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3. Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials

Author

Daniele, Gennaro, Arenare, Laura, Scambia, Giovanni, Pisano, Carmela, Sorio, Roberto, Breda, Enrico, De Placido, Sabino, Savarese, Antonella, Ferrandina, Gabriella, Raspagliesi, Francesco, Panici, Pierluigi Benedetti, Ferro, Antonella, Rimanti, Anita, Cormio, Gennaro, Lorusso, Domenica, Cecere, Sabrina Chiara, Scalone, Simona, Marsico, Valentina Angela, Cardalesi, Cinzia, Cognetti, Francesco, Salutari, Vanda, Attademo, Laura, Guizzaro, Lorenzo, Schettino, Clorinda, Piccirillo, Maria Carmela, Perrone, Francesco, Gallo, Ciro, and Pignata, Sandro

Published
2019
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4. Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial

Author

Vergote, Ignace, Scambia, Giovanni, Park, Sang Yoon, Song, Yong Sang, Makarova, Yulia, Trinidad, Joshua, Ngan, Hextan Yuen Sheung, Bamias, Aristotelis, Aravantinos, Gerasimos, Nam, Joo-Hyun, Gorbunova, Vera, Krikunova, Ludmila, Bae, Duk-Soo, Arija, Jose Angel Arranz, Mirza, Mansoor Raza, Zamagni, Claudio, Papandreou, Christos, Raspagliesi, Francesco, Lisyanskaya, Alla, Benzaquen, Ana Oaknin, Tognon, Germana, Ortega, Eugenia, Herraez, Antonio Casado, Buscema, Joseph, Green, Andrew, Burger, Robert, Sakaeva, Dina, Sanchez, Andres Redondo, Ghamande, Sharad, King, Laurel, Petru, Edgar, Peen, Ulla, Takeuchi, Satoshi, Ushijima, Kimio, Martin, Antonio Gonzalez, Kamelle, Scott, Carney, Michael, Marth, Christian, Forget, Frédéric, Bentley, James, Sehouli, Jalid, Colombo, Nicoletta, Zola, Paolo, Kato, Hidenori, Fadeeva, Natalya, Gotovkin, Evgeny, Vladimirov, Vladimir, Marin, Margarita Romeo, Alia, Eva Guerra, Shahin, Mark, Bhoola, Snehalkumar, Tewari, Krishnansu, Anderson, Daniel, Honhon, Brigitte, Pelgrims, Joseph (Gino), Oza, Amit, Jimenez, Jesus Garcia-Donas, Hansen, Vincent, O'Malley, David, Benjamin, Ivor, Renard, Vincent, Van den Bulck, Heidi, Meier, Werner, Haenle, Claudia, Koumakis, Georgios, Yokota, Harushige, Popov, Vadim, Bradley, William, Wenham, Robert, Reid, Robert, McNamara, Donna, Friedman, Richard, Barlin, Joyce, Spirtos, Nicola, Chapman, Julia, Sevelda, Paul, Huizing, Manon, Lamot, Caroline, Goffin, Frédéric, Hondt, Lionel D, Covens, Allan, Spadafora, Silvana, Rautenberg, Beate, Reimer, Toralf, Möbus, Volker, Hilpert, Felix, Gropp-Meier, Martina, Savarese, Antonella, Pignata, Sandro, Verderame, Francesco, Mizuno, Mika, Takano, Hirokuni, Ottevanger, Petronella, Velasco, Andres Poveda, Palacio-Vazquez, Isabel, Law, Amy, McIntyre, Kristi, Teneriello, Michael, Fields, Abbie, Lentz, Samuel, Street, Daron, Schwartz, Benjamin, Mannel, Robert, Lim, Peter, Pulaski, Heather, Janni, Wolfgang, Zorr, Andreas, Karck, Ulrich, Cheng, Ashley Chi Kin, Sorio, Roberto, Gridelli, Cesare, Aoki, Daisuke, Oishi, Tetsuro, Hirashima, Yasuyuki, Boere, Ingrid, Ferrer, Esther Falco, Braly, Patricia, Wilks, Sharon, Lee, Christine, Schilder, Jeanne, Veljovich, Dan, Secord, Angeles, Davis, Kevin, Rojas-Espaillat, Luis, Lele, Shashikant, DePasquale, Stephen, Squatrito, Robert, Schauer, Christian, Dirix, Luc, Vuylsteke, Peter, Joosens, Eric, Provencher, Diane, Lueck, Hans-Joachim, Hein, Alexander, Burges, Alexander, Canzler, Ulrich, Park-Simon, Tjoung-Won, Griesinger, Frank, Gadducci, Angiolo, Alabiso, Oscar, Okamoto, Aikou, Sawasaki, Takashi, Saito, Toshiaki, Ibañez, Ana