1. Anti-inflammatory drugs suppress injury-induced NADPH-d activity in CA1 pyramidal neurones.
- Author
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Regidor J, Montesdeoca J, Ramírez-González JA, Sosa-Pérez CD, Hernández-Urquía CM, Feria M, and Divac I
- Subjects
- Animals, Arginine analogs & derivatives, Arginine pharmacology, Dexamethasone pharmacology, Enzyme Induction drug effects, Hippocampus cytology, Hippocampus drug effects, Hippocampus injuries, Indomethacin pharmacology, NG-Nitroarginine Methyl Ester, Nitric Oxide antagonists & inhibitors, Pyramidal Cells drug effects, Rats, Rats, Sprague-Dawley, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Brain Injuries enzymology, NADPH Dehydrogenase biosynthesis, Pyramidal Cells enzymology
- Abstract
Inducibility of NADPH-diaphorase (NADPH-d) or nitric oxide synthase (NOS) has been demonstrated in pyramidal neurones of the hippocampus, but the mechanisms of this induction are not known. The present study aimed to assess the role of anti-inflammatory drugs in injury-induced production of NADPH-d/NOS in CA1 pyramidal neurones. We found that either a steroid, dexamethasone or a non-steroid, indomethacin, prevents induction of these enzymes. We also found that NO is not necessary for the induction. None of the three drugs used had detectable effect on the neurones which contain constitutive NADPH-d/NOS.
- Published
- 1994
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