1. Outcomes Up to Age 36 Months after Congenital Zika Virus Infection – U.S. States
- Author
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Varsha Neelam, Kate R. Woodworth, Daniel J. Chang, Nicole M. Roth, Megan R. Reynolds, Amanda Akosa, Christopher P. Carr, Kayla N. Anderson, Sarah B. Mulkey, Roberta L. DeBiasi, Cara Biddle, Ellen H. Lee, Amanda L. Elmore, Sarah J. Scotland, Similoluwa Sowunmi, Nicole D. Longcore, Muhammad Ahmed, Peter H. Langlois, Salma Khuwaja, Shea Elizabeth Browne, Leah Lind, Kyoo Shim, Michael Gosciminski, Rachel Blumenfeld, Shreya Khuntia, Umme-Aiman Halai, Autumn Locklear, Mary Chan, Teri' Willabus, Julius Tonzel, Natalie S. Marzec, Nianest Alers Barreto, Connie Sanchez, Jane Fornoff, Shelby Hale, Amy Nance, Sowmya N. Adibhatla, Emily Potts, Elizabeth Schiffman, Devin Raman, Morgan F. McDonald, Brandi Stricklin, Elizabeth Ludwig, Lindsay Denson, Dianna Contreras, Paul A. Romitti, Emily Ferrell, Meghan Marx, Kimberly Signs, Amie Cook, Suzann Beauregard, Lucia C. Orantes, Laura Cronquist, Lesley Roush, Shana Godfred-Cato, Suzanne M. Gilboa, Dana Meaney-Delman, Margaret A. Honein, Cynthia A. Moore, and Van T. Tong
- Abstract
Background: To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. Methods: From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥ 1 follow-up exam after 14 days of age or with ≥ 1 visit with development reported, respectively. Results: Among 2,248 infants, 9.9% were born preterm, and 10.0% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1,881 children ≥ 1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥ 1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay. Conclusion: Understanding the prevalence of developmental delays and healthcare needs these children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families.
- Published
- 2023
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