirus disease 2019 (COVID-19). This study compared the characteristics and outcomes of patients with inflammatory bowel disease (IBD) and SARS-CoV-2 infections between pandemic waves.MethodsObservational longitudinal study of IBD patients with SARS-CoV-2 infection. Patients with established diagnoses of IBD and of SARS-CoV-2 infection were consecutively enrolled in two periods: (i) first wave, from 1 March 2020 to 31 May 2020; and (ii) second wave, from 15 September to 15 December 2020.ResultsWe enrolled 937 IBD patients (219 in the first wave, 718 in the second wave). Patients of the first wave were older (mean & PLUSMN; SD: 46.3 & PLUSMN; 16.2 vs. 44.1 & PLUSMN; 15.4 years, p = 0.06), more likely to have ulcerative colitis (58.0% vs. 44.4%, p < 0.001) and comorbidities (48.9% vs. 38.9%; p < 0.01), and more frequently residing in Northern Italy (73.1% vs. 46.0%, p < 0.001) than patients of the second wave. There were no significant differences between pandemic waves in sex (male: 54.3% vs. 53.3%, p = 0.82) or frequency of active IBD (44.3% vs. 39.0%, p = 0.18). The rates of negative outcomes were significantly higher in the first than second wave: pneumonia (27.8% vs. 11.7%, p < 0.001), hospital admission (27.4% vs. 9.7%, p < 0.001), ventilatory support (11.9% vs. 5.4%, p < 0.003) and death (5.5% vs. 1.8%, p < 0.007).ConclusionBetween the first and second SARS-CoV-2 pandemic waves, demographic, clinical and geographical features of IBD patients were different as were the symptoms and outcomes of infection. These differences are likely due to the different epidemiological situations and diagnostic possibilities between the two waves.

Published
2023

25. Gastrointestinal Symptoms Impact Psychosocial Function and Quality of Life in Patients with Rheumatoid Arthritis and Spondyloarthritis: A Cross-Sectional Study

Author

Iaquinta, Francesco Salvatore, primary, Mauro, Daniele, additional, Pantano, Ilenia, additional, Naty, Saverio, additional, Iacono, Daniela, additional, Gaggiano, Emanuela, additional, Riccio, Luca, additional, Ciccia, Francesco, additional, Grembiale, Rosa Daniela, additional, and Spagnuolo, Rocco, additional

Published
2023
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26. 12 COMPARISON OF TWO STRATEGIES FOR THE MANAGEMENT OF POSTOPERATIVE RECURRENCE IN CROHN'S DISEASE PATIENTS WITH ONE CLINICAL RISK FACTOR: A MULTICENTRE ITALIAN STUDY

Author

Dragoni, Gabriele, primary, Castiglione, Fabiana, additional, Bezzio, Cristina, additional, Pugliese, Daniela, additional, Spagnuolo, Rocco, additional, Viola, Anna, additional, Bossa, Fabrizio, additional, Aratari, Annalisa, additional, Savarino, Edoardo V., additional, Balestrieri, Paola, additional, onali, sara, additional, Viganò, Chiara, additional, Ribaldone, Davide Giuseppe, additional, Innocenti, Tommaso, additional, Testa, Anna, additional, Saibeni, Simone, additional, Privitera, Giuseppe, additional, Milla, Monica, additional, Armuzzi, Alessandro, additional, Fantini, Massimo Claudio, additional, and Fiorino, Gionata, additional

Published
2023
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27. Comparison of two strategies for the management of postoperative recurrence in Crohn’s disease patients with one clinical risk factor: A multicentre IG‐IBD study

Author

Dragoni, Gabriele, primary, Castiglione, Fabiana, additional, Bezzio, Cristina, additional, Pugliese, Daniela, additional, Spagnuolo, Rocco, additional, Viola, Anna, additional, Cocomazzi, Francesco, additional, Aratari, Annalisa, additional, Savarino, Edoardo Vincenzo, additional, Balestrieri, Paola, additional, Onali, Sara, additional, Viganò, Chiara, additional, Ribaldone, Davide Giuseppe, additional, Innocenti, Tommaso, additional, Testa, Anna, additional, Saibeni, Simone, additional, Privitera, Giuseppe, additional, Milla, Monica, additional, Armuzzi, Alessandro, additional, Fantini, Massimo Claudio, additional, and Fiorino, Gionata, additional

Published
2023
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29. COVID-19 Vaccine Booster Shot Preserves T Cells Immune Response Based on Interferon-Gamma Release Assay in Inflammatory Bowel Disease (IBD) Patients on Anti-TNFα Treatment

