39 results on '"Sou Y"'
Search Results
2. Higher Dietary Non-enzymatic Antioxidant Capacity Is Associated with Decreased Risk of All-Cause and Cardiovascular Disease Mortality in Japanese Adults
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Kashino, Ikuko, Mizoue, Tetsuya, Serafini, Mauro, Akter, Shamima, Sawada, Norie, Ishihara, Junko, Kotemori, Ayaka, Inoue, Manami, Yamaji, Taiki, Goto, Atsushi, Iwasaki, Motoki, Noda, Mitsushiko, Tsugane, Shoichiro, Tsugane, S, Sawada, N, Iwasaki, M, Inoue, M, Yamaji, T, Goto, A, Shimazu, T, Charvat, H, Budhathoki, S, Muto, M, Suzuki, H, Minamizono, T, Kobayashi, Y, Irei, M, Doi, M, Katagiri, M, Tagami, T, Sou, Y, Uehara, M, Kokubo, Y, Yamagishi, Noda, M, Mizoue, T, Kawaguchi, Y, Nakamura, K, Takachi, R, Ishihara, J, Iso, H, Sobue, T, Saito, I, Yasuda, N, Mimura, M, and Sakata, K
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- 2019
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3. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study
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Tsugane, S., Sawada, N., Iwasaki, M., Sasazuki, S., Yamaji, T., Shimazu, T., Goto, A., Hidaka, A., Hanaoka, T., Ogata, J., Baba, S., Mannami, T., Okayama, A., Kokubo, Y., Miyakawa, K., Saito, F., Koizumi, A., Sano, Y., Hashimoto, I., Ikuta, T., Tanaba, Y., Sato, H., Roppongi, Y., Takashima, T., Suzuki, H., Miyajima, Y., Suzuki, N., Nagasawa, S., Furusugi, Y., Nagai, N., Ito, Y., Komatsu, S., Minamizono, T., Sanada, H., Hatayama, Y., Kobayashi, F., Uchino, H., Shirai, Y., Kondo, T., Sasaki, R., Watanabe, Y., Miyagawa, Y., Kobayashi, Y., Machida, M., Kobayashi, K., Tsukada, M., Kishimoto, Y., Takara, E., Fukuyama, T., Kinjo, M., Irei, M., Sakiyama, H., Imoto, K., Yazawa, H., Seo, T., Seiko, A., Ito, F., Shoji, F., Saito, R., Murata, A., Minato, K., Motegi, K., Fujieda, T., Yamato, S., Doi, M., Matsui, K., Abe, T., Katagiri, M., Suzuki, M., Terao, A., Ishikawa, Y., Tagami, T., Sueta, H., Doi, H., Urata, M., Okamoto, N., Ide, F., Goto, H., Fujita, R., Sou, Y., Onga, N., Takaesu, H., Uehara, M., Nakasone, T., Yamakawa, M., Horii, F., Asano, I., Yamaguchi, H., Aoki, K., Maruyama, S., Ichii, M., Takano, M., Tsubono, Y., Suzuki, K., Honda, Y., Yamagishi, K., Sakurai, S., Tsuchiya, N., Kabuto, M., Yamaguchi, M., Matsumura, Y., Sasaki, S., Watanabe, S., Akabane, M., Kadowaki, T., Inoue, M., Noda, M., Mizoue, T., Kawaguchi, Y., Takashima, Y., Yoshida, Y., Nakamura, K., Takachi, R., Ishihara, J., Matsushima, S., Natsukawa, S., Shimizu, H., Sugimura, H., Tominaga, S., Hamajima, N., Iso, H., Sobue, T., Iida, M., Ajiki, W., Ioka, A., Sato, S., Maruyama, E., Konishi, M., Okada, K., Saito, I., Yasuda, N., Kono, S., Akiba, S., Isobe, T., Sato, Y., Hamazaki, Kei, Iso, Hiroyasu, Eshak, Ehab S., Ikehara, Satoyo, Ikeda, Ai, Iwasaki, Motoki, Hamazaki, Tomohito, and Tsugane, Shoichiro
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- 2018
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4. Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol.
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Tan Boon Toh, Dexter Kai Hao Thng, Nagarjun Bolem, Balamurugan A Vellayappan, Bryce Wei Quan Tan, Yating Shen, Sou Yen Soon, Yvonne Li En Ang, Nivedh Dinesh, Kejia Teo, Vincent Diong Weng Nga, Shiong Wen Low, Pek Lan Khong, Edward Kai-Hua Chow, Dean Ho, Tseng Tsai Yeo, and Andrea Li Ann Wong
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Medicine ,Science - Abstract
IntroductionHigh grade astrocytic glioma (HGG) is a lethal solid malignancy with high recurrence rates and limited survival. While several cytotoxic agents have demonstrated efficacy against HGG, drug sensitivity testing platforms to aid in therapy selection are lacking. Patient-derived organoids (PDOs) have been shown to faithfully preserve the biological characteristics of several cancer types including HGG, and coupled with the experimental-analytical hybrid platform Quadratic Phenotypic Optimization Platform (QPOP) which evaluates therapeutic sensitivity at a patient-specific level, may aid as a tool for personalized medical decisions to improve treatment outcomes for HGG patients.MethodsThis is an interventional, non-randomized, open-label study, which aims to enroll 10 patients who will receive QPOP-guided chemotherapy at the time of first HGG recurrence following progression on standard first-line therapy. At the initial presentation of HGG, tumor will be harvested for primary PDO generation during the first biopsy/surgery. At the point of tumor recurrence, patients will be enrolled onto the main study to receive systemic therapy as second-line treatment. Subjects who undergo surgery at the time of recurrence will have a second harvest of tissue for PDO generation. Established PDOs will be subject to QPOP analyses to determine their therapeutic sensitivities to specific panels of drugs. A QPOP-guided treatment selection algorithm will then be used to select the most appropriate drug combination. The primary endpoint of the study is six-month progression-free survival. The secondary endpoints include twelve-month overall survival, RANO criteria and toxicities. In our radiological biomarker sub-study, we plan to evaluate novel radiopharmaceutical-based neuroimaging in determining blood-brain barrier permeability and to assess in vivo drug effects on tumor vasculature over time.Trial registrationThis trial was registered on 8th September 2022 with ClinicalTrials.gov Identifier: NCT05532397.
