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2. Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries

Author

Machado, Pedro M, Schäfer, Martin, Mahil, Satveer K, Liew, Jean, Gossec, Laure, Dand, Nick, Pfeil, Alexander, Strangfeld, Anja, Regierer, Anne Constanze, Fautrel, Bruno, Alonso, Carla Gimena, Saad, Carla GS, Griffiths, Christopher EM, Lomater, Claudia, Miceli-Richard, Corinne, Wendling, Daniel, Rodriguez, Deshire Alpizar, Wiek, Dieter, Mateus, Elsa F, Sirotich, Emily, Soriano, Enrique R, Ribeiro, Francinne Machado, Omura, Felipe, Martins, Frederico Rajão, Santos, Helena, Dau, Jonathan, Barker, Jonathan N, Hausmann, Jonathan, Hyrich, Kimme L, Gensler, Lianne, Silva, Ligia, Jacobsohn, Lindsay, Carmona, Loreto, Pinheiro, Marcelo M, Zelaya, Marcos David, de los Ángeles Severina, María, Yates, Mark, Dubreuil, Maureen, Gore-Massy, Monique, Romeo, Nicoletta, Haroon, Nigil, Sufka, Paul, Grainger, Rebecca, Hasseli, Rebecca, Lawson-Tovey, Saskia, Bhana, Suleman, Pham, Thao, Olofsson, Tor, Bautista-Molano, Wilson, Wallace, Zachary S, Yiu, Zenas ZN, Yazdany, Jinoos, Robinson, Philip C, and Smith, Catherine H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Clinical Research, Arthritis, Autoimmune Disease, Psoriasis, Good Health and Well Being, Adult, Humans, Male, Arthritis, Psoriatic, Rheumatology, COVID-19, Axial Spondyloarthritis, Physicians, Glucocorticoids, Interleukin-12, Registries, Covid-19, Psoriatic, Autoimmunity, Spondylitis, Ankylosing, Spondylitis, Ankylosing, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectivesTo investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).MethodsDemographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression.ResultsOf 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19.ConclusionOlder age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.

Published
2023

3. Does the Use of Immunosuppressive Drugs Impact on SARS-CoV-2 Infection Outcome? Data From A National Cohort of Patients With Immune-Mediated Inflammatory Diseases (SAR-COVID Registry)

Author

Isnardi, Carolina Ayelen, Soriano, Enrique R, Graf, Cesar, de la Vega, María Celina, Pons-Estel, Bernardo A, Roberts, Karen, Quintana, Rosana, Gomez, Gimena, Yazdany, Jinoos, Saurit, Verónica, Báez, Roberto Miguel, Coello, Vanessa Viviana Castro, Pisoni, Cecilia Nora, Berbotto, Guillermo, Vivero, Florencia, Zelaya, Marcos David, Salinas, María J Haye, Torres, Álvaro A Reyes, Ornella, Sofía, Nieto, Romina Estefanía, Maldonado, Federico Nicolás, Gamba, María Julieta, de los Ángeles Severina, María, Tissera, Yohana, Alba, Paula, Cogo, Adriana Karina, Alle, Gelsomina, Gobbi, Carla, Baños, Andrea, Velozo, Edson, Pera, Mariana, Tanten, Romina, Albiero, Juan Alejandro, Ficco, Hernán Maldonado, Martire, María Victoria, Elkin, María Soledad Gálvez, Cosatti, Micaela, Cusa, María Alejandra, Pereira, Dora, Savio, Verónica G, and Pons-Estel, Guillermo J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Arthritis, Clinical Research, Autoimmune Disease, Lung, Infectious Diseases, Inflammatory and immune system, Good Health and Well Being, Adult, Humans, COVID-19, SARS-CoV-2, Immunomodulating Agents, Arthritis, Rheumatoid, Immunosuppressive Agents, Registries, rheumatic diseases, Argentina, Arthritis & Rheumatology, Clinical sciences
Abstract

