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6 results on '"Soumya K. Chandrasekhar"'

1. Contributors

Author

Devendra K. Agrawal, Samad Ahadian, Ajoy Aloysius, P.R. Anil Kumar, Sudha Anjali, Veena B. Antony, S. Arya, Aleksandra Benko, Marco Cícero Bottino, Soumya K. Chandrasekhar, Thomas Chandy, John Lalith Charles Richard, Huizhi Chen, Smitha Chenicheri, Jorge L. Cholula-Díaz, Eva C. Das, Madhusmita Dash, Kevin G. Dsouza, Gregory R.D. Evans, Renjitha Gopurappilly, Lianxian Guo, Gerardo Hernandez-Moreno, Johnson V. John, Maji Jose, Arun Jyothidasan, Ajay Kashi, Gilson Khang, Wooyoup Kim, Manoj Komath, Dae Hoon Lee, Jianqiang Liu, S. Sharareh Mahdavi, João Mano, Shohreh Mashayekhan, Alec McCarthy, David Medina-Cruz, L.P. Merlin Rajesh Lal, Ebrahim Mostafavi, Jahnavi Mudigonda, Eliseu Aldrighi Münchow, Sara Nadine, Anaga Nair, Deepthi S. Rajendran Nair, Rajasekaran Namakkal Soorappan, Himansu Sekhar Nanda, Joshi C. Ouseph, Rakhi Pal, Rakesh Pemmada, Xinsheng Peng, Anitha Radhakrishnan, Abinayaa Rajkumar, Rajesh Ramachandran, Seeram Ramakrishna, null Remya Kommeri, Rajalekshmi Resmi, Prosenjit Saha, Subrata Saha, Ramakrishna Perumal Saravana, Nisha Shankhwar, Chandra P. Sharma, Jeong Eun Song, Isaac Jordão de Souza Araújo, Sreekanth Sreekumaran, Sini Sunny, Ranu Surolia, Puneet Tandon, Nader Tanideh, Alexander M. Tatara, Vicky Subhash Telang, Finosh G. Thankam, Biju B. Thomas, Sabu Thomas, Vinoy Thomas, Saidah Tootla, Linh B. Truong, Aynur Unal, Vineeth M. Vijayan, Liyan Wang, Thomas J. Webster, Alan D. Widgerow, Jingwei Xie, Hui Zhou, Yubin Zhou, Mary E. Ziegler, and Marta Zurek-Mortka

Published
2022
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3. Engineered cardiac tissue: Concepts and future

Author

Devendra K. Agrawal, Joshi C. Ouseph, Finosh G. Thankam, and Soumya K. Chandrasekhar

Subjects
Heart transplantation, Management strategy, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine, Molecular pathogenesis, Myocardial infarction, Intensive care medicine, medicine.disease, business
Abstract

The significantly increasing mortality rate due to CVDs, especially myocardial infarction (MI), has markedly increased the global agony. Heart transplantation has been the ultimate lifesaving management strategy for end stage cardiac failure; however, the lack of enough donors offers a major constrain. In addition, the multitude of complications associated with heart transplantation has led to the emergence of cardiac tissue engineering (CTE) as a promising regenerative strategy. This chapter focusses on the fundamentals of molecular pathogenesis of myocardial injury, basics of CTE, advancements CTE strategies with emphasis on biointegration and functional performance and the current challenges. The chapter portrays the promise of next generation regenerative cardiology which gives pleasant hope for the millions of CVD sufferers throughout the globe.

Published
2021
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4. List of contributors

