Search

Radiography is widely used in orthopedics for its affordability and low radiation exposure. 3D reconstruction from a single radiograph, so-called 2D-3D reconstruction, offers the possibility of various clinical applications, but achieving clinically viable accuracy and computational efficiency is still an unsolved challenge. Unlike other areas in computer vision, X-ray imaging's unique properties, such as ray penetration and fixed geometry, have not been fully exploited. We propose a novel approach that simultaneously learns multiple depth maps (front- and back-surface of multiple bones) derived from the X-ray image to computed tomography registration. The proposed method not only leverages the fixed geometry characteristic of X-ray imaging but also enhances the precision of the reconstruction of the whole surface. Our study involved 600 CT and 2651 X-ray images (4 to 5 posed X-ray images per patient), demonstrating our method's superiority over traditional approaches with a surface reconstruction error reduction from 4.78 mm to 1.96 mm. This significant accuracy improvement and enhanced computational efficiency suggest our approach's potential for clinical application., Comment: MICCAI 2024. 12 pages, 4 figures

Deep learning-based image segmentation has allowed for the fully automated, accurate, and rapid analysis of musculoskeletal (MSK) structures from medical images. However, current approaches were either applied only to 2D cross-sectional images, addressed few structures, or were validated on small datasets, which limit the application in large-scale databases. This study aimed to validate an improved deep learning model for volumetric MSK segmentation of the hip and thigh with uncertainty estimation from clinical computed tomography (CT) images. Databases of CT images from multiple manufacturers/scanners, disease status, and patient positioning were used. The segmentation accuracy, and accuracy in estimating the structures volume and density, i.e., mean HU, were evaluated. An approach for segmentation failure detection based on predictive uncertainty was also investigated. The model has shown an overall improvement with respect to all segmentation accuracy and structure volume/density evaluation metrics. The predictive uncertainty yielded large areas under the receiver operating characteristic (AUROC) curves (AUROCs>=.95) in detecting inaccurate and failed segmentations. The high segmentation and muscle volume/density estimation accuracy, along with the high accuracy in failure detection based on the predictive uncertainty, exhibited the model's reliability for analyzing individual MSK structures in large-scale CT databases., Comment: 29 pages, 7+10supp figures, 8 tables

Safe Reinforcement Learning (Safe RL) is one of the prevalently studied subcategories of trial-and-error-based methods with the intention to be deployed on real-world systems. In safe RL, the goal is to maximize reward performance while minimizing constraints, often achieved by setting bounds on constraint functions and utilizing the Lagrangian method. However, deploying Lagrangian-based safe RL in real-world scenarios is challenging due to the necessity of threshold fine-tuning, as imprecise adjustments may lead to suboptimal policy convergence. To mitigate this challenge, we propose a unified Lagrangian-based model-free architecture called Meta Soft Actor-Critic Lagrangian (Meta SAC-Lag). Meta SAC-Lag uses meta-gradient optimization to automatically update the safety-related hyperparameters. The proposed method is designed to address safe exploration and threshold adjustment with minimal hyperparameter tuning requirement. In our pipeline, the inner parameters are updated through the conventional formulation and the hyperparameters are adjusted using the meta-objectives which are defined based on the updated parameters. Our results show that the agent can reliably adjust the safety performance due to the relatively fast convergence rate of the safety threshold. We evaluate the performance of Meta SAC-Lag in five simulated environments against Lagrangian baselines, and the results demonstrate its capability to create synergy between parameters, yielding better or competitive results. Furthermore, we conduct a real-world experiment involving a robotic arm tasked with pouring coffee into a cup without spillage. Meta SAC-Lag is successfully trained to execute the task, while minimizing effort constraints., Comment: Main text accepted to the IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) 2024, 10 pages, 4 figures, 3 tables

While most vision tasks are essentially visual in nature (for recognition), some important tasks, especially in the medical field, also require quantitative analysis (for quantification) using quantitative images. Unlike in visual analysis, pixel values in quantitative images correspond to physical metrics measured by specific devices (e.g., a depth image). However, recent work has shown that it is sometimes possible to synthesize accurate quantitative values from visual ones (e.g., depth from visual cues or defocus). This research aims to improve quantitative image synthesis (QIS) by exploring pretraining and image resolution scaling. We propose a benchmark for evaluating pretraining performance using the task of QIS-based bone mineral density (BMD) estimation from plain X-ray images, where the synthesized quantitative image is used to derive BMD. Our results show that appropriate pretraining can improve QIS performance, significantly raising the correlation of BMD estimation from 0.820 to 0.898, while others do not help or even hinder it. Scaling-up the resolution can further boost the correlation up to 0.923, a significant enhancement over conventional methods. Future work will include exploring more pretraining strategies and validating them on other image synthesis tasks., Comment: SASHIMI, 2024 (MICCAI workshop). 13 pages, 3 figures

