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336 results on '"Sooronbaev, Talant"'

1. The FRESHAIR4Life study: Global implementation research on non-communicable disease prevention targeting adolescents’ exposure to tobacco and air pollution in disadvantaged populations

Author

Hoffman, Charlotte M., Versluis, Anke, Chirila, Sergiu, Kirenga, Bruce J., Khan, Amina, Saeed, Saima, Sooronbaev, Talant, Tsiligianni, Ioanna, Arvind, D. K., Bauld, Linda C., van den Brand, Floor A., Chavannes, Niels H., Pinnock, Hilary, Powell, Pippa D., van der Schans, Jurjen, Siddiqi, Kamran, Williams, Siân, and van der Kleij, M. J. J. Rianne

Published
2024
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2. Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Author

Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Cherkaski, Hamid Hacene, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Chandra Das, Shyamal, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Lawin, Herve, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Tan, Wan C., Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jin-ping, Zhou, Yumin, Jogi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, SchwedaLinow, Alexandra, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jorundsdottir, Kristin, Lovisa Gudmundsdottir, Gudmundsdottir, Sigrun, Gudmundsson, Gunnar, Rao, Mahesh, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Aquart-Stewart, Althea, Aikman, Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mortimer, Kevin, Nyapigoti, Wezzie, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Loh, Li-Cher, Rashid, Abdul, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Wouters, E.F.M., Wesseling, G.J., Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Nafees, Asaad A., Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Barbara, Cristina, Rodrigues, Fatima, Dias, Herminia, Cardoso, Joao, Almeida, João, Matos, Maria Joao, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Al Ghobain, M., Alorainy, H., El-Hamad, E., Al Hajjaj, M., Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsony, Asma, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Akasha Ahmed Osman, Hasab Alrasoul, Moham ed Elhassan, Namarig, El Zain, Abdel Mu’is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, SpetzNystrom, Ulrike, Hagg, Gunilla, Lund, GunMarie, Seemungal, Terence, Lutchmansingh, Fallon, Conyette, Liane, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabas, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Burney, Peter G.J., Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, Buist, A. Sonia, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Abozid, Hazim, Burney, Peter, Hartl, Sylvia, Breyer-Kohansal, Robab, Al Ghobain, Mohammed, Denguezli, Meriam, Loh, Li Cher, Paraguas, Stefanni Nonna, Franssen, Frits M.E., Mannino, David, Anand, Mahesh Padukudru, Buist, Sonia, El Sony, Asma, Breyer, Marie-Kathrin, Burghuber, Otto C., Wouters, Emiel F.M., and Amaral, Andre F.S.

Published
2024
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4. Mapping low-resource contexts to prepare for lung health interventions in four countries (FRESH AIR): a mixed-method study

Author

Brakema, Evelyn A, van der Kleij, Rianne M J J, Poot, Charlotte C, An, Pham Le, Anastasaki, Marilena, Crone, Matty R, Hong, Le Huynh Thi Cam, Kirenga, Bruce, Lionis, Christos, Mademilov, Maamed, Numans, Mattijs E, Oanh, Lê Thi Tu, Tsiligianni, Ioanna, Sooronbaev, Talant, Walusimbi, Simon, Williams, Siân, Chavannes, Niels H, and Reis, Ria

Published
2022
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5. The Feasibility of C-Reactive Protein Point-of-Care Testing to Reduce Overuse of Antibiotics in Children with Acute Respiratory Tract Infections in Rural Kyrgyzstan: A Pilot Study

Author

Isaeva,Elvira, Akylbekov,Azamat, Bloch,Joakim, Poulsen,Anja, Kurtzhals,Jørgen, Siersma,Volkert, Sooronbaev,Talant, Aabenhus,Rune Munck, Kjærgaard,Jesper, Isaeva,Elvira, Akylbekov,Azamat, Bloch,Joakim, Poulsen,Anja, Kurtzhals,Jørgen, Siersma,Volkert, Sooronbaev,Talant, Aabenhus,Rune Munck, and Kjærgaard,Jesper

