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243 results on '"Sosef, Meindert N."'

1. Interval Metastases After Neoadjuvant Chemoradiotherapy for Patients with Locally Advanced Esophageal Cancer: A Multicenter Observational Cohort Study

Author

van der Zijden, Charlène J., van der Sluis, Pieter C., Mostert, Bianca, Nuyttens, Joost J. M. E., van Lanschot, J. Jan B., Spaander, Manon C. W., Valkema, Roelf, Coene, Peter Paul L. O., Dekker, Jan Willem T., Fiets, Willem E., Hartgrink, Hendrik H., Hazen, Wouter L., Kouwenhoven, Ewout A., Nieuwenhuijzen, Grard A. P., Rosman, Camiel, van Sandick, Johanna W., Sosef, Meindert N., van der Zaag, Edwin S., Lagarde, Sjoerd M., and Wijnhoven, Bas P. L.

Published
2024
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3. Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., van Berge Henegouwen, Mark I., Baas, Peter C., Bahadoer, Renu R., Belt, Eric J. T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J., van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P. R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, E. G. J. M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A. M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B. A. C., Stoop, Fanny J., Voeten, Daan M., Vugts, Guusje, Vijgen, Guy H. E. J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G. H., and Gisbertz, Suzanne S.

Published
2023
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4. Postoperative intensive care unit stay after minimally invasive esophagectomy shows large hospital variation. Results from the Dutch Upper Gastrointestinal Cancer Audit

Author

van Det, Marc J., van Duijvendijk, Peter, van Esser, Stijn, van Etten, Boudewijn, van der Harst, Erwin, Hartgrink, Henk H., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., van der Peet, Donald L., Pierie, Jean-Pierre E.N., Rosman, Camiel, van Sandick, Johanna W., Sosef, Meindert N., Wijnhoven, Bas P.L., Voeten, Daan M., van der Werf, Leonie R., Gisbertz, Suzanne S., Ruurda, Jelle P., van Berge Henegouwen, Mark I., and van Hillegersberg, Richard

Published
2021
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5. Nationwide Association of Surgical Performance of Minimally Invasive Esophagectomy With Patient Outcomes

Author

Ketel, Mirte H M, Klarenbeek, Bastiaan R, Abma, Inger, Belgers, Eric H J, Coene, Peter-Paul L O, Dekker, Jan Willem T, van Duijvendijk, Peter, Emous, Marloes, Gisbertz, Suzanne S, Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard A P, Ruurda, Jelle P, van Sandick, Johanna W, van der Sluis, Pieter C, van Det, Marc J, van Esser, Stijn, Law, Simon, de Steur, Wobbe O, Sosef, Meindert N, Wijnhoven, Bas, Hannink, Gerjon, Rosman, Camiel, van Workum, Frans, Ketel, Mirte H M, Klarenbeek, Bastiaan R, Abma, Inger, Belgers, Eric H J, Coene, Peter-Paul L O, Dekker, Jan Willem T, van Duijvendijk, Peter, Emous, Marloes, Gisbertz, Suzanne S, Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard A P, Ruurda, Jelle P, van Sandick, Johanna W, van der Sluis, Pieter C, van Det, Marc J, van Esser, Stijn, Law, Simon, de Steur, Wobbe O, Sosef, Meindert N, Wijnhoven, Bas, Hannink, Gerjon, Rosman, Camiel, and van Workum, Frans

Abstract

IMPORTANCE: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote better surgical performance of MIE and improve patient outcomes.OBJECTIVE: To investigate associations between surgical performance and postoperative outcomes after MIE.DESIGN, SETTING, AND PARTICIPANTS: In this nationwide cohort study of 15 Dutch hospitals that perform more than 20 MIEs per year, 7 masked expert MIE surgeons assessed surgical performance using videos and a previously developed and validated competency assessment tool (CAT). Each hospital submitted 2 representative videos of MIEs performed between November 4, 2021, and September 13, 2022. Patients registered in the Dutch Upper Gastrointestinal Cancer Audit between January 1, 2020, and December 31, 2021, were included to examine patient outcomes.EXPOSURE: Hospitals were divided into quartiles based on their MIE-CAT performance score. Outcomes were compared between highest (top 25%) and lowest (bottom 25%) performing quartiles. Transthoracic MIE with gastric tube reconstruction.MAIN OUTCOME AND MEASURE: The primary outcome was severe postoperative complications (Clavien-Dindo ≥3) within 30 days after surgery. Multilevel logistic regression, with clustering of patients within hospitals, was used to analyze associations between performance and outcomes.RESULTS:In total, 30 videos and 970 patients (mean [SD] age, 66.6 [9.1] years; 719 men [74.1%]) were included. The mean (SD) MIE-CAT score was 113.6 (5.5) in the highest performance quartile vs 94.1 (5.9) in the lowest. Severe postoperative complications occurred in 18.7% (41 of 219) of patients in the highest performance quartile vs 39.2% (40 of 102) in the lowest (risk ratio [RR], 0.50; 95% CI, 0.24-0.99). The highes

