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2. Immune response profiles induced by silk-based biomaterials: a journey from 'immunogenicity' towards 'immuno-compatibility.

Author

Majumder, Nilotpal, Bhattacharjee, Maumita, Spagnoli, Giulio C., and Ghosh, Sourabh

Abstract

Silk is a widely accepted biomaterial for tissue regeneration owing to its tunable biomechanical properties and ease of chemical modification. However, a number of aspects associated with its clinical use are still debated. Indeed, to achieve clinical success, a biomaterial must favorably interact with host tissues without evoking local or systemic immuno-inflammatory responses. The analysis of immune responses associated with silk under in vitro and in vivo conditions provides useful insights, improving the understanding of the functional characteristics of silk biomaterials and further promoting their clinical application. Silk evokes moderate immune responses upon implantation in vivo, depending on the material structure, fabrication method, degradation time, and implantation in soft or hard tissue sites, which rapidly subside within a few days/weeks. In vitro studies indicate that its immune-stimulatory properties are largely due to inherent protein conformation and differential processing parameters. Strategically controlled levels of immune responses in vivo with marginal immunogenicity of silk-based biomaterials may contribute to matrix remodeling and replacement by native tissue matrix around the implanted site. Therefore, immunomodulatory strategies should be developed to promote the use of silk-based biomaterials as promising candidates for numerous clinical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Supplementary Materials and Methods from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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6. Supplementary Table 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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7. Supplementary Figure 2 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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8. Supplementary Figure 3 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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9. Supplementary Figure 2 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Author

Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary

Published
2023
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10. Supplementary Figure 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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11. Supplementary Table 1 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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12. Supplementary Figure 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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13. Supplementary Table 2 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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14. Legend from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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15. Supplementary Table 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer

Author

Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary

Published
2023
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16. Supplementary Figure 1 from Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer

Author

Le Magnen, Clémentine, primary, Bubendorf, Lukas, primary, Rentsch, Cyrill A., primary, Mengus, Chantal, primary, Gsponer, Joel, primary, Zellweger, Tobias, primary, Rieken, Malte, primary, Thalmann, George N., primary, Cecchini, Marco G., primary, Germann, Markus, primary, Bachmann, Alexander, primary, Wyler, Stephen, primary, Heberer, Michael, primary, and Spagnoli, Giulio C., primary

Published
2023
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17. Supplementary Figure 1 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer

Author

Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary

Published
2023
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25. Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment

Author

Sconocchia, Giuseppe, primary, Lanzilli, Giulia, additional, Cesarini, Valeriana, additional, Silvestris, Domenico A, additional, Rezvani, Katayoun, additional, Arriga, Roberto, additional, Caratelli, Sara, additional, Chen, Ken, additional, Dou, Jinzhuang, additional, Cenciarelli, Carlo, additional, Toietta, Gabriele, additional, Baldari, Silvia, additional, Sconocchia, Tommaso, additional, De Paolis, Francesca, additional, Aureli, Anna, additional, Iezzi, Giandomenica, additional, Irno Consalvo, Maria, additional, Buccisano, Francesco, additional, del Principe, Maria I, additional, Maurillo, Luca, additional, Venditti, Adriano, additional, Ottaviani, Alessio, additional, and Spagnoli, Giulio C, additional

Published
2022
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27. Cytotoxic T-cell Induction in Metastatic Melanoma Patients Undergoing Recombinant Vaccinia Virus-based Immuno-gene Therapy

Author

Spagnoli, Giulio C., Zajac, Paul, Marti, Walter R., Oertli, Daniel, Padovan, Elisabetta, Noppen, Christoph, Kocher, Thomas, Adamina, Michel, Heberer, Michael, Schlag, P. M., editor, Senn, H.-J., editor, Kleihues, P., editor, Stiefel, F., editor, Groner, B., editor, Wallgren, A., editor, Dummer, Reinhard, editor, Nestle, Frank O., editor, and Burg, Günter, editor

Published
2002
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29. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells

Author

Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, Iezzi, Giandomenica, Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, and Iezzi, Giandomenica

Abstract

Stromal infiltration is associated with poor prognosis in human colon cancers. However, the high heterogeneity of human tumor-associated stromal cells (TASCs) hampers a clear identification of specific markers of prognostic relevance. To address these issues, we established short-term cultures of TASCs and matched healthy mucosa-associated stromal cells (MASCs) from human primary colon cancers and, upon characterization of their phenotypic and functional profiles in vitro and in vivo, we identified differentially expressed markers by proteomic analysis and evaluated their prognostic significance. TASCs were characterized by higher proliferation and differentiation potential, and enhanced expression of mesenchymal stem cell markers, as compared to MASCs. TASC triggered epithelial-mesenchymal transition (EMT) in tumor cells in vitro and promoted their metastatic spread in vivo, as assessed in an orthotopic mouse model. Proteomic analysis of matched TASCs and MASCs identified a panel of markers preferentially expressed in TASCs. The expression of genes encoding two of them, calponin 1 (CNN1) and tropomyosin beta chain isoform 2 (TPM2), was significantly associated with poor outcome in independent databases and outperformed the prognostic significance of currently proposed TASC markers. The newly identified markers may improve prognostication of primary colon cancers and identification of patients at risk.

