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1. Exploring Semi-Active TMD Performance on Lively Footbridges Considering Human–Structure Interaction in Vertical Direction.

Author

Soria, J. M., Jiménez-Alonso, J. F., Renedo, C. M. C., and Gallegos-Calderón, C.

Subjects
*TUNED mass dampers, *HABITAT suitability index models, *FOOTBRIDGES, *PEDESTRIANS, *PERFORMANCE theory
Abstract

Human–Structure Interaction (HSI) can significantly influence the dynamic characteristics of pedestrian footbridges, particularly those distinguished by their lightness and slenderness. This study examines the performance of Tuned Mass Dampers (TMD) and Semi-Active Tuned Mass Dampers (STMD) on pedestrian footbridges when their modal parameters change due to the influence of HSI. For this purpose, a 30 m long simply-supported footbridge with linear mass values ranging from 200kg/m to 2000kg/m and a fundamental frequency varying from 1Hz to 5Hz has been considered. In addition, several pedestrian streams with different pedestrian densities have been used to assess the structural dynamic response. The analysis highlights that structural lightness and slenderness are critical factors in determining whether the incorporation of an HSI model is relevant to accurately predict the dynamic performance of the structure. The findings indicate that while TMDs can become ineffective due to shifts in natural frequencies caused by HSI, resulting in a degradation of vibration reduction from 70–75% to 40–45%, STMDs demonstrate a robust capability to adjust and cope with these frequency changes, maintaining a higher average vibration reduction of around 55–60%. Consequently, STMDs emerge as a necessary solution for very slender structures where HSI significantly alters the global frequency response. This study highlights the importance of considering HSI in the design and implementation of damping solutions to ensure optimal functionality and user comfort on lightweight pedestrian bridges. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Estudio de las fluctuaciones del nivel del agua en la laguna de Gallocanta (Aragón, España) mediante imágenes satelitales de Sentinel-2

Author

Morales, S., Ruiz, M., Soria, J. M., Morales, S., Ruiz, M., and Soria, J. M.

Abstract

[EN] This study has been monitored for five years by Sentinel-2 satellite images, at different seasons of the year, of the fluctuations in the water level of the Gallocanta Lake (between the provinces of Teruel and Zaragoza, Spain) considered a hypersaline and endorheic wetland, which has characteristics that make it unique in the geographical area in which it is located, as well as for the operation of the system. Rainfall in the area has a wide variation giving the maximums in the moths of May and June and the minimums in January and February, with considerable fluctuations in the water level from the almost total drying of the lagoon to the filling with a depth of approximately 3 meters., [ES] En este estudio se ha realizado un seguimiento de cinco años mediante imágenes satelitales de Sentinel-2, en diferentes estaciones del año, de las fluctuaciones del nivel del agua de la Laguna de Gallocanta (entre las provincias de Teruel y Zaragoza. Aragón, España) considerado un humedal hipersalino y endorreico, el cual posee características que la hacen única en la zona geográfica en la que se encuentra, así como para el funcionamiento del sistema. Las precipitaciones en la zona poseen una amplia variación, dándose las máximas en los meses de mayo y junio y las mínimas en enero y febrero, produciéndose considerables fluctuaciones en el nivel del agua desde la desecación casi total de la laguna hasta el llenado con una profundidad aproximada de 3 metros.

Published
2021

17. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

Author

DE VRIES, P. S., SABATER-LLEAL, M., HUFFMAN, J. E., MARTEN, J., Song, C., PANKRATZ, N., BARTZ, T. M., DE HAAN, H. G., DELGADO, G. E., EICHER, J. D., MARTINEZ-PEREZ, A., WARD-CAVINESS, C. K., BRODY, J. A., CHEN, M. H., DE MAAT, M. P. M., Franberg, M., Gill, D., KLEBER, M. E., Rivadeneira, F., SORIA, J. M., Tang, W., TOFLER, G. H., UITTERLINDEN, A. G., van Hylckama Vlieg, A., SESHADRI, S., BOERWINKLE, E., DAVIES, N. M., GIESE, A. K., IKRAM, M. K., KITTNER, S. J., MCKNIGHT, B., PSATY, B. M., REINER, A. P., Sargurupremraj, Muralidharan, TAYLOR, K. D., CONSORTIUM, Invent, FORNAGE, M., HAMSTEN, A., MARZ, W., ROSENDAAL, F. R., SOUTO, J. C., DEHGHAN, A., JOHNSON, A. D., MORRISON, A. C., O'DONNELL, C. J., SMITH, N. L., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
VINTAGE, hemic and lymphatic diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, cardiovascular diseases
Abstract