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- 2024
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5. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios alone or combined with prostate-specific antigen for the diagnosis of prostate cancer and clinically significant prostate cancer
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Sat Prasad Nepal, Takehiko Nakasato, Takashi Fukagai, Yoshio Ogawa, Yoshihiro Nakagami, Takeshi Shichijo, Jun Morita, Yoshiko Maeda, Kazuhiko Oshinomi, Tsutomu Unoki, Tetsuo Noguchi, Tatsuki Inoue, Ryosuke Kato, Satoshi Amano, Moyuru Mizunuma, Masahiro Kurokawa, Yoshiki Tsunokawa, and Sou Yasuda
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Blood parameter ,Gleason score ,Neutrophil-to-lymphocyte ratio ,Platelet-to-lymphocyte ratio ,Prostate cancer ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer (PCa) and clinically significant PCa (Gleason score [GS] ≥7) in our hospital. Methods: This study included patients with increased prostate-specific antigen (PSA) up to 20 ng/mL. The associations of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) alone or with PSA with PCa and clinically significant PCa were analyzed. Results: We included 365 patients, of whom 52.9% (193) had PCa including 66.8% (129) with GS of ≥7. PSA density (PSAD) and PSA had better the area under the curve (AUC) of 0.722 and 0.585, respectively with p=0.001 for detecting PCa compared with other blood parameters. PSA combined with PLR (PsPLR) and PSA with NLR (PsNLR) had better AUC of 0.608 and 0.610, respectively with p
- Published
- 2023
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6. Plasma levels of n-3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study
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Hamazaki, Kei, primary, Iso, Hiroyasu, additional, Eshak, Ehab S., additional, Ikehara, Satoyo, additional, Ikeda, Ai, additional, Iwasaki, Motoki, additional, Hamazaki, Tomohito, additional, Tsugane, Shoichiro, additional, Tsugane, S., additional, Sawada, N., additional, Iwasaki, M., additional, Sasazuki, S., additional, Yamaji, T., additional, Shimazu, T., additional, Goto, A., additional, Hidaka, A., additional, Hanaoka, T., additional, Ogata, J., additional, Baba, S., additional, Mannami, T., additional, Okayama, A., additional, Kokubo, Y., additional, Miyakawa, K., additional, Saito, F., additional, Koizumi, A., additional, Sano, Y., additional, Hashimoto, I., additional, Ikuta, T., additional, Tanaba, Y., additional, Sato, H., additional, Roppongi, Y., additional, Takashima, T., additional, Suzuki, H., additional, Miyajima, Y., additional, Suzuki, N., additional, Nagasawa, S., additional, Furusugi, Y., additional, Nagai, N., additional, Ito, Y., additional, Komatsu, S., additional, Minamizono, T., additional, Sanada, H., additional, Hatayama, Y., additional, Kobayashi, F., additional, Uchino, H., additional, Shirai, Y., additional, Kondo, T., additional, Sasaki, R., additional, Watanabe, Y., additional, Miyagawa, Y., additional, Kobayashi, Y., additional, Machida, M., additional, Kobayashi, K., additional, Tsukada, M., additional, Kishimoto, Y., additional, Takara, E., additional, Fukuyama, T., additional, Kinjo, M., additional, Irei, M., additional, Sakiyama, H., additional, Imoto, K., additional, Yazawa, H., additional, Seo, T., additional, Seiko, A., additional, Ito, F., additional, Shoji, F., additional, Saito, R., additional, Murata, A., additional, Minato, K., additional, Motegi, K., additional, Fujieda, T., additional, Yamato, S., additional, Doi, M., additional, Matsui, K., additional, Abe, T., additional, Katagiri, M., additional, Suzuki, M., additional, Terao, A., additional, Ishikawa, Y., additional, Tagami, T., additional, Sueta, H., additional, Doi, H., additional, Urata, M., additional, Okamoto, N., additional, Ide, F., additional, Goto, H., additional, Fujita, R., additional, Sou, Y., additional, Onga, N., additional, Takaesu, H., additional, Uehara, M., additional, Nakasone, T., additional, Yamakawa, M., additional, Horii, F., additional, Asano, I., additional, Yamaguchi, H., additional, Aoki, K., additional, Maruyama, S., additional, Ichii, M., additional, Takano, M., additional, Tsubono, Y., additional, Suzuki, K., additional, Honda, Y., additional, Yamagishi, K., additional, Sakurai, S., additional, Tsuchiya, N., additional, Kabuto, M., additional, Yamaguchi, M., additional, Matsumura, Y., additional, Sasaki, S., additional, Watanabe, S., additional, Akabane, M., additional, Kadowaki, T., additional, Inoue, M., additional, Noda, M., additional, Mizoue, T., additional, Kawaguchi, Y., additional, Takashima, Y., additional, Yoshida, Y., additional, Nakamura, K., additional, Takachi, R., additional, Ishihara, J., additional, Matsushima, S., additional, Natsukawa, S., additional, Shimizu, H., additional, Sugimura, H., additional, Tominaga, S., additional, Hamajima, N., additional, Iso, H., additional, Sobue, T., additional, Iida, M., additional, Ajiki, W., additional, Ioka, A., additional, Sato, S., additional, Maruyama, E., additional, Konishi, M., additional, Okada, K., additional, Saito, I., additional, Yasuda, N., additional, Kono, S., additional, Akiba, S., additional, Isobe, T., additional, and Sato, Y., additional
- Published
- 2018
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7. Does training with blurred images bring convolutional neural networks closer to humans with respect to robust object recognition and internal representations?