Published
2024

6. Prognostic value of Mandard score and nodal status for recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma

Author

Henckens, Sofie P.G., Liu, Dajia, Gisbertz, Suzanne S., Kalff, Marianne C., Anderegg, Maarten C.J., Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., van Duijvendijk, Peter, Eshuis, Wietse J., Groenendijk, Richard P.R., Haveman, Jan Willem, van Hillegersberg, Richard, Luyer, Misha D.P., Olthof, Pim B., Pierie, Jean Pierre E.N., Plat, Victor D., Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Sosef, Meindert N., Voeten, Daan M., Vijgen, Guy H.E.J., Bijlsma, Maarten F., Meijer, Sybren L., Hulshof, Maarten C.C.M., Oyarce, Cesar, Lagarde, Sjoerd M., van Laarhoven, Hanneke W.M., van Berge Henegouwen, Mark I., Henckens, Sofie P.G., Liu, Dajia, Gisbertz, Suzanne S., Kalff, Marianne C., Anderegg, Maarten C.J., Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., van Duijvendijk, Peter, Eshuis, Wietse J., Groenendijk, Richard P.R., Haveman, Jan Willem, van Hillegersberg, Richard, Luyer, Misha D.P., Olthof, Pim B., Pierie, Jean Pierre E.N., Plat, Victor D., Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Sosef, Meindert N., Voeten, Daan M., Vijgen, Guy H.E.J., Bijlsma, Maarten F., Meijer, Sybren L., Hulshof, Maarten C.C.M., Oyarce, Cesar, Lagarde, Sjoerd M., van Laarhoven, Hanneke W.M., and van Berge Henegouwen, Mark I.

Abstract

BACKGROUND: This study evaluated the association of pathological tumour response (tumour regression grade, TRG) and a novel scoring system, combining both TRG and nodal status (TRG-ypN score; TRG1-ypN0, TRG>1-ypN0, TRG1-ypN+ and TRG>1-ypN+), with recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma. METHODS: This Dutch nationwide cohort study included patients treated with neoadjuvant chemoradiotherapy followed by oesophagectomy for distal oesophageal or gastro-oesophageal junctional adenocarcinoma between 2007 and 2016. The primary endpoint was the association of Mandard score and TRG-ypN score with recurrence patterns (rate, location, and time to recurrence). The secondary endpoint was overall survival. RESULTS: Among 2746 inclusions, recurrence rates increased with higher Mandard scores (TRG1 30.6%, TRG2 44.9%, TRG3 52.9%, TRG4 61.4%, TRG5 58.2%; P < 0.001). Among patients with recurrent disease, the distribution (locoregional versus distant) was the same for the different TRG groups. Patients with TRG1 developed more brain recurrences (17.7 versus 9.8%; P = 0.001) and had a longer mean overall survival (44 versus 35 months; P < 0.001) than those with TRG>1. The TRG>1-ypN+ group had the highest recurrence rate (64.9%) and worst overall survival (mean 27 months). Compared with the TRG>1-ypN0 group, patients with TRG1-ypN+ had a higher risk of recurrence (51.9 versus 39.6%; P < 0.001) and worse mean overall survival (33 versus 41 months; P < 0.001). CONCLUSION: Improved tumour response to neoadjuvant therapy was associated with lower recurrence rates and higher overall survival rates. Among patients with recurrent disease, TRG1 was associated with a higher incidence of brain recurrence than TRG>1. Residual nodal disease influenced prognosis more negatively than residual disease at the primary tumour site.

Published
2024

7. Recurrent Disease After Esophageal Cancer Surgery: A Substudy of The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., Henckens, Sofie P.G., Voeten, Daan M., Heineman, David J., Hulshof, Maarten C.C.M., van Laarhoven, Hanneke W.M., Eshuis, Wietse J., Baas, Peter C., Bahadoer, Renu R., Belt, Eric J.T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P.R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan W., Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E.N., Pierik, E.G.J.M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A.M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B.A.C., Stoop, Fanny J., Vugts, Guusje, Vijgen, Guy H.E.J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G.H., van Berge Henegouwen, Mark I., and Gisbertz, Suzanne S.