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (seven FVII activity and two FVII antigen) among 27,495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the seven studies that measured FVII activity, and a secondary analysis included all nine studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell line (HuH7) using siRNA and then measuring F7 mRNA and FVII protein expression. Lastly, we used meta-analysis results to perform Mendelian randomization analysis to estimate the causal effect of FVII activity on coronary artery disease, ischemic stroke, and venous thromboembolism. We identified two novel (REEP3 and JAZF1-AS1) and six known loci associated with FVII activity, explaining 19.0% of the phenotypic variance. Adding FVII antigen data to the meta-analysis did not result in the discovery of further loci. Silencing REEP3 in HuH7 cells upregulated FVII, while silencing JAZF1 downregulated FVII. Mendelian randomization analyses suggest that FVII activity has a positive causal effect on the risk of ischemic stroke. Variants at REEP3 and JAZF1 contribute to FVII activity by regulating F7 expression levels. FVII activity appears to contribute to the etiology of ischemic stroke in the general population.

Published
2019
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22. A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins

Author

European Cooperation in Science and Technology, Hernández, Armand [0000-0001-7245-9863], Mantzouki, E., Campbell, James, van Loon, E., Visser, P., Konstantinou, I., Antoniou, M., Giuliani, G., Machado-Vieira, D., Gurjão de Oliveira, Alinne, Maronić, D.Š., Stević, F., Hiskia, A., Gkelis, S., Walusiak, E., Panou, M., McCarthy, V., Budzyńska, A., Perello, V.C., Kostrzewska-Szlakowska, I., Gonçalves, V., Skjelbred, B., Palomino, Roberto L., Obertegger, U., Boscaini, A., Flaim, G., Salmaso, N., Gagala, I., Cerasino, L., Mankiewicz-Boczek, J., Hansson, L. A., Grabowska, M., Karpowicz, M., Rodríguez-Pérez, E., Chmura, D., Nawrocka, L., Kozak, A., Kobos, J., Rosińska, J., Seelen, L., Toporowska, M., Pawlik-Skowronska, B., Urrutia-Cordero, Pablo, Niedźwiecki, M., Maliaka, V., Pęczuła, W., Wasilewicz, M., Napiórkowska-Krzebietke, A., Ochocka, A., Beklioğlu, M., Szeląg-Wasielewska, E., Domek, P., Teurlincx, S., Jakubowska-Krepska, N., Tavşanoğlu, ÜN., Carballeira, R., Kwasizur, K., Drastichova, I., Messyasz, B., Chomova, L., Soylu, E.N., Pasztaleniec, A., Jasser, I., Filiz, N., Antão-Geraldes, A. M., Bilgin, F., Camacho, A., Özen, A., Leira, M., Hernández, Armand, Vasconcelos, V., Remec-Rekar, S., Pfeiffer, T.Ž., Eleršek, Tina, Delgado-Martín, Jordi, Yağcı, M.A., García, D., Bezirci, G., Bláha, L., Bravo, Andrea G., Verstijnen, Y., Cereijo, J. L., Gomà, Joan, Trapote, M.C., Vegas-Vilarrúbia, Teresa, Obrador, B., García-Murcia, A., Real, M., Picazo, Antoni, Vucelić, I.B., Romans, E., Cesur, M., Çınar, Ş., Lürling, M., Levi, E., Noguero-Ribes, J., Duque, D.P., Fernández-Morán, E., Úbeda, B., Yağcı, A., Gálvez, J.Á., Marcé, Rafael, Catalán, N., Buck, Moritz, Pérez-Martínez, Carmen, Ramos-Rodríguez, E., Tsiarta, N., Žutinić, P., Iskin, U., Çapkın, K., Udovič, M.G., Cillero-Castro, C., Moreno-Ostos, Enrique, Blanco, J. M., Rodríguez, V., Plenković-Moraj, Anđelka, Montes-Pérez, J.J., Colom-Montero, W., Koreivienė, J., Rochera, C., Santamans, A. C., Ferriol, C., Romo, S., Faassen, E.J., Soria, J. M., Latour, D., Mazur-Marzec, Hanna, Mustonen, K., Pierson, D., Kasperovičienė, J., Yang, Y., Verspagen, Jolanda M. H., Çelik, K., de Senerpont