Abstract

Elvira Isaeva,1 Azamat Akylbekov,2 Joakim Bloch,3 Anja Poulsen,3 Jørgen Kurtzhals,4,5 Volkert Siersma,6 Talant Sooronbaev,2 Rune Munck Aabenhus,6 Jesper Kjærgaard3 1Allergology Department, National Centre of Maternity and Childhood Care (NCMCC), Bishkek, Kyrgyzstan; 2Pulmonology Department, National Centre of Cardiology and Internal Medicine Named After Academician M. Mirrakhimov, Bishkek, Kyrgyzstan; 3Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 4Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 5Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; 6Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Elvira Isaeva, Allergology Department, National Centre of Maternity and Childhood Care (NCMCC), Postal Address: 720038, 190, Akhunbaev St, Bishkek, Kyrgyzstan, Tel +996 (709) 795 979, Email rhc358@sund.ku.dkBackground: In Kyrgyzstan, the morbidity prevalence of and morbidity from acute respiratory tract infections (ARTI) in children is high. Local healthcare workers (HCW) often prescribe antibiotics that are not indicative due to a mix of professional and societal factors. It is suggested to precede with a decision on antibiotics by a point-of-care test (POCT) on the appropriateness of the treatment, eg, a measurement of C-reactive protein (CRP). CRP-guided antibiotic stewardship in children with ARTI has not previously been studied in Central Asia.Purpose: This pilot study was conducted to examine the feasibility of the methods and procedures to be used in the upcoming randomised controlled COORDINATE clinical trial (NCT05195866) and in daily clinical practice in primary care.Patients and methods: HCWs from three selected rural healthcare facilities were trained in

Published
2024

6. The feasibility of C-reactive protein point-of-care testing to reduce overuse of antibiotics in children with acute respiratory tract infections in rural Kyrgyzstan:A Pilot Study

Author

Isaeva, Elvira, Akylbekov, Azamat, Bloch, Joakim, Poulsen, Anja, Kurtzhals, Jørgen, Siersma, Volkert, Sooronbaev, Talant, Aabenhus, Rune Munck, Kjærgaard, Jesper, Isaeva, Elvira, Akylbekov, Azamat, Bloch, Joakim, Poulsen, Anja, Kurtzhals, Jørgen, Siersma, Volkert, Sooronbaev, Talant, Aabenhus, Rune Munck, and Kjærgaard, Jesper

Abstract

BACKGROUND: In Kyrgyzstan, the morbidity prevalence of and morbidity from acute respiratory tract infections (ARTI) in children is high. Local healthcare workers (HCW) often prescribe antibiotics that are not indicative due to a mix of professional and societal factors. It is suggested to precede with a decision on antibiotics by a point-of-care test (POCT) on the appropriateness of the treatment, eg, a measurement of C-reactive protein (CRP). CRP-guided antibiotic stewardship in children with ARTI has not previously been studied in Central Asia.PURPOSE: This pilot study was conducted to examine the feasibility of the methods and procedures to be used in the upcoming randomised controlled COORDINATE clinical trial (NCT05195866) and in daily clinical practice in primary care.PATIENTS AND METHODS: HCWs from three selected rural healthcare facilities were trained in the CRP POCT and in interpretation of results. Children aged 6 months to 12 years attending the primary healthcare facilities with respiratory symptoms were randomly assigned to CRP-guided management or standard care, guided by clinical findings only. Children were followed up for 14 days by scheduled telephone calls to caregivers.RESULTS: Eighty-one children participated in this pilot study. The CRP POCT and the trial procedures were acceptable to the target group as well as to the HCWs. Children from both groups recovered equally well, with an observed significant lower use of antibiotics in the CRP group. HCWs generally adhered to the CRP guidelines, and only once was an antibiotic prescribed despite low CRP results. No safety concerns were observed. Four parents provided wrong phone numbers impeding follow-up. We will collect all mobile phone numbers in the household for the main trial.CONCLUSION: The pilot provided satisfactory results, suggesting that the COORDINATE trial of CRP POCT is effective, feasible with minor adjustments and without apparent safety concerns for t