Herrero, Calomeni, Coralia, Spillman, Monique, Choksi, Janak, Taylor, Nicholas, Muller, Carolyn, Moore, David, DiSilvestro, Paul, Cunningham, Mary, Rose, Peter, Oppelt, Peter, Verhoeven, Didier, Graas, Marie-Pascale, Ghatage, Prafull, Tonkin, Katia, Kurzeder, Christian, Schnappauf, Benjamin, Müller, Volkmar, Schmalzrie, Hannah, Kalofonos, Haralambos, Bruzzone, Milena, Kroep, Judith, Diaz, Cristina Caballero, Garcia, Jeronimo Martinez, Polo, Susana Hernando, Garrison, Mitchell, Rocconi, Rodney, Andrews, Stephen, Bristow, Robert, McHale, Michael, Basil, Jack, Houck III, William, Bell, Maria, Cosin, Jonathan, Modesitt, Susan, Kendrick, James, Wade III, James, Wong, Cheung, Evans, Anthony, Buekers, Thomas, Vanderkwaak, Timothy, Ferriss, James, Darus, Christopher, DAndre, Stacy, Higgins, Robert, Monk, Bradley, Bakkum-Gamez, Jamie, DeMars, Leslie, Van Le, Linda, Puls, Larry, Trehan, Shruti, LaPolla, James, Michelson, Elizabeth Dickson, Merchant, Joseph, Peterson, Christopher, Reid, Gary, Seago, Donald, Zweizig, Susan, Gajewski, Walter, Panwalkar, Amit, Leikermoser, Rudolf, Bogner, Gerhard, Debruyne, Philip, D'hondt, Randal, Berteloot, Patrick, Kerger, Joseph, Biagi, James, Castonguay, Vincent, Welch, Stephen, Muhic, Aida, Heubner, Martin, Grischke, Eva-Maria, Rack, Brigitte, Fleisch, Markus, Lordick, Florian, Pectasides, Dimitrios, Ho, Wing Ming, Selvaggi, Luigi, Vasquez, Flavia Morales, Villanueva, William Orlando Brito, Alavez, Alejandro Molina, Kessels, Lonneke, Bertran, Ana Santaballa, Fernandez, Cesar Mendiola, Fabregat, Miguel Beltran, Del Prete, Salvatore, Elkas, John, Cecchi, Gary, Kumar, Pallavi, Huh, Warner, Messing, Mark, Karimi, Misagh, Kelley, Ann, Edraki, Babak, Mutch, David, Leiserowitz, Gary, Anderson, Jeanne, Lentz, Scott, Chambers, Setsuko, Morris, Robert, Waggoner, Steven, Gordon, Alan, Method, Michael, Johnson, Peter, Lord, Raymond, Drake, Janet, Sivarajan, Kulumani, Midathada, Madhu, Rice, Kristen, Wadsworth, Troy, Pavelka, James, Edwards, Robert, Miller, David Scott, Ford, Patricia Locantore, Hurteau, Jean, Bender, David, Schimp, Veronica, Creasman, William, Lerner, Rachel, Chamberlain, Donald, Kueck, Angela, McDonald, John, Malad, Salman, Robinson-Bennett, Bernice, Davidson, Susan, Krivak, Thomas, Lestingi, Timothy, Arango, Hector, Berard, Paul, Finkelstein, Karen, Gaur, Rakesh, Krasner, Carolyn, Ueland, Frederick, Talmage, Lance, Yamada, Seiko, Sutton, Gregory, Potkul, Ronald, Prasad-Hayes, Monica, Osborne, Janet, Celano, Paul, Thigpen, James, Sharma, Sudarshan, Schilder, Russell, Tammela, Jonathan, Kemeny, Mary, Brown, Amy, Eisenhauer, Eric, Williams, James, Rowland, Kendrith, Nahum, Kenneth, Burke, James, Dar, Zahid, Fleming, Nicole, Gibb, Randall, Guirguis, Alfred, Herzog, Thomas, John, Veena, Kumar, Santhosh, Kamat, Aparna, Kassar, Mohamad, Leitao, Mario, Levine, Lyuba, Mendez, Luis, Patel, Dhimant, Berry, Emily, Warshal, David, Wolf, Judith, Zarwan, Corrine, Collins, Yvonne, Spitzer, Gary, Miller, Brigitte, Einstein, Mark, O'Malley, David M, Van Calster, Ben, Park, Sang-Yoon, del Campo, Josep M, Wenham, Robert M, Covens, Al, Raza Mirza, Mansoor, Kroep, Judith R, Ma, Haijun, Pickett, Cheryl A, and Monk, Bradley J