Multi-object tracking (MOT) is a prominent task in computer vision with application in autonomous driving, responsible for the simultaneous tracking of multiple object trajectories. Detection-based multi-object tracking (DBT) algorithms detect objects using an independent object detector and predict the imminent location of each target. Conventional prediction methods in DBT utilize Kalman Filter(KF) to extrapolate the target location in the upcoming frames by supposing a constant velocity motion model. These methods are especially hindered in autonomous driving applications due to dramatic camera motion or unavailable detections. Such limitations lead to tracking failures manifested by numerous identity switches and disrupted trajectories. In this paper, we introduce a novel KF-based prediction module called the Ego-motion Aware Target Prediction (EMAP) module by focusing on the integration of camera motion and depth information with object motion models. Our proposed method decouples the impact of camera rotational and translational velocity from the object trajectories by reformulating the Kalman Filter. This reformulation enables us to reject the disturbances caused by camera motion and maximizes the reliability of the object motion model. We integrate our module with four state-of-the-art base MOT algorithms, namely OC-SORT, Deep OC-SORT, ByteTrack, and BoT-SORT. In particular, our evaluation on the KITTI MOT dataset demonstrates that EMAP remarkably drops the number of identity switches (IDSW) of OC-SORT and Deep OC-SORT by 73% and 21%, respectively. At the same time, it elevates other performance metrics such as HOTA by more than 5%. Our source code is available at https://github.com/noyzzz/EMAP., Comment: 7 pages, 4 figures, submitted to IROS2024

This paper addresses the challenge of geometric quality assurance in manufacturing, particularly when human assessment is required. It proposes using Blender, an open-source simulation tool, to create synthetic datasets for machine learning (ML) models. The process involves translating expert information into shape key parameters to simulate deformations, generating images for both deformed and non-deformed objects. The study explores the impact of discrepancies between real and simulated environments on ML model performance and investigates the effect of different simulation backgrounds on model sensitivity. Additionally, the study aims to enhance the model's robustness to camera positioning by generating datasets with a variety of randomized viewpoints. The entire process, from data synthesis to model training and testing, is implemented using a Python API interfacing with Blender. An experiment with a soda can object validates the accuracy of the proposed pipeline., Comment: 6 pages, 4 figures, 2024 IEEE 20th International Conference on Automation Science and Engineering (CASE)

The rise of automation has provided an opportunity to achieve higher efficiency in manufacturing processes, yet it often compromises the flexibility required to promptly respond to evolving market needs and meet the demand for customization. Human-robot collaboration attempts to tackle these challenges by combining the strength and precision of machines with human ingenuity and perceptual understanding. In this paper, we conceptualize and propose an implementation framework for an autonomous, machine learning-based manipulator that incorporates human-in-the-loop principles and leverages Extended Reality (XR) to facilitate intuitive communication and programming between humans and robots. Furthermore, the conceptual framework foresees human involvement directly in the robot learning process, resulting in higher adaptability and task generalization. The paper highlights key technologies enabling the proposed framework, emphasizing the importance of developing the digital ecosystem as a whole. Additionally, we review the existent implementation approaches of XR in human-robot collaboration, showcasing diverse perspectives and methodologies. The challenges and future outlooks are discussed, delving into the major obstacles and potential research avenues of XR for more natural human-robot interaction and integration in the industrial landscape., Comment: Published in IEEE International Conference on Robot and Human Interactive Communication (RO-MAN) 2024

Progression of hip osteoarthritis (hip OA) leads to pain and disability, likely leading to surgical treatment such as hip arthroplasty at the terminal stage. The severity of hip OA is often classified using the Crowe and Kellgren-Lawrence (KL) classifications. However, as the classification is subjective, we aimed to develop an automated approach to classify the disease severity based on the two grades using digitally-reconstructed radiographs (DRRs) from CT images. Automatic grading of the hip OA severity was performed using deep learning-based models. The models were trained to predict the disease grade using two grading schemes, i.e., predicting the Crowe and KL grades separately, and predicting a new ordinal label combining both grades and representing the disease progression of hip OA. The models were trained in classification and regression settings. In addition, the model uncertainty was estimated and validated as a predictor of classification accuracy. The models were trained and validated on a database of 197 hip OA patients, and externally validated on 52 patients. The model accuracy was evaluated using exact class accuracy (ECA), one-neighbor class accuracy (ONCA), and balanced accuracy.The deep learning models produced a comparable accuracy of approximately 0.65 (ECA) and 0.95 (ONCA) in the classification and regression settings. The model uncertainty was significantly larger in cases with large classification errors (P<6e-3). In this study, an automatic approach for grading hip OA severity from CT images was developed. The models have shown comparable performance with high ONCA, which facilitates automated grading in large-scale CT databases and indicates the potential for further disease progression analysis. Classification accuracy was correlated with the model uncertainty, which would allow for the prediction of classification errors.