Author

Pavia, Grazia, primary, Spagnuolo, Rocco, additional, Quirino, Angela, additional, Marascio, Nadia, additional, Giancotti, Aida, additional, Simeone, Silvio, additional, Cosco, Cristina, additional, Tino, Elena, additional, Carrabetta, Federico, additional, Di Gennaro, Gianfranco, additional, Nobile, Carmelo, additional, Bianco, Aida, additional, Matera, Giovanni, additional, and Doldo, Patrizia, additional

Published
2023
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31. Reduced humoral response to two doses of COVID-19 vaccine in patients with inflammatory bowel disease: Data from ESCAPE-IBD, an IG-IBD study

Author

Macaluso, Fabio Salvatore, primary, Principi, Mariabeatrice, additional, Facciotti, Federica, additional, Contaldo, Antonella, additional, Todeschini, Alessia, additional, Saibeni, Simone, additional, Bezzio, Cristina, additional, Castiglione, Fabiana, additional, Nardone, Olga Maria, additional, Spagnuolo, Rocco, additional, Fantini, Massimo Claudio, additional, Riguccio, Gaia, additional, Caprioli, Flavio, additional, Viganò, Chiara, additional, Felice, Carla, additional, Fiorino, Gionata, additional, Correale, Carmen, additional, Bodini, Giorgia, additional, Milla, Monica, additional, Scardino, Giulia, additional, Vernero, Marta, additional, Desideri, Federico, additional, Mannino, Mariella, additional, Rizzo, Giuseppe, additional, Orlando, Ambrogio, additional, Amato, Arnaldo, additional, Ascolani, Marta, additional, Calabrese, Giulio, additional, Casà, Angelo, additional, Comberlato, Michele, additional, Conforti, Francesco Simone, additional, De Bona, Manuela, additional, Demarzo, Maria Giulia, additional, Doldo, Patrizia, additional, Dragoni, Gabriele, additional, Furfaro, Federica, additional, Mulinacci, Giacomo, additional, Olmo, Oriana, additional, O'Sed, Nicole Piazza, additional, Paba, Salvatore, additional, Radice, Simona, additional, Renna, Sara, additional, Ribaldone, Davide Giuseppe, additional, and Rizzuto, Giulia, additional

Published
2023
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34. Ultrasound Prevalence and Clinical Features of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Diseases: A Real-Life Cross-Sectional Study.

Author

Abenavoli, Ludovico, Spagnuolo, Rocco, Scarlata, Giuseppe Guido Maria, Scarpellini, Emidio, Boccuto, Luigi, and Luzza, Francesco

Subjects
FATTY liver, INFLAMMATORY bowel diseases, NON-alcoholic fatty liver disease, CROHN'S disease, LIVER histology, DISEASE duration, ULCERATIVE colitis
Abstract

Background and Objectives: Inflammatory bowel disease (IBD) is a condition characterized by chronic intestinal inflammation. We can identify two major forms: Crohn's disease (CD) and ulcerative colitis (UC). One of the extraintestinal manifestations of IBD is nonalcoholic fatty liver disease (NAFLD). IBD and NAFLD share common pathogenetic mechanisms. Ultrasound (US) examination is the most commonly used imaging method for the diagnosis of NAFLD. This cross-sectional observational retrospective study aimed to evaluate the US prevalence of NAFLD in IBD patients and their clinical features. Materials and Methods: A total of 143 patients with IBD underwent hepatic US and were divided into two different groups according to the presence or absence of NAFLD. Subsequently, new exclusion criteria for dysmetabolic comorbidities (defined as plus) were applied. Results: The US prevalence of NAFLD was 23% (21% in CD and 24% in UC, respectively). Most IBD–NAFLD patients were male and older and showed significantly higher values for body mass index, waist circumference, disease duration, and age at onset than those without NAFLD. IBD–NAFLD patients showed a significantly higher percentage of stenosing phenotype and left-side colitis. Regarding metabolic features, IBD–NAFLD patients showed a significantly higher percentage of hypertension and IBD plus dysmetabolic criteria. Also, higher values of alanine aminotransferase and triglycerides and lower levels of high-density lipoproteins are reported in these patients. Conclusions: We suggest performing liver US screening in subjects affected by IBD to detect NAFLD earlier. Also, patients with NAFLD present several metabolic comorbidities that would fall within the new definition of metabolic-associated fatty liver disease. Finally, we encourage larger longitudinal studies, including healthy controls, to provide further confirmation of our preliminary data. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Biologics for Inflammatory Bowel Disease in Clinical Practice: A Calabria (Southern Italy) Prospective Pharmacovigilance Study