Published
2019
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5. Patient-Reported Outcome Results From the Open-Label Phase III AURELIA Trial Evaluating Bevacizumab-Containing Therapy for Platinum-Resistant Ovarian Cancer

Author

Stockler, Martin R, Hilpert, Felix, Friedlander, Michael, King, Madeleine T, Wenzel, Lari, Lee, Chee Khoon, Joly, Florence, de Gregorio, Nikolaus, Arranz, José Angel, Mirza, Mansoor Raza, Sorio, Roberto, Freudensprung, Ulrich, Sneller, Vesna, Hales, Gill, and Pujade-Lauraine, Eric

Subjects
Cancer, Rare Diseases, Ovarian Cancer, Clinical Research, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Bevacizumab, Doxorubicin, Drug Administration Schedule, Drug Resistance, Neoplasm, Female, Humans, Middle Aged, Organoplatinum Compounds, Ovarian Neoplasms, Paclitaxel, Polyethylene Glycols, Self Report, Topotecan, Treatment Outcome, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeTo determine the effects of bevacizumab on patient-reported outcomes (PROs; secondary end point) in the AURELIA trial.Patients and methodsPatients with platinum-resistant ovarian cancer were randomly assigned to chemotherapy alone (CT) or with bevacizumab (BEV-CT). PROs were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Ovarian Cancer Module 28 (EORTC QLQ-OV28) and Functional Assessment of Cancer Therapy-Ovarian Cancer symptom index (FOSI) at baseline and every two or three cycles (8/9 weeks) until disease progression. The primary PRO hypothesis was that more patients receiving BEV-CT than CT would achieve at least a 15% (≥ 15-point) absolute improvement on the QLQ-OV28 abdominal/GI symptom subscale (items 31-36) at week 8/9. Patients with missing week 8/9 questionnaires were included as unimproved. Questionnaires from all assessments until disease progression were analyzed using mixed-model repeated-measures (MMRM) analysis. Sensitivity analyses were used to determine the effects of differing assumptions and methods for missing data.ResultsBaseline questionnaires were available from 89% of 361 randomly assigned patients. More BEV-CT than CT patients achieved a ≥ 15% improvement in abdominal/GI symptoms at week 8/9 (primary PRO end point, 21.9% v 9.3%; difference, 12.7%; 95% CI, 4.4 to 20.9; P = .002). MMRM analysis covering all time points also favored BEV-CT (difference, 6.4 points; 95% CI, 1.3 to 11.6; P = .015). More BEV-CT than CT patients achieved ≥ 15% improvement in FOSI at week 8/9 (12.2% v 3.1%; difference, 9.0%; 95% CI, 2.9% to 15.2%; P = .003). Sensitivity analyses gave similar results and conclusions.ConclusionBevacizumab increased the proportion of patients achieving a 15% improvement in patient-reported abdominal/GI symptoms during chemotherapy for platinum-resistant ovarian cancer.