Domis, L.N., Özhan, K., Dunalska, J., Carey, C.C., Paerl, Hans, Alcaraz-Párraga, P., Torokne, A., Goldyn, R., Karan, T., Bulut, C., Demir, N., Uysal, R., Pełechata, A., Karakaya, N., Koçer, M.A.T., Sieńska, J., Yilmaz, M., Bańkowska-Sobczak, A., Savadova, K., Maraşlıoğlu, F., Geriš, R., Fakioglu, Ö., Fránková, M., Morais, J., Köker, L., Bergkemper, V., Pełechaty, M., O'Leary, S., Nemova, H., Vitonytė, I., Wilk-Woźniak, E., Beirne, E., Cromie, H., Ibelings, Bas W., Christoffersen, K. S., Warming, T.P., Feldmann, T., Laas, A., Vale, M., Panksep, K., Frąk, M., Kokocinski, M., Krztoń, W., Szymański, D., Tuvikene, L., Kangro, K., Häggqvist, K., Salmi, P., Arvola, L., Fastner, J., Straile, D., Haande, S., Rothhaupt, K. O., Fonvielle, J., Krstić, S., Raposeiro, P. M., Kruk, M., Madrecka, B., Grossart, Hans-Peter, Avagianos, C., Kaloudis, T., Triantis, T., Aleksovski, B., Zervou, S. K., European Cooperation in Science and Technology, Hernández, Armand [0000-0001-7245-9863], Mantzouki, E., Campbell, James, van Loon, E., Visser, P., Konstantinou, I., Antoniou, M., Giuliani, G., Machado-Vieira, D., Gurjão de Oliveira, Alinne, Maronić, D.Š., Stević, F., Hiskia, A., Gkelis, S., Walusiak, E., Panou, M., McCarthy, V., Budzyńska, A., Perello, V.C., Kostrzewska-Szlakowska, I., Gonçalves, V., Skjelbred, B., Palomino, Roberto L., Obertegger, U., Boscaini, A., Flaim, G., Salmaso, N., Gagala, I., Cerasino, L., Mankiewicz-Boczek, J., Hansson, L. A., Grabowska, M., Karpowicz, M., Rodríguez-Pérez, E., Chmura, D., Nawrocka, L., Kozak, A., Kobos, J., Rosińska, J., Seelen, L., Toporowska, M., Pawlik-Skowronska, B., Urrutia-Cordero, Pablo, Niedźwiecki, M., Maliaka, V., Pęczuła, W., Wasilewicz, M., Napiórkowska-Krzebietke, A., Ochocka, A., Beklioğlu, M., Szeląg-Wasielewska, E., Domek, P., Teurlincx, S., Jakubowska-Krepska, N., Tavşanoğlu, ÜN., Carballeira, R., Kwasizur, K., Drastichova, I., Messyasz, B., Chomova, L., Soylu, E.N., Pasztaleniec, A., Jasser, I., Filiz, N., Antão-Geraldes, A. M., Bilgin, F., Camacho, A., Özen, A., Leira, M., Hernández, Armand, Vasconcelos, V., Remec-Rekar, S., Pfeiffer, T.Ž., Eleršek, Tina, Delgado-Martín, Jordi, Yağcı, M.A., García, D., Bezirci, G., Bláha, L., Bravo, Andrea G., Verstijnen, Y., Cereijo, J. L., Gomà, Joan, Trapote, M.C., Vegas-Vilarrúbia, Teresa, Obrador, B., García-Murcia, A., Real, M., Picazo, Antoni, Vucelić, I.B., Romans, E., Cesur, M., Çınar, Ş., Lürling, M., Levi, E., Noguero-Ribes, J., Duque, D.P., Fernández-Morán, E., Úbeda, B., Yağcı, A., Gálvez, J.Á., Marcé, Rafael, Catalán, N., Buck, Moritz, Pérez-Martínez, Carmen, Ramos-Rodríguez, E., Tsiarta, N., Žutinić, P., Iskin, U., Çapkın, K., Udovič, M.G., Cillero-Castro, C., Moreno-Ostos, Enrique, Blanco, J. M., Rodríguez, V., Plenković-Moraj, Anđelka, Montes-Pérez, J.J., Colom-Montero, W., Koreivienė, J., Rochera, C., Santamans, A. C., Ferriol, C., Romo, S., Faassen, E.J., Soria, J. M., Latour, D., Mazur-Marzec, Hanna, Mustonen, K., Pierson, D., Kasperovičienė, J., Yang, Y., Verspagen, Jolanda M. H., Çelik, K., de Senerpont Domis, L.N., Özhan, K., Dunalska, J., Carey, C.C., Paerl, Hans, Alcaraz-Párraga, P., Torokne, A., Goldyn, R., Karan, T., Bulut, C., Demir, N., Uysal, R., Pełechata, A., Karakaya, N., Koçer, M.A.T., Sieńska, J., Yilmaz, M., Bańkowska-Sobczak, A., Savadova, K., Maraşlıoğlu, F., Geriš, R., Fakioglu, Ö., Fránková, M., Morais, J., Köker, L., Bergkemper, V., Pełechaty, M., O'Leary, S., Nemova, H., Vitonytė, I., Wilk-Woźniak, E., Beirne, E., Cromie, H., Ibelings, Bas W., Christoffersen, K. S., Warming, T.P., Feldmann, T., Laas, A., Vale, M., Panksep, K., Frąk, M., Kokocinski, M., Krztoń, W., Szymański, D., Tuvikene, L., Kangro, K., Häggqvist, K., Salmi, P., Arvola, L., Fastner, J., Straile, D., Haande, S., Rothhaupt, K. O., Fonvielle, J., Krstić, S., Raposeiro, P. M., Kruk, M., Madrecka, B., Grossart, Hans-Peter, Avagianos, C., Kaloudis, T., Triantis, T., Aleksovski, B., and Zervou, S. K.