Published
2022
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10. Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., Henegouwen, Mark I. van Berge, Baas, Peter C., Bahadoer, Renu R., Belt, Eric J. T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J., van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P. R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, E. G. J. M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A. M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B. A. C., Stoop, Fanny J., Voeten, Daan M., Vugts, Guusje, Vijgen, Guy H. E. J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G. H., and Gisbertz, Suzanne S.

Published
2021
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11. Learning Curves of Ivor Lewis Totally Minimally Invasive Esophagectomy by Hospital and Surgeon Characteristics: A Retrospective Multinational Cohort Study

Author

Claassen, Linda, Hannink, Gerjon, Luyer, Misha D. P., Ainsworth, Alan P., Henegouwen, Mark I. van Berge, Cheong, Edward, Daams, Freek, van Det, Marc J., van Duijvendijk, Peter, Gisbertz, Suzanne S., Gutschow, Christian A., Heisterkamp, Joos, Kauppi, Juha T., Klarenbeek, Bastiaan R., Kouwenhoven, Ewout A., Langenhoff, Barbara S., Larsen, Michael H., Martijnse, Ingrid S., Nieuwenhoven, Ernst Jan van, van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, Robert E. G. J. M., Polat, Fatih, Rusanen, Jari V., Rouvelas, Ioannis, Sosef, Meindert N., Wassenaar, Eelco B., Wildenberg, Frits J. H. van den, van der Zaag, Edwin S., Nilsson, Magnus, Nieuwenhuijzen, Grard A. P., van Workum, Frans, and Rosman, Camiel

Published
2022
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13. Active Surveillance Versus Immediate Surgery in Clinically Complete Responders After Neoadjuvant Chemoradiotherapy for Esophageal Cancer: A Multicenter Propensity Matched Study

Author

van der Wilk, Berend J., Noordman, Bo J., Neijenhuis, Lisanne K. A., Nieboer, Daan, Nieuwenhuijzen, Grard A. P., Sosef, Meindert N., van Berge Henegouwen, Mark I., Lagarde, Sjoerd M., Spaander, Manon C. W., Valkema, Roelf, Biermann, Katharina, Wijnhoven, Bas P. L., van der Gaast, Ate, van Lanschot, J. Jan B., Doukas, Michael, Nikkessen, Suzan, Luyer, Misha, Schoon, Erik J., Roef, Mark J., van Lijnschoten, Ineke, Oostenbrug, Liekele E., Riedl, Robert G., Gisbertz, Suzanne S., Krishnadath, Kausilia K., Bennink, Roel J., and Meijer, Sybren L.

Published
2021
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18. Trends in best‐case, typical and worst‐case survival scenarios of patients with non‐metastatic esophagogastric cancer between 2006 and 2020: A population‐based study

Author

Kuijper, Steven C., primary, Pape, Marieke, additional, Vissers, Pauline A. J., additional, Jeene, Paul M., additional, Kouwenhoven, Ewout A., additional, Haj Mohammad, Nadia, additional, Ruurda, Jelle P., additional, Sosef, Meindert N., additional, Verhoeven, Rob H. A., additional, and van Laarhoven, Hanneke W. M., additional

Published
2023
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19. Development of a Core Set of Self-Management Support Needs of Esophageal Cancer Patients: Results from a Delphi Study among Healthcare Professionals

Author

Adriaans, Daniëlle J. M., primary, Heesakkers, Fanny B. M., additional, Teijink, Joep A. W., additional, Dierick-van Daele, Angelique T. M., additional, Haveman, Jan Willem, additional, Sosef, Meindert N., additional, van den Berg, Jan Willem, additional, van Det, Marc J., additional, Hartgrink, Henk H., additional, Jansen, Walther J. B. M., additional, Rosman, Camiel, additional, Lagarde, Sjoerd M., additional, van Esser, Stijn, additional, van der Harst, Erwin, additional, van Laarhoven, Hanneke W. M., additional, and Nieuwenhuijzen, Grard A. P., additional

Published
2023
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20. Development of a Core Set of Self-Management Support Needs of Esophageal Cancer Patients: Results from a Delphi Study among Healthcare Professionals

Author

Adriaans, Danielle J.M., Heesakkers, Fanny B.M., Teijink, Joep A.W., Dierick-van Daele, Angelique T.M., Haveman, Jan Willem, Sosef, Meindert N., Rosman, C., Laarhoven, Hanneke W.M. van, Nieuwenhuijzen, Grard A. P., Adriaans, Danielle J.M., Heesakkers, Fanny B.M., Teijink, Joep A.W., Dierick-van Daele, Angelique T.M., Haveman, Jan Willem, Sosef, Meindert N., Rosman, C., Laarhoven, Hanneke W.M. van, and Nieuwenhuijzen, Grard A. P.