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Sou Yoshihara, Taiki Fukiage, and Shin'ya Nishida
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convolutional neural networks ,object recognition ,visual development ,perceptual organization ,optical blur ,Psychology ,BF1-990 - Abstract
It has been suggested that perceiving blurry images in addition to sharp images contributes to the development of robust human visual processing. To computationally investigate the effect of exposure to blurry images, we trained convolutional neural networks (CNNs) on ImageNet object recognition with a variety of combinations of sharp and blurred images. In agreement with recent reports, mixed training on blurred and sharp images (B+S training) brings CNNs closer to humans with respect to robust object recognition against a change in image blur. B+S training also slightly reduces the texture bias of CNNs in recognition of shape-texture cue conflict images, but the effect is not strong enough to achieve human-level shape bias. Other tests also suggest that B+S training cannot produce robust human-like object recognition based on global configuration features. Using representational similarity analysis and zero-shot transfer learning, we also show that B+S-Net does not facilitate blur-robust object recognition through separate specialized sub-networks, one network for sharp images and another for blurry images, but through a single network analyzing image features common across sharp and blurry images. However, blur training alone does not automatically create a mechanism like the human brain in which sub-band information is integrated into a common representation. Our analysis suggests that experience with blurred images may help the human brain recognize objects in blurred images, but that alone does not lead to robust, human-like object recognition.
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- 2023
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8. Hard bilateral syphilitic testes with vasculitis: a case report and literature review
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Sat Prasad Nepal, Takehiko Nakasato, Takashi Fukagai, Takeshi Shichijo, Jun Morita, Yoshiko Maeda, Kazuhiko Oshinomi, Yoshihiro Nakagami, Tsutomu Unoki, Tetsuo Noguchi, Tatsuki Inoue, Ryosuke Kato, Satoshi Amano, Moyuru Mizunuma, Masahiro Kurokawa, Yoshiki Tsunokawa, Sou Yasuda, and Yoshio Ogawa
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Gumma ,Testis ,Syphilis ,Vasculitis ,Aortitis ,Hard ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background We report the case of a patient with syphilitic testicular gumma and vasculitis with adrenal failure due to chronic steroid use. Case presentation A 63-year-old male presented with hard right eye swelling and very firm bilateral testes on palpation, which he had for 2 years. Testicular tumor markers were negative; syphilis test was positive. Radiological examination suggested aortitis and bilateral testicular malignancy. The patient received ampicillin for the infection and prednisolone for vasculitis. Left orchidectomy was performed to confirm the presence of testicular tumor; histological examinations revealed granulomatous orchitis. The prednisolone doses were adjusted because of relapses and adverse effects of steroid use. Unfortunately, the patient died in the intensive care unit because of uncontrolled blood pressure and pneumonia. Conclusions This is a rare case of syphilis with testicular involvement and vasculitis. This report shows the importance of broadening the differential diagnoses of testicular firmness.
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- 2021
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9. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
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Krikin, V, Lamark, T, Sou, Y S, et al, Theurillat, J P, and University of Zurich
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1307 Cell Biology ,10049 Institute of Pathology and Molecular Pathology ,1312 Molecular Biology ,610 Medicine & health - Published
- 2009
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10. Crystal structure of the UBA domain of p62 and its interaction with ubiquitin
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Isogai, S., primary, Morimoto, D., additional, Arita, K., additional, Unzai, S., additional, Tenno, T., additional, Hasegawa, J., additional, Sou, Y., additional, Komatsu, M., additional, Tanaka, K., additional, Shirakawa, M., additional, and Tochio, H., additional
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- 2011
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11. Solution structure of the UBA omain of p62 and its interaction with ubiquitin
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Isogai, S., primary, Morimoto, D., additional, Arita, K., additional, Unzai, S., additional, Tenno, T., additional, Hasegawa, J., additional, Sou, Y., additional, Komatsu, M., additional, Tanaka, K., additional, Shirakawa, M., additional, and Tochio, H., additional
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- 2011
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12. Crystal Structure of LC3-p62 complex
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Ichimura, Y., primary, Kumanomidou, T., additional, Sou, Y., additional, Mizushima, T., additional, Ezaki, J., additional, Ueno, T., additional, Kominami, E., additional, Yamane, T., additional, Tanaka, K., additional, and Komatsu, M., additional
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- 2008
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13. Antigen tests for COVID-19
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Yuta Kyosei, Sou Yamura, Mayuri Namba, Teruki Yoshimura, Satoshi Watabe, and Etsuro Ito
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antigen test ,covid-19 ,real-time pcr ,sars-cov-2 ,ultrasensitive elisa ,Biology (General) ,QH301-705.5 ,Physiology ,QP1-981 ,Physics ,QC1-999 - Abstract
PCR diagnosis has been considered as the gold standard for coronavirus disease 2019 (COVID-19) and other many diseases. However, there are many problems in using PCR, such as non-specific (i.e., false-positive) and false-negative amplifications, the limits of a target sample volume, deactivation of the enzymes used, complicated techniques, difficulty in designing probe sequences, and the expense. We, thus, need an alternative to PCR, for example an ultrasensitive antigen test. In the present review, we summarize the following three topics. (1) The problems of PCR are outlined. (2) The antigen tests are surveyed in the literature that was published in 2020, and their pros and cons are discussed for commercially available antigen tests. (3) Our own antigen test on the basis of an ultrasensitive enzyme-linked immunosorbent assay (ELISA) is introduced. Finally, we discuss the possibility that our antigen test by an ultrasensitive ELISA technique will become the gold standard for diagnosis of COVID-19 and other diseases.
