81 results on '"Soyupek S."'
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2. Sildenafil citrate as a phosphodiesterase inhibitor has an antioxidant effect in the blood of men
- Author
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Perk, H., Armagan, A., Nazroğlu, M., Soyupek, S., Hoscan, M. B., Sütcü, R., Ozorak, A., and Delibas, N.
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- 2008
3. A survey of patient preparation and technique of ultrasound-guided prostate biopsy: A multicenter study og urooncological association [Ultrasonografi k?lavuzlu?unda yap?lan prostat biyopsisinde hasta haz?rl??? ve teknik anketi: Üroonkoloji derne?i çcok merkezli çal?şmas?]
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Bozlu M., Akduman B., Mungan U., Özen H., Baltaci S., Türkeri L., Kirkali Z., Akdaş A., Adsan Ö., Akdo?an B., Altinel M., Ataus S., Ayan S., Bilen C.Y., Çal Ç., Çek M., Dündar M., Işeri C., Koşan M., Lekili M., Müezzino?lu T., Özer G., Özgök Y., Perk H., Soyupak B., Soyupek S., Soylu A., Sözen S., Şengör F., Tansu? Z., Tekin A., Yildirim A., and Bozlu, M., Mersin Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Mersin, Turkey -- Akduman, B., Karaelmas Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Zonguldak, Turkey -- Mungan, U., Dokuz Eylül Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Izmir, Turkey -- Özen, H., Hacettepe Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Ankara, Turkey -- Baltaci, S., Ankara Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Ankara, Turkey -- Türkeri, L., Marmara Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Istanbul, Turkey -- Kirkali, Z., Dokuz Eylül Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Izmir, Turkey -- Akdaş, A., Üro Tip Üroloji Tant Merkezi, Istanbul, Turkey -- Adsan, Ö., Ankara Numune E?itim ve Araştirma Hastanesi 2, Ürologi Klini?i, Ankara, Turkey -- Akdo?an, B., Hacettepe Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Ankara, Turkey -- Altinel, M., Türkiye Yüksek Ihtisas Hastanesi, Üroloji Klini?i, Ankara, Turkey -- Ataus, S., Istanbul Üniversitesi, Cerrahpaşa Tip Fakültesi, Üroloji Anabilim Dali, Istanbul, Turkey -- Ayan, S., Cumhuriyet Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Sivas, Turkey -- Bilen, C.Y., Ondokuz Mayis Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Samsun, Turkey -- Çal, Ç., Ege Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Izmir, Turkey -- Çek, M., S.B. Taksim E?itim, Araştirma Hastanesi, Üroloji Klini?i, Istanbul, Turkey -- Dündar, M., Adnan Menderes Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Aydin, Turkey -- Işeri, C., GATA Haydarpaşa, E?itim Hastanesi, Üroloji Klini?i, Istanbul, Turkey -- Koşan, M., Ankara Numune E?itim, Araştirma Hastanesi 2, Üroloji Klini?i, Ankara, Turkey -- Lekili, M., Celal Bayar Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Manisa, Turkey -- Müezzino?lu, T., Celal Bayar Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Manisa, Turkey -- Özer, G., Türkiye Yüksek Ihtisas Hastanesi, Üroloji Klini?i, Ankara, Turkey -- Özgök, Y., Gülhane Askeri, Tip Akademisi, Üroloji Anabilim Dali, Ankara, Turkey -- Perk, H., Süleyman Demirel Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Isparta, Turkey -- Soyupak, B., Çukurova Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Adana, Turkey -- Soyupek, S., Süleyman Demirel Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Isparta, Turkey -- Soylu, A., Inönü Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Malatya, Turkey -- Sözen, S., Gazi Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Ankara, Turkey -- Şengör, F., Haydarpaşa Numune E?itim, Araştirma Hastanesi, Üroloji Klini?i, Istanbul, Turkey -- Tansu?, Z., Çukurova Üniversitesi, Tip Fakültesi, Üroloji Anabilim Dali, Adana, Turkey -- Tekin, A., Haydarpaşa Numune E?itim, Araştirma Hastanesi, Üroloji Klini?i, Istanbul, Turkey -- Yildirim, A., S.B. Istanbul Göztepe E?itim, Araştirma Hastanesi, Üroloji Klini?i, Istanbul, Turkey
- Subjects
Biopsy ,Prostate ,urologic and male genital diseases ,Survey - Abstract
Introduction: Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. The aim of the present survey is to assess the variability in patient preparation and technique of ultrasound-guided prostate biopsy among Turkish Urologists. Materials and Methods: In July 2004, a questionnaire was sent out to e-mail addresses of the members of Urooncological Association, asking about the details of prostate biopsy protocol of the members. The survey consisted of multiple choice questions about the patient preparation and prostate biopsy technique. Responses were acquired via e-mail and analyzed in detail. Results: Thirty two urologists from 24 centers responded. The biopsy procedure was performed by the urologist only in 54.16% of the centers, both urologist and radiologist in 37.5%, and radiologist only in 8.33%. Transrectal route was the most common method for ultrasound-guided prostate biopsy. A half of the responders performed biopsy when PSA was greater than 4 ng/ml. All of the centers administered antibiotic and a half of them used enema before the procedure. Approximately 37% of responders did not administer any type of analgesia, but 29.1% of all responders administered a periprostatic nerve block for reducing pain during the procedure. Most urologists obtained 10 or 12 biopsy cores and only 20.8% of them obtained routine transitional zone biopsy during the initial biopsy session. Conclusion: This survey demonstrated that patient preparation and technique of ultrasound-guided prostate biopsy is not standardized among Turkish Urologists, and a guideline on prostate biopsy is needed.
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- 2007
4. Extracorporeal magnetic innervation for the treatment of stress urinary incontinence: Results of two years follow-up
- Author
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Tukel, O., Armagan, A., Soyupek, S., Perk, H., Dilmen, C., Hoscan, B., and Ekinci, M.
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- 2007
5. Clinical results of transurethral electrovaporization resection of prostate (TUVRP) with two different electrodes versus TURP: A randomized prospective clinical study [Prostatin Iki Farkli Elektrotla Yapilan Transüretral Elektrovaporizasyon Rezeksiyonu (TUVRP) ile TURP Kli?ik Sonuçlarinin Karşilaştirilmasi: Randomize Prospektif Kl·inik Bir Çalişma]
- Author
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Özdiler E., Yaman Ö., Soyupek S., Seçkiner I., Bozlu M., Tükel O., and Zonguldak Bülent Ecevit Üniversitesi
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TURP ,Vapor cut electrode ,Vaporization of prostate ,urologic and male genital diseases ,TUVRP - Abstract
Introduction: The aim of our study was to compare the results of conventional transurethral electroresection of the prostate (TURP) and transurethral vaporization and resection of the prostate (TUVRP) operations in patients with symptomatic bladder outlet obstruction due to prostatic enlargement. Materials and Methods: 59 consecutive patients with symptomatic bladder outlet obstruction due to prostatic enlargement and prostate size between 20-60 g were prospectively randomized to two treatment groups; one group underwent standard TURP and the other TUVRP. Eligibility criteria included IPSS result 8 or grater, Qmax
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- 2003
6. brief report
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Serel, TA, Turan, T, Soyupek, S, Aybek, Z, and Perk, H
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bladder cancer ,free insulin-like growth factor-1 - Abstract
Insulin-like growth factor (IGF)-1, a mitogenic and anti-apoptotic peptide, can affect the proliferation of epithelial cells, and is thought to play a role in cancer development. The free IGF-1 represents the biologically active fraction of IGF-1. We hypothesised that there is a difference in free IGF-1 levels in the urine and serum from patients with TCC and normal subjects. Urine and blood samples were collected from 30 cases of superficial TCC and an equal number control subjects without malignancy. Free IGF-1 levels were measured in duplicate by radioimmunoassay. Specimens of bladder carcinoma were staged histopathologically using the Mostoffi grading system. Statistical analyses were performed using the Mann-Whitney U-test, Pearson correlation and covariate analysis. There was no significant difference in urine and serum free IGF-1 levels between the two groups. The correlation between urine and serum free IGF-1 levels and age was not significant. There was also no significant relationship between free IGF-1 levels and histopathological grading. The results of this pilot study reveal that the free IGF-1 level does not help predict tumour marker in the patients with bladder cancer.