Background/objectiveThis study describes the impact of immunomodulatory and/or immunosuppressive (IM/IS) drugs in the outcomes of COVID-19 infection in a cohort of patients with immune-mediated inflammatory diseases (IMIDs).MethodsAdult patients with IMIDs with a confirmed SARS-CoV-2 infection were included. Data were reported by the treating physician between August 13, 2020 and July 31, 2021. Sociodemographic data, comorbidities, and DMARDs, as well as clinical characteristics, complications, and treatment of the SARS-CoV-2 infection, were recorded. Descriptive analysis and multivariable logistic regression models were carried out.ResultsA total of 1672 patients with IMIDs were included, of whom 1402 were treated with IM/IS drugs. The most frequent diseases were rheumatoid arthritis (47.7%) and systemic lupus erythematosus (18.4%). COVID-19 symptoms were present in 95.2% of the patients. A total of 461 (27.6%) patients were hospitalized, 8.2% were admitted to the intensive care unit, and 4.4% died due to COVID-19.Patients without IM/IS treatment used glucocorticoids less frequently but at higher doses, had higher levels of disease activity, were significantly older, were more frequently hospitalized, admitted to the intensive care unit, and died due to COVID-19. After adjusting for these factors, treatment with IM/IS drugs was not associated with a worse COVID-19 outcome (World Health Organization-Ordinal Scale ≥5) (odds ratio, 1.24; 95% confidence interval, 0.73-2.06).ConclusionsSAR-COVID is the first multicenter Argentine registry collecting data from patients with rheumatic diseases and SARS-CoV-2 infection. After adjusting for relevant covariates, treatment with IM/IS drugs was not associated with severe COVID-19 in patients with IMIDs.Study registrationThis study has been registered in ClinicalTrials.gov under the number NCT04568421.

Published
2023

5. Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis

Author

Bautista-Molano, Wilson, Fernández-Ávila, Daniel G., Brance, María Lorena, Ávila Pedretti, María Gabriela, Burgos-Vargas, Ruben, Corbacho, Inés, Cosentino, Vanesa Laura, Díaz Coto, José Francisco, Giraldo Ho, Enrique, Gomes Resende, Gustavo, Gutiérrez, Luis Arturo, Gutiérrez, Marwin, Ibáñez Vodnizza, Sebastián Eduardo, Jáuregui, Edwin, Ocampo, Vanessa, Palleiro Rivero, Daniel Ruben, Palominos, Penélope Esther, Pacheco Tena, Cesar, Quiceno, Guillermo Andrés, Saldarriaga-Rivera, Lina María, Sommerfleck, Fernando Andrés, Goecke Sariego, Annelise, Vera Barrezueta, Claudia, Vega Espinoza, Luis Enrique, Vega Hinojosa, Oscar, Citera, Gustavo, Lozada, Carlos, Sampaio-Barros, Percival D., Schneeberger, Emilce, and Soriano, Enrique R.

Published
2023
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7. Sociodemographic and clinical factors associated with poor COVID-19 outcomes in patients with rheumatic diseases: data from the SAR-COVID Registry

Author

Isnardi, Carolina A., Roberts, Karen, Saurit, Verónica, Petkovic, Ingrid, Báez, Roberto M., Quintana, Rosana, Tissera, Yohana, Ornella, Sofía, D.Angelo Exeni, Maria Eugenia, Pisoni, Cecilia N., Castro Coello, Vanessa V., Berbotto, Guillermo, Haye Salinas, María J., Velozo, Edson, Reyes Torres, Álvaro A., Tanten, Romina, Zelaya, Marcos D., Gobbi, Carla, Alonso, Carla G., de los Ángeles Severina, María, Vivero, Florencia, Paula, Alba, Cogo, Adriana K., Alle, Gelsomina, Pera, Mariana, Nieto, Romina E., Cosatti, Micaela, Asnal, Cecilia, Pereira, Dora, Albiero, Juan A., Savio, Verónica G., Maldonado, Federico N., Gamba, María Julieta, Germán, Noelia F., Baños, Andrea, Gallino Yanzi, Josefina, Gálvez Elkin, María Soledad, Morbiducci, Julieta S., Martire, María Victoria, Maldonado Ficco, Hernán, Schmid, Maria Marcela, Villafañe Torres, Jaime A., de los Ángeles Correa, Maria, Medina, María Alejandra, Cusa, María Alejandra, Scafati, Julia, Agüero, Santiago E., Lloves Schenone, Nicolás M., Soriano, Enrique R., Graf, Cesar, Pons-Estel, Bernardo A., Gomez, Gimena, Landi, Margarita, De la Vega, María Celina, and Pons-Estel, Guillermo J.