Abstract

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Published
2023

21. A comparison between real-time intraoperative voice dictation and the operative report in laparoscopic cholecystectomy:a multicenter prospective observational study

Author

Eryigit, Özgür, van de Graaf, Floyd W., Nieuwenhuijs, Vincent B., Sosef, Meindert N., de Graaf, Eelco J.R., Menon, Anand G., Lange, Marilyne M., Lange, Johan F., Eryigit, Özgür, van de Graaf, Floyd W., Nieuwenhuijs, Vincent B., Sosef, Meindert N., de Graaf, Eelco J.R., Menon, Anand G., Lange, Marilyne M., and Lange, Johan F.

Abstract

Purpose: The current operative report often inadequately reflects events occurring during laparoscopic cholecystectomy (LC). The addition of intraoperative video recording to the operative report has already proven to add important information. It was hypothesized that real-time intraoperative voice dictation (RIVD) can provide an equal or more complete overview of the operative procedure compared to the narrative operative report (NR) produced postoperatively. Methods: SONAR is a multicenter prospective observational trial, conducted at four surgical centers in the Netherlands. Elective LCs of patients aged 18 years and older were included. Participating surgeons were requested to dictate the essential steps of LC during surgery. RIVDs and NRs were reviewed according to the stepwise LC guideline of the Dutch Society for Surgery. The cumulative adequacy rates for RIVDs were compared with those of the postoperatively written NR. Results: 79 of 90 cases were eligible for inclusion and available for further analysis. RIVD resulted in a significantly higher adequacy rate compared to NR for the circumferential dissection of the cystic duct and artery (NR 32.5% vs. RIVD 61.0%, P = 0.016). NR had higher adequacy rates in reporting the transection of the cystic duct (NR 100% vs. RIVD 77.9%, P = < 0.001) and the removal of the gallbladder from the liver bed (NR 98.7% vs. RIVD 68.8%, P < 0.001). The total adequacy was not significantly different between the two reporting methods (NR 78.0% vs. RIVD 76.4%, P = 1.00). Conclusion: Overall, the adequacy of RIVD is comparable to the postoperatively written NR in reporting surgical steps in LC. However, the most essential surgical step, the circumferential dissection of the cystic duct and artery, was reported more adequately in RIVD.

Published
2023

22. Trends in best-case, typical and worst-case survival scenarios of patients with non-metastatic esophagogastric cancer between 2006 and 2020: a population-based study

Author

MS Medische Oncologie, Cancer, MS CGO, Kuijper, Steven C, Pape, Marieke, Vissers, Pauline A J, Jeene, Paul M, Kouwenhoven, Ewout A, Haj Mohammad, Nadia, Ruurda, Jelle P, Sosef, Meindert N, Verhoeven, Rob H A, van Laarhoven, Hanneke W M, MS Medische Oncologie, Cancer, MS CGO, Kuijper, Steven C, Pape, Marieke, Vissers, Pauline A J, Jeene, Paul M, Kouwenhoven, Ewout A, Haj Mohammad, Nadia, Ruurda, Jelle P, Sosef, Meindert N, Verhoeven, Rob H A, and van Laarhoven, Hanneke W M