Author

Tallarico, Martina, primary, Palleria, Caterina, additional, Ruffolo, Livia, additional, Spagnuolo, Rocco, additional, Naturale, Maria Diana, additional, De Francesco, Adele Emanuela, additional, De Sarro, Caterina, additional, Romeo, Rossella, additional, Citraro, Rita, additional, Doldo, Patrizia, additional, Abenavoli, Ludovico, additional, Gallelli, Luca, additional, Luzza, Francesco, additional, Leo, Antonio, additional, and De Sarro, Giovambattista, additional

Published
2022
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37. Safety, hesitancy of coronavirus disease 2019 vaccination and pandemic burden in patients with inflammatory bowel disease: data of a national study (ESCAPE-IBD).

Author

Principi, Mariabeatrice, Macaluso, Fabio Salvatore, Todeschini, Alessia, Facciotti, Federica, Contaldo, Antonella, Castiglione, Fabiana, Nardone, Olga Maria, Spagnuolo, Rocco, Doldo, Patrizia, Riguccio, Gaia, Conforti, Francesco Simone, Viganò, Chiara, Ascolani, Marta, Fiorino, Gionata, Correale, Carmen, Bodini, Giorgia, Milla, Monica, Scardino, Giulia, Vernero, Marta, and Desideri, Federico

Published
2023
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39. Satisfaction with Social Roles and Physical Function in Immune-mediated Inflammatory Diseases: A Cross-Sectional Study

Author

Spagnuolo, Rocco, primary, Iaquinta, Francesco Salvatore, additional, Mauro, Daniele, additional, Pantano, Ilenia, additional, Dastoli, Stefano, additional, Naty, Saverio, additional, Cosco, Cristina, additional, Mancina, Rosellina Margherita, additional, Iacono, Daniela, additional, Gaggiano, Emanuela, additional, Ruggiero, Annarita, additional, Nisticò, Steven Paul, additional, Ciccia, Francesco, additional, Grembiale, Rosa Daniela, additional, and Patrizia, Doldo, additional

Published
2022
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40. Fatigue and Associated Factors in an Immune-Mediated Inflammatory Disease Population: A Cross-Sectional Study

Author

Iaquinta, Francesco Salvatore, primary, Grembiale, Rosa Daniela, additional, Mauro, Daniele, additional, Pantano, Ilenia, additional, Naty, Saverio, additional, Cosco, Cristina, additional, Iacono, Daniela, additional, Gaggiano, Emanuela, additional, Ruggiero, Annarita, additional, Ciccia, Francesco, additional, Doldo, Patrizia, additional, and Spagnuolo, Rocco, additional

Published
2022
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42. Tu1819 REAL-LIFE EFFECTIVENESS AND SAFETY OF TOFACITINIB AND VEDOLIZUMAB AS A SECOND-LINE THERAPY IN ANTI-TNFS EXPERIENCED PATIENTS ULCERATIVE COLITIS: PRELIMINARY RESULTS OF AN IGIBD STUDY (VE2TO-UC)

Author

Noviello, Daniele, Savarino, Edoardo V., Fries, Walter, Fantini, Massimo Claudio, Conforti, Francesco Simone, Orlando, Ambrogio, Ribaldone, Davide Giuseppe, Mocci, Giammarco, Viganò, Chiara, Festa, Stefano, Spagnuolo, Rocco, Campigotto, Michele, Grossi, Laurino, Gravina, Antonietta G., Principi, Mariabeatrice, Imperatore, Nicola, Gabrielli, Anna M Carvalhas, Scardino, Giulia, Scaldaferri, Franco, Ceccarelli, Linda, Neri, Benedetto, Sario, Antonio Di, De Barba, Caterina, De Francesco, Clara, Calderone, Silvia, onali, sara, Vecchi, Maurizio, Ventimiglia, Marco, and Caprioli, Flavio

Published
2024
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43. Phytomedicines to Target Hepatitis B Virus DNA Replication: Current Limitations and Future Approaches

Author

Sadiea, Rahila Zannat, primary, Sultana, Shahnaj, additional, Chaki, Bijan Mohon, additional, Islam, Tasnim, additional, Dash, Sharmy, additional, Akter, Sharmin, additional, Islam, Md Sayeedul, additional, Kazi, Taheruzzaman, additional, Nagata, Abir, additional, Spagnuolo, Rocco, additional, Mancina, Rosellina Margherita, additional, and Hossain, Md Golzar, additional