Published
2022

30. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells

Author

Mele, Valentina, primary, Basso, Camilla, additional, Governa, Valeria, additional, Glaus Garzon, Jesus F., additional, Muraro, Manuele G., additional, Däster, Silvio, additional, Nebiker, Christian A., additional, Mechera, Robert, additional, Bolli, Martin, additional, Schmidt, Alexander, additional, Geiger, Roger, additional, Spagnoli, Giulio C., additional, Christoforidis, Dimitri, additional, Majno, Pietro E., additional, Borsig, Lubor, additional, and Iezzi, Giandomenica, additional

Published
2022
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31. High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival

Author

Lalos, Alexandros, primary, Neri, Ornella, additional, Ercan, Caner, additional, Wilhelm, Alexander, additional, Staubli, Sebastian, additional, Posabella, Alberto, additional, Weixler, Benjamin, additional, Terracciano, Luigi, additional, Piscuoglio, Salvatore, additional, Stadlmann, Sylvia, additional, Spagnoli, Giulio C., additional, Droeser, Raoul A., additional, and Singer, Gad, additional

Published
2021
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33. Nestin and CD34 expression in colorectal cancer predicts improved overall survival

Author

Tampakis, Athanasios Weixler, Benjamin Rast, Silvan Tampaki, Ekaterini-Christina Cremonesi, Eleonora Kancherla, Venkatesh and Tosti, Nadia Kettelhack, Christoph Ng, Charlotte K. Y. and Delko, Tarik Soysal, Savas D. von Holzen, Urs Felekouras, Evangelos Nikiteas, Nikolaos Bolli, Martin Tornillo, Luigi and Terracciano, Luigi Eppenberger-Castori, Serenella Spagnoli, Giulio C. Piscuoglio, Salvatore von Flue, Markus Daster, Silvio Droeser, Raoul A.

Abstract

Background Nestin, a class VI intermediate filament protein of the cytoskeleton, and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor cells. This study aimed to evaluate their expression and clinical significance in colorectal cancer. Methods A clinically annotated tissue microarray, including 599 patients with colorectal cancer, was analyzed by immunohistochemistry. Furthermore, nestin and CD34 correlations with HIF-1a and a panel of cytokines and chemokines were assessed using quantitative reverse transcription PCR and The Cancer Genome Atlas dataset. Results Expression of nestin and CD34 was observed only in the tumor stroma. Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong correlation (r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated for the following markers; HIF-1 alpha, CD4, CD8, FOXP3, IRF1, GATA3, CCL2, CCL3, CXCL12 and CCL21. Conclusions Combined expression of nestin and CD34 expression is associated with better overall survival possibly by modulating a favorable immune response.

Published
2021

40. Fibrosis and cancer: shared features and mechanisms suggest common targeted therapeutic approaches.

Author

Landolt, Lea, Spagnoli, Giulio C, Hertig, Alexandre, Brocheriou, Isabelle, and Marti, Hans-Peter

Subjects
*THERAPEUTICS, *FIBROSIS, *TRANSFORMING growth factors, *HIPPO signaling pathway, *KIDNEY diseases, *EPITHELIAL-mesenchymal transition, *CHRONIC kidney failure
Abstract

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers. Moreover, clinical and experimental investigations consistently indicate that these diseases intertwine and share strikingly overlapping features. As a deregulated response to injury occurring in all body tissues, fibrosis is characterized by activation of fibroblasts and immune cells, contributing to progressive deposition of extracellular matrix (ECM) and inflammation. Cancers are driven by genetic alterations resulting in dysregulated cell survival, proliferation and dissemination. However, non-cancerous components of tumour tissues including fibroblasts, inflammatory cells and ECM play key roles in oncogenesis and cancer progression by providing a pro-mutagenic environment where cancer cells can develop, favouring their survival, expansion and invasiveness. Additional commonalities of fibrosis and cancer are also represented by overproduction of growth factors, like transforming growth factor β, epithelial-to-mesenchymal transition, high oxidative stress, Hippo pathway dysfunctions and enhanced cellular senescence. Here, we review advances in the analysis of cellular and molecular mechanisms involved in the pathogenesis of both organ fibrosis and cancer, with particular reference to chronic kidney diseases and renal cell cancers. Most importantly, improved understanding of common features is contributing to the development of innovative treatment strategies targeting shared mechanisms. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Nestin and CD34 expression in colorectal cancer predicts improved overall survival

Author

Tampakis, Athanasios, primary, Weixler, Benjamin, additional, Rast, Silvan, additional, Tampaki, Ekaterini-Christina, additional, Cremonesi, Eleonora, additional, Kancherla, Venkatesh, additional, Tosti, Nadia, additional, Kettelhack, Christoph, additional, Ng, Charlotte K. Y., additional, Delko, Tarik, additional, Soysal, Savas D., additional, von Holzen, Urs, additional, Felekouras, Evangelos, additional, Nikiteas, Nikolaos, additional, Bolli, Martin, additional, Tornillo, Luigi, additional, Terracciano, Luigi, additional, Eppenberger-Castori, Serenella, additional, Spagnoli, Giulio C., additional, Piscuoglio, Salvatore, additional, von Flüe, Markus, additional, Däster, Silvio, additional, and Droeser, Raoul A., additional

Published
2021
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42. Supplemental Material, Supplemental_tables - Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer

Author

Haak, Fabian, Obrecht, Isabelle, Tosti, Nadia, Weixler, Benjamin, Mechera, Robert, Däster, Silvio, Strauss, Marco Von, Delko, Tarik, Spagnoli, Giulio C., Terracciano, Luigi, Sconocchia, Giuseppe, Flüe, Markus Von, Kraljević, Marko, and Droeser, Raoul A.

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental Material, Supplemental_tables for Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer by Fabian Haak, Isabelle Obrecht, Nadia Tosti, Benjamin Weixler, Robert Mechera, Silvio Däster, Marco von Strauss, Tarik Delko, Giulio C. Spagnoli, Luigi Terracciano, Giuseppe Sconocchia, Markus von Flüe, Marko Kraljević and Raoul A. Droeser in Cancer Control

Published
2020
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