Published
2023

23. Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Author

MS CGO, Cancer, Externen Med. Onco, Kalff, Marianne C, Henegouwen, Mark I van Berge, Baas, Peter C, Bahadoer, Renu R, Belt, Eric J T, Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D, Dekker, Jan Willem T, van Det, Marc J, Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J, van Esser, Stijn, Gaspersz, Marcia P, Görgec, Burak, Groenendijk, Richard P R, Hartgrink, Henk H, van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B Feike, Koemans, Willem J, Kouwenhoven, Ewout A, Lagarde, Sjoerd M, Lecot, Frederik, van der Linden, Philip P, Luyer, Misha D P, Nieuwenhuijzen, Grard A P, Olthof, Pim B, van der Peet, Donald L, Pierie, Jean-Pierre E N, Pierik, E G J M Robert, Plat, Victor D, Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P, van Sandick, Johanna W, Scheer, Rene, Slootmans, Cettela A M, Sosef, Meindert N, Sosef, Odin V, de Steur, Wobbe O, Stockmann, Hein B A C, Stoop, Fanny J, Voeten, Daan M, Vugts, Guusje, Vijgen, Guy H E J, Weeda, Víola B, Wiezer, Marinus J, van Oijen, Martijn G H, Gisbertz, Suzanne S, MS CGO, Cancer, Externen Med. Onco, Kalff, Marianne C, Henegouwen, Mark I van Berge, Baas, Peter C, Bahadoer, Renu R, Belt, Eric J T, Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D, Dekker, Jan Willem T, van Det, Marc J, Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J, van Esser, Stijn, Gaspersz, Marcia P, Görgec, Burak, Groenendijk, Richard P R, Hartgrink, Henk H, van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B Feike, Koemans, Willem J, Kouwenhoven, Ewout A, Lagarde, Sjoerd M, Lecot, Frederik, van der Linden, Philip P, Luyer, Misha D P, Nieuwenhuijzen, Grard A P, Olthof, Pim B, van der Peet, Donald L, Pierie, Jean-Pierre E N, Pierik, E G J M Robert, Plat, Victor D, Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P, van Sandick, Johanna W, Scheer, Rene, Slootmans, Cettela A M, Sosef, Meindert N, Sosef, Odin V, de Steur, Wobbe O, Stockmann, Hein B A C, Stoop, Fanny J, Voeten, Daan M, Vugts, Guusje, Vijgen, Guy H E J, Weeda, Víola B, Wiezer, Marinus J, van Oijen, Martijn G H, and Gisbertz, Suzanne S

Published
2023

25. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study

Author

Hagens, Eliza R. C., van Berge Henegouwen, Mark I., van Sandick, Johanna W., Cuesta, Miguel A., van der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A. P., Rosman, Camiel, Scheepers, Joris J. G., Sosef, Meindert N., van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, de Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin-ichi, Chen, Haiquan, Law, Simon Y. K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J. G. H. M., Hulshof, Maarten C. C. M., van Laarhoven, Hanneke W. M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G. W., and Gisbertz, Suzanne S.

Published
2019
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26. Organ Preservation in Rectal Cancer After Chemoradiation: Should We Extend the Observation Period in Patients with a Clinical Near-Complete Response?

Author

Hupkens, Britt J. P., Maas, Monique, Martens, Milou H., van der Sande, Marit E., Lambregts, Doenja M. J., Breukink, Stéphanie O., Melenhorst, Jarno, Houwers, Janneke B., Hoff, Christiaan, Sosef, Meindert N., Leijtens, Jeroen W. A., Berbee, Maaike, Beets-Tan, Regina G. H., and Beets, Geerard L.

Published
2017
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29. Recurrent Disease after Esophageal Cancer Surgery: A Substudy of The Dutch Nationwide Ivory Study

Author

MS CGO, Cancer, Heelkunde Opleiding, Externen Med. Onco, Kalff, Marianne C, Henckens, Sofie P G, Voeten, Daan M, Heineman, David J, Hulshof, Maarten C C M, van Laarhoven, Hanneke W M, Eshuis, Wietse J, Baas, Peter C, Bahadoer, Renu R, Belt, Eric J T, Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D, Dekker, Jan Willem T, van Det, Marc J, Drost, Manon, Duijvendijk, Peter van, Esser, Stijn van, Gaspersz, Marcia P, Görgec, Burak, Groenendijk, Richard P R, Hartgrink, Henk H, Harst, Erwin van der, Haveman, Jan Willem, Heisterkamp, Joos, Hillegersberg, Richard van, Kelder, Wendy, Kingma, B Feike, Koemans, Willem J, Kouwenhoven, Ewout A, Lagarde, Sjoerd M, Lecot, Frederik, van der Linden, Philip P, Luyer, Misha D P, Nieuwenhuijzen, Grard A P, Olthof, Pim B, van der Peet, Donald L, Pierie, Jean-Pierre En, Pierik, E G J M Robert, Plat, Victor D, Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P, van Sandick, Johanna W, Scheer, Rene, Slootmans, Cettela AM, Sosef, Meindert N, Sosef, Odin V, de Steur, Wobbe O, Stockmann, Hein B A C, Stoop, Fanny J, Vugts, Guusje, Vijgen, Guy H E J, Weeda, Víola B, Wiezer, Marinus J, van Oijen, Martijn G H, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, MS CGO, Cancer, Heelkunde Opleiding, Externen Med. Onco, Kalff, Marianne C, Henckens, Sofie P G, Voeten, Daan M, Heineman, David J, Hulshof, Maarten C C M, van Laarhoven, Hanneke W M, Eshuis, Wietse J, Baas, Peter C, Bahadoer, Renu R, Belt, Eric J T, Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D, Dekker, Jan Willem T, van Det, Marc J, Drost, Manon, Duijvendijk, Peter van, Esser, Stijn van, Gaspersz, Marcia P, Görgec, Burak, Groenendijk, Richard P R, Hartgrink, Henk H, Harst, Erwin van der, Haveman, Jan Willem, Heisterkamp, Joos, Hillegersberg, Richard van, Kelder, Wendy, Kingma, B Feike, Koemans, Willem J, Kouwenhoven, Ewout A, Lagarde, Sjoerd M, Lecot, Frederik, van der Linden, Philip P, Luyer, Misha D P, Nieuwenhuijzen, Grard A P, Olthof, Pim B, van der Peet, Donald L, Pierie, Jean-Pierre En, Pierik, E G J M Robert, Plat, Victor D, Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P, van Sandick, Johanna W, Scheer, Rene, Slootmans, Cettela AM, Sosef, Meindert N, Sosef, Odin V, de Steur, Wobbe O, Stockmann, Hein B A C, Stoop, Fanny J, Vugts, Guusje, Vijgen, Guy H E J, Weeda, Víola B, Wiezer, Marinus J, van Oijen, Martijn G H, van Berge Henegouwen, Mark I, and Gisbertz, Suzanne S