Published
2024

8. Effect of altitude and acetazolamide on postural control in healthy lowlanders 40 years of age or older. Randomized, placebo-controlled trial

Author

Mutschler, Tim, primary, Furian, Michael, additional, Lichtblau, Mona, additional, Buergin, Aline, additional, Schneider, Simon R., additional, Appenzeller, Paula, additional, Mayer, Laura, additional, Muralt, Lara, additional, Mademilov, Maamed, additional, Abdyraeva, Ainura, additional, Aidaralieva, Shoira, additional, Muratbekova, Aibermet, additional, Akylbekov, Azamat, additional, Shabykeeva, Saltanat, additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, and Bloch, Konrad E., additional

Published
2024
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9. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Bousquet, J., Hellings, P.W., Aberer, W., Agache, I., Akdis, C.A., Akdis, M., Alberti, M.R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B.A., Basagana, X., Bateman, E.D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E.H., Bergmann, K.C., Bennoor, K.S., Benson, M., Bertorello, L., Białoszewski, A.Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevich, C.S., Bosse, I., Bouchard, J., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briedis, V., Brightling, C.E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M.A., Camargos, P.A.M., Camuzat, T., Canfora, G., Canonica, G.W., Cardona, V., Carlsen, K.H., Carreiro-Martins, P., Carriazo, A.M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A.M., Chavannes, N.H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F., Costa, E., Costa-Dominguez, M.C., Courbis, A.L., Cox, L., Crescenzo, M., Cruz, A.A., Custovic, A., Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J.A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M.G., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Du Toit, G., Dykewicz, M.S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W.J., Fonseca, J.A., Fontaine, J.F., Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C.Y., Garcia-Cruz, M.H., Gemicioğlu, B., Genova, S., George, C., Gereda, J.E., Gerth van Wijk, R., Gomez, R.M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N.A., Gutter, Z., Guzmán, M.A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J.O.'B., Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J.C., Jares, E.J., Jassem, E., Johnston, S.L., Joos, G., Jung, K.S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A.F., Karjalainen, J., Kardas, P., Keil, T., Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M.L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L.T.T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R., Lourenço, O., Luna-Pech, J.A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R., Maspero, J.F., Mathieu-Dupas, E., Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F.F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D., O'Hehir, R.E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G.L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N.G., Park, H.S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J.L., Pereira, A.M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R.E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, H.J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F.S., Shamai, S., Sheikh, A., Sierra, M., Simons, F.E.R., Siroux, V., Sisul, J.C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P.V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M.T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M.T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D.Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D.M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B.P., Yiallouros, P.K., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zhang, L., Zhong, N., Zernotti, M.E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-François, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T.T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlos, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zuberbier, Torsten

Published
2019
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11. The FRESHAIR4Life study: Global implementation research on non-communicable disease prevention targeting adolescents’ exposure to tobacco and air pollution in disadvantaged populations

Author

Hoffman, Charlotte, primary, Versluis, Anke, additional, Chirila, Sergiu, additional, Kirenga, Bruce, additional, Khan, Amina, additional, Saeed, Saima, additional, Sooronbaev, Talant, additional, Tsiligianni, Ioanna, additional, Arvind, DK, additional, Bauld, Linda, additional, Brand, Floor van den, additional, Chavannes, Niels, additional, Pinnock, Hilary, additional, Powell, Pippa, additional, Schans, Jurjen van der, additional, Siddiqi, Kamran, additional, Williams, Siân, additional, and Kleij, Rianne van der, additional

Published
2023
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12. Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study