Abstract

Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.

Published
2018

24. The Pliocene Mediterranean infilling of the Messinian Erosional Surface: New biostratigraphic data based on calcareous nannofossils (Bajo Segura Basin, SE Spain)

Author

LANCIS, C., TENT-MANCLÚS, J. E., FLORES, J. A., and SORIA, J. M.

Subjects
Pliocene, Messinian Erosional Surface, Calcareous nannofossils, Zanclean, Messinian Salinity Crisis
Abstract

The Bajo Segura Basin (eastern Betic Cordillera) is a Mediterranean marginal basin where the Messinian Erosional Surface (MES), formed during the Messinian Salinity Crisis sea-level fall, is well developed. Overlying this major discontinuity the lower Pliocene transgressive sediments record the reflooding of the Mediterranean and the return to an open marine environment, the continental shelf being rebuilt after the Messinian erosion. The stratigraphic and biostratigraphic study of seven sections allow two transgressive-regressive sequences filling the MES to be distinguished, correlated with the previously distinguished Mediterranean offshore seismic units. Ten calcareous nannofossil bioevents have been identified. The lower sequence can be dated according to nannofossil biozones NN12 to NN14 and the upper sequence by NN15 to NN16. The boundary between both lower Pliocene sedimentary sequences is dated by the First Common Occurrence (FCO) of Discoaster asymmetricus in the uppermost sediment of the lower sequence and the First Occurrence (FO) of Discoaster tamalis in the lowermost part of the upper sequence. This discontinuity can be calibrated at between 4.1 and 4.0 Ma ago.

Published
2015

25. PDGFB, a new candidate plasma biomarker for venous thromboembolism : Results from the VEREMA affinity proteomics study

Author

Bruzelius, M., Iglesias, Maria Jesus, Hong, Mun-Gwan, Sanchez-Rivera, Laura, Gyorgy, B., Souto, J. C., Franberg, M., Fredolini, Claudia, Strawbridge, R. J., Holmström, M., Hamsten, A., Uhlén, Mathias, Silveira, A., Soria, J. M., Smadja, D. M., Butler, L. M., Schwenk, Jochen M., Morange, P. -E, Trégouët, D. -A, Odeberg, Jacob, Bruzelius, M., Iglesias, Maria Jesus, Hong, Mun-Gwan, Sanchez-Rivera, Laura, Gyorgy, B., Souto, J. C., Franberg, M., Fredolini, Claudia, Strawbridge, R. J., Holmström, M., Hamsten, A., Uhlén, Mathias, Silveira, A., Soria, J. M., Smadja, D. M., Butler, L. M., Schwenk, Jochen M., Morange, P. -E, Trégouët, D. -A, and Odeberg, Jacob

Abstract

There is a clear clinical need for high-specificity plasma biomarkers for predicting risk of venous thromboembolism (VTE), but thus far, such markers have remained elusive. Utilizing affinity reagents from the Human Protein Atlas project and multiplexed immuoassays, we extensively analyzed plasma samples from 2 individual studies to identify candidate protein markers associated with VTE risk. We screened plasma samples from 88 VTE cases and 85 matched controls, collected as part of the Swedish ¡°Venous Thromboembolism Biomarker Study,¡± using suspension bead arrays composed of 755 antibodies targeting 408 candidate proteins. We identified significant associations between VTE occurrence and plasma levels of human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1), von Willebrand factor (VWF), glutathione peroxidase 3 (GPX3), and platelet-derived growth factor β (PDGFB). For replication, we profiled plasma samples of 580 cases and 589 controls from the French FARIVE study. These results confirmed the association of VWF and PDGFB with VTE after correction for multiple testing, whereas only weak trends were observed for HIVEP1 and GPX3. Although plasma levels of VWF and PDGFB correlated modestly (p ~ 0.30) with each other, they were independently associated with VTE risk in a joint model in FARIVE (VWF P < .001; PDGFB P 5 .002). PDGF was verified as the target of the capture antibody by immunocapture mass spectrometry and sandwich enzyme-linked immunosorbent assay. In conclusion, we demonstrate that high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with VTE., QC 20170523