Published
2014

6. Supplementary Figure S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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7. Supplementary Table S2 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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8. Data from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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9. Supplementary Appendix S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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10. Safety and efficacy of single-agent bevacizumab-containing therapy in elderly patients with platinum-resistant recurrent ovarian cancer: Subgroup analysis of the randomised phase III AURELIA trial

Author

Sorio, Roberto, Roemer-Becuwe, Célia, Hilpert, Felix, Gibbs, Emma, García, Yolanda, Kaern, Janne, Huizing, Manon, Witteveen, Petronella, Zagouri, Flora, Coeffic, David, Lück, Hans-Joachim, González-Martín, Antonio, Kristensen, Gunnar, Levaché, Charles-Briac, Lee, Chee Khoon, Gebski, Val, and Pujade-Lauraine, Eric

Published
2017
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11. Human epidermal growth factor receptor-2 (HER2) is a potential therapeutic target in extramammary Paget’s disease of the vulva

Author

Bartoletti, Michele, Mazzeo, Roberta, De Scordilli, Marco, Del Fabro, Anna, Vitale, Maria Grazia, Bortot, Lucia, Nicoloso, Milena Sabrina, Corsetti, Serena, Bonotto, Marta, Scalone, Simona, Giorda, Giorgio, Sorio, Roberto, Andreetta, Claudia, Meacci, Maria Luisa, De Vivo, Rocco, Fasola, Gianpiero, Sopracordevole, Francesco, and Puglisi, Fabio

Published
2020
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12. Machine Learning Application Identifies Germline Markers of Hypertension in Ovarian Cancer Patients Treated with Carboplatin, Taxane and Bevacizumab

Author

Polano, Maurizio, primary, Bedon, Luca, additional, Bo, Michele Dal, additional, Sorio, Roberto, additional, Bartoletti, Michele, additional, De Mattia, Elena, additional, Cecchin, Erika, additional, Pisano, Carmela, additional, Lorusso, Domenica, additional, Lissoni, Andrea Alberto, additional, De Censi, Andrea, additional, Cecere, Sabrina Chiara, additional, Scollo, Paolo, additional, Marchini, Sergio, additional, Arenare, Laura, additional, De Giorgi, Ugo, additional, Califano, Daniela, additional, Biagioli, Elena, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, Pignata, Sandro, additional, and Toffoli, Giuseppe, additional