Reinforcement learning (RL) for motion planning of multi-degree-of-freedom robots still suffers from low efficiency in terms of slow training speed and poor generalizability. In this paper, we propose a novel RL-based robot motion planning framework that uses implicit behavior cloning (IBC) and dynamic movement primitive (DMP) to improve the training speed and generalizability of an off-policy RL agent. IBC utilizes human demonstration data to leverage the training speed of RL, and DMP serves as a heuristic model that transfers motion planning into a simpler planning space. To support this, we also create a human demonstration dataset using a pick-and-place experiment that can be used for similar studies. Comparison studies in simulation reveal the advantage of the proposed method over the conventional RL agents with faster training speed and higher scores. A real-robot experiment indicates the applicability of the proposed method to a simple assembly task. Our work provides a novel perspective on using motion primitives and human demonstration to leverage the performance of RL for robot applications.

Purpose: Manual annotations for training deep learning (DL) models in auto-segmentation are time-intensive. This study introduces a hybrid representation-enhanced sampling strategy that integrates both density and diversity criteria within an uncertainty-based Bayesian active learning (BAL) framework to reduce annotation efforts by selecting the most informative training samples. Methods: The experiments are performed on two lower extremity (LE) datasets of MRI and CT images, focusing on the segmentation of the femur, pelvis, sacrum, quadriceps femoris, hamstrings, adductors, sartorius, and iliopsoas, utilizing a U-net-based BAL framework. Our method selects uncertain samples with high density and diversity for manual revision, optimizing for maximal similarity to unlabeled instances and minimal similarity to existing training data. We assess the accuracy and efficiency using Dice and a proposed metric called reduced annotation cost (RAC), respectively. We further evaluate the impact of various acquisition rules on BAL performance and design an ablation study for effectiveness estimation. Results: In MRI and CT datasets, our method was superior or comparable to existing ones, achieving a 0.8\% Dice and 1.0\% RAC increase in CT (statistically significant), and a 0.8\% Dice and 1.1\% RAC increase in MRI (not statistically significant) in volume-wise acquisition. Our ablation study indicates that combining density and diversity criteria enhances the efficiency of BAL in musculoskeletal segmentation compared to using either criterion alone. Conclusion: Our sampling method is proven efficient in reducing annotation costs in image segmentation tasks. The combination of the proposed method and our BAL framework provides a semi-automatic way for efficient annotation of medical image datasets., Comment: 15 pages, 5 figures

Osteoporosis is a prevalent bone disease that causes fractures in fragile bones, leading to a decline in daily living activities. Dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) are highly accurate for diagnosing osteoporosis; however, these modalities require special equipment and scan protocols. To frequently monitor bone health, low-cost, low-dose, and ubiquitously available diagnostic methods are highly anticipated. In this study, we aim to perform bone mineral density (BMD) estimation from a plain X-ray image for opportunistic screening, which is potentially useful for early diagnosis. Existing methods have used multi-stage approaches consisting of extraction of the region of interest and simple regression to estimate BMD, which require a large amount of training data. Therefore, we propose an efficient method that learns decomposition into projections of bone-segmented QCT for BMD estimation under limited datasets. The proposed method achieved high accuracy in BMD estimation, where Pearson correlation coefficients of 0.880 and 0.920 were observed for DXA-measured BMD and QCT-measured BMD estimation tasks, respectively, and the root mean square of the coefficient of variation values were 3.27 to 3.79% for four measurements with different poses. Furthermore, we conducted extensive validation experiments, including multi-pose, uncalibrated-CT, and compression experiments toward actual application in routine clinical practice., Comment: 20 pages and 22 figures