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- 2003
7. Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat
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Armagan, A, primary, Uzar, E, additional, Uz, E, additional, Yilmaz, HR, additional, Kutluhan, S, additional, Koyuncuoglu, HR, additional, Soyupek, S, additional, Cam, H, additional, and Serel, TA, additional
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- 2008
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8. THE EFFECTS OF SILDENAFIL CITRATE ON LIPID PER OXIDATION AND ANTI-OXIDANT ENZYMES IN ERYTHROCYTES OF HEALTHY MEN
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Perk, H., primary, Armagan, A., additional, Soyupek, S., additional, Hoscan, M.B., additional, Sutcu, R., additional, and Ozorak, A., additional
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- 2008
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9. Extracorporeal Magnetic Innervation for the Treatment of Stress Urinary Incontinence: Results of Two-Year Follow-Up
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Hoşcan, M.B., primary, Dilmen, C., additional, Perk, H., additional, Soyupek, S., additional, Armağan, A., additional, Tükel, O., additional, and Ekinci, M., additional
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- 2008
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10. 870 EXTRACORPOREAL MAGNETIC INNERVATION FOR THE TREATMENT OF STRESS URINARY INCONTINENCE: RESULTS OF TWO YEARS FOLLOW-UP
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Hoscan, B., primary, Dilmen, C., additional, Perk, H., additional, Soyupek, S., additional, Armagan, A., additional, Tukel, O., additional, and Ekinci, M., additional
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- 2007
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11. LEPTIN EXPRESSION IN THE TESTICULAR TISSUE OF FERTILE AND INFERTILE MEN
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Soyupek, S., primary, Arma ğan, A., additional, Serel, T. A., additional, Hoşcan, M. B., additional, Perk, H., additional, Karaöz, E., additional, and Çandir, Ö, additional
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- 2005
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12. RE: INFLUENCE OF TUMOR STAGE, SIZE, GRADE, VASCULAR INVOLVEMENT, HISTOLOGICAL CELL TYPE AND HISTOLOGICAL PATTERN ON MULTIFOCALITY OF RENAL CELL CARCINOMA
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Baltaci, S., primary, Orhan, D., additional, Soyupek, S., additional, Bedük, Y., additional, Tulunay, Ö., additional, and Göğüs, O., additional
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- 2001
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13. RE: INFLUENCE OF TUMOR STAGE, SIZE, GRADE, VASCULAR INVOLVEMENT, HISTOLOGICAL CELL TYPE AND HISTOLOGICAL PATTERN ON MULTIFOCALITY OF RENAL CELL CARCINOMA
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Wunderlich, Heiko, primary, Zermann, Dirk-Henrik, additional, Kosmehl, Hartwig, additional, Schubert, Jörg, additional, Baltaci, S., additional, Orhan, D., additional, Soyupek, S., additional, Bedük, Y., additional, Tulunay, Ö., additional, and Göğüs, O., additional
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- 2001
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14. The relation between biochemical recurrence and surgical border positiveness and grading of prostate needle biopsy specimen following radical prostatectomy.
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Ergün O, Oksay T, Armagan A, Soyupek S, Kosar A, and Perk H
- Abstract
Copyright of Turkish Journal of Urology is the property of Turkish Association of Urology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2010
15. Spinal and psoas abscesses in a patient with diabetes mellitus: a case report.
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Soyupek F, Koroglu M, Bozkurt HG, Albayrak SB, Kaya O, and Soyupek S
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Diabetes mellitus predisposes to infections. We aimed to report a patient with psoas and epidural abscesses at the same time without discitis/spondylitis and osteomyelitis formation, and to discuss the treatment options. We report a 58-year-old insulin-dependent woman with sudden onset of low back pain and difficulty in walking after a traumatic event. The patient had neurological deficits including neurogenic bladder. Psoas abscess and epidural abscess were diagnosed using imaging methods. Percutaneus drainage of psoas abscess was performed. Growth of enterococcus species was observed. We treated the epidural abscess with antibiotics. The signs and symptoms of infection in the patient disappeared after cutaneus drainage and antibiotic therapy. Psoas and epidural abscesses can be seen at the same time in patients with diabetes mellitus, and drainage and antibiotic therapy are beneficial. [ABSTRACT FROM AUTHOR]
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- 2010
16. The coexistence of the fibromyalgia syndrome and the overactive bladder syndrome.
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Soyupek F, Soyupek S, Akkus S, and Ozorak A
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Objectives: Overactive bladder syndrome [OBS] and fibromyalgia syndrome [FMS] have similar etiopathological factors such as serotonine, endoteline-1, noradrenaline, etc. The aim of this study was to investigate the relation between OBS and FMS. Methods: This was a prospective study. Patients with OBS and healthy normal control subjects were included in this study. The diagnosis of FMS was based on the 1990 criteria of American College Rheumatology and the diagnosis of OBS was based on urgency and urge incontinence symptoms. All participants completed a questionnaire to gather information including demographic features, medical history such as presence of headache, poor sleep, and urological symptoms, and the Beck depression scale. Patients with OBS were divided into two subgroups according to coexistence of FMS [OBS or OBS + FMS.] Results: Forty patients with OBS and 40 healthy normal control subjects were included in this study. All of the subjects with FMS were female. The FMS was present in 30 percent of OBS subjects and five percent of healthy normal controls [P < 0.05]. Urge incontinence was more common in the OBS than the OBS + FMS subgroup [P < 0.05]. There was not any significant difference with respect to headache, poor sleep, and Beck depression scale score [P > 0.05]. There was a positive correlation between the duration of OBS and FMS [r = 0.614, P < 0.05]. Conclusion: Our findings suggest that there is an association between OBS and FMS, especially in female patients. This may be due to altered serotonin function. [ABSTRACT FROM AUTHOR]
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- 2007
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17. LEPTIN EXPRESSION IN THE TESTICULAR TISSUE OF FERTILE AND INFERTILE MEN
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Soyupek, S., an, A. Arma, Serel, T. A., Hocan, M. B., Perk, H., Karaöz, E., and Çandir, Ö
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There have been several studies about the presence of leptin in serum and testicular tissue, and none of them compares the leptin expression in the testicular tissue of fertile and infertile men. We assessed the presence of leptin expression in the testicular tissue of fertile and infertile men. 20 azoospermic infertile men were included in the study. All patients underwent testicular sperm extraction (TESE) for ICSI. For the detection of leptin, the immunohistochemistry was carried out. Intensity of immunohistochemical staining was subjectively estimated and expressed as negative (-), weak positive (+), intermediate positive (++) and strong positive (+++). Testicular tissues of 5 fertile patients, aged 50–60 years, was stained with leptin for control group. Mann-Whitney U test was used as the statistical method. There was no statistically significant difference in leptin staining between infertile patients and control group (p < 0.05). Leptin staining in tubuli seminiferi and Leydig cells were generally equal or Leydig cells were stained (+) much. This difference was not statistically significant. We found that there is leptin staining in Leydig cells and tubuli seminiferi. There is no difference in normal and infertile men for leptin staining properties in testicular tissue. This condition suggests that the effect of leptin on reproductive functions originates from a systemic effect related to central neuroendocrine system, androgen levels or spermatogenic existence rather than its direct effect on testicular tissue.
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- 2005
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18. BiLATERAL TRAVMATİK TESTİKÜLER DİSLOKASYON: OLGU SUNUMU VE LİTERATÜRE BAKIŞ.
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SOYUPEK, S., OKSAY, T., and KOŞAR, A.
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- 2001
19. 585 THE EFFECTS OF SILDENAFIL CITRATE ON LIPID PER OXIDATION AND ANTI-OXIDANT ENZYMES IN ERYTHROCYTES OF HEALTHY MEN
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Perk, H., Armagan, A., Soyupek, S., Hoscan, M.B., Sutcu, R., and Ozorak, A.
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- 2008
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20. Increased Plasma Ignition Distance Practice may Prevent the Obturator Reflex Occurrences and Compare of its Effectiveness Versus Obturator Block: A Prospective, Randomized, Controlled Study.
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Ergün O, Alperen Öztürk S, Kırçiçek F, Gürdal O, Soyupek S, Oksay T, and Özorak A
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- Humans, Prospective Studies, Urinary Bladder diagnostic imaging, Urinary Bladder surgery, Urinary Bladder innervation, Urologic Surgical Procedures methods, Reflex, Obturator Nerve pathology, Urinary Bladder Neoplasms surgery, Urinary Bladder Neoplasms pathology
- Abstract
Objective: To compare the ability of the obturator nerve block (ONB) and increased plasma ignition distance practice (IPDP) techniques to inhibit obturator nerve reflex (ONR) occurring with bipolar transurethral resection of the bladder., Methods: Sixty patients who had a tumor placed at the lateral sidewall or had a tumor in another part of the bladder along with the lateral wall were randomly enrolled. Cystoscopic and ultrasonographic examinations and a computerized tomography scanning of the urinary bladder were used to determine the ONB side. Group 1 consisted of patients who had the ONB procedure. Group 2 consisted of patients who had IPIDP. The severity of the ONR was classified as severe, mild, and very mild. The study's primary endpoint was ONR occurrences and successful completion of the surgery. The secondary endpoints were bleeding and bladder perforation., Results: There was a significant difference in the occurrence of ONR between the two groups (P = 0.0011). However, there was no significant difference between the two groups in the ability to resect the tumor and complete the surgery (P = .764). There was no correlation between the ONR and the tumor size (P = 0.478)., Conclusion: Our study concluded that both ONB and IPIDP have comparable results, especially in resecting tumors and completing the operation. IPIDP has some advantages over ONB, such as shorter operative time, lower total costs, and less trained personnel requirements., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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21. Bladder Urothelial Carcinoma: Machine Learning-based Computed Tomography Radiomics for Prediction of Histological Variant.