Published
2023
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13. Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Pignata, Sandro, primary, Scambia, Giovanni, additional, Schettino, Clorinda, additional, Arenare, Laura, additional, Pisano, Carmela, additional, Lombardi, Davide, additional, De Giorgi, Ugo, additional, Andreetta, Claudia, additional, Cinieri, Saverio, additional, De Angelis, Carmine, additional, Priolo, Domenico, additional, Casanova, Claudia, additional, Rosati, Marta, additional, Greco, Filippo, additional, Zafarana, Elena, additional, Schiavetto, Ilaria, additional, Mammoliti, Serafina, additional, Cecere, Sabrina Chiara, additional, Salutari, Vanda, additional, Scalone, Simona, additional, Farolfi, Alberto, additional, Di Napoli, Marilena, additional, Lorusso, Domenica, additional, Gargiulo, Piera, additional, Califano, Daniela, additional, Russo, Daniela, additional, Spina, Anna, additional, De Cecio, Rossella, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, Accinno, Valentina, additional, Altavilla, Chiara, additional, Antonelli, Giovanna, additional, Artioli, Grazia, additional, Avola, Francesco, additional, Barbara, Bonifacio, additional, Barbato, Valentina, additional, Bartoletti, Michele, additional, Bevilacqua, Simona, additional, Bordonaro, Roberto, additional, Borghese, Oriana, additional, Buonfanti, Gaetano, additional, Camarda, Floriana, additional, Canzanella, Giuliana, additional, Carbone, Vittoria, additional, Carbone, Maria Rita, additional, Carlo Stella, Giulia, additional, Cassani, Chiara, additional, Castagna, Fabrizio, additional, Cattaneo, Monica, additional, Cinefra, Margherita, additional, Colombo, Nicoletta, additional, Corsetti, Serena, additional, Dall'Agata, Monia, additional, D'Amico, Maria, additional, Daniele, Gennaro, additional, De Marino, Elvira, additional, De Matteis, Giovanni, additional, De Placido, Sabino, additional, Del Bene, Gabriella, additional, Del Giudice, Antonia, additional, Del Monte, Francesca, additional, Del Sesto, Michele, additional, Donini, Maddalena, additional, Drudi, Giuliana, additional, Falcone, Gianluca, additional, Favaretto, Adolfo, additional, Ferrera, Giulia, additional, Florio, Manuela, additional, Forestieri, Valeria, additional, Gallo, Maria Stella, additional, Gallo, Ciro, additional, Garibaldi, Francesca, additional, Gerevini, Fabiana, additional, Ghizzoni, Viola, additional, Giganti, Maria Olga, additional, Gimigliano, Anna, additional, Giudice, Elena, additional, Gnocchi, Nicoletta, additional, Gravina, Adriano, additional, Greggi, Stefano, additional, Iaia, Maria Laura, additional, Ilardi, Annalisa, additional, Iovine, Gelsomina, additional, Ippoliti, Gabriella, additional, Irollo, Giulia, additional, Isidori, Ilenia, additional, Lapresa, Mariateresa, additional, Lavenia, Giuseppe, additional, Longhitano, Laura, additional, Lucia, Bortot, additional, Luzi, Gabriella, additional, Mariano, Sara, additional, Marino, Valentina, additional, Marrapese, Giovanna, additional, Martino, Marilena, additional, Matocci, Roberta, additional, Mazzoni, Enrica, additional, Mercuri, Daniela, additional, Mirto, Maria, additional, Mollo, Giovanna, additional, Montinaro, Abbondanza, additional, Moscatelli, Marta, additional, Mosconi, Anna Maria, additional, Musacchio, Lucia, additional, Nanni, Nicoletta, additional, Natalucci, Pamela, additional, Nicoloso, Milena Sabrina, additional, Orditura, Michele, additional, Parma, Gabriella Maria, additional, Passalacqua, Rodolfo, additional, Pelone, Michela, additional, Perri, Maria Teresa, additional, Perrucci, Bruno, additional, Piancastelli, Alessandra, additional, Piccirillo, Maria Carmela, additional, Piccolo, Antonio, additional, Pignata, Sandro, additional, Rapisardi, Stefania, additional, Ravaglia, Giorgia, additional, Ribecco, Teresa, additional, Ricci, Caterina, additional, Roccio, Marianna, additional, Romano, Fiorella, additional, Sambataro, Daniela, additional, Savio, Alfonso, additional, Sbriglia, Ada, additional, Scaffa, Cono, additional, Sergi, Concetta, additional, Sgandurra, Francesca, additional, Sorio, Roberto, additional, Stabile, Stefano, additional, Tabaro, Gianna, additional, Tambaro, Margherita, additional, Tamberi, Stefano, additional, Tecchiato, Angelica, additional, Trujillo, Angela Maria, additional, and Zaccarelli, Eleonora, additional

Published
2023
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14. Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study

Author

Bagnoli, Marina, Canevari, Silvana, Califano, Daniela, Losito, Simona, Maio, Massimo Di, Raspagliesi, Francesco, Carcangiu, Maria Luisa, Toffoli, Giuseppe, Cecchin, Erika, Sorio, Roberto, Canzonieri, Vincenzo, Russo, Daniela, Scognamiglio, Giosué, Chiappetta, Gennaro, Baldassarre, Gustavo, Lorusso, Domenica, Scambia, Giovanni, Zannoni, Gian Franco, Savarese, Antonella, Carosi, Mariantonia, Scollo, Paolo, Breda, Enrico, Murgia, Viviana, Perrone, Francesco, Pignata, Sandro, De Cecco, Loris, and Mezzanzanica, Delia

Published
2016
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15. Machine Learning Application Identifies Germline Markers of Hypertension in Patients With Ovarian Cancer Treated With Carboplatin, Taxane, and Bevacizumab.