Musculoskeletal diseases such as sarcopenia and osteoporosis are major obstacles to health during aging. Although dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) can be used to evaluate musculoskeletal conditions, frequent monitoring is difficult due to the cost and accessibility (as well as high radiation exposure in the case of CT). We propose a method (named MSKdeX) to estimate fine-grained muscle properties from a plain X-ray image, a low-cost, low-radiation, and highly accessible imaging modality, through musculoskeletal decomposition leveraging fine-grained segmentation in CT. We train a multi-channel quantitative image translation model to decompose an X-ray image into projections of CT of individual muscles to infer the lean muscle mass and muscle volume. We propose the object-wise intensity-sum loss, a simple yet surprisingly effective metric invariant to muscle deformation and projection direction, utilizing information in CT and X-ray images collected from the same patient. While our method is basically an unpaired image-to-image translation, we also exploit the nature of the bone's rigidity, which provides the paired data through 2D-3D rigid registration, adding strong pixel-wise supervision in unpaired training. Through the evaluation using a 539-patient dataset, we showed that the proposed method significantly outperformed conventional methods. The average Pearson correlation coefficient between the predicted and CT-derived ground truth metrics was increased from 0.460 to 0.863. We believe our method opened up a new musculoskeletal diagnosis method and has the potential to be extended to broader applications in multi-channel quantitative image translation tasks. Our source code will be released soon., Comment: MICCAI 2023 early acceptance (12 pages and 6 figures)

Finding an efficient way to adapt robot trajectory is a priority to improve overall performance of robots. One approach for trajectory planning is through transferring human-like skills to robots by Learning from Demonstrations (LfD). The human demonstration is considered the target motion to mimic. However, human motion is typically optimal for human embodiment but not for robots because of the differences between human biomechanics and robot dynamics. The Dynamic Movement Primitives (DMP) framework is a viable solution for this limitation of LfD, but it requires tuning the second-order dynamics in the formulation. Our contribution is introducing a systematic method to extract the dynamic features from human demonstration to auto-tune the parameters in the DMP framework. In addition to its use with LfD, another utility of the proposed method is that it can readily be used in conjunction with Reinforcement Learning (RL) for robot training. In this way, the extracted features facilitate the transfer of human skills by allowing the robot to explore the possible trajectories more efficiently and increasing robot compliance significantly. We introduced a methodology to extract the dynamic features from multiple trajectories based on the optimization of human-likeness and similarity in the parametric space. Our method was implemented into an actual human-robot setup to extract human dynamic features and used to regenerate the robot trajectories following both LfD and RL with DMP. It resulted in a stable performance of the robot, maintaining a high degree of human-likeness based on accumulated distance error as good as the best heuristic tuning.

Reinforcement learning demonstrates significant potential in automatically building control policies in numerous domains, but shows low efficiency when applied to robot manipulation tasks due to the curse of dimensionality. To facilitate the learning of such tasks, prior knowledge or heuristics that incorporate inherent simplification can effectively improve the learning performance. This paper aims to define and incorporate the natural symmetry present in physical robotic environments. Then, sample-efficient policies are trained by exploiting the expert demonstrations in symmetrical environments through an amalgamation of reinforcement and behavior cloning, which gives the off-policy learning process a diverse yet compact initiation. Furthermore, it presents a rigorous framework for a recent concept and explores its scope for robot manipulation tasks. The proposed method is validated via two point-to-point reaching tasks of an industrial arm, with and without an obstacle, in a simulation experiment study. A PID controller, which tracks the linear joint-space trajectories with hard-coded temporal logic to produce interim midpoints, is used to generate demonstrations in the study. The results of the study present the effect of the number of demonstrations and quantify the magnitude of behavior cloning to exemplify the possible improvement of model-free reinforcement learning in common manipulation tasks. A comparison study between the proposed method and a traditional off-policy reinforcement learning algorithm indicates its advantage in learning performance and potential value for applications.

Simulation is essential to reinforcement learning (RL) before implementation in the real world, especially for safety-critical applications like robot manipulation. Conventionally, RL agents are sensitive to the discrepancies between the simulation and the real world, known as the sim-to-real gap. The application of domain randomization, a technique used to fill this gap, is limited to the imposition of heuristic-randomized models. {We investigate the properties of intrinsic stochasticity of real-time simulation (RT-IS) of off-the-shelf simulation software and its potential to improve RL performance. This improvement includes a higher tolerance to noise and model imprecision and superiority to conventional domain randomization in terms of ease of use and automation. Firstly, we conduct analytical studies to measure the correlation of RT-IS with the utilization of computer hardware and validate its comparability with the natural stochasticity of a physical robot. Then, we exploit the RT-IS feature in the training of an RL agent. The simulation and physical experiment results verify the feasibility and applicability of RT-IS to robust agent training for robot manipulation tasks. The RT-IS-powered RL agent outperforms conventional agents on robots with modeling uncertainties. RT-IS requires less heuristic randomization, is not task-dependent, and achieves better generalizability than the conventional domain-randomization-powered agents. Our findings provide a new perspective on the sim-to-real problem in practical applications like robot manipulation tasks.