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5 results on '"Spaans, Remy Hoek"'

1. Schistosoma mansoni‐specific immune responses and allergy in Uganda

Author

Nkurunungi, G., Kabagenyi, J., Nampijja, M., Sanya, R. E., Walusimbi, B., Nassuuna, J., Webb, E. L., Elliott, A. M., Mpairwe, Harriet, O’Hara, Geraldine, Nerima, Barbara, Kizito, Dennison, Tushabe, John Vianney, Verweij, Jaco, Cose, Stephen, Wammes, Linda, Kabuubi, Prossy, Niwagaba, Emmanuel, Oduru, Gloria, Kabami, Grace, Abayo, Elson, Ssebagala, Eric, Muwonge, Fred, Spaans, Remy Hoek, Muhangi, Lawrence, Lubyayi, Lawrence, Akurut, Helen, Nalukenge, Fatuma, Mirembe, Beatrice, Okello, Justin, Owilla, Sebastian, Levin, Jonathan, Nash, Stephen, Zziwa, Christopher, Nakazibwe, Esther, Tumusiime, Josephine, Ninsiima, Caroline, Amongi, Susan, Kamukama, Grace, Iwala, Susan, Akello, Mirriam, Kizindo, Robert, Sewankambo, Moses, Nsubuga, Denis, Tumwesige, Edward, Abiriga, David, Walusimbi, Richard, Nannozi, Victoria, Kabonesa, Cynthia, Kaweesa, James, Tukahebwa, Edridah, Kizza, Moses, and Elliott, Alison

Published
2018
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2. Ethical considerations related to drone use for environment and health research: a scoping review protocol

Author

Silveira, Bruna Drumond and Spaans, Remy Hoek

Subjects
Environmental Health Life Sciences, Remote Sensing, Bioethics and Medical Ethics, Sociology, Geography, Pharmacology, Toxicology and Environmental Health, Medicine and Health Sciences, Life Sciences, Social and Behavioral Sciences, Science and Technology Studies, ethics, FOS: Sociology
Abstract

Introduction: The use of drones in environment and health research is a relatively new phenomenon. A principal research activity drones are used for is environmental monitoring, which can raise concerns in local communities. Existing ethical guidance for researchers is often not specific to drone technology and practices vary between research settings. Therefore, this scoping review aims to gather the evidence available on how the use of drones is perceived by local communities, as well as current research practices, and ethical guidance related to drone deployment. Methods and analysis: This scoping review will follow the PRISMA-ScR and the Joana Briggs Institute guidelines. The literature search will be conducted using academic databases and grey literature sources. After pilot testing the inclusion criteria and data extraction tool, two researchers will double-screen and then chart available evidence independently. A content analysis will be carried out to identify patterns of categories or terms used to describe ethical considerations related to drone usage for environmental monitoring in the literature using the R Package RQDA. Discrepancies in any phase of the project are solved through consensus. Ethics and dissemination: Ethical approval is not required, only secondary data will be used. This protocol is registered on the Open Science Framework (www.osf.io). The results will be disseminated through publication in a scientific journal and will be used to inform drone field campaigns in the Wellcome Trust funded HARMONIZE project. HARMONIZE aims to develop cost-effective and reproducible digital infrastructure for stakeholders in climate change hotspots in Latin America & the Caribbean and will use drone technology to collect data on fine scale landscape changes

Published
2023
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5. The Impact of Intensive Versus Standard Anthelminthic Treatment on Allergy-related Outcomes, Helminth Infection Intensity, and Helminth-related Morbidity in Lake Victoria Fishing Communities, Uganda: Results From the LaVIISWA Cluster-randomized Trial.

Author

Team, LaVIISWA Trial, Sanya, Richard E, Nkurunungi, Gyaviira, O'Hara, Geraldine, Elliott, Alison M, Spaans, Remy Hoek, Nampijja, Margaret, Kizindo, Robert, Oduru, Gloria, Nakawungu, Prossy Kabuubi, Niwagaba, Emmanuel, Kabagenyi, Joyce, Zziwa, Christopher, Akello, Mirriam, Lubyayi, Lawrence, Mpairwe, Harriet, Abayo, Elson, Tumusiime, Josephine, Nakazibwe, Esther, and Kaweesa, James

Subjects
SCHISTOSOMIASIS prevention, SCHISTOSOMIASIS, HELMINTHIASIS, DRUG allergy, ALLERGIES, ANEMIA, COMBINATION drug therapy, ANTHELMINTICS, INFECTIOUS disease transmission, CONFIDENCE intervals, DISEASES, DRUG administration, HEMOGLOBINS, HOOKWORM disease, IMMUNOGLOBULINS, ISOQUINOLINE, PUBLIC health, RESPIRATORY organ sounds, SURVEYS, RANDOMIZED controlled trials, RELATIVE medical risk, DISEASE prevalence, PREVENTION, THERAPEUTICS
Abstract

Background The prevalence of allergy-related diseases is increasing in low-income countries. Parasitic helminths, common in these settings, may be protective. We hypothesized that intensive, community-wide, anthelminthic mass drug administration (MDA) would increase allergy-related diseases, while reducing helminth-related morbidity. Methods In an open, cluster-randomized trial (ISRCTN47196031), we randomized 26 high-schistosomiasis-transmission fishing villages in Lake Victoria, Uganda, in a 1:1 ratio to receive community-wide intensive (quarterly single-dose praziquantel plus albendazole daily for 3 days) or standard (annual praziquantel plus 6 monthly single-dose albendazole) MDA. Primary outcomes were recent wheezing, skin prick test positivity (SPT), and allergen-specific immunoglobulin E (asIgE) after 3 years of intervention. Secondary outcomes included helminths, haemoglobin, and hepatosplenomegaly. Results The outcome survey comprised 3350 individuals. Intensive MDA had no effect on wheezing (risk ratio [RR] 1.11, 95% confidence interval [CI] 0.64–1.93), SPT (RR 1.10, 95% CI 0.85–1.42), or asIgE (RR 0.96, 95% CI 0.82–1.12). Intensive MDA reduced Schistosoma mansoni infection intensity: the prevalence from Kato Katz examinations of single stool samples from each patient was 23% versus 39% (RR 0.70, 95% CI 0.55–0.88), but the urine circulating cathodic antigen test remained positive in 85% participants in both trial arms. Hookworm prevalence was 8% versus 11% (RR 0.55, 95% CI 0.31–1.00). There were no differences in anemia or hepatospenomegaly between trial arms. Conclusions Despite reductions in S. mansoni intensity and hookworm prevalence, intensive MDA had no effect on atopy, allergy-related diseases, or helminth-related pathology. This could be due to sustained low-intensity infections; thus, a causal link between helminths and allergy outcomes cannot be discounted. Intensive community-based MDA has a limited impact in high-schistosomiasis-transmission fishing communities, in the absence of other interventions. Clinical Trials Registration ISRCTN47196031. [ABSTRACT FROM AUTHOR]

Published
2019
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