Author

Polano, Maurizio, Bedon, Luca, Dal Bo, Michele, Sorio, Roberto, Bartoletti, Michele, De Mattia, Elena, Cecchin, Erika, Pisano, Carmela, Lorusso, Domenica, Lissoni, Andrea Alberto, De Censi, Andrea, Cecere, Sabrina Chiara, Scollo, Paolo, Marchini, Sergio, Arenare, Laura, De Giorgi, Ugo, Califano, Daniela, Biagioli, Elena, Chiodini, Paolo, and Perrone, Francesco

Subjects
OVARIAN cancer, CANCER patients, MACHINE learning, HYPERTENSION, BEVACIZUMAB, GENETIC variation, PRECISION farming
Abstract

Pharmacogenomics studies how genes influence a person's response to treatment. When complex phenotypes are influenced by multiple genetic variations with little effect, a single piece of genetic information is often insufficient to explain this variability. The application of machine learning (ML) in pharmacogenomics holds great potential — namely, it can be used to unravel complicated genetic relationships that could explain response to therapy. In this study, ML techniques were used to investigate the relationship between genetic variations affecting more than 60 candidate genes and carboplatin‐induced, taxane‐induced, and bevacizumab‐induced toxicities in 171 patients with ovarian cancer enrolled in the MITO‐16A/MaNGO‐OV2A trial. Single‐nucleotide variation (SNV, formerly SNP) profiles were examined using ML to find and prioritize those associated with drug‐induced toxicities, specifically hypertension, hematological toxicity, nonhematological toxicity, and proteinuria. The Boruta algorithm was used in cross‐validation to determine the significance of SNVs in predicting toxicities. Important SNVs were then used to train eXtreme gradient boosting models. During cross‐validation, the models achieved reliable performance with a Matthews correlation coefficient ranging from 0.375 to 0.410. A total of 43 SNVs critical for predicting toxicity were identified. For each toxicity, key SNVs were used to create a polygenic toxicity risk score that effectively divided individuals into high‐risk and low‐risk categories. In particular, compared with low‐risk individuals, high‐risk patients were 28‐fold more likely to develop hypertension. The proposed method provided insightful data to improve precision medicine for patients with ovarian cancer, which may be useful for reducing toxicities and improving toxicity management. [ABSTRACT FROM AUTHOR]

Published
2023
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16. TP033/#1441 MITO 25.1: a randomized, molecular driven phase II trial of carboplatin-paclitaxel-bevacizumab vs carboplatin-paclitaxel-bevacizumab-rucaparib vs carboplatin-paclitaxel-rucaparib, selected according to HRD status, in patients with advanced ovarian cancer

Author

Musacchio, Lucia, primary, Salutari, Vanda, additional, Pignata, Sandro, additional, Valabrega, Giorgio, additional, Zavallone, Laura, additional, Cormio, Gennaro, additional, Mosconi, Anna Maria, additional, Giolitto, Serena, additional, Camarda, Floriana, additional, Ricci, Caterina, additional, Zamagni, Claudio, additional, Nero, Camilla, additional, Carbone, Maria Vittoria, additional, Ghizzoni, Viola, additional, Sorio, Roberto, additional, Salvatore, Siena, additional, Tronconi, Francesca, additional, Savarese, Antonella, additional, Scambia, Giovanni, additional, and Lorusso, Domenica, additional

Published
2022
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19. 2022-RA-1540-ESGO MITO 25.1: a randomized, molecular driven phase II trial of carboplatin-paclitaxel-bevacizumab vs carboplatin-paclitaxel-bevacizumab-rucaparib vs carboplatin-paclitaxel-rucaparib, selected according to HRD status, in patients with advanced (Stage III B-C-IV) ovarian, primary peritoneal and fallopian tube cancer

Author

Musacchio, Lucia, primary, Salutari, Vanda, additional, Pignata, Sandro, additional, Valabrega, Giorgio, additional, Zavallone, Laura, additional, Cormio, Gennaro, additional, Mosconi, Anna Maria, additional, Giolitto, Serena, additional, Giudice, Elena, additional, Ricci, Caterina, additional, Zamagni, Claudio, additional, Nero, Camilla, additional, Carbone, Maria Vittoria, additional, Ghizzoni, Viola, additional, Sorio, Roberto, additional, Siena, Salvatore, additional, Tronconi, Francesca, additional, Savarese, Antonella, additional, Scambia, Giovanni, additional, and Lorusso, Domenica, additional

Published
2022
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20. Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trial