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Evrimler S, Ali Gedik M, Ahmet Serel T, Ertunc O, Alperen Ozturk S, and Soyupek S
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- Humans, Urinary Bladder diagnostic imaging, Urinary Bladder pathology, Radiomics, Tomography, X-Ray Computed methods, Machine Learning, Urinary Bladder Neoplasms diagnostic imaging, Urinary Bladder Neoplasms surgery, Urinary Bladder Neoplasms pathology, Carcinoma, Transitional Cell diagnostic imaging, Carcinoma, Transitional Cell pathology, Carcinoma, Transitional Cell surgery
- Abstract
Rationale and Objectives: Histological variant (HV) of bladder urothelial carcinoma (UC) is a significant factor for therapy management. We aim to assess the predictive performance of machine learning (ML)-based Computed Tomography radiomics of UC for HV., Materials and Methods: Volume of interest of 37 bladder UC tumors, of which 21 were pure and 16 were HV, were manually segmented. The extracted first- and second-order texture features (n = 117) using 3-D Slicer radiomics were compared to the radical cystectomy histopathological results. ML algorithms were performed to determine the significant models using Python 2.3, Pycaret library. The sample size was increased to 74 by synthetic data generation, and three outliers from the training set were removed (training dataset; n = 52, test dataset; n = 19). The predictive performances of 15 ML algorithms were compared. Then, the best two models were evaluated on the test set and ensembled by Voting Classifier., Results: The ML algorithms demonstrated area under curve (AUC) and accuracy ranging 0.79-0.97 and 50%-90%, respectively on the train set. The best models were Gradient Boosting Classifier (AUC: 0.95, accuracy: 90%) and CatBoost Classifier (AUC: 0.97, accuracy: 85%). On the test set; the Voting Classifier of these two models demonstrated AUC, accuracy, recall, precision, and F1 scores as follows; 0.93, 79%, 86%, 67%, and 75%, respectively., Conclusion: ML-based Computed Tomography radiomics of UC can predict HV, a prognostic factor that is indeterminable by qualitative radiological evaluation and can be missed in the preoperative histopathological specimens., (Copyright © 2022 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
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- 2022
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22. Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: A prospective, randomized, cross-over, clinical trial.
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Gungor G, Perk H, Soyupek S, Baykal B, Demir M, and Sezer MT
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- Adrenergic beta-Antagonists, Antihypertensive Agents, Ethanolamines, Humans, Male, Metoprolol, Nebivolol, Nitric Oxide, Prospective Studies, Erectile Dysfunction, Hypertension
- Abstract
Introduction: Both hypertension and β-blocker drugs used for treating hypertension (HT) can cause erectile dysfunction (ED). Nebivolol, unlike other β-blockers, may not cause impotence since it increases the release of Nitric Oxide (NO), which is the main mediator of erection. This study investigated the effect of Nebivolol and Metoprolol on erectile functions in hypertensive men., Materials and Methods: Married men whose blood pressure were >140/90 mmHg were included in the study. All patients were assessed for ED, and the cause of ED was then investigated. Nebivolol or Metoprolol was started for one month in all patients. After one-month drugless period, the β-blockers were switched. Blood pressures, pulses and sexual function tests were evaluated, and plasma NO levels were measured at the end of the treatments and during the drugless period., Results: There was no difference in antihypertensive efficacy between the two drugs (p = 0.828;0.194 for systolic and diastolic BP). Metoprolol caused a significant decrease in IIEF-5 score, whereas Nebivolol did not cause a decrease in IIEF-5 score on patients with psychogenic, arteriogenic, and venous failure related ED (respectively, p<0.001,0.004,0.005 for Metoprolol; p = 0.201,0.598,0.088 for Nebivolol). In the non-ED group, both drugs decreased the IIEF-5 score, but the decrease for Metoprolol (p = 0.001) was more than that for Nebivolol (p = 0.012). Plasma NO levels did not change with Metoprolol (p = 0.268) but increased with Nebivolol (p<0.001). There was a positive correlation between plasma NO values and IIEF-5 score used for the assessment of sexual functions (r = 0.284, p = 0.026)., Conclusion: Nebivolol may be advantageous in terms of preserving sexual functions because of increasing NO in eligible hypertensive male patients., (Copyright © 2022. Published by Elsevier B.V.)
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- 2022
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23. Deep Learning in Urological Images Using Convolutional Neural Networks: An Artificial Intelligence Study.
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Serel A, Ozturk SA, Soyupek S, and Serel HB
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Objective: Using artificial intelligence and a deep learning algorithm can differentiate vesicoureteral reflux and hydronephrosis reliably., Material and Methods: An online dataset of vesicoureteral reflux and hydronephrosis images were abstracted. We developed image analysis and deep learning workflow. The images were trained to distinguish between vesicoureteral reflux and hydronephrosis. The discriminative capability was quantified using receiver-operating characteristic curve analysis. We used Scikit learn to interpret the model., Results: Thirty-nine of the hydronephrosis and 42 of the vesicoureteral reflux images were abstracted from an online dataset. First, we randomly divided the images into training and validation. In this example, we put 68 cases into training and 13 into validation. We did inference on 2 cases and in return their predictions were predicted: [[0.00006]] hydronephrosis, predicted: [[0.99874]] vesicoureteral reflux on 2 test cases., Conclusion: This study showed a high-level overview of building a deep neural network for urological image classification. It is concluded that using artificial intelligence with deep learning methods can be applied to differentiate all urological images.
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- 2022
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24. Comparison of Tumor Enucleation and Standard Partial Nephrectomy According to Trifecta Outcomes: A Multicenter Study by the Turkish Academy of Urology, Uro-Oncology Working Group.
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Culpan M, Atis G, Sanli O, Bozkurt Y, Atmaca AF, Semerci B, Kutsal C, Canda AE, Akbulut F, Tugcu V, Boylu U, Erturhan S, Koca O, Ateş F, Halis F, Soyupek S, Turna B, Cakmak S, Sahin S, Erdem S, and Yildirim A
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- Adult, Aged, Female, Humans, Male, Margins of Excision, Middle Aged, Nephrectomy adverse effects, Nephrectomy methods, Retrospective Studies, Treatment Outcome, Kidney Neoplasms etiology, Kidney Neoplasms pathology, Kidney Neoplasms surgery, Robotic Surgical Procedures adverse effects, Robotic Surgical Procedures methods, Urology
- Abstract
Introduction: We aimed to evaluate the impact of the resection technique (tumor enucleation (TE) or standard partial nephrectomy (SPN)) on trifecta outcomes in patients having undergone partial nephrectomy (PN)., Materials and Methods: We retrospectively analyzed the clinical and pathologic parameters in patients with localized renal cell carcinoma (pT1-2N0M0) who had undergone PN between January 2001-December 2018 at one of 15 different tertiary referral centers. Multivariable logistic regression analysis was applied to investigate independent predictors of trifecta failure, decreased postoperative renal functions (decreased estimated glomerular filtration rate (eGFR) > 10%), perioperative complications (Clavien-Dindo > 1), and positive surgical margins., Results: A total of 1070 patients with a mean age 56.11 ± 11.88 years were included in our study. PN was performed with TE in 848 (79.25%) and SPN in 222 (20.75%) patients. Trifecta failure rate was 56.2% for TE and 64.4% for SPN ( p = 0.028). On multivariable analysis, TE was associated with less trifecta failure ( p = 0.025) and eGFR decrease >10% rates ( p = 0.024). On the other hand, there was no statistically significant difference between TE and SPN according to positive surgical margins ( p = 0.450) and complication > Clavien-Dindo grade 1 ( p = 0.888) rates. The only independent predictive factor for complications > Clavien-Dindo 1 was the Charlson comorbidity index (CCI) ( p = 0.001)., Conclusion: TE is associated with less trifecta failure than SPN. This result is mainly due to better preservation of renal function with TE.
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- 2022
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25. Can we Predict Preoperative Tumor Aggressivity with Hemogram Parameters in Renal Cell Carcinoma? a Novel Calculation Method.
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Uçar M, Soyupek S, Oksay T, Özorak A, Akkoç A, Topçuoğlu M, Demir M, and Koşar A
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- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Carcinoma, Renal Cell diagnosis, Carcinoma, Renal Cell pathology, Hematologic Tests methods, Virulence
- Abstract
We aim to investigate the prognostic significance of the hemoglobin X lymphocyte / neutrophil ratio (HLNR) and hemoglobin x lymphocyte / platelet ratio (HLPR) with tumor aggressivity in patients with renal cell carcinoma. We retrospectively analyzed 127 patients' data who had diagnosed as renal cell carcinoma between 2008 and 2019 in Suleyman Demirel University Hospital. Tumor and patient characteristics, hemoglobin, neutrophil, lymphocyte, platelet values HLNR and HLPR were calculated in preoperative hemogram parameters. The relationship between tumor pathological stage, Fuhrman nuclear grade and tumor necrosis with HLPR and HLNR analyzed with statistically. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLNR. P values are 0.003, 0.012 and 0.015 respectively. HLNR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. There was a negative correlation between pathologic stage, Fuhrman nuclear grade and tumor necrosis with HLPR. P values are 0.001, 0.014 and 0.047 respectively. HLPR was lower in patients with high pathologic stage, high Fuhrman nuclear grade and accompanying tumor necrosis positiveness. High pathological stage, high Fuhrman nuclear grade and existence of tumor necrosis are associates with preoperative low HLNR and low HLPR in renal cell carcinoma patients. They can be used as prognostic markers in patients with renal mass preoperatively.
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- 2019
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26. Management of vesicovaginal fistulas after gynecologic surgery.