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- 2021
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14. Lack of association between Helicobacter pylori infection and IgA nephropathy
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Sekikawa, A., primary, Saita, H., additional, Sou, Y., additional, Ashida, C., additional, Takeoka, H., additional, and Kanatsu, K., additional
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- 1998
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15. The effects of BaTiO3 nanodots density support on epitaxial LiCoO2 thin-film for high-speed rechargeability
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Sou Yasuhara, Shintaro Yasui, Takashi Teranishi, Yumi Yoshikawa, Tomoyasu Taniyama, and Mitsuru Itoh
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Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
LiCoO2 (LCO) is one of the most promising cathode materials for Li ion batteries (LIBs). However, LCO shows a rate-limiting step of Li+ migration between electrode and electrolyte interfaces, requiring LIBs to be charged under low-current conditions. For next generation batteries, it will be necessary to meet the demand for a shorter charging-time. We investigated a support method for the LCO surface to improve high C-rate performance, and revealed that the Li+ intercalation/de-intercalation reaction into/from LCO was accelerated by the introduction of a BaTiO3-LCO-electrolyte interface (triple-phase interface; TPI), due to the electric field concentration near the TPI. In this report, we investigate the dependence of high C-rate performance on the density of surface BaTiO3 nanodots using epitaxial LiCoO2 thin films created via pulsed laser deposition (PLD). As the number of nanodots increased, so did discharge capacity at 50C, becoming saturated at surface coverage over 22%. However, at 100C, the discharge capacity decreased at surface coverage over 40%. These results indicate that coalescence of nanodots reduces not only the TPI length but also the electrochemically active range at quite high C-rate. Therefore, we infer that optimal surface coverage should be varied depending on the C-rate. Keywords: High speed chargeability, Nanodots, Density, Dielectrics, LiCoO2
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- 2019
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16. Proposal of De Novo Antigen Test for COVID-19: Ultrasensitive Detection of Spike Proteins of SARS-CoV-2
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Yuta Kyosei, Mayuri Namba, Sou Yamura, Rikiya Takeuchi, Noriko Aoki, Kazunari Nakaishi, Satoshi Watabe, and Etsuro Ito
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COVID-19 ,SARS-CoV-2 ,spike protein ,thio-NAD cycling ,ultrasensitive ELISA ,Medicine (General) ,R5-920 - Abstract
Polymerase chain reaction (PCR)-based antigen tests are technically difficult, time-consuming, and expensive, and may produce false negative results requiring follow-up confirmation with computed tomography. The global coronavirus disease 2019 (COVID-19) pandemic has increased the demand for accurate, easy-to-use, rapid, and cost-effective antigen tests for clinical application. We propose a de novo antigen test for diagnosing COVID-19 using the combination of sandwich enzyme-linked immunosorbent assay and thio-nicotinamide adenine dinucleotide (thio-NAD) cycling. Our test takes advantage of the spike proteins specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The limit of detection of our test was 2.3 × 10−18 moles/assay. If the virus has ~25 spike proteins on its surface, our method should detect on the order of 10−20 moles of virus/assay, corresponding to ~104 copies of the virus RNA/assay. The detection sensitivity approaches that of PCR-based assays because the average virus RNA load used for PCR-based assays is ~105 copies per oro- or naso-pharyngeal swab specimen. To our knowledge, this is the first ultrasensitive antigen test for SARS-CoV-2 spike proteins that can be performed with an easy-to-use microplate reader. Sufficient sensitivity can be achieved within 10 min of thio-NAD cycling. Our antigen test allows for rapid, cost-effective, specific, ultrasensitive, and simultaneous multiple measurements of SARS-CoV-2, and has broad application for the diagnosis for COVID-19.
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- 2020
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17. Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats.
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Chu, Pin C., Lin, Mao T., Shian, Lee R., Leu, Sou Y., Chu, P C, Lin, M T, Shian, L R, and Leu, S Y
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- 1986
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18. Institute of Tropical Medicine, Nagasaki University
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Safai, Bijan, Johnson, Katherine G., Myskowski, Patricia L., Koziner, Benjamin, Yang, Sou Y., Sussana, Cunningham-Rundles, Godbold, James H., and Dupont, Bo
- Abstract
熱帯医学 Tropical medicine 28(Supplement). p9-34, 1986
- Published
- 1986
19. Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats
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Pin C Chu, Sou Y Leu, Lee R Shian, and Mao T. Lin
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Male ,medicine.medical_specialty ,Serotonin ,Epinephrine ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Dopamine ,Hypothalamus ,Pain ,Motor Activity ,Diabetes Mellitus, Experimental ,Norepinephrine ,Diabetic Neuropathies ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Animals ,Humans ,Insulin ,Amphetamine ,Brain Chemistry ,Morphine ,business.industry ,Brain ,Rats, Inbred Strains ,Streptozotocin ,medicine.disease ,Corpus Striatum ,Rats ,Endocrinology ,Monoamine neurotransmitter ,Catecholamine ,business ,medicine.drug ,Body Temperature Regulation ,Brain Stem - Abstract
In the present study, we used streptozocin (STZ) to induce diabetes in rats and observed alterations in several physiologic functions and in monoamine content of different brain regions. Rats with STZ diabetes displayed a thermoregulatory deficit in the cold. Both the body temperature and metabolic rate of the diabetic animals were reduced at ambient temperatures below 22°C. These diabetic animals had a higher level of the spontaneous pain threshold, but displayed a reduced sensitivity of analgesic responses to morphine injection. In addition, these diabetic animals had a lower level of spontaneous motor activity, but displayed an increased sensitivity of locomotor stimulant responses to amphetamine administration. Biochemical examination revealed that the diabetic animals had a lower serotonin level in both the hypothalamus and the brainstem without changes in the serotonin levels of the corpus striatum. These diabetic animals also had a lower catecholamine level in the hypothalamus, but a higher catecholamine level in the corpus striatum. The alterations in brain monoamine content and in the above-mentioned physiologic parameters were reversed after insulin replacement therapy. The data suggest that alterations in various autonomic, somatosensory, and motor neural functions of untreated STZ-diabetic rats correlated with a reproducible pattern of monoamine content in various brain regions (a pattern that differed from that observed in healthy control rats), and that both the altered neural function and the altered brain monoamine pattern were reversed after insulin therapy.
- Published
- 1986
20. Landscape plan for the Nubia Museum of Aswan
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Gondolf, S., Sou, Y., and Werkmeister, H. F.
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PLANNING ,LANDSCAPE architecture - Published
- 1986
21. Diterpenes from the bark of Juniperus chinensis
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Fang, J.-M., Sou, Y.-C., Chiu, Y.-H., and Cheng, Y.-S.
- Published
- 1993
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22. DNA Damage in the Kidneys of Diabetic Rats Exhibiting Microalbuminuria
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Ha, H., Kim, C., Sou, Y., and Chung, M.-H.
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- 1994
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23. Lack of association between Helicobacter pyloriinfection and IgA nephropathy
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Sekikawa, A., Saita, H., Sou, Y., Ashida, C., Takeoka, H., and Kanatsu, K.