Author

Pignata, Sandro, Scambia, Giovanni, Katsaros, Dionyssios, Gallo, Ciro, Pujade-Lauraine, Eric, De Placido, Sabino, Bologna, Alessandra, Weber, Beatrice, Raspagliesi, Francesco, Panici, Pierluigi Benedetti, Cormio, Gennaro, Sorio, Roberto, Cavazzini, Maria Giovanna, Ferrandina, Gabriella, Breda, Enrico, Murgia, Viviana, Sacco, Cosimo, Cinieri, Saverio, Salutari, Vanda, Ricci, Caterina, Pisano, Carmela, Greggi, Stefano, Lauria, Rossella, Lorusso, Domenica, Marchetti, Claudia, Selvaggi, Luigi, Signoriello, Simona, Piccirillo, Maria Carmela, Di Maio, Massimo, and Perrone, Francesco

Published
2014
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21. An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer

Author

Bartoletti, Michele, primary, Giorda, Giorgio, additional, Viel, Alessandra, additional, Fornasarig, Mara, additional, Zdjelar, Adrian, additional, Segatto, Enrica, additional, Sorio, Roberto, additional, Corsetti, Serena, additional, Scalone, Simona, additional, Nicoloso, Milena Sabrina, additional, Pivetta, Tania, additional, Lucia, Emilio, additional, Clemente, Nicolò, additional, Palazzari, Elisa, additional, Canzonieri, Vincenzo, additional, and Puglisi, Fabio, additional

Published
2022
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22. Breast cancer incidence in patients with BRCA-related advanced ovarian cancer receiving olaparib-based maintenance therapy: A pooled analysis from phase III clinical trials.

Author

Bartoletti, Michele, primary, Montico, Marcella, additional, Mazzeo, Roberta, additional, De Scordilli, Marco, additional, Musacchio, Lucia, additional, Lucia, Emilio, additional, Giorda, Giorgio, additional, Massarut, Samuele, additional, Urbani, Martina, additional, Miolo, Gianmaria, additional, Viel, Alessandra, additional, Garutti, Mattia, additional, Da Ros, Lucia, additional, Scalone, Simona, additional, Nicoloso, Milena, additional, Corsetti, Serena, additional, Sorio, Roberto, additional, Lorusso, Domenica, additional, Pignata, Sandro, additional, and Puglisi, Fabio, additional

Published
2022
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23. A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis

Author

Vecchione, Andrea, Belletti, Barbara, Lovat, Francesca, Volinia, Stefano, Chiappetta, Gennaro, Giglio, Simona, Sonego, Maura, Cirombella, Roberto, Onesti, Elisa Concetta, Pellegrini, Patrizia, Califano, Daniela, Pignata, Sandro, Losito, Simona, Canzonieri, Vincenzo, Sorio, Roberto, Alder, Hansjuerg, Wernicke, Dorothee, Stoppacciaro, Antonella, Baldassarre, Gustavo, and Croce, Carlo M.

Published
2013

25. Fertility-sparing treatment for serous borderline ovarian tumors with extra-ovarian invasive implants: Analysis from the MITO14 study database

Author

Falcone, Francesca, primary, Malzoni, Mario, additional, Carnelli, Marco, additional, Cormio, Gennaro, additional, De Iaco, Pierandrea, additional, Di Donato, Violante, additional, Ferrandina, Gabriella, additional, Raspagliesi, Francesco, additional, Sorio, Roberto, additional, Losito, Nunzia S., additional, and Greggi, Stefano, additional

Published
2022
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28. A phase II study of capecitabine in the treatment of ovarian cancer resistant or refractory to platinum therapy: a multicentre Italian trial in ovarian cancer (MITO-6) trial

Author

Pisano, Carmela, Morabito, Alessandro, Sorio, Roberto, Breda, Enrico, Lauria, Rossella, Gebbia, Vittorio, Scaltriti, Laura, Scalone, Simona, Zagonel, Vittorina, Greggi, Stefano, Beneduce, Gerardo, Losito, Simona, Gallo, Ciro, Di Maio, Massimo, Forestieri, Valeria, and Pignata, Sandro

Published
2009
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29. Population Pharmacokinetics and Pharmacodynamics of Doxorubicin and Cyclophosphamide in Breast Cancer Patients: A Study by the EORTC-PAMM-NDDG