Published
2022
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44. Autoimmune colitis and neutropenia in adjuvant anti-PD-1 therapy for malignant melanoma: efficacy of Vedolizumab, a case report

Author

d’Apolito, Maria, primary, Spagnuolo, Rocco, additional, Siciliano, Maria Anna, additional, Barbieri, Vito, additional, Cosco, Cristina, additional, Fiorillo, Lucia, additional, Cuomo, Onofrio, additional, Zuccalà, Valeria, additional, Correale, Pierpaolo, additional, Pensabene, Licia, additional, Rossi, Marco, additional, Doldo, Patrizia, additional, Tassone, Pierfrancesco, additional, and Tagliaferri, Pierosandro, additional

Published
2022
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45. DEPDC5 Variants Increase Fibrosis Progression in Europeans with Chronic Hepatitis C Virus Infection

Author

Burza, Maria Antonella, Motta, Benedetta Maria, Mancina, Rosellina Margherita, Pingitore, Piero, Pirazzi, Carlo, Lepore, Saverio Massimo, Spagnuolo, Rocco, Doldo, Patrizia, Russo, Cristina, Lazzaro, Veronica, Fischer, Janett, Berg, Thomas, Aghemo, Alessio, Cheroni, Cristina, De Francesco, Raffaele, Fargion, Silvia, Colombo, Massimo, Datz, Christian, Stickel, Felix, Valenti, Luca, and Romeo, Stefano

Published
2016
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46. Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank

Author

De Vincentis, Antonio, primary, Tavaglione, Federica, additional, Spagnuolo, Rocco, additional, Pujia, Roberta, additional, Tuccinardi, Dario, additional, Mascianà, Gianluca, additional, Picardi, Antonio, additional, Antonelli Incalzi, Raffaele, additional, Valenti, Luca, additional, Romeo, Stefano, additional, and Vespasiani-Gentilucci, Umberto, additional

Published
2021
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47. Psychometric evaluation of an Italian custom 4-item short form of the PROMIS anxiety item bank in immune-mediated inflammatory diseases: an item response theory analysis

Author

Liuzza, Marco Tullio, primary, Spagnuolo, Rocco, additional, Antonucci, Gabriella, additional, Grembiale, Rosa Daniela, additional, Cosco, Cristina, additional, Iaquinta, Francesco Salvatore, additional, Funari, Vanessa, additional, Dastoli, Stefano, additional, Nistico, Steven, additional, and Doldo, Patrizia, additional

Published
2021
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48. PCSK9 rs11591147 R46L loss‐of‐function variant protects against liver damage in individuals with NAFLD

Author

Grimaudo, Stefania, Bartesaghi, Stefano, Rametta, Raffaela, Marra, Fabio, Margherita Mancina, Rosellina, Pihlajamäki, Jussi, Kakol‐Palm, Dorota, Andréasson, Anne‐Christine, Dongiovanni, Paola, Ludovica Fracanzani, Anna, Lori, Giulia, Männistö, Ville, Pellegrini, Giovanni, Bohlooly‐Y, Mohammad, Pennisi, Grazia, Maria Pipitone, Rosaria, Spagnuolo, Rocco, Craxì, Antonio, Lindén, Daniel, Valenti, Luca, Romeo, Stefano, Petta, Salvatore, University of Zurich, and Petta, Salvatore

Subjects
Hepatology, 570 Life sciences, biology, 10184 Institute of Veterinary Pathology, 2721 Hepatology
Published
2021
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49. Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

Author

Bianco, C., Jamialahmadi, O., Pelusi, S., Baselli, G., Dongiovanni, P., Zanoni, I., Santoro, L., Maier, S., Liguori, Antonio, Meroni, M., Borroni, V., D'Ambrosio, R., Spagnuolo, Rocco, Alisi, A., Federico, A., Bugianesi, E., Petta, S., Miele, Luca, Vespasiani-Gentilucci, U., Anstee, Q. M., Stickel, F., Hampe, J., Fischer, J., Berg, T., Fracanzani, A. L., Soardo, G., Reeves, H., Prati, D., Romeo, S., Valenti, L., Liguori A., Spagnuolo R., Miele L. (ORCID:0000-0003-3464-0068), Bianco, C., Jamialahmadi, O., Pelusi, S., Baselli, G., Dongiovanni, P., Zanoni, I., Santoro, L., Maier, S., Liguori, Antonio, Meroni, M., Borroni, V., D'Ambrosio, R., Spagnuolo, Rocco, Alisi, A., Federico, A., Bugianesi, E., Petta, S., Miele, Luca, Vespasiani-Gentilucci, U., Anstee, Q. M., Stickel, F., Hampe, J., Fischer, J., Berg, T., Fracanzani, A. L., Soardo, G., Reeves, H., Prati, D., Romeo, S., Valenti, L., Liguori A., Spagnuolo R., and Miele L. (ORCID:0000-0003-3464-0068)