Published
2023
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9. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021

Author

Coates, Laura C., Soriano, Enrique R., Corp, Nadia, Bertheussen, Heidi, Callis Duffin, Kristina, Campanholo, Cristiano B., Chau, Jeffrey, Eder, Lihi, Fernández-Ávila, Daniel G., FitzGerald, Oliver, Garg, Amit, Gladman, Dafna D., Goel, Niti, Helliwell, Philip S., Husni, M. Elaine, Jadon, Deepak R., Katz, Arnon, Laheru, Dhruvkumar, Latella, John, Leung, Ying-Ying, Lindsay, Christine, Lubrano, Ennio, Mazzuoccolo, Luis Daniel, Mease, Philip J., O’Sullivan, Denis, Ogdie, Alexis, Olsder, Wendy, Palominos, Penelope Esther, Schick, Lori, Steinkoenig, Ingrid, de Wit, Maarten, van der Windt, D. A., and Kavanaugh, Arthur

Published
2022
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13. Impact of COVID-19 pandemic on patients with rheumatic diseases in Latin America

Author

Fernández-Ávila, Daniel G., Barahona-Correa, Julián, Romero-Alvernia, Diana, Kowalski, Sergio, Sapag, Ana, Cachafeiro-Vilar, Antonio, Meléndez, Belia, Pastelín, Carlos, Palleiro, Daniel, Arrieta, Dina, Reyes, Gil, Pons-Estel, Guillermo J., Then-Báez, Jossiell, Ugarte-Gil, Manuel F., Cardiel, Mario H., Colman, Nelly, Chávez, Nilmo, Burgos, Paula I., Montufar, Rubén, Sandino, Sayonara, Fuentes-Silva, Yurilis J., and Soriano, Enrique R.

Published
2022
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14. Efficacy and safety of guselkumab in biologic-naïve patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial

Author

Gladman, Dafna D., Mease, Philip J., Bird, Paul, Soriano, Enrique R., Chakravarty, Soumya D., Shawi, May, Xu, Stephen, Quinn, Sean T., Gong, Cinty, Leibowitz, Evan, Poddubnyy, Denis, Tam, Lai-Shan, Helliwell, Philip S., Kavanaugh, Arthur, Deodhar, Atul, Østergaard, Mikkel, and Baraliakos, Xenofon

Published
2022
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16. Current status of the rheumatologists’ workforce in Latin America: a PANLAR collaborative study

Author

Fernández-Ávila, Daniel Gerardo, Patino-Hernandez, Daniela, Kowalskii, Sergio, Vargas-Caselles, Alfredo, Sapag, Ana Maria, Cachafeiro-Vilar, Antonio, Meléndez-Muñoz, Lucia, Santiago-Pastelín, Carlos, Graf, Cesar, Rossetto, Chayanne, Palleiro, Daniel, Trincado, Daniela, Fernández-Ávila, Diana, Arrieta, Dina, Reyes, Gil, Then Baez, Jossiel, Ugarte-Gil, Manuel F., Cardiel, Mario, Colman, Nelly, Chávez, Nilmo, Burgos, Paula I, Montúfar, Ruben, Sandino, Sayonara, Fuentes-Silva, Yurilis, and Soriano, Enrique R.