Published
2016
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26. Verema - an affinity proteomics study to identify and translate plasma biomarkers for venous thromboembolism

Author

Bruzelius, M., Iglesias, Maria Jesus, Hong, Mun-Gwan, Tregouet, D. A., Souto, J. C., Holmström, M., Frånberg, M., Strawbridge, R. J., Sabater-Lleal, M., Sennblad, B., Silveira, A., Soria, J. M., Morange, P. E., Butler, L., Schwenk, Jochen M., Hamsten, A., Odeberg, Jacob, Bruzelius, M., Iglesias, Maria Jesus, Hong, Mun-Gwan, Tregouet, D. A., Souto, J. C., Holmström, M., Frånberg, M., Strawbridge, R. J., Sabater-Lleal, M., Sennblad, B., Silveira, A., Soria, J. M., Morange, P. E., Butler, L., Schwenk, Jochen M., Hamsten, A., and Odeberg, Jacob

Abstract

QC 20150727

Published
2015

27. Organización estratigráfica y bioestratigrafía del plioceno en el borde sur de la Cuenca del Bajo Segura (sector de Rojales, Alicante), cordillera Bética Oriental

Author

Serrano, F., Ruiz Bustos, A., Alfaro, P., and Soria, J. M.

Subjects
lcsh:Geology, Pliocene, Cuenca del Bajo Segura, estratigrafía, lcsh:QE1-996.5, stratigraphy, Cordillera Bética Oriental, Low Segura Basin, biostratigrafía, Plioceno, biostratigraphy, Eastern Betic Cordillera
Abstract

In the Rojales area, at the southem border of the Low Segura Basin (province of Alicante), we have studied four formations already defined by Montenat (1973, 1977). All of them constitute a continue stratigraphic succession and represent a general regressive sequence, where open basin facies (Hurchillo Marls Fm.), shelf and coastal facies (Rojales Sandstone Fm.) and continental facies (Variegated Sandstones and Marls Fm. and Segura Conglomerates Fm.) gradually evolve from the bottom to the topo The biostratigraphic data of planktonic foraminifera allows the date the top of the Hurchillo Marls Fm. as the upper part of the lower Pliocene (NI9-N2ü of the Blow zonation). The study of a new site of microvertebrates, named as Rojales, allows the dating the top of the Variegated Sandstones and Marls Fm. (in the transition with the Segura Conglomerates Fm.) as upper Ruscinian (start of MN15 of the Mein biozonation). These chronological data show that the whole stratigraphic succession of the Rojales area has a age corresponding to the final part of the lower Pliocene.En el sector de Rojales (Alicante), situado en el borde meridional de la Cuenca del Bajo Segura, se han estudiado cuatro formaciones ya definidas por Montenat (1977). Todas ellas se suceden en continuidad estratigráfica y representan una secuencia general regresiva en la que evolucionan gradualmente (desde la base hasta el techo) conjuntos de facies marinas de cuenca abierta y de transición a plataforma (Fm. Margas de Hurchillo), de plataforma y litorales (Fm. Areniscas de Rojales) y continentales (Fm. de Areniscas y Margas Versicolores y Fm. Conglomerados del Segura). Los datos biostratigráficos basados en foraminíferos planctónicos permiten asignar el techo de la Fm. Margas de Hurchillo a la parte más alta del Plioceno inferior (intervalo N19-N2ü de la zonación de Blow). El estudio de los microvertebrados de un nuevo yacimiento, denominado yacimiento de Rojales, situado en el tránsito entre la Fm. Areniscas y Margas Versicolores y la Fm. Conglomerados del Segura, permite datar el Rusciniense superior basal (comienzo de la biozona MN15 de Mein). Estos datos cronológicos indican que toda la sucesión estratigráfica de Rojales presenta una edad Plioceno inferior muy alto.

