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2. Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats

Author

Rieu, Isabelle, Sornet, Claire, Bayle, Gerard, Prugnaud, Jacques, Pouyet, Corinne, Balage, Michele, Papet, Isabelle, Grizard, Jean, and Dardevet, Dominique

Subjects
Muscle proteins -- Physiological aspects, Protein metabolism -- Measurement, Leucine -- Physiological aspects, Aging -- Physiological aspects, Food/cooking/nutrition
Abstract

Acute leucine supplementation of the diet has been shown to blunt defects in postprandial muscle protein metabolism in old rats. This study was undertaken to determine whether the effect of leucine persists in a 10-d experiment. For this purpose, adult (9 mo) and old (21 mo) rats were fed a semiliquid 18.2 g/100 g protein standard diet during the 8-h dark period for 1 mo. Then, each group was given either a leucine-supplemented meal or an alanine-supplemented meal (as the control meal) for 1 h and the standard diet the rest of the feeding period. On d 10, rats were fed either no food (postabsorptive group) or the supplemented meal for 1 h. Muscle protein synthesis was assessed in vivo 90-120 min after meal distribution using the flooding dose method (1-[sup.13]C phenylalanine). Leucinemia was similar in rats of both ages in the postabsorptive state. Postprandial plasma leucine concentrations were one- to twofold greater after the leucine meal than after the control meal. In the postabsorptive state, leucine supplementation did not modify the muscle protein synthesis rate in old rats but enhanced it to the postprandial rate in adult rats. As expected, muscle protein synthesis was stimulated by the control meal in adult rats but not in old rats. The leucine meal restored this stimulation in old rats but did not further stimulate muscle protein synthesis in adult rats. In conclusion, the beneficial effect of leucine supplementation on postprandial muscle protein anabolism persists for at least 10 d. The long-term utilization of leucine-rich diets may therefore limit muscle protein wasting during aging. J. Nutr. 133: 1198-1205, 2003. KEY WORDS: * aging * muscle protein synthesis * leucine * chronic * rats

Published
2003

3. Acute phase protein levels and thymus, spleen and plasma protein synthesis rates differ in adult and old rats

Author

Papet, Isabelle, Dardevet, Dominique, Sornet, Claire, Bechereau, Fabienne, Prugnaud, Jacques, Pouyet, Corinne, and Obled, Christiane

Subjects
Aging -- Physiological aspects, Aged -- Food and nutrition, Food/cooking/nutrition
Abstract

Aging induces a dysregulation of immune and inflammation functions that may affect protein synthesis rates in lymphoid tissue and plasma proteins. We quantified in vivo synthesis rates of thymus, spleen and plasma proteins, including albumin and acute phase proteins, in adult (8 mo old) and old (22 mo old) rats using the flooding dose method [L-(1-[sup.13]C) phenylalanine]. Immunosenescence was reflected by thymus atrophy and spleen hypertrophy in old rats but not in adult rats. A low albumin plasma level associated with high concentrations of fibrinogen, [[alpha].sub.2]-macroglobulin, [[alpha].sub.1]-acid glycoprotein and proteins other than albumin revealed a low grade inflammation in old rats. Protein fractional synthesis rates (FSR) and protein synthesis efficiencies of thymus were 29 and 26% lower in old than in adult rats, respectively; these variables did not differ in spleen. Protein absolute synthesis rates (ASR) of the thymus and spleen were 76% lower and 67% greater in old than adult rats, respectively. The FSR and ASR of albumin and other plasma proteins were greater in old than in adult rats. Protein synthesis measurement is a valuable nonimmunological tool to assess, in vivo, immune and inflammatory variables. Alterations in secondary lymphoid organs and plasma protein synthesis may contribute to the significant repartitioning of amino acids in old compared with adult rats and may be involved in sarcopenia. KEY WORDS: * aging * inflammation * lymphoid tissues * protein synthesis * rats

Published
2003

4. Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal. (Nutrition and Aging)

Author

Dardevet, Dominique, Sornet, Claire, Bayle, Gerard, Prugnaud, Jacques, Pouyet, Corrine, and Grizard, Jean

Subjects
Cell research -- Reports, Nutrition -- Research, Aging -- Physiological aspects, Proteins -- Synthesis, Leucine -- Physiological aspects, Muscles -- Physiological aspects, Rats -- Usage, Food/cooking/nutrition
Abstract