Author

Devendra K. Agrawal, Swati Agrawal, Nidhi Arora, Ashutosh Bandyopadhyay, Bibrita Bhar, Nandana Bhardwaj, Bhaskar Birru, Hema Bora, John P. Bradford, Soumya K. Chandrasekhar, Thomas Chandy, Subrata K. Das, Santanu Dhara, Abir Dutta, Prachi Hanwatkar, Santanu Hati, Gerardo Hernandez-Moreno, Maji Jose, Sanju P. Joy, Ajay Kashi, Oormila Kovilam, Merlin Rajesh Lal, Biman B. Mandal, A. Maya Nandkumar, Joseph Christakiran Moses, Raghav A. Murthy, Prabha D. Nair, Joshi C. Ouseph, Willi Paul, S.S. Pradeep Kumar, Anitha Radhakrishnan, D.P. Rahul, Vikrant Rai, Vrinda Rajagopal, Ragavi Rajasekaran, Greeshma Ratheesh, Preetam Guha Ray, Trina Roy, Baisakhee Saha, Aditya Sengupta, Chandra P. Sharma, Yogendra Pratap Singh, V.P. Sivadas, Prashant Sonar, Sreekanth Sreekumaran, Finosh G. Thankam, Vinoy Thomas, Aynur Unal, Cedryck Vaquette, and Yin Xiao

Published
2021
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5. Contributors

Author

Kiran R. Adhikari, Devendra K. Agrawal, A. Anitha, Suresh S. Babu, Vamsi Krishna Balla, Amit Bandyopadhyay, Subhadip Bodhak, Susmita Bose, A. Chandler-Temple, Soumya K. Chandrasekhar, Thomas Chandy, Smitha Chenicheri, Mitun Das, Pradyot Datta, Kaushik D. Deb, F.B. Fernandez, Lisbeth Grøndahl, Namitha Haridas, Rani James, A. Kashi, Manoj Komath, Remya Komeri, Priyanka Kumari, Biswanath Kundu, Gwendolyn Lawrie, Bernadette K. Madathil, Raghav Murthy, Joshi C. Ouseph, Umashankar P.R., Anil Kumar P.R., Willi Paul, Donald E. Pfeifer, C.K.S. Pillai, S. Saha, Aditya Sengupta, Chandra P. Sharma, Aparna Shejwalkar, Jeffery D. St. Jeor, Finosh G. Thankam, Vinoy Thomas, Bernabe S. Tucker, Harikrishna Varma, Balu Venugopal, Sunita Prem Victor, Krishna S. Vyas, and E. Wentrup-Byrne

Published
2020
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6. Interface biology of stem cell–driven tissue engineering

Author

Joshi C. Ouseph, Soumya K. Chandrasekhar, Finosh G. Thankam, and Devendra K. Agrawal

Subjects
Scaffold, Tissue engineering, Regeneration (biology), Biomaterial, Stem cell, Biology, Embryonic stem cell, Regenerative medicine, Homing (hematopoietic), Cell biology
Abstract

Organ transplantation has been considered to be a promising strategy to treat end-stage organ failure. However, the difficulty to procure healthy organs and tissues offers the major challenge for this treatment modality. Recently, tissue engineering (TE) and regenerative medicine emerged as an alternative approach, wherein the intrinsic healing capacity of the body is exploited to stimulate the repair/regeneration of the damaged tissues and organs. The success of TE relies on several factors such as the biomaterials employed to fabricate scaffold or preengineered tissue, type and source of cells used, and the integration of scaffolds to the host tissue. The TE approaches have thrown light to stem cells owing to their versatile regenerative potential. The promising practice is the in vitro design of preengineered tissue by seeding various preprogramed stem cells onto biomaterial scaffolds for in vivo implantation. Both adult and embryonic stem cells have been explored in combination with different biomaterial scaffolds for tissue regeneration. Still in its infancy, this approach faces certain limitations such as lack of typical stem cell biomarkers, high cost of commercialization, difficulty in clinical translations, and teratoma formation. Another strategy is to promote the homing of endogenous stem cells to injury site to initiate inherent healing response. Here, the stem cells are mobilized from their niches to circulation employing different chemokines in association with biomaterial scaffolds, as the stem cell attracting chemical cues released from the trauma site may be insufficient in severe casualties. Therefore, the exogenous supply of such signals in combination with scaffolds facilitates their local concentration to recruit stem cells to activate the tissue regeneration. Interestingly, the biomaterial-based tissue regeneration solely depends on the favorable molecular interactions at the interface between the biomaterial and host tissue. This chapter is focused on interface biology of soft tissues in regard to stem cell–based TE with a briefing on various strategies employed to improve the integration of stem cells or associated mediators onto biomaterials.

Published
2020
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