1. Antenatal oral glucose tolerance test abnormalities in the prediction of future risk of postpartum diabetes in women with gestational diabetes: Results from the LIVING study
- Author
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Yashdeep Gupta, Deksha Kapoor, Josyula K. Lakshmi, Devarsetty Praveen, Joseph Alvin Santos, Laurent Billot, Aliya Naheed, H. Asita deSilva, Ishita Gupta, Noshin Farzana, Renu John, Saumiyah Ajanthan, Neerja Bhatla, Ankush Desai, Arunasalam Pathmeswaran, Dorairaj Prabhakaran, Helena Teede, Sophia Zoungas, Anushka Patel, and Nikhil Tandon
- Subjects
antenatal OGTT ,gestational diabetes mellitus ,postpartum ,risk prediction ,South Asia ,type 2 diabetes mellitus ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Objectives To explore associations between type and number of abnormal glucose values on antenatal oral glucose tolerance test (OGTT) with postpartum diabetes in South Asian women diagnosed with gestational diabetes (GDM) using International Association of the Diabetes and Pregnancy Study Groups criteria. Methods This post‐hoc evaluation of the Lifestyle Intervention IN Gestational Diabetes (LIVING) study, a randomized controlled trial, was conducted among women with GDM in the index pregnancy, across 19 centers in Bangladesh, India, and Sri Lanka. Postpartum diabetes (outcome) was defined on OGTT, using American Diabetes Association (ADA) criteria. Results We report data on 1468 women with GDM, aged 30.9 (5.0) years, and with median (interquartile range) follow‐up period of 1.8 (1.4–2.4) years after childbirth following the index pregnancy. We found diabetes in 213 (14.5%) women with an incidence of 8.7 (7.6–10.0)/100 women‐years. The lowest incidence rate was 3.8/100 women years, in those with an isolated fasting plasma glucose (FPG) abnormality, and highest was 19.0/100 women years in participants with three abnormal values. The adjusted hazard ratios for two and three abnormal values compared to one abnormal value were 1.73 (95% confidence interval [CI], 1.18–2.54; p = .005) and 3.56 (95% CI, 2.46–5.16; p
- Published
- 2024
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