Author

Luyken, Matthias C., primary, Appenzeller, Paula, additional, Scheiwiller, Philipp M., additional, Lichtblau, Mona, additional, Mademilov, Maamed, additional, Muratbekova, Aybermet, additional, Sheraliev, Ulan, additional, Abdraeva, Ainura, additional, Marazhapov, Nuriddin, additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, Bloch, Konrad E., additional, and Furian, Michael, additional

Published
2023
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13. Qualitative evaluation of culturally adapted pulmonary rehabilitation (PR) for people with post-tuberculosis lung disease (pTBLD) in Kyrgyz Republic

Author

Mirzalieva, Gulzada, primary, Mademilov, Maamed, additional, Orme, Mark, additional, Akylbekov, Azamat, additional, Taalaibekova, Aijan, additional, Ozonova, Aigul, additional, Shakiev, Nurdin, additional, Azizbekov, Syimyk, additional, Bolotbek U., Azat, additional, Barradell, Amy, additional, Malcolm, Dominic, additional, Sooronbaev, Talant, additional, and Singh, Sally, additional

Published
2023
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14. Acute mountain sickness in women – A pilot study

Author

Taalaibekova, Aijan, primary, Meyer, Michelle, additional, Ulrich, Stefanie, additional, Mirzalieva, Gulzada, additional, Mademilov, Maamed, additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, Bloch, Konrad E., additional, and Furian, Michael, additional

Published
2023
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17. C reactive protein-guided prescription of antibiotics for children under 12 years with respiratory symptoms in Kyrgyzstan: protocol for a randomised controlled clinical trial with 14 days follow-up

Author

Isaeva, Elvira, primary, Bloch, Joakim, additional, Poulsen, Anja, additional, Kurtzhals, Jørgen, additional, Reventlow, Susanne, additional, Siersma, Volkert, additional, Akylbekov, Azamat, additional, Sooronbaev, Talant, additional, Munck Aabenhus, Rune, additional, and Kjærgaard, Jesper, additional

Published
2023
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18. Mitigating antimicrobial resistance (AMR) using implementation research: a development funder’s approach

Author

Khurana, Mark P, primary, Essack, Sabiha, additional, Zoubiane, Ghada, additional, Sreenivasan, Nandini, additional, Cordoba, Gloria Cristina, additional, Westwood, Erica, additional, Dalsgaard, Anders, additional, Mdegela, Robinson H, additional, Mpundu, Mirfin, additional, Scotini, Rodrigo, additional, Matondo, Augustine B, additional, Mzula, Alexanda, additional, Chanishvili, Nina, additional, Gogebashvili, Dimitri, additional, Beruashvili, Maia, additional, Tsereteli, Marika, additional, Sooronbaev, Talant, additional, Kjærgaard, Jesper, additional, Bloch, Joakim, additional, Isaeva, Elvira, additional, Mainda, Geoffrey, additional, Muuka, Geoffrey, additional, Mudenda, Ntombi B, additional, Goma, Fusya Y, additional, Chu, Duc-Huy, additional, Chanda, Duncan, additional, Chirwa, Uchizi, additional, Yamba, Kaunda, additional, Kapolowe, Kenneth, additional, Fwoloshi, Sombo, additional, Mwenge, Lawrence, additional, and Skov, Robert, additional

Published
2023
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19. C reactive protein-guided prescription of antibiotics for children under 12 years with respiratory symptoms in Kyrgyzstan:protocol for a randomised controlled clinical trial with 14 days follow-up

Author

Isaeva, Elvira, Bloch, Joakim, Poulsen, Anja, Kurtzhals, Jørgen, Reventlow, Susanne, Siersma, Volkert, Akylbekov, Azamat, Sooronbaev, Talant, Munck Aabenhus, Rune, Kjærgaard, Jesper, Isaeva, Elvira, Bloch, Joakim, Poulsen, Anja, Kurtzhals, Jørgen, Reventlow, Susanne, Siersma, Volkert, Akylbekov, Azamat, Sooronbaev, Talant, Munck Aabenhus, Rune, and Kjærgaard, Jesper