Abstract

Background & Aims: Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into the causal relationship between NAFLD and HCC, and to improve HCC risk stratification. Methods: We examined at-risk individuals (NAFLD cohort, n = 2,566; 226 with HCC; and a replication cohort of 427 German patients with NAFLD) and the general population (UK Biobank [UKBB] cohort, n = 364,048; 202 with HCC). Variants in PNPLA3-TM6SF2-GCKR-MBOAT7 were combined in a hepatic fat PRS (PRS-HFC), and then adjusted for HSD17B13 (PRS-5). Results: In the NAFLD cohort, the adjusted impact of genetic risk variants on HCC was proportional to the predisposition to fatty liver (p = 0.002) with some heterogeneity in the effect. PRS predicted HCC more robustly than single variants (p <10-13). The association between PRS and HCC was mainly mediated through severe fibrosis, but was independent of fibrosis in clinically relevant subgroups, and was also observed in those without severe fibrosis (p <0.05). In the UKBB cohort, PRS predicted HCC independently of classical risk factors and cirrhosis (p <10-7). In the NAFLD cohort, we identified high PRS cut-offs (≥0.532/0.495 for PRS-HFC/PRS-5) that in the UKBB cohort detected HCC with ~90% specificity but limited sensitivity; PRS predicted HCC both in individuals with (p <10-5) and without cirrhosis (p <0.05). Conclusions: Our results are consistent with a causal relationship between hepatic fat and HCC. PRS improved the accuracy of HCC detection and may help stratify HCC risk in individuals with dysmetabolism, including those without severe liver fibrosis. Further studies are needed to validate our findings. Lay summary: By analyzing variations in genes that contribute to fatty liver disease, we developed

Published
2021

50. Knowledge of Diagnostic and Therapeutic Aspects of IBD Among Nurses Working in Digestive Endoscopy: A Nationwide Italian Survey

Author

Napolitano, Daniele, Scaldaferri, Franco, Fiorino, Gionata, Spagnuolo, Rocco, Leonetti, Alessia, Lopetuso, Loris Riccardo, Cocchieri, Antonello, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Cocchieri, Antonello (ORCID:0000-0002-7694-4986), Napolitano, Daniele, Scaldaferri, Franco, Fiorino, Gionata, Spagnuolo, Rocco, Leonetti, Alessia, Lopetuso, Loris Riccardo, Cocchieri, Antonello, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Cocchieri, Antonello (ORCID:0000-0002-7694-4986)

Abstract

The importance of inflammatory bowel disease (IBD) dedicated nurses in endoscopy services is poorly explored. Non-IBD healthcare professionals who work in endoscopy units may underestimate the discomfort and the secondary psychological distress that endoscopic procedures cause in IBD patients. We performed a nationwide survey to evaluate nurses' level of knowledge working in endoscopy facilities throughout Italy related to IBD patients' needs undergoing endoscopic procedures. A non-validate 45 items questionnaire divided into six sections was assembled by a group of experts and supervised by nurses and IBD physicians as part of the board of IGIBD, ANOTE-ANIGEA, and AGGEI. The questionnaire was sent to 397 nurses of which 335 (84.4%) responded to the questionnaire. The median level of knowledge registered was 29 ± 12, corresponding to a medium level of knowledge based on the scores described in the method section. One hundred eighty-three nurses (54.6%) reported a high score, 113 (33.7%) a medium score, and 39 (11.6%) a low score. The majority of nurses worked in high-volume endoscopy centers, where 48% were educated in IBD management. A low level of knowledge was recorded regarding disease severity definition, bowel preparation strategies in severe colitis, and evaluation of perianal fistula. This nationwide survey clearly shows that there is a need for endoscopic nurses to acquire specific knowledge in the IBD field. Dedicated pathways for IBD management in endoscopy, continuous educational programs for nurses, and further studies to improve nurse education are needed.

Published
2021

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