Published
2022

32. Accuracy of Detecting Residual Disease After Cross Neoadjuvant Chemoradiotherapy for Esophageal Cancer (preSANO Trial): Rationale and Protocol

Author

Noordman, Bo Jan, Shapiro, Joel, Spaander, Manon CW, Krishnadath, Kausilia K, van Laarhoven, Hanneke WM, van Berge Henegouwen, Mark I, Nieuwenhuijzen, Grard AP, van Hillegersberg, Richard, Sosef, Meindert N, Steyerberg, Ewout W, Wijnhoven, Bas PL, and van Lanschot, J Jan B

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundResults from the recent CROSS trial showed that neoadjuvant chemoradiotherapy (nCRT) significantly increased survival as compared to surgery alone in patients with potentially curable esophageal cancer. Furthermore, in the nCRT arm 49% of patients with a squamous cell carcinoma (SCC) and 23% of patients with an adenocarcinoma (AC) had a pathologically complete response in the resection specimen. These results provide a rationale to reconsider and study the timing and necessity of esophagectomy in (all) patients after application of the CROSS regimen. ObjectiveWe propose a “surgery as needed” approach after completion of nCRT. In this approach, patients will undergo active surveillance after completion of nCRT. Surgical resection would be offered only to those patients in whom residual disease or a locoregional recurrence is highly suspected or proven. However, before a surgery as needed approach in oesophageal cancer patients (SANO) can be tested in a randomized controlled trial, we aim to determine the accuracy of detecting the presence or absence of residual disease after nCRT (preSANO trial). MethodsThis study is set up as a prospective, single arm, multicenter, diagnostic trial. Operable patients with potentially curable SCC or AC of the esophagus or esophagogastric junction will be included. Approximately 4-6 weeks after completion of nCRT all included patients will undergo a first clinical response evaluation (CRE-I) including endoscopy with (random) conventional mucosal biopsies of the primary tumor site and of any other suspected lesions in the esophagus and radial endo-ultrasonography (EUS) for measurement of tumor thickness and area. Patients in whom no locoregional or disseminated disease can be proven by cytohistology will be offered a postponed surgical resection 6-8 weeks after CRE-I (ie, approximately 12-14 weeks after completion of nCRT). In the week preceding the postponed surgical resection, a second clinical response evaluation (CRE-II) will be planned that will include a whole body PET-CT, followed again by endoscopy with (random) conventional mucosal biopsies of the primary tumor site and any other suspected lesions in the esophagus, radial EUS for measurement of tumor thickness and area, and linear EUS plus fine needle aspiration of PET-positive lesions and/or suspected lymph nodes. The main study parameter is the correlation between the clinical response assessment during CRE-I and CRE-II and the final pathological response in the resection specimen. ResultsThe first patient was enrolled on July 23, 2013, and results are expected in January 2016. ConclusionsIf this preSANO trial shows that the presence or absence of residual tumor can be predicted reliably 6 or 12 weeks after completion of nCRT, a randomized trial comparing nCRT plus standard surgery versus chemoradiotherapy plus “surgery as needed” will be conducted (SANO trial). Trial RegistrationNetherlands Trial Register: NTR4834; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4834 (archived by Webcite at http://www.webcitation.org/6Ze7mn67B).