Aging is characterized by a progressive loss of muscle mass. A decrease of muscle protein synthesis stimulation has been detected in the postprandial state and correlated to a decrease of muscle protein synthesis sensitivity to leucine in vitro. This study was undertaken to examine the effect of a leucine-supplemented meal on postprandial (PP) muscle protein synthesis during aging. Adult (8 mo old) and old (22 mo old) rats were fed a semiliquid 18.2% protein control diet for 1 mo. The day of the experiment, rats received no food (postabsorptive group) or either an alanine or leucine-supplemented meal for 1 h (postprandial groups: PP and PP + Leu groups, respectively). Muscle protein synthesis was assessed in vivo 90-120 min after the meal distribution using the flooding dose method (1-[sup.13]C phenylalanine). Plasma leucine concentrations were significantly greater in the PP + Leu group compared with the PP group at both ages. Muscle protein synthesis was significantly greater in the adult PP group, whereas it was not stimulated in the old PP group. When supplemented with leucine, muscle protein synthesis in old rats was stimulated and similar to that observed in adults. We conclude that acute meal supplementation with leucine is sufficient to restore postprandial stimulation of muscle protein synthesis in old rats. Whether chronic leucine meal supplementation may limit muscle protein wasting during aging remains to be verified. KEY WORDS: * aging * protein synthesis * leucine * muscle * rats

Published
2002

11. Chronic leucine supplementation induced alteration of insulin signalling pathways in skeletal muscle without resistance of glucose transport in rats

Author

Dupont, Joëlle, Balage, Michelle, SORNET, Claire, Tesseraud, Sophie, Dardevet, Dominique, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Unité de Recherches Avicoles (URA), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, SUPPLEMENTATION
Abstract

International audience

Published
2008

12. Leucine supplementation improves muscle protein synthesis in the elderly men independently of hyperaminoacidemia

Author

Rieu, Isabelle, Balage, Michelle, SORNET, Claire, Giraudet, Christophe, Pujos, Estelle, Grizard, Jean, Mosoni, Laurent, Dardevet, Dominique, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine, and Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université

Subjects
[SDV]Life Sciences [q-bio], SUPPLEMENTATION
Abstract

International audience; The present study was designed to assess the effects of dietary leucine supplementation on muscle protein synthesis and whole body protein kinetics in elderly individuals. Twenty healthy male subjects (70 +/- 1 years) were studied before and after continuous ingestion of a complete balanced diet supplemented or not with leucine. A primed (3.6 micromol kg(-1)) constant infusion (0.06 micromol kg(-1) min(-1)) of L-[1-13C]phenylalanine was used to determine whole body phenylalanine kinetics as well as fractional synthesis rate (FSR) in the myofibrillar fraction of muscle proteins from vastus lateralis biopsies. Whole body protein kinetics were not affected by leucine supplementation. In contrast, muscle FSR, measured over the 5-h period of feeding, was significantly greater in the volunteers given the leucine-supplemented meals compared with the control group (0.083 +/- 0.008 versus 0.053 +/- 0.009% h(-1), respectively, P < 0.05). This effect was due only to increased leucine availability because only plasma free leucine concentration significantly differed between the control and leucine-supplemented groups. We conclude that leucine supplementation during feeding improves muscle protein synthesis in the elderly independently of an overall increase of other amino acids. Whether increasing leucine intake in old people may limit muscle protein loss during ageing remains to be determined.

Published
2006
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13. Un stress catabolique provoqué par un traitement à la dexamethasone induit une résistance prolongée ... l'action de la leucine sur la synthèse protéique musculaire du rat âgé

Author

Rieu, L., Sornet, Claire, Grizard, Jean, Dardevet, Dominique, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2004

14. Inflammatory state and thymus, spleen and plasma protein synthesis rates differ in adult and old rats

Author

Papet, Isabelle, Dardevet, Dominique, Sornet, Claire, Béchereau, F., PRUGNAUD, J., Pouyet, C., Obled, Christiane, ProdInra, Migration, Unité de nutrition et métabolisme protéique, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

15. La supplémentation en leucine stimule la synthèse protéique et les activités enzymatiques mitochondriales chez le rat adulte et agé

Author

Guillet, C., Dardevet, Dominique, Giraudet, Christophe, Rousset, Paulette, Sornet, Claire, ProdInra, Migration, Unité de nutrition et métabolisme protéique, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2003

19. Effet de la dexaméthasone sur la synthèse protéique de muscles squelettiques de rats adultes et âgés

Author

Savary, Isabelle, Debras, Elisabeth, Dardevet, Dominique, Sornet, Claire, Capitan, Pierre, Prugnaud, P., Patureau-Mirand, Philippe, Grizard, Jean, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