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- 1998
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24. Association between physical performance and bone mass in community-dwelling postmenopausal Japanese women: The Unzen study.
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Suiko M, Mizukami S, Arima K, Nakashima H, Nishimura T, Tomita Y, Abe Y, Tanaka N, Honda Y, Kojima M, Okawachi T, Hasegawa M, Sou Y, Tsujimoto R, Kanagae M, Osaki M, and Aoyagi K
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- Humans, Female, Japan, Cross-Sectional Studies, Bone Density, Physical Functional Performance, Hand Strength, Independent Living, Postmenopause
- Abstract
Background: Low bone mass is an independent risk factor for osteoporotic fractures. We examined the association between physical performance and bone mass using quantitative ultrasound in community-dwelling postmenopausal Japanese women., Methods: We conducted a cross-sectional study on 524 community-dwelling postmenopausal Japanese women who were not being administered osteoporosis medications. Physical performance was assessed on the basis of grip strength, chair stand time, and functional reach. The stiffness index was measured as a quantitative ultrasound parameter for heel bone mass., Results: Physical performance, assessed by grip strength, chair stand time, and functional reach, and the stiffness index significantly decreased with age (both p<0.001). The multiple linear regression analysis showed that grip strength (p = 0.001), chair stand time (p = 0.004), and functional reach (p = 0.048) were significantly associated with the stiffness index after adjusting for age, body mass index, smoking, drinking, and exercise., Conclusions: Physical performance was significantly associated with heel bone mass in community-dwelling postmenopausal Japanese women., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Suiko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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25. Chemistry Combining Elemental Profile, Stable Isotopic Ratios, and Chemometrics for Fine Classification of a Chinese Herb Licorice ( Glycyrrhiza uralensis Fisch.) from 37 Producing Area.
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Lu Z, Hai C, Yan S, Xu L, Lu D, Sou Y, Chen H, Yang X, Fu H, and Yang J
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A method based on elemental fingerprint, stable isotopic analysis and combined with chemometrics was proposed to trace the geographical origins of Licorice ( Glycyrrhiza uralensis Fisch) from 37 producing areas. For elemental fingerprint, the levels of 15 elements, including Ca, Cu, Mg, Pb, Zn, Sr, Mn, Se, Cd, Fe, Na, Al, Cr, Co, and K, were analyzed by inductively coupled plasma atomic emission spectrometry (ICP-AES). Three stable isotopes, including δ
13 C, δ15 N, and δ18 O, were measured using an isotope-ratio mass spectrometer (IRMS). For fine classification, three multiclass strategies, including the traditional one-versus-rest (OVR) and one-versus-one (OVO) strategies and a new ensemble strategy (ES), were combined with two binary classifiers, partial least squares discriminant analysis (PLSDA) and least squares support vector machines (LS-SVM). As a result, ES-PLSDA and ES-LS-SVM achieved 0.929 and 0.921 classification accuracy of GUF samples from the 37 origins. The results show that element fingerprint and stable isotope combined with chemometrics is an effective method for GUF traceability and provides a new idea for the geographical traceability of Chinese herbal medicine., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2022 Zhongying Lu et al.)- Published
- 2022
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26. A case of temporary anhydramnios after COVID-19 infection.
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Kasuga Y, Sou Y, Fukuoka M, Kawaida M, Ikenoue S, Okita H, Tanaka M, and Ochiai D
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- Amniotic Fluid, Female, Humans, Pregnancy, COVID-19 complications, Oligohydramnios
- Published
- 2022
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27. Association between fat mass by bioelectrical impedance analysis and bone mass by quantitative ultrasound in relation to grip strength and serum 25-hydroxyvitamin D in postmenopausal Japanese women: the Unzen study.
- Author
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Mizukami S, Arima K, Abe Y, Tomita Y, Nakashima H, Honda Y, Uchiyama M, Ookawachi T, Goto H, Hasegawa M, Sou Y, Kanagae M, Osaki M, and Aoyagi K
- Subjects
- Aged, Body Composition physiology, Cross-Sectional Studies, Electric Impedance, Female, Humans, Japan, Vitamin D analogs & derivatives, Hand Strength, Postmenopause
- Abstract
Background: Whether fat mass or lean mass affects bone mass in postmenopausal women is controversial. This study aimed to explore the association between body composition measured by bioelectrical impedance analysis (BIA) and bone mass measured by quantitative ultrasound (QUS) in postmenopausal women in Japan., Methods: We conducted a cross-sectional study, The Unzen Study, on 382 community-dwelling postmenopausal Japanese women (mean (standard deviation) age: 68.2 (7.2) years) who participated in periodic health examinations. The stiffness index (SI) was measured using QUS, and body composition (e.g., fat mass and muscle mass) was measured using BIA. Grip strength was measured. Fasting blood samples were collected, and 25-hydroxyvitamin D (25(OH)D), tartrate-resistant acid phosphatase-5b (TRACP-5b), and parathyroid hormone (PTH) levels were measured. Data on current smoking, alcohol consumption, exercise, and any comorbidities (heart disease, lung disease, stroke, or diabetes mellitus) were collected., Results: The SI increased with increasing quartiles of fat mass and muscle mass (both p for trend < 0.001), respectively. There were positive correlations between SI and log (25(OH)D) or grip strength. Fat mass significantly correlated with grip strength. Multiple linear regression analysis showed that higher fat mass was independently and significantly associated with higher SI after adjusting for age, height, comorbidity, current smoking, alcohol consumption, exercise, log (25(OH)D), log (TRACP-5b), log (PTH), and grip strength (p = 0.001). In contrast, no association was observed between muscle mass and SI., Conclusions: Fat mass, but not muscle mass, was a significant determinant of SI in community-dwelling postmenopausal Japanese women., (© 2022. The Author(s).)
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- 2022
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- View/download PDF
28. Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study.