Published
2015
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35. Postoperative intensive care unit stay after minimally invasive esophagectomy shows large hospital variation. Results from the Dutch Upper Gastrointestinal Cancer Audit

Author

Voeten, Daan M., primary, van der Werf, Leonie R., additional, Gisbertz, Suzanne S., additional, Ruurda, Jelle P., additional, van Berge Henegouwen, Mark I., additional, van Hillegersberg, Richard, additional, van Det, Marc J., additional, van Duijvendijk, Peter, additional, van Esser, Stijn, additional, van Etten, Boudewijn, additional, van der Harst, Erwin, additional, Hartgrink, Henk H., additional, Heisterkamp, Joos, additional, Nieuwenhuijzen, Grard A.P., additional, van der Peet, Donald L., additional, Pierie, Jean-Pierre E.N., additional, Rosman, Camiel, additional, van Sandick, Johanna W., additional, Sosef, Meindert N., additional, and Wijnhoven, Bas P.L., additional

Published
2021
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36. High CD8 + tumour‐infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy

Author

Koemans, Willem J, primary, Dieren, Jolanda M, additional, Berg, Jose G, additional, Meijer, Gerrit A, additional, Snaebjornsson, Petur, additional, Chalabi, Myriam, additional, Lecot, Frederig, additional, Riedl, Robert, additional, Krijgsman, Oscar, additional, Hofland, Ingrid, additional, Broeks, Annegien, additional, Voncken, Francine E M, additional, Peppelenbosch, Maikel P, additional, Sosef, Meindert N, additional, Sandick, Johanna W, additional, and Kodach, Liudmila L, additional

Published
2021
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38. Feasibility of extended chemoradiotherapy plus surgery for patients with cT4b esophageal carcinoma

Author

Anderegg, Martinus C J, Ruurda, Jelle P, Gisbertz, Suzanne S, Blom, Rachel L G M, Sosef, Meindert N, Wijnhoven, Bas P L, Hulshof, Maarten C C M, Bergman, Jacques J G H M, van Laarhoven, Hanneke W M, van Berge Henegouwen, Mark I, Anderegg, Martinus C J, Ruurda, Jelle P, Gisbertz, Suzanne S, Blom, Rachel L G M, Sosef, Meindert N, Wijnhoven, Bas P L, Hulshof, Maarten C C M, Bergman, Jacques J G H M, van Laarhoven, Hanneke W M, and van Berge Henegouwen, Mark I

Published
2020

39. Feasibility of extended chemoradiotherapy plus surgery for patients with cT4b esophageal carcinoma

Author

MS CGO, Cancer, Anderegg, Martinus C J, Ruurda, Jelle P, Gisbertz, Suzanne S, Blom, Rachel L G M, Sosef, Meindert N, Wijnhoven, Bas P L, Hulshof, Maarten C C M, Bergman, Jacques J G H M, van Laarhoven, Hanneke W M, van Berge Henegouwen, Mark I, MS CGO, Cancer, Anderegg, Martinus C J, Ruurda, Jelle P, Gisbertz, Suzanne S, Blom, Rachel L G M, Sosef, Meindert N, Wijnhoven, Bas P L, Hulshof, Maarten C C M, Bergman, Jacques J G H M, van Laarhoven, Hanneke W M, and van Berge Henegouwen, Mark I

Published
2020

40. Learning Curves of Ivor Lewis Totally Minimally Invasive Esophagectomy by Hospital and Surgeon Characteristics

Author

Claassen, Linda, primary, Hannink, Gerjon, additional, Luyer, Misha D. P., additional, Ainsworth, Alan P., additional, van Berge Henegouwen, Mark I., additional, Cheong, Edward, additional, Daams, Freek, additional, van Det, Marc J., additional, van Duijvendijk, Peter, additional, Gisbertz, Suzanne S., additional, Gutschow, Christian A., additional, Heisterkamp, Joos, additional, Kauppi, Juha T., additional, Klarenbeek, Bastiaan R., additional, Kouwenhoven, Ewout A., additional, Langenhoff, Barbara S., additional, Larsen, Michael H., additional, Martijnse, Ingrid S., additional, Nieuwenhoven, Ernst Jan van, additional, van der Peet, Donald L., additional, Pierie, Jean-Pierre E. N., additional, Pierik, Robert E. G. J. M., additional, Polat, Fatih, additional, Räsänen, Jari V., additional, Rouvelas, Ioannis, additional, Sosef, Meindert N., additional, Wassenaar, Eelco B., additional, Wildenberg, Frits J. H. van den, additional, van der Zaag, Edwin S., additional, Nilsson, Magnus, additional, Nieuwenhuijzen, Grard A. P., additional, van Workum, Frans, additional, and Rosman, Camiel, additional

