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One hundred patients with cancer of the uterine cervix (cervical intraepithelial neoplasia) suitable for partial removal were treated either by laser vaporization (the conversion of a tumor to liquid) or by laser excision conization (removal of a cone of tissue in the partial removal of the uterine cervix). The effectiveness and complications of the two methods were comparable in most respects, and both were well accepted by the patients. Laser excision was preferred because it provided further material for examination.

The article focuses on a symposium on the association between surgical treatment of cervical intraepithelial neoplasia (CIN) and subsequent preterm birth held on February 16, 2015 in London, Great Britain. It is stated that CIN grades 2 and 3 that have been managed surgically were the main focus of the meeting.

Please cite this paper as: Ghaem-Maghami S, De-Silva D, Tipples M, Lam S, Perryman K, Soutter W. Determinants of success in treating cervical intraepithelial neoplasia. BJOG 2011;118:679-684. To determine the important factors affecting the long-term failure rate of treatment for cervical intraepithelial neoplasia (CIN). Multivariate analysis of prospectively collected clinical data. Colposcopy clinic in a university teaching hospital. A total of 2455 consecutive women treated for CIN for the first time between 1 January 1989 and 31 December 2004 using excisional techniques. The data were obtained from a clinical database into which information had been entered prospectively. Data on community follow-up were obtained from the national Exeter database of cervical screening results. The parameters studied were age, parity, severity of the lesion, extent to which the lesion involved the endocervical canal, seniority of the surgeon, type of treatment, anaesthesia used, dimensions of the treatment biopsy specimen, number of treatment biopsy fragments and completeness of excision. High-grade post-treatment cervical disease detected by biopsy or cytology. Univariate analysis eliminated several potential factors and identified interactions between some factors. Multivariate analysis identified the grade of disease ( P < 0.001) and the extent to which the lesion involved the endocervical canal ( P = 0.008) as the most important determinants of high-grade post-treatment disease. Of the factors which the surgeon could control, depth of biopsy ( P = 0.002) and completeness of excision ( P = 0.007) were the most important. This study confirms that clear margins are important to reduce the failure rate of excisional treatment for CIN. An adequate depth of treatment is important when the lesion involves the endocervical canal. [ABSTRACT FROM AUTHOR]

The article discusses the study which determines the number of median lymph node counts present in patients with vulval squamous cell cancer (VSCC). Physicians have used adequate inguinofemoral lymphadenectomy (IFL) to detect isolated groin recurrences (IGR) in both disease-specific and overall survival patients. It found that an increase rate of IGR was occurred in patients with increased age, tumor size and lymphovascular space invasion.