- Author
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Uchiyama M, Mizukami S, Arima K, Nishimura T, Tomita Y, Abe Y, Tanaka N, Honda Y, Goto H, Hasegawa M, Sou Y, Tsujimoto R, Kanagae M, Osaki M, and Aoyagi K
- Subjects
- Aged, Female, Hand Strength, Humans, Independent Living, Japan, Male, Middle Aged, Vitamin D blood, Physical Functional Performance, Vitamin D analogs & derivatives, Vitamin D Deficiency blood
- Abstract
Purpose: Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate the associations between 25-hydroxyvitamin D [25(OH)D] and physical performance among community-dwelling middle-aged and old Japanese men and women., Methods: The subjects were community-dwelling 297 men and 415 women aged 50 years and over. Data on height (m) and weight (kg) were collected. Serum 25(OH)D, parathyroid hormone, calcium, and albumin levels were measured. Serum 25(OH)D was classified into deficiency group: < 20 ng/mL, insufficiency group: 20-30 ng/mL, and sufficiency group: ≧ 30 ng/mL. Physical performance was assessed by grip strength, chair stand time, and functional reach. Information on current smoking, alcohol drinking, regular exercise, any comorbidities (hypertension, heart disease, diabetes mellitus, lung disease, and stroke), and pain (lumbar and knee) was collected., Results: Vitamin D deficiency and insufficiency based on serum 25(OH)D levels were observed in 15.2% and 56.9% of men and 52.0% and 43.6% of women, respectively. In men, higher serum 25(OH)D levels were associated with better grip strength (p for trend = 0.003), chair stand time (p for trend = 0.042), and functional reach (p for trend <0.001). On the other hand, these parameters were not associated with serum 25(OH)D levels in women., Conclusion: A higher level of serum 25(OH)D was associated with better physical performance in men but not in women., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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29. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study.
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Ota A, Li Y, Yatsuya H, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Arima K, Sou Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, and Tsugane S
- Subjects
- Cross-Sectional Studies, Female, Health Status, Humans, Japan epidemiology, Male, Survivors, Cancer Survivors, Neoplasms
- Abstract
Purpose: This study compared working cancer survivors' self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers., Methods: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds., Results: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39-1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16-1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34-2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56-2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01-1.45)) but not in women (76.1% vs. 74.9%)., Conclusions: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers., Implications for Cancer Survivors: Continuous support to improve cancer survivors' SRHS and physical functional capacity would be necessary even while they are working., (© 2021. The Author(s).)
- Published
- 2021
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30. Association between vitamin D and bone mineral density in Japanese adults: the Unzen study.
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Honda Y, Arima K, Nishimura T, Tomita Y, Mizukami S, Abe Y, Tanaka N, Kojima M, Jeng TP, Goto H, Hasegawa M, Sou Y, Tsujimoto R, Kanagae M, Osaki M, and Aoyagi K
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Japan epidemiology, Male, Middle Aged, Ultrasonography, Vitamin D, Bone Density, Calcaneus diagnostic imaging
- Abstract
We showed an association between serum concentrations of vitamin D and bone health among community-dwelling adults in Japan after adjustment for confounding factors, with 730 participants in a city, with concentrations of 25(OH) vitamin D, and with parameters of quantitative ultrasound., Purpose: The primary objective of this study was to examine the correlation between serum 25-hydroxyvitamin D (25(OH)D) concentration and bone indicators as measured by quantitative ultrasound in middle-aged and older Japanese adults living in low-latitude seaside areas during summer and autumn., Methods: We conducted a cross-sectional study, the Unzen study, on community-dwelling Japanese adults who participated to periodic health examinations between 2011 and 2013 (during the months of May to November)., Results: A total of 301 men (mean (SD) age, 67.9 (8.2) years; range, 50-92 years) and 429 women (mean (SD) age, 67.9 (7.7); range, 50-89 years) participated in this study. Serum 25(OH)D levels and quantitative ultrasound parameters (broadband ultrasound (BUA), speed of sound (SOS), and stiffness index of the calcaneus were measured for the participants. We excluded two men and 28 women from the 730 participants because they were on medication for osteoporosis. So, 299 men and 401 women were included in the final data analysis. The prevalence of vitamin D insufficiency (< 30 ng/ml) was very high: 71.9% in men and 95.5% in women. In women, the log(25(OH)D) positively and significantly correlated with SOS (p = 0.011) and stiffness index (p = 0.028) but not with BUA (p = 0.176). In men, the log(25(OH)D) did not correlate with the BUA, SOS, or stiffness index (p = 0.218, 0.420, and 0.262, respectively)., Conclusions: Serum 25(OH)D levels were associated with SOS or stiffness index in women but not in men., (© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation.)
- Published
- 2021
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31. Infection Control Strategy Using a Hybrid Resuscitation Room System During the COVID-19 Pandemic in Tokyo, Japan.
- Author
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Ito K, Sou Y, Koizumi G, Kanda J, Miyake Y, Sakamoto T, and Nakahara S
- Subjects
- COVID-19 epidemiology, COVID-19 therapy, Emergency Medical Services organization & administration, Humans, Infection Control organization & administration, Pandemics, Tokyo epidemiology, COVID-19 diagnostic imaging, COVID-19 prevention & control, COVID-19 Testing methods, Emergency Medical Services methods, Infection Control methods, Resuscitation methods, Tomography, X-Ray Computed
- Published
- 2020
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32. Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women.
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Tomita Y, Arima K, Mizukami S, Tsujimoto R, Kawashiri SY, Nishimura T, Okabe T, Tanaka N, Honda Y, Nakahara K, Yamamoto N, Ohmachi I, Goto H, Hasegawa M, Sou Y, Horiguchi I, Kanagae M, Abe Y, Nonaka F, Tamai M, Yamanashi H, Nagata Y, Kawakami A, Maeda T, and Aoyagi K
- Subjects
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Japan epidemiology, Middle Aged, Self Report, Walking, Postmenopause, Walking Speed
- Abstract
Background: Osteoporosis and related fractures, a worldwide public health issue of growing concern, is characterized by compromised bone strength and an increased risk of fracture. Here we show an association between self-reported walking speed and bone mass among community-dwelling postmenopausal Japanese women aged 50 years and older. DESIGN; CROSS-SECTIONAL STUDY: Setting and Participants; The survey population included 1008 postmenopausal women 50-92 years of age residing in rural communities., Methods: Self-reported walking speed was ascertained by asking the participants: "Is your walking speed faster than others of the same age and sex?" to which participants responded "yes (faster)" or "no (moderate/slower)." Calcaneal stiffness index was measured., Results: Women with a faster self-reported walking speed were younger and had a lower BMI, higher stiffness index, and higher grip strength than women with a slower walking speed. Multiple linear regression analysis adjusted for age, BMI, grip strength, comorbidity, current smoking, and alcohol drinking status showed a significant association between faster self-reported walking speed and higher calcaneal stiffness index (p < 0.001)., Conclusions: Our findings suggest that questionnaires of walking speed may be useful for predicting bone mass and that a fast self-reported walking may benefit bone health in postmenopausal women.