Abstract

INTRODUCTION: While lower respiratory tract infections are the main cause of death for children under 5 globally, only a small proportion of children with respiratory tract infections need antibiotics. Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance. In Kyrgyzstan, healthcare workers regularly prescribe antibiotics when clinical uncertainty is present to err on the side of caution. Targeting antibiotic use with biomarkers of inflammation such as C reactive protein (CRP) testing at the point-of-care test (POCT) has been shown to reduce antibiotic use in general, but only few studies have been done in children and no studies exist from Central Asia. This study aims to assess whether the use of a CRP POCT can safely decrease prescription of antibiotics for children with acute respiratory symptoms in primary level healthcare centres in Kyrgyzstan. METHODS AND ANALYSIS: Multicentre, open-label, individually randomised, controlled clinical trial with 14 days follow-up (follow-up by phone on days 3, 7 and 14) in rural lowland Chui and highland Naryn regions of Kyrgyzstan. The population are children aged 6 months to 12 years attending the primary level healthcare centres during normal business hours with acute respiratory symptoms. CRP POCT equipment will be supplied to healthcare centres, along with a short training session in CRP use, including the interpretation of results to support the clinical evaluation of the child with acute respiratory infection. The primary outcomes are the proportion of patients prescribed an antibiotic within 14 days of index consultation (superiority analysis) and days to recovery (non-inferiority analysis). Secondary outcomes are antibiotics prescribed at index consultation, reconsultations, hospital admission and vital status within 14 days. Analysis of the first primary outcome, antibiotic use, will be intention to treat using a logistic regression model. Analysis of the second primary outcome, da

Published
2023

20. Mitigating antimicrobial resistance (AMR) using implementation research:a development funder's approach

Author

Khurana, Mark P., Essack, Sabiha, Zoubiane, Ghada, Sreenivasan, Nandini, Cordoba, Gloria Cristina, Westwood, Erica, Dalsgaard, Anders, Mdegela, Robinson H., Mpundu, Mirfin, Scotini, Rodrigo, Matondo, Augustine B., Mzula, Alexanda, Chanishvili, Nina, Gogebashvili, Dimitri, Beruashvili, Maia, Tsereteli, Marika, Sooronbaev, Talant, Kjærgaard, Jesper, Bloch, Joakim, Isaeva, Elvira, Mainda, Geoffrey, Muuka, Geoffrey, Mudenda, Ntombi B., Goma, Fusya Y., Chu, Duc-Huy, Chanda, Duncan, Chirwa, Uchizi, Yamba, Kaunda, Kapolowe, Kenneth, Fwoloshi, Sombo, Mwenge, Lawrence, Skov, Robert, Khurana, Mark P., Essack, Sabiha, Zoubiane, Ghada, Sreenivasan, Nandini, Cordoba, Gloria Cristina, Westwood, Erica, Dalsgaard, Anders, Mdegela, Robinson H., Mpundu, Mirfin, Scotini, Rodrigo, Matondo, Augustine B., Mzula, Alexanda, Chanishvili, Nina, Gogebashvili, Dimitri, Beruashvili, Maia, Tsereteli, Marika, Sooronbaev, Talant, Kjærgaard, Jesper, Bloch, Joakim, Isaeva, Elvira, Mainda, Geoffrey, Muuka, Geoffrey, Mudenda, Ntombi B., Goma, Fusya Y., Chu, Duc-Huy, Chanda, Duncan, Chirwa, Uchizi, Yamba, Kaunda, Kapolowe, Kenneth, Fwoloshi, Sombo, Mwenge, Lawrence, and Skov, Robert