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Tatar B, Oksay T, Selcen Cebe F, Soyupek S, and Erdemoğlu E
- Abstract
Objective: In developed nations, surgery, especially gynecologic procedures, is the major cause of vesicovaginal fistulas (VVFs). We retrospectively evaluated our treatment modalities for VVF repair caused by a gynecologic surgery, and discussed the reasons of selecting certain surgical techniques and their outcomes., Materials and Methods: We compared the surgical procedure preferences of surgeons and their results with patient and surgeon characteristics for the management of VVFs after an inciting gynecologic surgery in Süleyman Demirel University Hospital, Isparta over a 10-year period. The surgical procedures were undertaken in departments of urology and obstetrics and gynecology., Results: Abdominal repair was chosen for 65%, vaginal repair for 25%, and laparoscopic repair for 10% of patients. For the 75% of the patients that urologists operated, they chose the abdominal route. The mean parity number of patients who underwent abdominal repair was lower than that for vaginal repairs (p<0.05). For the patients managed with the vaginal route, 20% had a Martius flap, and 80% had a simple excision and repair. For patients operated via the abdominal route, 18% needed omental flap; no tissue interposition was used for the rest. The mean hospitalization time was less in patients managed with transvaginal repair (3.4 days) compared with transabdominal repair (9.2 days) (p<0.05)., Conclusion: The choice of repair method depends on surgeon's training (gynecology vs. urology). The vaginal route should be the first choice because it does not compromise the success rate and the mean hospitalization time is less. For the transvaginal approach, access to the lesion is the most important factor for the success of the procedure. No flap is needed for tissues that appear well vascularized., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
- Published
- 2017
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27. Comparison of shockwave frequencies of 30 and 60 shocks per minute for kidney stones: a prospective randomized study.
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Altok M, Güneş M, Umul M, Şahin AF, Baş E, Oksay T, and Soyupek S
- Subjects
- Adult, Female, Humans, Lithotripsy adverse effects, Male, Middle Aged, Pain etiology, Pain Measurement, Prospective Studies, Retreatment, Treatment Outcome, Kidney Calculi therapy, Lithotripsy methods, Pain Perception
- Abstract
Objective: One of the factors that determines the treatment success of shockwave lithotripsy (SWL) is the frequency of the shockwaves during the procedure. This study compared the efficacy and pain perception of shockwave frequencies at 30 versus 60 shocks/min for kidney stones., Materials and Methods: From August 2013 to May 2015, 160 patients with solitary, radiopaque kidney stones were randomized to SWL at 30 shocks/min (group 1) or 60 shocks/min (group 2), with 80 patients in each group. The primary outcome measure was success rate at 3 months after the last SWL session. The secondary outcome measure was pain perception during the procedures., Results: Of the 160 randomized patients, data for a total of 148 patients (74 patients in group 1 and 74 patients in group 2) were analyzed, after the exclusion of the patients lost to follow-up or who required secondary intervention within 3 months. There was no statistically significant difference between the two groups in terms of the success rate at 3 months (68.9% vs 71.6%, p = .719). However, the mean visual analogue scale scores of all the sessions were significantly higher in group 1 than in group 2 (5.83 vs 4.06, p < .05). Stone location, especially the lower calyceal location, was the only significant negative predictor for success according to multivariate logistic regression analysis., Conclusions: The success rate was similar between these two frequencies. However, pain perception was significantly higher at 30 than at 60 shocks/min.
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- 2016
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28. Vesicocutaneus fistula after cesarean section-a curious complication: Case report and review.
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Tatar B, Erdemoğlu E, Soyupek S, Yalçın Y, and Erdemoğlu E
- Abstract
Vesicocutaneous fistulas are very rare pathologies in the urinary tract. We present the second case of a vesicocutaneus fistula after cesarean section, and discuss strategies for prevention, diagnosis, and treatment of this exceptional complication. A woman with a vesicocutaneous fistula after cesarean delivery was admitted and diagnostic tests including fluoroscopy, magnetic resonance imaging (MRI), and reconstructed MRI revealed the fistula tract and an urachal anomaly. The patient was treated through excision of the fistula tract. Laparotomy should be performed carefully, and the surgeon should be aware of the urachus. Inadvertent trauma to the urachus during laparotomy might cause serious unexpected complications. Possible etiologic factors for vesicocutaneous fistulae, prevention, and treatment methods are discussed., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
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- 2016
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29. The effect of thermochemotherapy with mitomycin C on normal bladder urothelium, an experimental study.
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Uçar M, Altok M, Umul M, Bayram D, Armağan İ, Güneş M, Çapkin T, and Soyupek S
- Subjects
- Administration, Intravesical, Animals, Cystectomy, Male, Mitomycin administration & dosage, Rabbits, Hyperthermia, Induced, Mitomycin pharmacology, Urinary Bladder drug effects, Urothelium drug effects
- Abstract
Purpose: To investigate the effects of thermochemotherapy with mitomycin C (MMC) on normal rabbit bladder urothelium and to compare it with standard intravesical MMC and hyperthermia with normal saline., Methods: Twenty-four male New Zealand rabbits, with a mean weight of 2.7 kg (in weight of 2.1–4.3 kg), were divided into three groups, each containing eight rabbits. Thermotherapy with only normal saline was performed in the first group, standard intravesical MMC was performed in the second group, and thermotherapy with MMC was performed in the last group. A week after the primary procedure, total cystectomy was performed and tissue samples were evaluated., Results: The presence of epithelial vacuolar degeneration (p = 0.001), epithelial hyperplasia (p = 0.000), subepithelial fibrosis (p = 0.001) and hemorrhagic areas in the connective tissue (p = 0.002) was observed statistically significantly higher in the standard MMC group than in thermotherapy with normal saline group. There was almost a significant difference among standard MMC and normal saline group in terms of vascular congestion in the connective tissue (p = 0.08). Presence of epithelial vacuolar degeneration (p = 0.002), epithelial hyperplasia (p = 0.002), subepithelial fibrosis (p = 0.030), hemorrhagic areas (p = 0.011) and vascular congestion (p = 0.36) in the connective tissue was observed statistically significantly higher in the thermochemotherapy with MMC group than in standard intravesical MMC group. Polymorphonuclear cell infiltration was not considerable in any of the groups, and there was no significant difference between each groups (p = 0.140)., Conclusion: Administration of intravesical MMC causes a toxic effect on the normal urothelium of the bladder rather than an inflammatory reaction. Heating MMC significantly increased this effect.
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- 2016
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30. Chromosomal aberrations in benign prostatic hyperplasia patients.
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Altok M, Bağcı Ö, Umul M, Güneş M, Akyüz M, Uruç F, Uz E, and Soyupek S
- Subjects
- Aged, Aged, 80 and over, Chromosomes, Human, Y genetics, Genetic Predisposition to Disease, Humans, Karyotype, Male, Middle Aged, Prostate-Specific Antigen blood, Prostatic Hyperplasia pathology, Prostatic Hyperplasia surgery, Transurethral Resection of Prostate, Chromosome Aberrations, Prostatic Hyperplasia genetics
- Abstract
Purpose: To investigate the chromosomal changes in patients with benign prostatic hyperplasia (BPH)., Materials and Methods: A total of 54 patients diagnosed with clinical BPH underwent transurethral prostate resection to address their primary urological problem. All patients were evaluated by use of a comprehensive medical history and rectal digital examination. The preoperative evaluation also included serum prostate-specific antigen (PSA) measurement and ultrasonographic measurement of prostate volume. Prostate cancer was detected in one patient, who was then excluded from the study. We performed conventional cytogenetic analyses of short-term cultures of 53 peripheral blood samples obtained from the BPH patients., Results: The mean (±standard deviation) age of the 53 patients was 67.8±9.4 years. The mean PSA value of the patients was 5.8±7.0 ng/mL. The mean prostate volume was 53.6±22.9 mL. Chromosomal abnormalities were noted in 5 of the 53 cases (9.4%). Loss of the Y chromosome was the most frequent chromosomal abnormality and was observed in three patients (5.7%). There was no statistically significant relationship among age, PSA, prostate volume, and chromosomal changes., Conclusions: Loss of the Y chromosome was the main chromosomal abnormality found in our study. However, this coexistence did not reach a significant level. Our study concluded that loss of the Y chromosome cannot be considered relevant for the diagnosis of BPH as it is for prostate cancer. Because BPH usually occurs in aging men, loss of the Y chromosome in BPH patients may instead be related to the aging process.
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- 2016
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31. Physical and mental workload in single-incision laparoscopic surgery and conventional laparoscopy.
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Koca D, Yıldız S, Soyupek F, Günyeli İ, Erdemoglu E, Soyupek S, and Erdemoglu E
- Subjects
- Adult, Cohort Studies, Female, Hand physiology, Humans, Male, Muscle, Skeletal physiology, Surgeons statistics & numerical data, Task Performance and Analysis, Laparoscopy methods, Laparoscopy statistics & numerical data, Muscle Fatigue physiology, Workload psychology
- Abstract
Objectives: The aim of the present study is to evaluate mental workload and fatigue in fingers, hand, arm, shoulder in single-incision laparoscopic surgery (SILS) and multiport laparoscopy., Methods: Volunteers performed chosen tasks by standard laparoscopy and SILS. Time to complete tasks and finger and hand strength were evaluated. Lateral, tripod, and pulp pinch strengths were measured. Hand dexterity was determined by pegboard. Electromyography recordings were taken from biceps and deltoid muscles of both extremities. The main outcome measurement was median frequency (MF) slope. NASA-TLX was used for mental workload., Results: Time to complete laparoscopic tasks were longer in the SILS group (P < .05). Decrease of strength in fingers and hand were similar in SILS and standard laparoscopy. Pegboard time was increased in both hands after SILS (P < .05). MF slope of biceps muscle and deltoid muscle in SILS was far away from the reference slope. MF slope of biceps muscle and deltoid muscle in standard laparoscopy was close to reference slope, indicating there was more fatigue in biceps and deltoid muscles of both upper extremities in SILS group. NASA-TLX score was 73 ± 13.3 and 42 ± 19.5 in SILS and multiport laparoscopy, respectively (P < .01). Mental demand, physical demand, temporal demand, performance, effort, and frustration were, respectively, scored 10.7 ± 3.8, 11.7 ± 3.5, 12.2 ± 2.7, 11 ± 3, 13.6 ± 2.7, and 13.5 ± 2.8 in SILS and 6.3 ± 3.1, 6.6 ± 3.3, 7.3 ± 3.3, 7.1 ± 4.1, 7.9 ± 3.9, and 6.6 ± 3.8 in standard laparoscopy (P < .01)., Conclusions: SILS is mentally and physically demanding, particularly on arms and shoulders. Fatigue of big muscles, effort, and frustration were major challenges of SILS. Ergonomic intervention of instruments are needed to decrease mental and physical workload., (© The Author(s) 2014.)