Published
2021
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18. Design of an algorithm for the diagnostic approach of patients with joint pain

Author

Fernández-Ávila, Daniel G., Rojas, María Ximena, Mora, Sergio A., Varela Rojas, Paola, Vanegas-García, Lucía, Sapag-Durán, Ana María, Hormaza, Andrés Alberto, Fernández, Andres Ricardo, Cachafeiro-Vilar, Antonio, Meléndez, Belia Lucía, Caballero-Uribe, Carlo V., Toro-Gutiérrez, Carlos Enrique, Palleiro-Rivero, Daniel Rubén, Jaimes-Fernández, Diego Alejandro, Arrieta, Dina Maria, Álvarez, Fausto, Pinto-Patarroyo, Gineth Paola, Quiceno, Guillermo Andrés, Pons-Estel, Guillermo, Gómez Puerta, Jose A., Báez, Jossiell Then, Bello-Gualtero, Juan Manuel, Gutiérrez, Juan Martín, Segura, Juan Sebastian, Ferreyra, Leandro Gabriel, Stange, Lilith, Saldarriaga, Lina Maria, Ugarte-Gil, Manuel Francisco, Cardiel, Mario H., Moreno, Mario Javier, Quintero, Maritza, Porras, Marlon B., Colman, Nelly, Chávez, Nilmo Noel, Ruiz, Oscar Orlando, Méndez-Patarroyo, Paul, Machado-Xavier, Ricardo, Caicedo, Tomás, Ocampo, Vanessa, Bautista-Molano, Wilson Armando, Medina, Yimy F., Fuentes-Silva, Yurilis Josefina, and Soriano, Enrique R.

Published
2021
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19. Author Correction: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021

Author

Coates, Laura C., Soriano, Enrique R., Corp, Nadia, Bertheussen, Heidi, Callis Duffin, Kristina, Campanholo, Cristiano B., Chau, Jeffrey, Eder, Lihi, Fernández-Ávila, Daniel G., FitzGerald, Oliver, Garg, Amit, Gladman, Dafna D., Goel, Niti, Helliwell, Philip S., Husni, M. Elaine, Jadon, Deepak R., Katz, Arnon, Laheru, Dhruvkumar, Latella, John, Leung, Ying-Ying, Lindsay, Christine, Lubrano, Ennio, Mazzuoccolo, Luis Daniel, Mease, Philip J., O’Sullivan, Denis, Ogdie, Alexis, Olsder, Wendy, Palominos, Penelope Esther, Schick, Lori, Steinkoenig, Ingrid, de Wit, Maarten, van der Windt, D. A., and Kavanaugh, Arthur

Published
2022
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21. Time to address the challenge of difficult to treat psoriatic arthritis: results from an international survey

Author

Marzo-Ortega, Helena, primary, Harrison, Stephanie Rose, additional, Nagy, György, additional, Machado, Pedro M, additional, McGonagle, Dennis G, additional, Aydin, Sibel Zehra, additional, Almodovar-González, Raquel, additional, Bautista-Molano, Wilson, additional, Gossec, Laure, additional, Lubrano, Ennio, additional, Nash, Peter, additional, Pimentel Santos, Fernando, additional, Soriano, Enrique R, additional, and Siebert, Stefan, additional

Published
2023
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22. ‘It’s about time’. Dissemination and evaluation of a global health systems strengthening roadmap for musculoskeletal health – insights and future directions

Author

Briggs, Andrew M, primary, Chua, Jason, additional, Cross, Marita, additional, Ahmad, Nighat Mir, additional, Finucane, Laura, additional, Haq, Syed Atiqul, additional, Joshipura, Manjul, additional, Kalla, Asgar Ali, additional, March, Lyn, additional, Moscogiuri, Federico, additional, Reis, Felipe J J, additional, Sarfraz, Shabnum, additional, Sharma, Saurab, additional, Soriano, Enrique R, additional, and Slater, Helen, additional