Suppl., résumé de poster P.8; National audience

Published
1997

20. Postprandial insulin suppression by diazoxide greatly impairs muscle protein synthesis

Author

Sinaud, S., Balage, Michelle, Bromont, S., Dardevet, Dominique, Sornet, Claire, Grizard, Jean, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1996

21. Phosphatidylinositol 3-kinase and p70 S6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I

Author

Dardevet, Dominique, Sornet, Claire, Vary, T., Grizard, Jean, ProdInra, Migration, Unité de nutrition et métabolisme protéique, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1996

22. Signal transduction in insulin and IGF-1 action on skeletal muscle protein turnover

Author

Dardevet, Dominique, Sornet, Claire, Sinaud, S., Grizard, Jean, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], TRANSDUCTION SIGNAL, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1995

23. Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats

Author

Dardevet, Dominique, Sornet, Claire, Attaix, Didier, Baracos, V.E., Grizard, Jean, Unité de nutrition et métabolisme protéique, and Institut National de la Recherche Agronomique (INRA)

Subjects
RAT, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

25. Alterations of IGF-1 and insulin action with aging in rat skeletal muscle

Author

Dardevet, Dominique, Sornet, Claire, Balage, Michelle, Grizard, Jean, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1992

26. Influence of low-and high-protein diets on insulin-like growth factor-1 binding to skeletal muscle and liver in the growing rat

Author

Dardevet, Dominique, Manin, M., Balage, Michelle, Sornet, Claire, Grizard, Jean, Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, RAT, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1991

27. Leucine in age-associated sarcopenia

Author

Rieu, Isabelle, primary, Mosoni, Laurent, additional, Combaret, Lydie, additional, Sornet, Claire, additional, Grizard, Jean, additional, and Dardevet, Dominique, additional

Published
2006
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28. Lactation failed to alter in vivo insulin effect on whole body leucine kinetics and insulin receptor tyrosine kinase activity in skeletal muscle from goats

Author

Balage, Michelle, Tesseraud, Sophie, CHAMPREDON, C., Sornet, Claire, Debras, Elisabeth, Grizard, Jean, ProdInra, Migration, Unité de nutrition et métabolisme protéique, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1990

30. Recepteurs d'insuline et activite tyrosine kinase dans le foie et le muscle de rat en croissance

Author

Balage, Michelle, Sornet, Claire, Grizard, Jean, Institut francilien recherche, innovation et société (IFRIS), Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1988

31. INFLUENCE DE LA PRISE ALIMENTAIRE SUR LES VARIATIONS DE DIFFÉRENTS CONSTITUANTS PLASMATIQUES CHEZ LA VACHE EN FIN DE GESTATION ET EN DÉBUT DE LACTATION

Author

Doreau, M., Flechet, Jeannette, Lefaivre, Renée, Ollier, A., Sornet, Claire, and Revues Inra, Import

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.BA] Life Sciences [q-bio]/Animal biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Published
1983

32. VARIATIONS DE QUELQUES CONSTITUANTS PLASMATIQUES CHEZ LA JUMENT ALLAITANTE EN FIN DE GESTATION ET DÉBUT DE LACTATION

Author

Doreau, M., Martin-Rosset, W., Barlet, J.P., Dubroeucq, H., Roux, R., Sornet, Claire, and Revues Inra, Import

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.BA] Life Sciences [q-bio]/Animal biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Published
1981

33. ÉVOLUTION DE DIFFÉRENTS PARAMÈTRES SANGUINS DU MÉTABOLISME ÉNERGÉTIQUE CHEZ LA VACHE LAITIERE EN DÉBUT DE LACTATION

Author

Coulon, J.B., Remond, B., Doreau, M., Journet, M., Flechet, Jeanne, Lefaivre, Renée, Marquis, B., Sornet, Claire, and Revues Inra, Import

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.BA] Life Sciences [q-bio]/Animal biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Published
1985

34. URAEMIA IN THE MARE: EFFECTS OF SEASONAL VARIATIONS, OF ENERGY LEVEL OF THE DIET AND INDIVIDUAL DIFFERENCES

Author

Doreau, M., Martin-Rosset, W., Dubroeuco, H., Sornet, Claire, and Revues Inra, Import

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.BA] Life Sciences [q-bio]/Animal biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Published
1985

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