- Published
- 2015
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32. The evaluation of anxiety and depression status in spouses of sexually active reproductive women with fibromyalgia.
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Yener M, Askin A, Soyupek F, Akpinar A, Demirdas A, Sonmez S, and Soyupek S
- Subjects
- Adult, Anxiety etiology, Anxiety psychology, Case-Control Studies, Depression etiology, Depression psychology, Emotions, Female, Fibromyalgia diagnosis, Fibromyalgia physiopathology, Fibromyalgia psychology, Humans, Male, Predictive Value of Tests, Psychiatric Status Rating Scales, Risk Factors, Severity of Illness Index, Sexual Dysfunctions, Psychological diagnosis, Sexual Dysfunctions, Psychological physiopathology, Sexual Dysfunctions, Psychological psychology, Surveys and Questionnaires, Anxiety diagnosis, Depression diagnosis, Fibromyalgia complications, Sexual Behavior, Sexual Dysfunctions, Psychological etiology, Spouses psychology
- Abstract
Objectives: Fibromyalgia (FM) can cause neuropsychiatric symptoms and sexual dysfunction. However, no data exist regarding anxiety and depression status in spouses of sexually active women with FM. Accordingly, we aimed to evaluate whether emotional status are affected in spouses of women with FM, and to search whether there was a relationship between sexual dysfunction of women with FM and emotional status of their spouses., Methods: Thirty newly diagnosed, never treated reproductive women with FM and 30 age-matched healthy women as well as their spouses were included. Psychological status was evaluated using Beck depression/anxiety inventory (BDI/BAI). Sexual function was evaluated using Female Sexual Function Index (FSFI) and Index of Female Sexual Function (IFSF)., Results: BDI, BAI, FSFI and IFSF scores were significantly higher in women with FM than in controls. The spouses of women with FM had increased BDI and BAI scores as compared to spouses of controls (7.10 ± 7.76 vs. 2.10 ± 2.68, 6.96 ± 6.62 vs. 2.20 ± 3.16, respectively, p<0.001). BDI scores of women with FM significantly correlated to BDI scores of their spouses, but there was no significant relationship between BDI scores of spouses and sexual functions of women with FM., Conclusions: FM can cause deterioration of emotional status and lead to sexual dysfunction. Also, psychological status could be affected in spouses of women with FM at reproductive age, and the severity of depression of their spouses was significantly correlated to that of women with FM. However, this affection in psychological status did not relate to sexual problems of the women with FM.
- Published
- 2015
33. Cancer detection rates of different prostate biopsy regimens in patients with renal failure.
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Hoşcan MB, Özorak A, Oksay T, Perk H, Armağan A, Soyupek S, Serel TA, and Koşar A
- Subjects
- Adenocarcinoma complications, Adult, Aged, Aged, 80 and over, Biopsy methods, Humans, Male, Middle Aged, Prostatic Neoplasms complications, Adenocarcinoma diagnosis, Prostatic Neoplasms diagnosis, Renal Insufficiency complications
- Abstract
We aimed to evaluate the cancer detection rates of 6-, 10-, 12-core biopsy regimens and the optimal biopsy protocol for prostate cancer diagnosis in patients with renal failure. A total of 122 consecutive patients with renal failure underwent biopsy with age-specific prostate-specific antigen (PSA) levels up to 20 ng/mL. The 12-core biopsy technique (sextant biopsy + lateral base, lateral mid-zone, lateral apex, bilaterally) performed to all patients. Pathology results were examined separately for each sextant, 10-core that exclude parasagittal mid-zones from 12-cores (10a), 10-core that exclude apex zones from 12-cores (10b) and 12-core biopsy regimens. Of 122 patients, 37 (30.3%) were positive for prostate cancer. The cancer detection rates for sextant, 10a, 10b and 12 cores were 17.2%, 29%, 23.7% and 30.7%, respectively. Biopsy techniques of 10a, 10b and 12 cores increased the cancer detection rates by 40%, 27.5% and 43.2% among the sextant technique, respectively. Biopsy techniques of 10a and 12 cores increased the cancer detection rates by 17.1% and 21.6% among 10b biopsy technique, respectively. There were no statistical differences between 12 core and 10a core about cancer detection rate. Adding lateral cores to sextant biopsy improves the cancer detection rates. In our study, 12-core biopsy technique increases the cancer detection rate by 5.4% among 10a core but that was not statistically different. On the other hand, 12-core biopsy technique includes all biopsy regimens. We therefore suggest 12-core biopsy or minimum 10-core strategy incorporating six peripheral biopsies with elevated age- specific PSA levels up to 20 ng/mL in patients with renal failure.
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- 2014
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34. Comparison of different autogenous graft materials for reconstruction of large segment vas deferens defect: experimental study in rat.
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Nasir S, Soyupek S, Altuntas S, Konas E, Roach EC, Özorak A, and Bircan S
- Subjects
- Animals, Male, Rats, Rats, Wistar, Vas Deferens surgery, Arteries transplantation, Autografts, Vas Deferens transplantation, Vasovasostomy methods, Veins transplantation
- Abstract
Purpose: Vasectomy is one of the most common urological operations performed, and provides permanent contraception. Many vasectomized men ultimately seek vasectomy reversal because of unforeseen changes in lifestyle. Vasovasostomy has varying rates of success. In this study, we utilize vas deferens (VD), artery, and vein grafts to reconstruct 30% and 50%defects of the total vas deferens length., Materials and Methods: Forty two male Wistar rats were divided into three groups as VD graft, carotid artery and external jugular vein transplantations. Each group was equally divided into 2 different subgroups according to the length of transplant material as 1.0 cm (n = 7) and 1.5 cm (n = 7). To evaluate whether these materials may be used for long segment vas deferens reconstruction, the patency rate, partial or total graft occlusion, and histologic examination of all specimens were examined., Results: No patency was found in any of the grafts and many of them suffered destructive changes in anatomic structure. Sperm granulomas were determined around the testicular side anastomosis due to accumulated semen fluid which was in our belief, a result of aperistaltic zone caused by the grafts., Conclusion: When the poor results obtained in our study are put into perspective, vasoepididymostomy is the only treatment method to date for reconstruction of large segment vas deferens defects.
- Published
- 2014
35. The effect of cadmium toxicity on renal nitric oxide synthase isoenzymes.
- Author
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Soyupek S, Oksay T, Sütçü R, Armagan A, Gökalp O, Perk H, and Delibas N
- Subjects
- Animals, Cadmium blood, Kidney chemistry, Kidney metabolism, Kidney Diseases chemically induced, Kidney Diseases enzymology, Male, Rats, Rats, Wistar, Toxicity Tests, Cadmium toxicity, Isoenzymes metabolism, Kidney drug effects, Kidney enzymology, Nitric Oxide Synthase metabolism
- Abstract
The aim of this study was to assess the cadmium (Cd) toxicity on renal nitric oxide synthase (NOS) isoenzymes. The study was carried out on 18 inbred male (Cd group: 10 and control group: 8) Wistar rats. Cd group received drinking water containing 15 mg/L Cd for 30 days; and at the end of the 30 days, plasma Cd was analysed. One kidney was snap frozen to assess the endothelial NOS (eNOS), inducible NOS (iNOS) and neuronal NOS (nNOS) expressions by Western blot analyses, and the other kidney was preserved for histopathological examination. Plasma Cd levels were significantly elevated in the Cd group. The Western blot analyses found higher levels of eNOS, iNOS and nNOS in the Cd group but only eNOS and nNOS levels were statistically significant. There was no difference in pathological assessment of the renal tissues. Cd toxicity increases NOS isoenzyme levels and may affect renal physiology.
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- 2012
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36. Topiramate and vitamin e modulate antioxidant enzyme activities, nitric oxide and lipid peroxidation levels in pentylenetetrazol-induced nephrotoxicity in rats.