Published
2023
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25. Rheumatology Training in Latin America: A Collaborative Study by the Pan American League of Associations for Rheumatology

Author

Fernández-Ávila, Daniel G., Patino-Hernandez, Daniela, Kowalskii, Sergio, Vargas-Caselles, Alfredo, Sapag, Ana Maria, Cachafeiro-Vilar, Antonio, Meléndez, Belia, Santiago-Pastelín, Carlos, Graf, Cesar, Rossetto, Chayanne, Palleiro, Daniel, Trincado, Daniela, Fernández-Ávila, Diana Carolina, Arrieta, Dina, Reyes, Gil, Baez, Jossiel Then, Ugarte-Gil, Manuel F., Cardiel, Mario, Colman, Nelly, Chávez, Nilmo, Burgos, Paula I., Montufar, Ruben, Sandino, Sayonara, Fuentes-Silva, Yurilis, and Soriano, Enrique R.

Published
2022
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26. Clinical predictors of remission and low disease activity in Latin American early rheumatoid arthritis: data from the GLADAR cohort

Author

Gamboa-Cárdenas, Rocio V, Ugarte-Gil, Manuel F., Loreto, Massardo, Sacnun, Mónica P., Saurit, Verónica, Cardiel, Mario H., Soriano, Enrique R., Pisoni, Cecilia, Galarza-Maldonado, Claudio M., Rios, Carlos, Radominski, Sebastião C., Castelar-Pinheiro, Geraldo da R., Bianchi, Washington Alves, Appenzeller, Simone, da Silveira, Inés Guimarães, de Freitas Zerbini, Cristiano A., Caballero-Uribe, Carlo V., Rojas-Villarraga, Adriana, Guibert-Toledano, Marlene, Ballesteros, Francisco, Montufar, Rubén, Vázquez-Mellado, Janitzia, Esquivel-Valerio, Jorge, De La Torre, Ignacio García, Barile-Fabris, Leonor A., Palezuelos, Fedra Irazoque, Andrade-Ortega, Lilia, Monge, Pablo, Teijeiro, Raquel, Achurra-Castillo, Ángel F., Esteva Spinetti, María H., Alarcón, Graciela S., and Pons-Estel, Bernardo A.

Published
2019
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30. Proceedings of the GRAPPA 2022 Executive Retreat

Author

Ng, Beverly Cheok Kuan, primary, Jadon, Deepak, additional, Adebajo, Adewale, additional, Ayan, Gizem, additional, Callis Duffin, Kristina, additional, Chandran, Vinod, additional, Coates, Laura C., additional, D'Agostino, Maria Antonietta, additional, de Vlam, Kurt, additional, Deodhar, Atul, additional, Eder, Lihi, additional, Garg, Amit, additional, Gladman, Dafna D., additional, Goel, Niti, additional, Gottlieb, Alice B., additional, Husni, M. Elaine, additional, Katz, Arnon, additional, Kavanaugh, Arthur, additional, Lubrano, Ennio, additional, Mease, Philip J., additional, Merola, Joseph F., additional, Nash, Peter, additional, Ogdie, Alexis, additional, Pennington, Stephen R., additional, Perez-Chada, Lourdes M., additional, Proft, Fabian, additional, Rosen, Cheryl F., additional, Savage, Laura, additional, Goldenstein-Schainberg, Claudia, additional, Siebert, Stefan, additional, Soriano, Enrique R., additional, Steinkoenig, Ingrid, additional, Tillett, William, additional, Armstrong, April W., additional, and FitzGerald, Oliver, additional

Published
2023
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31. GRAPPA 2021 Pilot Grant Award Reports

Author

Kasiem, Fazira R., primary, Yamada, Daisuke, additional, Marin, Josefina, additional, Vis, Marijn, additional, Tillett, William, additional, Hwang, Samuel T., additional, Soriano, Enrique R., additional, FitzGerald, Oliver, additional, and Armstrong, April W., additional