Abstract

Despite the escalating burden of antimicrobial resistance (AMR), the global response has not sufficiently matched the scale and scope of the issue, especially in low- and middle-income countries (LMICs). While many countries have adopted national action plans to combat AMR, their implementation has lagged due to resource constraints, dysfunctional multisectoral coordination mechanisms and, importantly, an under-recognized lack of technical capacity to adapt evidence-based AMR mitigation interventions to local contexts. AMR interventions should be tailored, context-specific, cost-effective and sustainable. The implementation and subsequent scale-up of these interventions require multidisciplinary intervention-implementation research (IIR). IIR involves both quantitative and qualitative approaches, occurs across a three-phase continuum (proof of concept, proof of implementation and informing scale-up), and across four context domains (inner setting, outer setting, stakeholders and the implementation process). We describe the theoretical underpinnings of implementation research (IR), its various components, and how to construct different IR strategies to facilitate sustainable uptake of AMR interventions. Additionally, we provide real-world examples of AMR strategies and interventions to demonstrate these principles in practice. IR provides a practical framework to implement evidence-based and sustainable AMR mitigation interventions., Despite the escalating burden of antimicrobial resistance (AMR), the global response has not sufficiently matched the scale and scope of the issue, especially in low- and middle-income countries (LMICs). While many countries have adopted national action plans to combat AMR, their implementation has lagged due to resource constraints, dysfunctional multisectoral coordination mechanisms and, importantly, an under-recognized lack of technical capacity to adapt evidence-based AMR mitigation interventions to local contexts. AMR interventions should be tailored, context-specific, cost-effective and sustainable. The implementation and subsequent scale-up of these interventions require multidisciplinary intervention-implementation research (IIR). IIR involves both quantitative and qualitative approaches, occurs across a three-phase continuum (proof of concept, proof of implementation and informing scale-up), and across four context domains (inner setting, outer setting, stakeholders and the implementation process). We describe the theoretical underpinnings of implementation research (IR), its various components, and how to construct different IR strategies to facilitate sustainable uptake of AMR interventions. Additionally, we provide real-world examples of AMR strategies and interventions to demonstrate these principles in practice. IR provides a practical framework to implement evidence-based and sustainable AMR mitigation interventions.

Published
2023

21. Echocardiography and extravascular lung water during 3 weeks of exposure to high altitude in otherwise healthy asthmatics

Author

Saxer, Stéphanie; https://orcid.org/0000-0002-3278-6277, Bader, Patrick R; https://orcid.org/0000-0002-9663-9962, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Sheraliev, Ulan, Appenzeller, Paula, Müller, Julian, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Ulrich, Silvia, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Saxer, Stéphanie; https://orcid.org/0000-0002-3278-6277, Bader, Patrick R; https://orcid.org/0000-0002-9663-9962, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Sheraliev, Ulan, Appenzeller, Paula, Müller, Julian, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Ulrich, Silvia, and Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758

Abstract

Background: Asthma rehabilitation at high altitude is common. Little is known about the acute and subacute cardiopulmonary acclimatization to high altitude in middle-aged asthmatics without other comorbidities.Methods: In this prospective study in lowlander subjects with mostly mild asthma who revealed an asthma control questionnaire score >0.75 and participated in a three-week rehabilitation program, we assessed systolic pulmonary artery pressure (sPAP), cardiac function, and extravascular lung water (EVLW) at 760 m (baseline) by Doppler-echocardiography and on the second (acute) and last day (subacute) at a high altitude clinic in Kyrgyzstan (3100 m).Results: The study included 22 patients (eight male) with a mean age of 44.3 ± 12.4 years, body mass index of 25.8 ± 4.7 kg/m$^{2}$, a forced expiratory volume in 1 s of 92% ± 19% predicted (post-bronchodilator), and partially uncontrolled asthma. sPAP increased from 21.8 mmHg by mean difference by 7.5 [95% confidence interval 3.9 to 10.5] mmHg (p < 0.001) during acute exposure and by 4.8 [1.0 to 8.6] mmHg (p = 0.014) during subacute exposure. The right-ventricular-to-pulmonary-artery coupling expressed by TAPSE/sPAP decreased from 1.1 by −0.2 [−0.3 to −0.1] mm/mmHg (p < 0.001) during acute exposure and by −0.2 [−0.3 to −0.1] mm/mmHg (p = 0.002) during subacute exposure, accordingly. EVLW significantly increased from baseline (1.3 ± 1.8) to acute hypoxia (5.5 ± 3.5, p < 0.001) but showed no difference after 3 weeks (2.0 ± 1.8).Conclusion: In otherwise healthy asthmatics, acute exposure to hypoxia at high altitude increases pulmonary artery pressure (PAP) and EVLW. During subacute exposure, PAP remains increased, but EVLW returns to baseline values, suggesting compensatory mechanisms that contribute to EVLW homeostasis during acclimatization.