- Author
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Armagan A, Kutluhan S, Yilmaz M, Yilmaz N, Bülbül M, Vural H, Soyupek S, and Naziroglu M
- Subjects
- Animals, Anticonvulsants administration & dosage, Antioxidants administration & dosage, Catalase metabolism, Dose-Response Relationship, Drug, Drug Therapy, Combination, Epilepsy chemically induced, Epilepsy enzymology, Epilepsy metabolism, Epilepsy prevention & control, Fructose administration & dosage, Fructose pharmacology, Fructose therapeutic use, Glutathione Peroxidase metabolism, Kidney drug effects, Kidney enzymology, Kidney metabolism, Male, Rats, Rats, Wistar, Superoxide Dismutase metabolism, Topiramate, Vitamin E administration & dosage, Anticonvulsants therapeutic use, Antioxidants therapeutic use, Fructose analogs & derivatives, Kidney Diseases chemically induced, Kidney Diseases enzymology, Kidney Diseases metabolism, Kidney Diseases prevention & control, Lipid Peroxidation drug effects, Nitric Oxide metabolism, Pentylenetetrazole toxicity, Vitamin E therapeutic use
- Abstract
Previous studies have shown that generation of free radicals is increased following pentylenetetrazol kindling, due to increased cytosolic Ca2+ concentrations. Topiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxicity. We investigated the effects of topiramate and vitamin E administration on pentylenetetrazol-induced nephrotoxicity in rats by evaluation of lipid peroxidation, nitric oxide, glutathione peroxidase, catalase and superoxide dismutase values. Forty male Wistar rats were randomly divided into five equal groups. Group 1 was used as control and group II received a single dose of pentylenetetrazol. Fifty and 100 mg/kg topiramate daily were intragastrically administered to rats in groups III and IV for 7 days, respectively. Intragastric 100 mg topiramate (daily for 7 days) and intraperitoneal vitamin E (150 mg/kg, daily for 3 days) combination were given to animals in group V before a single-dose pentylenetetrazol administration. Serum and kidney samples were taken after 3 hr of pentylenetetrazol administration. Pentylenetetrazol resulted in a significant increase in nitric oxide levels of serum and kidney, and lipid peroxidation levels of kidney although superoxide dismutase and catalase activities in the kidney was reduced by pentylenetetrazol administration. The lipid peroxidation levels in serum and kidneys and the nitric oxide levels in kidneys of groups III, IV and V were decreased by topiramate although the superoxide dismutase and catalase activities in the kidneys were increased. Lipid peroxidation and nitric oxide levels were reduced by the topiramate and vitamin E combination compared to only topiramate. Glutathione peroxidase activity was not affect by pentylenetetrazol, topiramate and vitamin E administrations. In conclusion, topiramate and vitamin E have protective effects on pentylenetetrazol-induced nephrotoxicity by inhibition of free radicals and by support of the antioxidant redox system.
- Published
- 2008
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37. Androgen deprivation therapy for prostate cancer: effects on hand function.
- Author
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Soyupek F, Soyupek S, Perk H, and Ozorak A
- Subjects
- Aged, Case-Control Studies, Humans, Male, Prospective Studies, Androgen Antagonists adverse effects, Androgen Antagonists therapeutic use, Depression chemically induced, Gonadotropin-Releasing Hormone agonists, Hand physiology, Prostatic Neoplasms drug therapy, Quality of Life
- Abstract
Objectives: Prostate cancer is the most frequently diagnosed malignancy. Luteinizing hormone-releasing hormone (LH-RH) agonists are used in most patients with locally advanced and metastatic prostate cancer, and decrease testosterone production. We aimed to find out the effects of androgen deprivation therapy with LH-RH agonist on the hand function, quality of life, and mood of the patients with prostate cancer., Subjects: A total of 20 patients with locally advanced prostate cancer and 20 age-matched healthy men were included in the study as LH-RH and control groups, respectively., Main Measures: Age, body mass index, occupation and dominant hand, physical activity level, Beck depression inventory scores, 15D quality of life questionnaire scores, and Duruoz hand index scores were recorded. Handgrip strength was tested in the dominant hand using the Jamar hand dynamometer (Sammons Preston, Inc., Bollingbrook, IL). The Grooved Pegboard Test was used to test manual dexterity. Serum concentrations of total and free testosterone, estradiol levels were measured., Results: There were no differences between the groups in body mass index, physical activity level, and age (P > 0.05). Serum total and free testosterone, estradiol level, and the mean grip strength score were statistically lower in the LH-RH group. Manual dexterity was diminished in the LH-RH group (P < 0.001). The Duruoz hand index, and Beck depression inventory and 15D quality of life questionnaire scores were statistically lower in the LH-RH group (P < 0.005). We found a correlation between handgrip strength, dexterity, Beck depression inventory scores, 15D quality of life questionnaire scores, and total and free testosterone., Conclusion: Men with low testosterone levels caused by androgen deprivation therapy have worse grip strength, dexterity, 15D quality of life questionnaire scores, and depressive symptoms than age-matched men who have not received androgen deprivation therapy.
- Published
- 2008
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38. Electrocardiographic abnormalities in patients with organic erectile dysfunction: comparison with an age-matched control group.
- Author
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Tokgoz H, Yaman O, Gulec S, Soyupek S, Sahinli S, and Anafarta K
- Subjects
- Adult, Aged, Aged, 80 and over, Cardiovascular Diseases physiopathology, Comorbidity, Erectile Dysfunction physiopathology, Humans, Male, Middle Aged, Prospective Studies, Cardiovascular Diseases epidemiology, Electrocardiography, Erectile Dysfunction epidemiology
- Abstract
Aims: Our purpose was to determine the incidence of electrocardiographic (ECG) abnormalities in patients with organic erectile dysfunction (ED) and to compare the results with an age-matched control (potent) group., Methods: A total of 218 men with ED of organic etiology formed our study group. A total of 210 age-matched men who had urologic disease other than ED served as control group. An experienced cardiologist who was blind to the primary diagnosis evaluated the ECGs in the entire group. The results were reported as either normal or abnormal according to the presence or absence of an abnormality suggestive for cardiovascular disease., Results: The mean age of the study and control groups was 58 years (range for the study group 28-82 years and for the control group 28-80 years). Abnormal ECG rates among patients with ED and control subjects were comparable. The incidences of ECG abnormalities in the study and control groups were 21.1% and 17.1%, respectively (P = 0,298). No ECG abnormality was detected in males younger than 40 in either group., Conclusion: Middle-aged or older men with ED may carry potential risk for cardiovascular diseases in the absence of cardiovascular symptoms. However, patients with organic ED are not under increased risk for ECG abnormalities.
- Published
- 2008
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39. Does experimental pain assessment before biopsy predict for pain during transrectal ultrasound-guided prostate biopsy?
- Author
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Soyupek S, Bozlu M, Armağan A, Ozorak A, and Perk H
- Subjects
- Aged, Humans, Male, Middle Aged, Organ Size, Prostate-Specific Antigen blood, Tourniquets, Biopsy, Needle adverse effects, Pain Measurement, Prostate pathology, Ultrasonography, Interventional
- Abstract
Objectives: To evaluate whether assessment of experimental pain perception using the modified tourniquet test before a biopsy procedure could predict the pain scores during transrectal ultrasound-guided prostate biopsy. However, the relationship between the experimental pain assessment before prostate biopsy and the pain scores during the biopsy procedure has not been established., Methods: A total of 67 men who underwent transrectal ultrasound-guided 12-core prostate biopsy were prospectively enrolled in the study. The day before biopsy, a modified submaximal effort tourniquet test was performed on all patients. During the test, pain scores were recorded at 30, 60, 90, and 120 seconds after inflation of the blood pressure cuff. Pain scores were also recorded during probe introduction into the rectum and prostate biopsy. Pain was assessed using a visual analogue scale (VAS)., Results: A significant correlation was found between the VAS scores in the tourniquet test and the VAS scores during probe introduction and the VAS scores during prostate biopsy (P <0.0001). The most significant correlation was found between the VAS scores during prostate biopsy and the VAS 60-second scores during the tourniquet test (P <0.0001, r=0.756). No significant relation was found between the VAS scores and age, prostate volume, or prostate-specific antigen level (P >0.05)., Conclusions: Our results have shown that a simple and quick tourniquet test could be useful in identifying those men who will experience greater pain during transrectal ultrasound-guided prostate biopsy. In the light of these data, additional studies will be planned to evaluate whether experimental pain assessment before the procedure could predict the analgesic potency of pain-relieving treatment during prostate biopsy.
- Published
- 2007
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40. Clinical importance of intratumoral and normal renal parenchymal inflammatory cell infiltration in renal cell carcinoma.
- Author
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Soyupek S, Tulunay O, Armağan A, Hoscan B, and Perk H
- Subjects
- Adult, Aged, Female, Humans, Inflammation, Lymphocytes pathology, Male, Middle Aged, Carcinoma, Renal Cell pathology, Kidney Neoplasms pathology
- Abstract
Objective: To assess the relationship between inflammatory cell infiltration and tumor type, stage and grade, the presence of multifocality and survival in tumors and in tumor-free normal parenchyma., Material and Methods: A total of 99 patients who underwent radical nephrectomy for renal cell carcinoma (RCC) between 1995 and 2001 and were subsequently followed up were included in the study. Formalin-fixed, paraffin-embedded tissues from the patients were reassessed by a pathologist and inflammation in both tumor and normal renal tissue was scored using a five-point scale. We evaluated the relationship between these scores and tumor type, stage, grade, the presence of multifocality and survival., Results: There were positive correlations between tumor grade and both the intratumoral inflammation score (IIS) and the extratumoral inflammation score (EIS) (p=0.001 and 0.01, respectively). There were no relations between pathological stage and either the IIS or EIS. We found higher multifocality rates in patients who died because of metastasis than those who survived (p=0.002). The EIS was 1.76+/-1.54 in the non-multifocality group and 2.64+/-1.15 in the multifocality group and this difference was statistically significant (p=0.03). There was no statistically significant relationship between the IIS and multifocality. Oncocytomas and chromophobe carcinomas did not show inflammatory infiltrates in either tumors or normal renal tissue., Conclusions: Higher EIS and IIS are associated with increasing tumor grade and a higher EIS is associated with multifocality in RCC. We propose to evaluate tumor tissue and normal renal parenchyma for the presence of inflammatory infiltration in RCC.