Published
2023
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36. Pan American League of Associations for Rheumatology Recommendations for the Treatment of Psoriatic Arthritis

Author

Fernández-Ávila, Daniel G., Bautista-Molano, Wilson, Brance, María Lorena, Ávila Pedretti, María Gabriela, Vargas, Rubén Burgos, Díaz Coto, José Francisco, Gutiérrez, Luis Arturo, Gutiérrez, Marwin, Ho, Enrique Giraldo, Ibáñez Vodnizza, Sebastián Eduardo, Jáuregui, Edwin, Ocampo, Vanessa, Palominos, Penélope Esther, Palleiro Rivero, Daniel Ruben, Quiceno, Guillermo Andrés, Sommerfleck, Fernando Andrés, Vega Espinoza, Luis Enrique, Hinojosa, Oscar Vega, Barrezueta, Claudia Vera, Corbacho, Inés, Cosentino, Vanesa Laura, Sariego, Annelise Goecke, Resende, Gustavo Gomes, Saldarriaga-Rivera, Lina María, Pacheco Tena, Cesar Francisco, Citera, Gustavo, Lozada, Carlos, Ranza, Roberto, Sampaio-Barros, Percival D., Schneeberger, Emilce, and Soriano, Enrique R.

Abstract

ObjectivePsoriatic arthritis (PsA) is chronic disease that compromises multiple domains and might be associated with progressive joint damage, increased mortality, functional limitation, and considerably impaired quality of life. Our objective was to generate evidence-based recommendations on the management of PsA in Pan American League of Associations for Rheumatology (PANLAR) countries.MethodsWe used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE)-ADOLOPMENT approach to adapt the 2019 recommendations of the European Alliance of Associations for Rheumatology. A working group consisting of rheumatologists from various countries in Latin America identified relevant topics for the treatment of PsA in the region. The methodology team updated the evidence and synthesized the information used to generate the final recommendations. These were then discussed and defined by a panel of 31 rheumatologists from 15 countries.ResultsTheses guidelines report 15 recommendations addressing therapeutic targets, use of antiinflammatory agents and corticosteroids, treatment with disease-modifying antirheumatic drugs (conventional synthetic, biologic, and targeted synthetic), therapeutic failure, optimization of biologic therapy, nonpharmacological interventions, assessment tools, and follow-up of patients with PsA.ConclusionHere we present a set of recommendations to guide decision making in the treatment of PsA in Latin America, based on the best evidence available, considering resources, medical expertise, and the patient’s values and preferences. The successful implementation of these recommendations should be based on clinical practice conditions, healthcare settings in each country, and a tailored evaluation of patients.

Published
2024
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37. Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis

Author

Machado, Pedro M, Schäfer, Martin, Mahil, Satveer K, Liew, Jean, Gossec, Laure, Dand, Nick, Pfeil, Alexander, Strangfeld, Anja, Regierer, Anne Constanze, Fautrel, Bruno, Alonso, Carla Gimena, Saad, Carla G S, Griffiths, Christopher E M, Lomater, Claudia, Miceli-Richard, Corinne, Wendling, Daniel, Alpizar Rodriguez, Deshire, Wiek, Dieter, Mateus, Elsa F, Sirotich, Emily, Soriano, Enrique R, Ribeiro, Francinne Machado, Omura, Felipe, Rajão Martins, Frederico, Santos, Helena, Dau, Jonathan, Barker, Jonathan N, Hausmann, Jonathan, Hyrich, Kimme L, Gensler, Lianne, Silva, Ligia, Jacobsohn, Lindsay, Carmona, Loreto, Pinheiro, Marcelo M, Zelaya, Marcos David, Severina, María de Los Ángeles, Yates, Mark, Dubreuil, Maureen, Gore-Massy, Monique, Romeo, Nicoletta, Haroon, Nigil, Sufka, Paul, Grainger, Rebecca, Hasseli, Rebecca, Lawson-Tovey, Saskia, Bhana, Suleman, Pham, Thao, Olofsson, Tor, Bautista-Molano, Wilson, Wallace, Zachary S, Yiu, Zenas Z N, Yazdany, Jinoos, Robinson, Philip C, Smith, Catherine H, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
SDG 3 - Good Health and Well-being
Abstract