Published
1996

28. Organización estratigráfica y bioestratigrafía del plioceno en el borde sur de la Cuenca del Bajo Segura (sector de Rojales, Alicante), cordillera Bética Oriental

Author

Soria, J. M., Alfaro, P., Ruiz Bustos, Antonio, Serrano, Francisco, Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, and Cambios Paleoambientales

Subjects
QE1-996.5, Pliocene, plioceno, Stratigraphy, Estratigrafía, Biostratigraphy, Plioceno, Low Segura Basin, Geology, cordillera bética oriental, estratigrafía, Cordillera Bética Oriental, cuenca del bajo segura, Biostratigrafía, Cuenca del Bajo Segura, Eastern Betic Cordillera, biostratigrafía
Abstract

9 páginas, 6 figuras., [ES] En el sector de Rojales (Alicante), situado en el borde meridional de la Cuenca del Bajo Segura, se han estudiado cuatro formaciones ya definidas por Montenat (1977). Todas ellas se suceden en continuidad estratigráfica y representan una secuencia general regresiva en la que evolucionan gradualmente (desde la base hasta el techo) conjuntos de facies marinas de cuenca abierta y de transición a plataforma (Fm. Margas de Hurchillo), de plataforma y litorales (Fm. Areniscas de Rojales) y continentales (Fm. de Areniscas y Margas Versicolores y Fm. Conglomerados del Segura). Los datos biostratigráficos basados en foraminíferos planctónicos permiten asignar el techo de la Fm. Margas de Hurchillo a la parte más alta del Plioceno inferior (intervalo N19-N2ü de la zonación de Blow). El estudio de los microvertebrados de un nuevo yacimiento, denominado yacimiento de Rojales, situado en el tránsito entre la Fm. Areniscas y Margas Versicolores y la Fm. Conglomerados del Segura, permite datar el Rusciniense superior basal (comienzo de la biozona MN15 de Mein). Estos datos cronológicos indican que toda la sucesión estratigráfica de Rojales presenta una edad Plioceno inferior muy alto., [EN] In the Rojales area, at the southem border of the Low Segura Basin (province of Alicante), we have studied four formations already defined by Montenat (1973, 1977). All of them constitute a continue stratigraphic succession and represent a general regressive sequence, where open basin facies (Hurchillo Marls Fm.), shelf and coastal facies (Rojales Sandstone Fm.) and continental facies (Variegated Sandstones and Marls Fm. and Segura Conglomerates Fm.) gradually evolve from the bottom to the topo The biostratigraphic data of planktonic foraminifera allows the date the top of the Hurchillo Marls Fm. as the upper part of the lower Pliocene (NI9-N2ü of the Blow zonation). The study of a new site of microvertebrates, named as Rojales, allows the dating the top of the Variegated Sandstones and Marls Fm. (in the transition with the Segura Conglomerates Fm.) as upper Ruscinian (start of MN15 of the Mein biozonation). These chronological data show that the whole stratigraphic succession of the Rojales area has a age corresponding to the final part of the lower Pliocene., Este trabajo ha sido financiado por la CICYT, Proyecto AMB92-053 l.

Published
1996
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29. Precisiones biostratigráficas y paleoecológicas en el Neogeno de la Cuenca del Bajo Segura (Cordillera Bética oriental)

Author

Alfaro, P., Soria, J. M., Ruiz Bustos, A., Cambios Paleoambientales, Evolución Geodinámica de la Cordillera Bética Oriental y de la Plataforma Marina de Alicante, and Universidad de Alicante. Departamento de Ciencias Ambientales y Recursos Naturales

Subjects
QE1-996.5, Cordillera Bética oriental, Estratigrafía, Micromammals, Geology, cordillera bética oriental, cuenca del bajo segura, Neógeno, Micromamiferos, Micromamíferos, Cuenca del Bajo Segura, Geodinámica Interna, Lower Segura Basin, Neogene, neógeno, micromamiferos, Eastern Betic Cordillera
Abstract

7 páginas, 5 figuras., [ES] En este trabajo se estudian tres yacimientos de microvertebrados dentro de los materiales neógenos que rellenan la Cuenca del Bajo Segura (Cordillera Bética oriental). Estos permiten precisar la edad de las Unidades estratigráficas MS-IV (Tortoniense terminal - Messiniense o Turoliense inferior parte alta - Ventiense) y P-I (Plioceno inferior). Los dos más bajos, denominados Castro y Pantano de Elche (Pantel), datan la base del Turoliense superior (zona MNI2) y el Ventiense (zona MNI3), respectivamente; ambos se encuentran en la unidad MS-IV. El yacimiento más moderno, denominado Barranco de Fayona (Fayona) data el Rusciniense inferior (zona MNI4) y se encuentra asociado a un conjunto hasta el momento considerado de edad Plioceno superior., [EN] In the Neogene sediments of the Lower Segura Basin (Eastern Betic Cordillera) have been studied three localities with fossil micromammals. They yielded a fauna which date the stratigraphic units MS-IV (Upper Tortonian-Messinian) and P-I (Lower Pliocene). The two older, named Castro and Pantano de Elche (Pantel) date the base of the Upper Turolian (zone MNI2) and the Ventian (zone MN13) respectively; they both belongs to the unit MS-IV. The younger one, locate in the Barranco de Fayona (Fayona) indicates a Lower Ruscinian age (zone MNI4) of the unit P-I, which was considered until now as Upper Pliocene., Este trabajo es una contribución del Proyecto AMB92-053I de la CICYT.