- Published
- 2007
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41. Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis.
- Author
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Armagan A, Uz E, Yilmaz HR, Soyupek S, Oksay T, and Ozcelik N
- Subjects
- Animals, Lipid Peroxidation, Male, Malondialdehyde metabolism, Rats, Rats, Sprague-Dawley, Reference Values, Testis drug effects, Catalase metabolism, Diabetes Mellitus, Experimental metabolism, Glutathione Peroxidase metabolism, Melatonin pharmacology, Superoxide Dismutase metabolism, Testis metabolism
- Abstract
Aim: To examine the effects of melatonin treatment on lipid peroxidation (LPO) and the activities of antioxidant enzymes in the testicular tissue of streptozotocin (STZ)-induced diabetic rats., Methods: Twenty-six male rats were randomly divided into three groups as follows: group I, control, non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, melatonin-treated (dose of 10 mg/kg . day) diabetic rats (n = 9). Following 8-week melatonin treatment, all rats were anaesthetized and then were killed to remove testes from the scrotum., Results: As compared to group I, in rat testicular tissues of group II , increased levels of malondialdehyde (MDA) (P < 0.01) and superoxide dismutase (SOD) (P < 0.01) as well as decreased levels of catalase (CAT) (P < 0.01) and glutathione peroxidase (GSH-Px) (P > 0.05) were found. In contrast, as compared to group II, in rat testicular tissues of group III, levels of MDA decreased (but this decrease was not significant, P > 0.05) and SOD (P < 0.01) as well as CAT (P < 0.05) increased. GSH-Px was not influenced by any of the treatment. Melatonin did not significantly affect the elevated glucose concentration of diabetic group. At the end of the study, there was no significant difference between the melatonin-treated group and the untreated group by means of body and testicular weight., Conclusion: Diabetes mellitus increases oxidative stress and melatonin inhibits lipid peroxidation and might regulate the activities of antioxidant enzymes of diabetic rat testes.
- Published
- 2006
- Full Text
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42. Free insulin-like growth factor-1 levels in bladder growth following spinal cord injury experimentally.
- Author
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Serel TA, Uysal E, Kutluhan S, Soyupek S, Kiliç S, and Hoşcan MB
- Subjects
- Animals, Biomarkers metabolism, Disease Models, Animal, Disease Progression, Hypertrophy metabolism, Hypertrophy pathology, Male, Radioimmunoassay, Rats, Rats, Wistar, Spinal Cord Injuries complications, Urinary Bladder innervation, Urinary Bladder Diseases etiology, Urinary Bladder Diseases metabolism, Urinary Bladder Diseases pathology, Insulin-Like Growth Factor I metabolism, Spinal Cord Injuries metabolism, Urinary Bladder growth & development, Urinary Bladder metabolism
- Abstract
Introduction: To determine the levels of spinal cord injury (SCI) on free insulin-like growth factor-1 (IGF-1) content in the bladder and the possible role of free IGF-1 in growth in hypertrophic bladders in an experimental model., Materials and Methods: The contents of free IGF-1 and protein in paraplegic and non-paraplegic rats which was induced experimentally by SCI were measured. The wet weights of the bladders were also determined. The results gained were compared., Results: The mean bladder free IGF-1 level in paraplegic rats was significantly higher than the corresponding bladder free IGF-1 level in sham-operated bladder (p<0.05). Mean wet weight bladder in paraplegic rats was significantly higher than the sham-operated rats (p<0.05). Paraplegic bladder had a significantly higher mean protein content than the sham-operated bladder (p<0.05). Serum free IGF-1 levels in the two groups were not different., Conclusion: Our pilot study reveals that free IGF-1 may be effective in SCI., (Copyright (c) 2005 S. Karger AG, Basel.)
- Published
- 2005
- Full Text
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43. Risk factors for the formation of a steinstrasse after shock wave lithotripsy.
- Author
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Soyupek S, Armağan A, Koşar A, Serel TA, Hoşcan MB, Perk H, and Oksay T
- Subjects
- Adolescent, Adult, Aged, Child, Female, Humans, Incidence, Kidney Calculi therapy, Male, Middle Aged, Risk Factors, Ureteral Calculi therapy, Lithotripsy adverse effects, Ureteral Calculi epidemiology, Ureteral Calculi etiology
- Abstract
Introduction: We studied the various stone, renal, and therapy factors that could affect steinstrasse formation after shock wave lithotripsy (SWL) to define their predictive value., Patients and Methods: Between May 1999 and September 2002, 563 patients were treated with a Stonelight V3 lithotriptor. A steinstrasse was recorded in 46 patients. All patient data, stone and renal characteristics, and data of SWL were reviewed. Statistical analyses of patients, stones, and therapy characteristics in correlation with the incidence of steinstrasse formation were performed to assign factors that had a significant impact on the formation of this complication., Results: The overall incidence of a steinstrasse was 8.17%. The steinstrasse was in the pelvic ureter in 84.3% of the cases, in the iliac ureter in 7.84% of them, and in pelvic and iliac ureter in 7.84% of the patients. The incidence of a steinstrasse significantly correlated with stone size and site. The incidence rates of a steinstrasse in renal stones <1 cm, 1-2 cm, and >2 cm were 4.46, 15.87, and 24.3% respectively. The incidence rates of this complication in ureteral stones <1 cm and 1-2 cm were 3.37 and 9.52%, respectively. The incidence rates of a steinstrasse in stones located in upper calices, middle calices, lower calices, and renal pelvis were 6.12, 10.52, 6.36, and 19.32%, respectively., Conclusions: Stone size and site are the significant factors predicting the formation of a steinstrasse. If a patient has a high probability of steinstrasse formation, close follow-up with early intervention or prophylactic pre-SWL ureteral stenting is indicated.
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- 2005
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44. Ileal orthotopic neobladder (modified Hautmann) via a shorter detubularized ileal segment: experience and results.
- Author
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Sevin G, Soyupek S, Armağan A, Hoşcan MB, and Oksay T
- Subjects
- Adult, Aged, Humans, Length of Stay, Male, Middle Aged, Postoperative Complications etiology, Reoperation, Treatment Outcome, Ureteral Obstruction etiology, Urinary Bladder Neoplasms physiopathology, Urinary Reservoirs, Continent, Urodynamics, Vesico-Ureteral Reflux etiology, Cystectomy methods, Prostatectomy methods, Urinary Bladder Neoplasms surgery, Urinary Diversion methods
- Abstract
Objective: To evaluate the clinical, urodynamic, functional, radiological and metabolic results of the ileal (modified Hautmann) orthotopic neobladder over 10 years of experience., Patients and Methods: Between January 1992 and March 2002, 124 men (mean age 62.4 years, range 44-76) with advanced bladder cancer had a radical cystoprostatectomy and urinary diversion via an ileal orthotopic neobladder (modified Hautmann). Only 40 cm of small bowel (detubularized ileum) was used to construct the reservoir, as a modification of the method described by Hautmann. All patients were followed periodically and their data recorded., Results: While no patients died during surgery six died (mortality rate was 5%) in the first 30 days afterward (two of them from causes unrelated to the urinary diversion surgery). The early reoperation rate was 14%; there were early complications not requiring surgery in 40 (34%) and later reoperation rate was required in 20.6%. The mean (range) maximum neobladder capacity was 550 (310-720) mL, the maximum intravesical pressure at maximum capacity 26.4 (11-48) cmH(2)O, and the minimum and maximum flow rates 25.2 (16-64) and 17.5 (11-30) mL/s, respectively. Day- and night-time continence rates were 92% and 90% after 4 years. While there was no electrolyte imbalance, there was mild to moderate metabolic acidosis in 58% of patients. There was no urethral tumour recurrence in any patient., Conclusion: Detubularization of ileum to form a neobladder gives a more favourable low-pressure and high-capacity reservoir. Therefore, a shorter ileal segment can be used for orthotopic urinary diversion, to avoid various metabolic dysfunctions when using detubularized bowel, but the surgery is not as free of complications as the original technique.
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- 2004
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45. Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study.
- Author
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Serel TA, Ozguner F, and Soyupek S
- Subjects
- Animals, Hemorrhage etiology, Kidney pathology, Kidney Diseases etiology, Leukocyte Count, Malondialdehyde antagonists & inhibitors, Rabbits, Uric Acid metabolism, Free Radical Scavengers pharmacology, Kidney drug effects, Kidney metabolism, Lithotripsy adverse effects, Melatonin pharmacology, Oxidative Stress drug effects
- Abstract
Our aim was to evaluate the effects of the potent endogenous free radical scavenger melatonin on extracorporeal-shock-wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups. Both groups were exposed to 3,000 shock waves at 18 Kv. The animals in the first group were treated with melatonin for 8 days. Controls and melatonin treated rabbits were killed a week after ESWL. MDA, uric acid and white cell counts were used as markers of oxidative stress. The mean levels of uric acid and white cell counts were significantly lower in the melatonin treated group than in the controls. The mean level of MDA was also significantly lower in the melatonin treated group compared to the controls. Our results show that melatonin may exhibit a protective effect on free radical mediated oxidative damage induced by ESWL in rabbit kidney.