Funding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR). OBJECTIVES: To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). METHODS: Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. RESULTS: Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. CONCLUSION: Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics. publishersversion published

Published
2023

39. Multidomain Efficacy and Safety of Guselkumab Through 1 Year in Patients With Active Psoriatic Arthritis With and Without Prior Tumor Necrosis Factor Inhibitor Experience: Analysis of the Phase 3, Randomized, Placebo‐Controlled DISCOVER ‐1 Study

Author

Ritchlin, Christopher T., primary, Deodhar, Atul, additional, Boehncke, Wolf‐Henning, additional, Soriano, Enrique R., additional, Kollmeier, Alexa P., additional, Xu, Xie L., additional, Zazzetti, Federico, additional, Shawi, May, additional, Jiang, Yusang, additional, Sheng, Shihong, additional, and Helliwell, Philip S., additional

Published
2023
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40. Towards healthy populations: A need to strengthen systems for musculoskeletal health

Author

Briggs, Andrew M, primary, Betteridge, Neil, additional, Dreinhöfer, Karsten E., additional, Haq, Syed Atiqul, additional, Huckel Schneider, Carmen, additional, Kalla, Asgar Ali, additional, Kopansky-Giles, Deborah, additional, March, Lyn, additional, Sharma, Saurab, additional, Soriano, Enrique R., additional, Woolf, Anthony D., additional, Young, James J., additional, and Slater, Helen, additional

Published
2023
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41. Comparison of disease activity index for psoriatic arthritis (DAPSA) and minimal disease activity (MDA) targets for patients with psoriatic arthritis: A post hoc analysis of data from phase 3 tofacitinib studies

Author

Schneeberger, Emilce E., primary, Citera, Gustavo, additional, Nash, Peter, additional, Smolen, Josef S., additional, Mease, Philip J., additional, Soriano, Enrique R., additional, Helling, Claudia, additional, Szumski, Annette E., additional, Mundayat, Rajiv, additional, and de León, Darío Ponce, additional

Published
2023
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42. Correction to: Clinical predictors of remission and low disease activity in Latin American early rheumatoid arthritis: data from the GLADAR cohort

Author

Gamboa-Cárdenas, Rocio V, Ugarte-Gil, Manuel F., Massardo, Loreto, Sacnun, Mónica P., Saurit, Verónica, Cardiel, Mario H., Soriano, Enrique R., Pisoni, Cecilia, Galarza-Maldonado, Claudio M., Rios, Carlos, Radominski, Sebastião C., Castelar-Pinheiro, Geraldo da R., Bianchi, Washington Alves, Appenzeller, Simone, da Silveira, Inés Guimarães, de Freitas Zerbini, Cristiano A., Caballero-Uribe, Carlo V., Rojas-Villarraga, Adriana, Guibert-Toledano, Marlene, Ballesteros, Francisco, Montufar, Rubén, Vázquez-Mellado, Janitzia, Esquivel-Valerio, Jorge, De La Torre, Ignacio García, Barile-Fabris, Leonor A., Palezuelos, Fedra Irazoque, Andrade-Ortega, Lilia, Monge, Pablo, Teijeiro, Raquel, Achurra-Castillo, Ángel F., Esteva Spinetti, María H., Alarcón, Graciela S., and Pons-Estel, Bernardo A.

