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Your search keyword '"Spagnuolo, Carlos C."' showing total 7 results
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7 results on '"Spagnuolo, Carlos C."'

2. Clinical and Analytical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay

Author

Wussler, Desiree, Puelacher, Christian, Huré, Gabrielle, Rentsch, Katharina, Gualandro, Danielle M., Reinhardt, Julia, Sanchez, Ana Yufera, Okamura, Bernhard, Shrestha, Samyut, Haaf, Philip, Badertscher, Patrick, Walter, Joan Elias, López, Beatriz, Martinez-Nadal, Gemma, Adrada, Esther Rodriguez, Parenica, Jiri, von Eckardstein, Arnold, Morawiec, Beata, Muzyk, Piotr, Schirmer, Henrik, Koechlin, Luca, Boeddinghaus, Jasper, Lopez-Ayala, Pedro, Reber, Cornelia, Nestelberger, Thomas, Wildi, Karin, Spagnuolo, Carlos C., Strebel, Ivo, Glaeser, Jonas, Bima, Paolo, Crisanti, Luca, Herraiz-Recuenco, Lourdes, Dubach, Elisa, Miró, Òscar, Martin-Sanchez, F. Javier, Kawecki, Damian, Keller, Dagmar I., Christ, Michael, Buser, Andreas, Giménez, Maria Rubini, Størvold, Gro Leite, Broughton, Marianne Nordlund, Omland, Torbjørn, Lyngbakken, Magnus N., Røsjø, Helge, and Mueller, Christian

Published
2024
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4. External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study

Author

Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Nestelberger, Thomas, Koechlin, Luca, Zimmermann, Tobias, Bima, Paolo, Glaeser, Jonas, Spagnuolo, Carlos C, Champetier, Arnaud, Miro, Oscar, Martin-Sanchez, Francisco Javier, Keller, Dagmar I, Christ, Michael, Wildi, Karin, Breidthardt, Tobias, Strebel, Ivo, Mueller, Christian, Reichlin, Tobias, Kaeslin, Marina, Potlukova, Eliska, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Shrestha, Samyut, Guzman-Tacla, Caroline A., Herraiz-Recuenco, Lourdes, Morawiec, Beata, Munzk, Piotr, Freese, Michael, Martinez-Nadal, Gemma, Fuenzalida, Carolina, Calderon, Sofia, Rodriguez Adrada, Esther, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, and Gea, Joachim

Abstract

The myocardial-ischaemic-injury-index (MI3) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI3, both when using early serial blood draws (eg, at 1 h or 2 h) and in direct comparison with guideline-recommended algorithms, remains unknown. Our aim was to externally validate MI3and compare its performance with that of the European Society of Cardiology (ESC) 0/1h-algorithm.

Published
2024
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6. Additional file 1 of Glucose control after glucocorticoid administration in hospitalized patients ��� a retrospective analysis

Author

Merkofer, Franzisca, Struja, Tristan, Delfs, Neele, Spagnuolo, Carlos C., Hafner, Jason F., Kupferschmid, Kevin, Baechli, Ciril, Schuetz, Philipp, Mueller, Beat, and Blum, Claudine A.

Abstract

Additional file 1: Supplemental Table 1. Results of the unadjusted and adjusted multinomial logistic regression. Supplemental Fig. 1. Glucose variability according to treatment strategy. Supplemental Fig. 2. Glucose variability in patients with and without hypoglycemia.

Published
2022
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7. Clinical and Analytical Performance of a Novel Point-of-Care High-Sensitivity Cardiac Troponin I Assay.

Author

Koechlin, Luca, Boeddinghaus, Jasper, Lopez-Ayala, Pedro, Reber, Cornelia, Nestelberger, Thomas, Wildi, Karin, Spagnuolo, Carlos C., Strebel, Ivo, Glaeser, Jonas, Bima, Paolo, Crisanti, Luca, Herraiz-Recuenco, Lourdes, Dubach, Elisa, Miró, Òscar, Martin-Sanchez, F. Javier, Kawecki, Damian, Keller, Dagmar I., Christ, Michael, Buser, Andreas, and Giménez, Maria Rubini

Subjects
*ACUTE coronary syndrome, *TROPONIN I, *MYOCARDIAL infarction, *PLASMA products, *TROPONIN
Abstract

Point-of-care (POC) high-sensitivity cardiac troponin assays may further accelerate the diagnosis of myocardial infarction (MI). This study sought to assess the clinical and analytical performance of the novel high-sensitivity cardiac troponin I (hs-cTnI)-SPINCHIP POC test. Adult patients presenting with acute chest discomfort to the emergency department were enrolled in an international, diagnostic, multicenter study. The final diagnosis was centrally adjudicated by 2 independent cardiologists using all clinical information. We compared the discriminatory performance of hs-cTnI-SPINCHIP with current established central laboratory assays and derived an assay-specific hs-cTnI-SPINCHIP 0/1-hour algorithm. Secondary analyses included sample type comparisons (whole blood, fresh/frozen plasma, and capillary finger prick) and precision analysis. MI was the adjudicated final diagnosis in 214 (19%) of 1,102 patients. Area under the receiver-operating characteristic curve was 0.94 (95% CI: 0.92-0.95) for hs-cTnI-SPINCHIP vs 0.94 (95% CI: 0.92-0.95) for hs-cTnI-Architect (P = 0.907) and 0.93 (95% CI: 0.91-0.95) for high-sensitivity cardiac troponin T Elecsys (P = 0.305). A cutoff <7 ng/L at presentation (if chest pain onset was >3 hours) or <7 ng/L together with a 0/1-hour delta of <4 ng/L ruled out 51% with a sensitivity and negative predictive value of 100% (95% CI: 97.7%-100%) and 100% (95% CI: 99.0%-100%), respectively. A hs-cTnI-SPINCHIP concentration ≥36 ng/L or a 0/1-hour delta ≥11 ng/L ruled in 27% with a specificity and positive predictive value of 90.9% (95% CI: 88.3%-92.9%) and 72.9% (95% CI: 66.4%-78.6%), respectively. Bootstrap internal validation confirmed excellent diagnostic performance. High agreement was observed between different sample types. The SPINCHIP hs-cTnI POC test has very high diagnostic accuracy. Its assay-specific 0/1-hour algorithm achieved very high sensitivity/negative predictive value and specificity/positive predictive value for rule-out/in MI. (Advantageous Predictors of Acute Coronary Syndromes Evaluation [APACE] Study [APACE]; NCT00470587) [ABSTRACT FROM AUTHOR]

Published
2024
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