- Published
- 2004
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46. Dermoid cyst in bony pelvis that coexists with pheochromocytoma: report of a case and review of the literature.
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Soyupek S, Koşar A, Hoşcan MB, Perk H, Oksay T, Serel TA, and Sevin G
- Subjects
- Adrenal Gland Neoplasms surgery, Adult, Dermoid Cyst pathology, Dermoid Cyst surgery, Humans, Male, Neoplasms, Multiple Primary surgery, Pelvic Neoplasms pathology, Pelvic Neoplasms surgery, Pheochromocytoma surgery, Adrenal Gland Neoplasms diagnosis, Dermoid Cyst diagnosis, Neoplasms, Multiple Primary diagnosis, Pelvic Neoplasms diagnosis, Pheochromocytoma diagnosis
- Abstract
A 42-year-old man presented with right lower quadrant abdominal pain and dysuria. The bladder was displaced to the right side of the pelvis in excretory urography. Abdominal CT revealed a mass in right adrenal gland, measuring 8 cm in diameter. There was also a cystic mass; filling left half of the bony pelvis and displacing bladder to the right, measuring 14.5 x 10, 5 x 7 cm. The patient underwent right adrenalectomy and pelvic mass excision. Pathologic examination showed that the adrenal mass was pheochromocytoma and pelvic mass was dermoid cyst. This case is the first one in literature that an intrapelvic dermoid cyst is not derived from an organ coexists with pheochromocytoma.
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- 2004
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47. Association between mast cells and bladder carcinoma.
- Author
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Serel TA, Soyupek S, and Candir O
- Subjects
- Humans, Carcinoma pathology, Mast Cells pathology, Urinary Bladder Neoplasms pathology
- Abstract
Introduction: The aim of this study was to determine whether there are quantitative variations in the numbers of mast cells (MCs) in bladder carcinoma tissue associated with the histopathological grading of tumours., Materials and Methods: Specimens of 56 bladder carcinomas were stained with toluidine blue and histologically staged using the Mostofi system. The MC counts were assessed within tumour tissue and lamina propria of the bladder. The MCs in the adjacent 'normal bladder tissue' of 14 specimens from patients who underwent cystectomy and of 10 specimens from patients having interstitial cystitis were also determined. The results were analyzed by using the Student t test, the Wilcoxon signed-rank test, and the Spearman correlation (r(s))., Results: The mean MC concentration was 0.57 within the tumour tissue and 3.36 in the lamina propria. The difference between the two MC groups was statistically significant (p < 0.0001); there were no correlations between mean MC counts in tumour tissue and histopathological tumour grade and between mean MC counts in lamina propria and histopathological tumour grade. Statistically significant differences were also observed between tumour group and interstitial cystitis group (p = 0.029) and between tumour group and normal 'adjacent' tissue group (p = 0.037)., Conclusions: Our findings suggest that MCs aggregate in small numbers in the lamina propria of bladder carcinomas and that the MC count is related to tumour differentiation. The number of MCs may be a useful prognostic indicator in patients with bladder carcinoma., (Copyright 2004 S. Karger AG, Basel)
- Published
- 2004
- Full Text
- View/download PDF
48. What is the ratio of urethral recurrence risk after radical cystoprostatectomy for bladder cancer?
- Author
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Sevin G, Soyupek S, Armağan A, Hoşcan MB, Dilmen C, and Tükel O
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Neoplasms, Second Primary pathology, Risk Assessment, Urethral Neoplasms pathology, Cystectomy, Neoplasms, Second Primary epidemiology, Prostatectomy, Urethral Neoplasms epidemiology, Urinary Bladder Neoplasms surgery
- Abstract
Objective: There is always a risk of urethral recurrence after radical cystoprostatectomy in patients with bladder transitional cell cancer. Taking these risk factors of urethral recurrence into account, orthotopic neobladders or urinary diversions without using the urethra are performed. But urethral tumour recurrence occurs much less than the expected. We assessed the etiological factors that affect the urethral recurrence in orthotopic and nonorthotopic urinary diversion cases., Methods: Sixty-four patients with bladder cancer who underwent radical cystoprostatectomy and urinary diversion between 1994 and 2002 were included this study. Conventional risk factors effecting the selection of operation type and urethral recurrence were evaluated in these patients. Cystoscopy and biopsy were done and pathologic specimen was obtained preoperatively, and cystoscopy and urethral washout cytology were done postoperatively. Routine bladder biopsies were done in uncertain cases at follow-up. Risk factors increasing the urethral recurrence are as follows: papillary and multiple tumours, tumour invading bladder neck and trigone, extensive CIS, prostatic stromal and urethral invasion, positive surgical margin and history of upper urinary tract tumour. In 31 patients having one or more of these criteria, continent nonorthotopic urinary diversion was performed, but 33 patients without these risk factors underwent orthotopic urinary diversion. Simultaneous urethrectomy was not done in any of these patients., Results: Among the patients who underwent radical cystoprostatectomy, none was with positive surgical margin in the distal end of the prostatic urethra. In preoperative cystoscopy, tumoural mass was seen near to collum in eight patients and in the prostatic urethra in three patients. Histopathological examination of cystoprostatectomy specimen displayed transient epithelial cell carcinoma of prostatic urethra in three patients, transient epithelial cell metaplasia inside the prostate in five patients and invasion to the urothelium of bladder neck in three patients. There were not any transient epithelial cell cancer metastases in prostatic stroma in any of these patients. One patient underwent urethrectomy, since atypical cells were observed in postradical prostatectomy urethral washout cytology but there was no tumour found in pathological examination of the specimen. Therefore, urethral tumour recurrence did not occur after 25 months follow up., Conclusion: These findings suggest that some of the conventional risk factors of urethral recurrence were exaggerated. We may also conclude that there is no need for prophylactic urethrectomy unless there is urethral cancer or cancer in the surgical margin. But if utilization of urethra is planned, evaluation of prostatic stroma by TUR biopsies and urethral anastomose margin by frozen section during the operation is necessary.
- Published
- 2004
- Full Text
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49. Urine and serum free IGF-1 levels in patients with bladder cancer: a brief report.
- Author
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Serel TA, Turan T, Soyupek S, Aybek Z, and Perk H
- Subjects
- Humans, Middle Aged, Insulin-Like Growth Factor I analysis, Insulin-Like Growth Factor I urine, Urinary Bladder Neoplasms blood, Urinary Bladder Neoplasms urine
- Abstract
Insulin-like growth factor (IGF)-1, a mitogenic and anti-apoptotic peptide, can affect the proliferation of epithelial cells, and is thought to play a role in cancer development. The free IGF-1 represents the biologically active fraction of IGF-1. We hypothesised that there is a difference in free IGF-1 levels in the urine and serum from patients with TCC and normal subjects. Urine and blood samples were collected from 30 cases of superficial TCC and an equal number control subjects without malignancy. Free IGF-1 levels were measured in duplicate by radioimmunoassay. Specimens of bladder carcinoma were staged histopathologically using the Mostoffi grading system. Statistical analyses were performed using the Mann-Whitney U-test, Pearson correlation and covariate analysis. There was no significant difference in urine and serum free IGF-1 levels between the two groups. The correlation between urine and serum free IGF-1 levels and age was not significant. There was also no significant relationship between free IGF-1 levels and histopathological grading. The results of this pilot study reveal that the free IGF-1 level does not help predict tumour marker in the patients with bladder cancer.
- Published
- 2003
- Full Text
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50. Tension-free vaginal tape for surgical treatment of stress urinary incontinence: two years follow-up.
- Author
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Perk H, Soyupek S, Serel TA, Koşar A, Sayin A, and Hoşcan MB
- Subjects
- Adult, Aged, Ambulatory Surgical Procedures methods, Female, Follow-Up Studies, Humans, Middle Aged, Postoperative Complications, Prospective Studies, Prosthesis Implantation methods, Treatment Outcome, Vagina pathology, Vagina surgery, Polypropylenes therapeutic use, Urinary Incontinence, Stress surgery, Urogenital Surgical Procedures methods
- Abstract
Background: The objective was to study prospectively the effectiveness of tension-free vaginal tape as an ambulatory and minimal invasive operation for the treatment of female stress incontinence., Methods: The tension-free vaginal tape procedure was performed in 25 patients with genuine stress incontinence and they were followed for a 2-year period. All patients were diagnosed with urodynamics to have genuine stress incontinence. Pad tests, cough stress test and quality-of-life assessments were carried out in all patients, both preoperatively and postoperatively. The majority of the women were discharged the morning after the surgical procedure., Results: Twenty of 25 (80%) patients were found to be cured 2 years after the operation. The vaginal tape was spontaneously dropped out from the vagina in one patient 2 weeks after the procedure. We did not see such a complication in previous studies., Conclusion: We conclude that the tension-free vaginal tape procedure is both a safe and effective method to cure genuine female stress incontinence. Furthermore, it can be performed as an ambulatory procedure under local anesthesia with a short operative time.
- Published
- 2003
- Full Text
- View/download PDF
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