Published
2019
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46. Management of Concomitant Inflammatory Bowel Disease or Uveitis in Patients With Psoriatic Arthritis: An Updated Review Informing the 2021 GRAPPA Treatment Recommendations

Author

Jadon, Deepak R., primary, Corp, Nadia, additional, van der Windt, Danielle A., additional, Coates, Laura C., additional, Soriano, Enrique R., additional, Kavanaugh, Arthur, additional, Raine, Tim, additional, Rieder, Florian, additional, Siebert, Stefan, additional, Zummer, Michel, additional, Schwartzman, Sergio, additional, Rosenbaum, James T., additional, Michelsen, Brigitte, additional, Laxminarayan, Ramasharan, additional, Wu, Dongze, additional, Gupta, Latika, additional, Ng, Beverly, additional, Jethwa, Hannah, additional, De Windt, Nick, additional, Gudu, Tania, additional, Hutton, Joseph, additional, O'Sullivan, Denis, additional, Luchetti, Michele M., additional, Stoll, Matthew, additional, Singh, Jasvinder A., additional, Peluso, Rosario, additional, Rademacher, Judith, additional, and Husni, M. Elaine, additional

Published
2022
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47. Management of Peripheral Arthritis in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Author

Leung, Ying-Ying, primary, Korotaeva, Tatiana, additional, Candia, Liliana, additional, Pedersen, Susanne Juhl, additional, Molano, Wilson Bautista, additional, Ruderman, Eric M., additional, Bisoendial, Radjesh, additional, Perez-Alamino, Rodolfo, additional, Olsder, Wendy, additional, Möller, Burkhard, additional, Grazio, Simeon, additional, Gudu, Tania, additional, Mody, Girish M., additional, Pineda, Carlos, additional, Raffayova, Helena, additional, Rohekar, Sherry, additional, Goldenstein-Schainberg, Claudia, additional, Gutierrez Urena, Sergio R., additional, Casasola Vargas, Julio César, additional, Meghnathi, Bhowmik, additional, Prasad, Roopa, additional, Richette, Pascal, additional, Miranda, Jose Roberto S., additional, Malliotis, Nikolas, additional, Lindqvist, Ulla, additional, Simon, David, additional, Ezeonyeji, Amara, additional, Soriano, Enrique R., additional, and FitzGerald, Oliver, additional

Published
2022
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48. Does the Use of Immunosuppressive Drugs Impact on SARS-CoV-2 Infection Outcome? Data From A National Cohort of Patients With Immune-Mediated Inflammatory Diseases (SAR-COVID Registry)

Author

Isnardi, Carolina Ayelen, primary, Soriano, Enrique R., additional, Graf, Cesar, additional, de la Vega, María Celina, additional, Pons-Estel, Bernardo A., additional, Roberts, Karen, additional, Quintana, Rosana, additional, Gomez, Gimena, additional, Yazdany, Jinoos, additional, Saurit, Verónica, additional, Báez, Roberto Miguel, additional, Coello, Vanessa Viviana Castro, additional, Pisoni, Cecilia Nora, additional, Berbotto, Guillermo, additional, Vivero, Florencia, additional, Zelaya, Marcos David, additional, Haye Salinas, María J., additional, Reyes Torres, Álvaro A., additional, Ornella, Sofía, additional, Nieto, Romina Estefanía, additional, Maldonado, Federico Nicolás, additional, Gamba, María Julieta, additional, Severina, María de los Ángeles, additional, Tissera, Yohana, additional, Alba, Paula, additional, Cogo, Adriana Karina, additional, Alle, Gelsomina, additional, Gobbi, Carla, additional, Baños, Andrea, additional, Velozo, Edson, additional, Pera, Mariana, additional, Tanten, Romina, additional, Albiero, Juan Alejandro, additional, Maldonado Ficco, Hernán, additional, Martire, María Victoria, additional, Elkin, María Soledad Gálvez, additional, Cosatti, Micaela, additional, Cusa, María Alejandra, additional, Pereira, Dora, additional, Savio, Verónica G., additional, and Pons-Estel, Guillermo J., additional

Published
2022
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