Published
1995
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30. Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk

Author

Camacho M., Martinez-Perez A., Buil A., Siguero L., Alcolea S., López S., Fontcuberta J., Souto J.-C., Vila L., and Soria J.-M.

Subjects
leukotriene C4 synthase, cardiovascular risk, Male, Adolescent, genetic association, sex difference, 5-Lipoxygenase-Activating Proteins, heritability, smoking, fatty acid blood level, environmental factor, Risk Factors, Humans, Thrombophilia, artery thrombosis, controlled study, Genetic Predisposition to Disease, human, Child, protein expression, Aged, Glutathione Transferase, leukotriene A4 hydrolase, Aged, 80 and over, Epoxide Hydrolases, arachidonate 5 lipoxygenase, Arachidonate 5-Lipoxygenase, quantitative analysis, human cell, adult, article, leukotriene B4, phenotypic variation, Middle Aged, arachidonate 5 lipoxygenase activating protein, major clinical study, genetic correlation, human tissue, household, female, Phenotype, priority journal, Spain, Cardiovascular Diseases, Child, Preschool, idiopathic disease, genetic trait, genetic susceptibility
Abstract

Objective: Leukotrienes (LT) play a role in inflammation, cardiovascular diseases, and cancer. Although some studies suggest that there are genes that determine variability of some LT-related phenotypes, the genetic influence on these phenotypes has not been evaluated. Methods: The relative contributions of genetic and environmental influences to the 5-lipoxygenase pathway-related phenotypes (5-Lipoxygenase, five lipoxygenase activating protein (FLAP), LTA4-hydrolase and LTC4-synthase expression, and LTB4-plasma concentration and LTB4 production by stimulated whole blood) were assessed in a sample of 934 individuals in 35 extended families. Our design is based on extended families recruited through a probands with idiopathic thrombophilia. This strategy allows us the analysis of the effects of measured covariates (such as sex, age and smoking), genes, and environmental variables shared by members of a household. Results: All of these phenotypes showed significant genetic contributions, with heritabilities ranging from 0.33 to 0.51 for enzyme expression and from 0.25 to 0.50 for LTB4 production of the residual phenotypic variance. Significant phenotypic and genetic correlation among the LT-related traits was found. More importantly, FLAP and LTA4-hydrolase expression exhibit significant genetic correlations with arterial thrombosis, indicating that some of the genes that influence quantitative variation in these phenotypes also influence the risk of thrombosis. Conclusion: This is the first study that quantifies the genetic component of 5-Lipoxygenase pathway phenotypes. The high heritability of these traits and the significant genetic correlations between arterial thrombosis and some of these phenotypes suggest that the exploitation of correlated quantitative phenotypes will aid the search for susceptibility genes. © 2012 Elsevier Ireland Ltd.

Published
2012

31. Rocas volcanoclasticas submarinas de edad Burdigaliense inferior en el sector del Mencal (Zona Subbetica, Cordillera Bética central). Contexto sedimentario y tectónico

Author

Soria, J. M.

Subjects
QE1-996.5, Volcaniclastic rocks, zona subbética, Geology, rocas volcanoclásticas, Zona Subbética, Lower Miocene, mioceno inferior, Betic Cordillera, Rocas volcanoclásticas, Cordillera Bética, Mioceno inferior, cordillera bética, Subbetic Zone
Abstract