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- 2020
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33. Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in post-menopausal Japanese women.
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Nishimura T, Arima K, Abe Y, Kanagae M, Mizukami S, Okabe T, Tomita Y, Goto H, Hasegawa M, Sou Y, Horiguchi I, and Aoyagi K
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Biomarkers blood, Cities, Female, Heel physiopathology, Humans, Japan, Middle Aged, Alkaline Phosphatase blood, Bone Remodeling physiology, Health Status Indicators, Heel diagnostic imaging, Independent Living, Tartrate-Resistant Acid Phosphatase blood
- Abstract
Background: Osteoporosis in women is a serious health problem. The relationships between biochemical markers of bone turnover and bone mineral density (BMD) in women have been reported, but no study has examined relationships between tartrate-resistant acid phosphatase-5b (TRACP-5b) or bone-specific alkaline phosphatase (BAP) and bone mass measured by quantitative ultrasound (QUS) in Japanese post-menopausal women. Aim: To investigate the serum TRACP-5b and BAP levels and to determine their associations with the heel stiffness index measured by QUS in post-menopausal women. Subjects and methods: The subjects were 510 post-menopausal women who were invited to participate in periodic health examinations in 2011-2013 (the Unzen Study). The heel stiffness index (bone mass) was measured by QUS. Serum samples were collected and TRACP-5b and BAP levels were measured. Results: Multiple regression analysis showed that a higher log (TRACP-5b) was correlated with a lower stiffness index ( p = 0.014) and log (BAP) was not correlated with stiffness index after adjusting for covariates ( p = 0.136). Conclusion: Higher rates of bone resorption are associated with a lower stiffness index in Japanese post-menopausal women. These results may indicate that high bone resorption affects bone mass more than bone formation, resulting in a low bone mass.
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- 2019
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34. [A case of pseudomembranous colitis concomitant with toxic megacolon and paralytic ileus].
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Aoki T, Kataoka M, Sou Y, Naitou S, Takeuchi M, Tsuji Y, Harada A, Sugimoto H, Hayama Y, Yamamoto K, Nonaka M, Yagi K, Fujiwara M, Fukuzawa M, Kawakami K, Kawai T, and Moriyasu F
- Subjects
- Anti-Bacterial Agents therapeutic use, Enterocolitis, Pseudomembranous drug therapy, Humans, Male, Middle Aged, Vancomycin therapeutic use, Enterocolitis, Pseudomembranous complications, Intestinal Pseudo-Obstruction complications, Megacolon, Toxic complications
- Abstract
A 60-year-old man was diagnosed as pseudomembranous colitis with chief complaint of fever and abdominal distension after a cerebral operation. It was ineffective although vancomycin hydrochloride (VCM) was given orally. Complications occurred. The patient had toxic megacolon and paralytic ileus. VCM was administrated via an ileus tube. In addition, the bowel was lavaged and VCM was sprayed by colonoscopy. This therapy was very effective. Generally, a patient with pseudomembranous colitis concomitant with toxic megacolon or/and paralytic ileus is considered to have a poor prognosis, however, he completely recovered by a combination of medical treatment.
- Published
- 2012
35. [Gastroenterological endoscopic findings in alcoholic liver disease patients--comparison of daily drinkers at physical check up].
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Sugano M, Saita H, Sou Y, Yoshinaga T, Matsumura T, Minami M, Nakashima E, and Kouchi Y
- Subjects
- Adult, Aged, Alcohol Drinking adverse effects, Gastrointestinal Diseases epidemiology, Humans, Liver Diseases, Alcoholic complications, Male, Middle Aged, Alcohol Drinking pathology, Endoscopy, Gastrointestinal, Gastrointestinal Diseases etiology, Gastrointestinal Diseases pathology, Gastrointestinal Tract pathology, Liver Diseases, Alcoholic pathology, Multiphasic Screening, Physical Examination
- Abstract
We compared findings of alcoholic liver disease patients used by gastroenterological endoscopes (31 patients hospitalized in Hyogo Prefectural Amagasaki Hospital: AA group, and 156 patients hospitalized in Suma Red Cross Hospital: AL group) with physical checkup patients (48 daily drinkers: A group, and 99 non drinkers: C group). Esophageal varices were seen by the majority of AA group, and the frequencies of esophageal cancers were also high in the gullet changed to morbid state. Although these things were seen AL group, there were few as compared with AA group. Moreover, frequencies of esophagitises in AL group were higher than C group (p < 0.05), though it was the same level in C group and AA group. In a strange stomach trouble, as for AL and A group, there were a lot of gastric erosions compared with C group (p < 0.05). However, AL group compared with the other groups, the gastric polyps were few (especially C group, p < 0.01). In the duodenum, changing to a morbid state, ulcers were high frequency (5/31) in AA group compared with the other groups (p < 0.05). Moreover AA and AL groups had a lot of polyps high frequency compared with C group (p < 0.05), and duodenitises were high frequencies in AL group compared with A and C group (p < 0.05, p < 0.01). It seemed stronger that the digestive organs changing to morbid state was tendency depended on alcohol consumption and the influence of smoking was not able to be disregarded.