Published
2021
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42. Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields

Author

Koemans, Willem J., primary, Larue, Ruben T. H. M., additional, Kloft, Maximilian, additional, Ruisch, Jessica E., additional, Compter, Inge, additional, Riedl, Robert G., additional, Heij, Lara R., additional, van Elmpt, Wouter, additional, Berbée, Maaike, additional, Buijsen, Jeroen, additional, Lambin, Philippe, additional, Sosef, Meindert N., additional, and Grabsch, Heike I., additional

Published
2020
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44. Pulmonary levels of biomarkers for inflammation and lung injury in protective versus conventional one-lung ventilation for oesophagectomy

Author

van der Woude, Margaretha C., primary, Bormans, Laura, additional, van der Horst, Robrecht P., additional, Sosef, Meindert N., additional, Belgers, Henricus J., additional, Hemmes, Sabrine N., additional, Tuip-de Boer, Anita, additional, Gama de Abreu, Marcelo, additional, Pelosi, Paolo, additional, Spronk, Peter E., additional, Neto, Ary Serpo, additional, and Schultz, Marcus J., additional

Published
2019
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48. Distribution of lymph node metastases in esophageal carcinoma [TIGER study] : Study protocol of a multinational observational study

Author

Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., Gisbertz, Suzanne S., Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., and Gisbertz, Suzanne S.

Published
2019

49. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: Study protocol of a multinational observational study

Author

Divisie Beeld & Oncologie, Cancer, Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., Gisbertz, Suzanne S., Divisie Beeld & Oncologie, Cancer, Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., and Gisbertz, Suzanne S.

Published
2019

50. High CD8+ tumour‐infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapy.

Author

Koemans, Willem J, Dieren, Jolanda M, Berg, Jose G, Meijer, Gerrit A, Snaebjornsson, Petur, Chalabi, Myriam, Lecot, Frederig, Riedl, Robert, Krijgsman, Oscar, Hofland, Ingrid, Broeks, Annegien, Voncken, Francine E M, Peppelenbosch, Maikel P, Sosef, Meindert N, Sandick, Johanna W, and Kodach, Liudmila L

Subjects
PROGRAMMED cell death 1 receptors, PROGNOSIS, TUMOR microenvironment, FORKHEAD transcription factors, CHEMORADIOTHERAPY, BIOMARKERS, PROGRESSION-free survival, BREAST cancer prognosis, TUMOR-infiltrating immune cells
Abstract

Aims: Determining prognosis following poor response to neoadjuvant chemoradiotherapy (nCRT) in oesophageal adenocarcinoma (OAC) remains challenging. An immunosuppressive tumour microenvironment (TME) as well as immune infiltrate density and composition are considered to play a critical role in the immune interaction between host and tumour and can predict therapy response and survival in many cancers, including gastrointestinal malignancies. The aim of this study was to establish the TME characteristics associated with survival following a poor response to nCRT. Methods and results: The prognostic significance of OAC‐associated CD3+, CD4+, CD8+, forkhead box protein 3 (FoxP3+) and programmed cell death ligand 1 (PD‐L1) expression was studied by immunohistochemistry and quantified by automated image analysis in 123 patients who underwent nCRT and curative resection. Results from good and poor responders were contrasted and immune infiltration was related to disease course in both groups. Subsequently a cohort of 57 patients with a moderate response to nCRT was analysed in a similar fashion. Tumour cell percentage positively correlated to immune infiltration markers. In good and moderate responders, none of the immune infiltrate parameters was associated with survival; in poor responders CD8+ was an independent negative predictor of OS in univariate analysis (P = 0.03) and high CD8+ infiltration was associated with worse OS (15 versus 32 months, P = 0.042). Conclusion: A high CD8+ density is an independent biomarker of poor OS in poor responders to nCRT, but not in good and moderate responders. Our results suggest that patients with a poor response to nCRT but concomitant high CD8+ counts in the resection specimen require adjuvant therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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