This paper discuss the petrologic features of volcaniclastic rocks and its geodynamic implications. This rocks are included in the pelagic marine sediments of lower Burdigalian from the Río Fardes region (Subbetic Zone, Betic Cordillera). There are two different kinds of volcaniclastic rocks: vitric and feldspathic sandstones, and vitric siltstones, both of them from fragmental volcanic emissions of a calc-alkaline rhyodacitic magma. In these rocks there are planktonic Foraminifera that indicate volcanism occurring in a submarine environment. The emission focus is placed close to the present-day location of these rocks, due to low dispersion of the pyroclastic fragments into the pelagic marine deposits. During lower Burdigalian several N70ºE strike-slip faults was working simultanously with the pelagic marine sedimentation. In this paper it is assumed that these faults are connected with the volcanic activity. During the lower Miocene the orogenic deformation of the Sudiberian PaJeomargin (External Betic Zones) are related to fracturarion and volcanism, in coincidence with a major tectonic event, best known as Burdigalian Paroxysm (Hermes, 1985). El presente trabajo se centra en la caracterización petrológica y significado geodinámico de las rocas volcanoclásticas que aparecen en los materiales marinos pelágicos del Burdigaliense inferior que afloran en el sector del Mencal (Zona Subbética del tercio central de la Cordillera Bética). Se diferencian dos tipos de rocas volcanoclásticas: areniscas vítricas y feldespáticas y limolitas vítricas, ambas procedentes de emisiones volcánicas fragmentales de un magma calcoalcalino-riodacítico. En los dos tipos se encuentran foraminíferos planctónicos, hecho que indica que el volcanismo se produjo en condiciones submarinas. La escasa dispersión de los piroclastos dentro de los depósitos marinos pelágicos permite deducir que el foco de emisión volcánica se localizó muy próximo al lugar de emplazamiento de estas rocas. Uno de los rasgos más característicos del área estudiada es la existencia de fracturas de desgarre N70ºE que actuaron durante el Burdigaliense inferior. Estas fracturas son contemporáneas a la sedimentación marina pelágica en la que se registran las emisiones volcánicas. Se plantea como hipótesis una relación del volcanismo con la actuación de tales fracturas. Ambos procesos, volcanismo y fracturación, se interpretan en el contexto de deformación orogénica del Paleomargen Sudibérico durante el Mioceno inferior, en coincidencia con el climax de una fase tectónica mayor definido como Paroxismo Burdigaliense por Hermes (1985).

Published
1994
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35. In vitro 3D culture of human chondrocytes using modified epsilon-caprolactone scaffolds with varying hydrophilicity and porosity

Author

Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular, Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada, Ministerio de Educación y Ciencia, Pérez Olmedilla, Marcos, Lebourg, Myriam Madeleine, Escobar Ivirico, Jorge Luis, Nebot, I., Garcia Giralt, N., Gallego Ferrer, Gloria, Soria, J. M., Gómez Ribelles, José Luís, Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular, Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada, Ministerio de Educación y Ciencia, Pérez Olmedilla, Marcos, Lebourg, Myriam Madeleine, Escobar Ivirico, Jorge Luis, Nebot, I., Garcia Giralt, N., Gallego Ferrer, Gloria, Soria, J. M., and Gómez Ribelles, José Luís

Abstract

[EN] Two series of 3D scaffolds based on epsilon-caprolactone were synthesized. The pore size and architecture (spherical interconnected pores) was the same in all the scaffolds. In one of the series of scaffolds, made of pure epsilon-polycaprolactone, the volume fraction of pores varied between 60% and 85% with the main consequence of varying the interconnectivity between pores since the pore size was kept constant. The other scaffolds were prepared with copolymers made of a epsilon-caprolactone-based hydrophobous monomer and hydroxyethyl acrylate, as the hydrophilic component. Thus, the hydrophilicity and, presumably, the adhesion properties varied monotonously in the copolymer series while porosity was kept constant. A suspension of human chondrocytes in culture medium was injected in the 3D scaffolds and cultured in static conditions up to 28 days. SEM and immunofluorescence assays allowed characterizing cells and extracellular matrix inside the scaffolds after different culture times. To do that, cross sections of the scaffolds were observed by SEM and confocal microscopy. The quantity of cells inside the scaffolds decreases with a decrease of the volume fraction of pores, due to the lack of interconnectivity between the cavities. The scaffolds up to a 30% of hydrophilicity behave in a similar way than the hydrophobous; a further increase of the hydrophilicity rapidly decreases cell viability. In all the experiments production of collagen type I, type II, and aggrecan was found, and some cells were Ki-67 positive, showing that some cells are adhered to the pore walls and maintain their dedifferentiated phenotype even when cultured in three-dimensional conditions.

Published
2012

45. Influence of the substrate's hydrophilicity on the in vitro Schwann cells viability

Author

Soria, J. M., primary, Martínez Ramos, C., additional, Bahamonde, O., additional, García Cruz, D. M., additional, Salmerón Sánchez, M., additional, García Esparza, M. A., additional, Casas, C., additional, Guzmán, M., additional, Navarro, X., additional, Gómez Ribelles, J. L., additional, García Verdugo, J. M., additional, Monleón Pradas, M., additional, and Barcia, J. A., additional

Published
2007
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