- Published
- 2006
36. Relapse of duodenal ulcers after successful eradication of Helicobacter pylori in gastric ulcer patients.
- Author
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Sou Y, Saita H, Takahashi Y, Yoshinaga T, Matsukawa Y, Sekikawa A, Nakazawa T, Shio S, and Kohigashi K
- Subjects
- 2-Pyridinylmethylsulfinylbenzimidazoles, Adult, Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents therapeutic use, Drug Therapy, Combination, Endoscopy, Gastrointestinal, Female, Humans, Lansoprazole, Male, Omeprazole analogs & derivatives, Omeprazole therapeutic use, Recurrence, Duodenal Ulcer prevention & control, Helicobacter Infections drug therapy, Helicobacter pylori, Stomach Ulcer drug therapy
- Abstract
Relapse of duodenal ulcers was observed endoscopically after Helicobacter pylori eradication therapy for gastric ulcer patients in 2 of 32 successful cases. One patient, a 40-year-old woman, received dual therapy with lansoprazole 60mg and amoxicillin 1000mg for 2 weeks because of an intractable, easily-relapsing gastric ulcer accompanied by duodenal ulcer scars that had not relapsed for 5 years. The H. pylori status was assessed by a rapid urease test, light microscopy, culture, and anti-H. pylori antibody. At 24 months after the cure of H. pylori she had upper abdominal pain and showed relapse not of the gastric ulcer but of the duodenal ulcer. The H. pylori status remained negative. The other patient, a 44-year-old man, showed an active gastric ulcer and duodenal ulcer scars at the first endoscopy. He received the same regimen as described above. Ten weeks after completion of the eradication therapy, endoscopy showed healing of the gastric ulcer and relapse of the duodenal ulcer despite successful eradication. These two cases suggest that H. pylori eradication modifies the pathophysiological condition of gastric acid secretion and facilitates relapse of duodenal ulcers.
- Published
- 1999
37. Factors influencing Helicobacter pylori eradication with 2 week combination therapy of lansoprazole and amoxycillin: intragastric distribution of colonization and gastric mucosal atrophy.
- Author
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Saita H, Murakami M, Takahashi Y, Sou Y, Kaitani K, Nishio K, and Kita T
- Subjects
- 2-Pyridinylmethylsulfinylbenzimidazoles, Drug Administration Schedule, Drug Therapy, Combination, Female, Gastric Mucosa microbiology, Gastric Mucosa pathology, Gastritis, Atrophic microbiology, Gastritis, Atrophic pathology, Helicobacter Infections pathology, Humans, Lansoprazole, Male, Middle Aged, Omeprazole administration & dosage, Peptic Ulcer microbiology, Time Factors, Amoxicillin administration & dosage, Anti-Bacterial Agents administration & dosage, Helicobacter Infections drug therapy, Helicobacter pylori, Omeprazole analogs & derivatives, Penicillins administration & dosage, Proton Pump Inhibitors
- Abstract
In Japan, gastric ulcers are often accompanied by marked gastric mucosal atrophy. We evaluated the dual therapy of double-dose lansoprazole and amoxycillin for Helicobacter pylori eradication in Japanese ulcer patients and investigated the effects of intragastric distribution of H. pylori colonization and gastric mucosal atrophy on eradication with this combination therapy. Seventy-six H. pylori-positive ulcer patients received lansoprazole (30 mg) plus amoxycillin (500 mg) twice daily for 2 weeks (LA-60 group), lansoprazole (30 mg once daily) plus amoxycillin (500 mg twice daily) for 2 weeks (LA-30 group) or lansoprazole (30 mg once daily) for 6 or 8 weeks (LPZ group). Infection was evaluated by light microscopy, culture and biopsy urease tests. Helicobacter pylori colonization was classified as localized to the corpus (localized type) or involving the antrum and corpus (whole type). Fundic mucosal atrophy was graded according to endoscopic and histological features. Eradication was achieved in 67.6% in the LA-60 group, 31.6% in the LA-30 group, and 0% in the LPZ group, and moderate or severe histological gastritis was improved in the LA-60 group. Eradication was better in localized-type colonization (92%) than whole-type (56%), and better with fundic mucosal atrophy (84%) than without, but poor in both whole-type colonization and scanty mucosal atrophy (47%). The LA-60 therapy achieves better eradication in Japanese ulcer patients with localized H. pylori colonization and/or gastric mucosal atrophy, which are likely to be important predictors for the successful eradication with dual therapy.
- Published
- 1998
- Full Text
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38. [A case of adenocarcinoma at the anastomotic site occurred 33 years after gastrojejunostomy].
- Author
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Maekawa T, Saita H, Sou Y, Takahashi Y, Kaneko S, Kaitani K, and Ikebukuro E
- Subjects
- Anastomosis, Surgical, Humans, Male, Middle Aged, Time Factors, Adenocarcinoma etiology, Jejunostomy, Neoplasms, Second Primary, Postoperative Complications, Stomach surgery, Stomach Neoplasms etiology
- Published
- 1994
39. [Hepatocellular carcinoma--a comparative study of MR imaging and angiography].
- Author
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Ono S, Moriyasu F, Ban N, Tamada T, Kawasaki T, Kimura T, Yamashita Y, Kajimura K, Someda H, and Sou Y
- Subjects
- Adult, Aged, Angiography, Carcinoma, Hepatocellular blood supply, Female, Humans, Liver Neoplasms blood supply, Magnetic Resonance Imaging, Male, Middle Aged, Neovascularization, Pathologic diagnosis, Predictive Value of Tests, Carcinoma, Hepatocellular diagnosis, Liver Neoplasms diagnosis
- Abstract
We used magnetic resonance imaging (MRI) at 0.2 T and angiography to evaluate hepatocellular carcinoma (HCC) in 43 patients who had not received therapy. Tumor detection rate by MRI was 84%, T2-weighted spin echo imaging being the best detection method, though one case could only be detected by T1-weighted imaging (Inversion Recovery method). The signal intensity of the tumor relative to the surrounding liver parenchyma was studied using MRI, and tumor staining using angiography. Where there was a high signal intensity in the T2-weighted spin echo images there was a corresponding tendency for tumor staining to be marked. MRI demonstrated the inner structure--which resembles random high-intensity threads on a lower-intensity background--of hypervascular tumors. Tumors with capsules appeared with the capsule clearly delineated irrespective of the signal intensity of the tumor itself.
- Published
- 1989
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