Author

Joerger, Markus, Huitema, Alwin D. R., Richel, Dick J., Dittrich, Christian, Pavlidis, Nikolas, Briasoulis, Evangelos, Vermorken, Jan B., Strocchi, Elena, Martoni, Andrea, Sorio, Roberto, Sleeboom, Henk P., Izquierdo, Miguel A., Jodrell, Duncan I., Féty, Régine, de Bruijn, Ernst, Hempel, Georg, Karlsson, Mats, Tranchand, Brigitte, Schrijvers, Ad H. G. J., Twelves, Chris, Beijnen, Jos H., and Schellens, Jan H. M.

Published
2007
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31. A European, Observational, Prospective Trial of Trabectedin Plus Pegylated Liposomal Doxorubicin in Patients with Platinum-Sensitive Ovarian Cancer

Author

Pignata, Sandro, primary, Scambia, Giovanni, additional, Villanucci, Alessandro, additional, Naglieri, Emanuele, additional, Ibarbia, Mikel Arruti, additional, Brusa, Federica, additional, Bourgeois, Hugues, additional, Sorio, Roberto, additional, Casado, Antonio, additional, Reichert, Dietmar, additional, Dopchie, Catherine, additional, De Rivas, Beatriz, additional, and Sande, Luis Miguel, additional

Published
2021
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32. CDKN1Bmutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer

Author

Viotto, Davide, primary, Russo, Francesca, additional, Anania, Ilaria, additional, Segatto, Ilenia, additional, Rampioni Vinciguerra, Gian Luca, additional, Dall'Acqua, Alessandra, additional, Bomben, Riccardo, additional, Perin, Tiziana, additional, Cusan, Martina, additional, Schiappacassi, Monica, additional, Gerratana, Lorenzo, additional, D'Andrea, Sara, additional, Citron, Francesca, additional, Vit, Filippo, additional, Musco, Lorena, additional, Mattevi, Maria Chiara, additional, Mungo, Giorgia, additional, Nicoloso, Milena S, additional, Sonego, Maura, additional, Massarut, Samuele, additional, Sorio, Roberto, additional, Barzan, Luigi, additional, Franchin, Giovanni, additional, Giorda, Giorgio, additional, Lucia, Emilio, additional, Sulfaro, Sandro, additional, Giacomarra, Vittorio, additional, Polesel, Jerry, additional, Toffolutti, Federica, additional, Canzonieri, Vincenzo, additional, Puglisi, Fabio, additional, Gattei, Valter, additional, Vecchione, Andrea, additional, Belletti, Barbara, additional, and Baldassarre, Gustavo, additional

Published
2020
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38. Pharmacogenetic score predicts overall survival, progression-free survival and platinum sensitivity in ovarian cancer

Author

Gagno, Sara, primary, Bartoletti, Michele, additional, Romualdi, Chiara, additional, Poletto, Elena, additional, Scalone, Simona, additional, Sorio, Roberto, additional, Zanchetta, Martina, additional, De Mattia, Elena, additional, Roncato, Rossana, additional, Cecchin, Erika, additional, Giorda, Giorgio, additional, and Toffoli, Giuseppe, additional

Published
2020
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39. Bevacizumab or PARP-Inhibitors Maintenance Therapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis

Author

Bartoletti, Michele, primary, Pelizzari, Giacomo, additional, Gerratana, Lorenzo, additional, Bortot, Lucia, additional, Lombardi, Davide, additional, Nicoloso, Milena, additional, Scalone, Simona, additional, Giorda, Giorgio, additional, Baldassarre, Gustavo, additional, Sorio, Roberto, additional, and Puglisi, Fabio, additional

Published
2020
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50. Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC)

Author

Garziera, Marica, primary, Cecchin, Erika, additional, Giorda, Giorgio, additional, Sorio, Roberto, additional, Scalone, Simona, additional, Mattia, Elena De, additional, Roncato, Rossana, additional, Gagno, Sara, additional, Poletto, Elena, additional, Romanato, Loredana, additional, Ecca, Fabrizio, additional, Canzonieri, Vincenzo, additional, and Toffoli, Giuseppe, additional

Published
2019
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