1. Regulatory T cells modulate monocyte functions in immunocompetent antiretroviral therapy naive HIV-1 infected people
- Author
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Ambada N. Georgia, Ntsama E. Claudine, Sake N. Carole, Ngu N. Loveline, Lissom Abel, Tchouangeu T. Flaurent, Sosso Martin, Alain Bopda Waffo, Malachy Okeke, Charles Esimone, Chae Gyu Park, Colizzi Vittorio, Etoa François-Xavier, and Nchinda W. Godwin
- Subjects
Antiretroviral therapy-naive HIV-1 infection ,Monocyte function ,Regulatory T cells ,Sustained activation/Inflammation ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract We previously demonstrated that the overall number of regulatory T (Treg) cells decrease proportionately with helper CD4+ T cells and their frequencies increase in antiretroviral therapy (ART)-naive human immunodeficiency virus type-1 (HIV-1) infected individuals. The question now is whether the discrepancies in Treg cell numbers and frequencies are synonymous to an impairment of their functions. To address this, we purified Treg cells and assessed their ability to modulate autologous monocytes functions. We observed that Treg cells were able to down modulate autologous monocytes activation as well as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) production during stimulation with polyinosinic-polycytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose (poly-ICLC). This activity of Treg cells has been shown to be influenced by immunocompetence including but not limited to helper CD4+ T cell counts, in individuals with HIV-1 infection. Compared to immunosuppressed participants (CD4
- Published
- 2024
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