Published
2023

22. Effect of acetazolamide on pulmonary vascular haemodynamics in patients with COPD going to altitude: a randomised, placebo-controlled, double-blind trial

Author

Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Saxer, Stéphanie; https://orcid.org/0000-0002-3278-6277, Mayer, Laura, Sheraliev, Ulan, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Buergin, Aline, Schweiwiller, Philipp M, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Tanner, Felix C, Sooronbaev, Talant; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Saxer, Stéphanie; https://orcid.org/0000-0002-3278-6277, Mayer, Laura, Sheraliev, Ulan, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Buergin, Aline, Schweiwiller, Philipp M, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Tanner, Felix C, Sooronbaev, Talant; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, and Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022

Abstract

Background: COPD may predispose to symptomatic pulmonary hypertension at high altitude. We investigated haemodynamic changes in lowlanders with COPD ascending to 3100 m and evaluated whether preventive acetazolamide treatment would attenuate the altitude-induced increase in pulmonary artery pressure (PAP). Methods: In this randomised, placebo-controlled, double-blind, parallel-group trial, patients with COPD Global Initiative for Chronic Obstructive Lung Disease grades 2–3 who were living <800 m and had peripheral oxygen saturation (S$_{pO_{2}}$) >92% and arterial carbon dioxide tension <6 kPa were randomised to receive either acetazolamide (125–250 mg·day$^{−1}$) or placebo capsules, starting 24 h before ascent from 760 m and during a 2-day stay at 3100 m. Echocardiography, pulse oximetry and clinical assessments were performed at 760 m and after the first night at 3100 m. Primary outcome was PAP assessed by tricuspid regurgitation pressure gradient (TRPG). Results: 112 patients (68% men, mean±sdage 59±8 years, forced expiratory volume in 1 s (FEV$_{1}$) 61±12% pred,S$_{pO_{2}}$95±2%) were included. Mean±sdTRPG increased from 22±7 to 30±10 mmHg in 54 patients allocated to placebo and from 20±5 to 24±7 mmHg in 58 patients allocated to acetazolamide (both p<0.05) resulting in a mean (95% CI) treatment effect of −5 (−9 to −1) mmHg (p=0.015). In patients assigned to placebo at 760/3100 m, mean±sdS$_{pO_{2}}$was 95±2%/88±3%; in the acetazolamide group, the respective values were 94±2%/90±3% (both p<0.05), resulting in a treatment effect of +2 (1 to 3)% (p=0.001). Conclusions: In lowlanders with COPD travelling to 3100 m, preventive acetazolamide treatment attenuated the altitude-induced rise in PAP and improved oxygenation.

Published
2023

23. Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patients

Author

Bauer, Meret, Müller, Julian; https://orcid.org/0000-0003-4059-5937, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Buenzli, Simone, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Ulrich, Tanja, Carta, Arcangelo F; https://orcid.org/0000-0001-8019-7429, Bader, Patrick R; https://orcid.org/0000-0002-9663-9962, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Taalaibekova, Ajian, Raimberdiev, Madiiar, Champigneulle, Benoit, Sooronbaev, Talant; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Bauer, Meret, Müller, Julian; https://orcid.org/0000-0003-4059-5937, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Buenzli, Simone, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Ulrich, Tanja, Carta, Arcangelo F; https://orcid.org/0000-0001-8019-7429, Bader, Patrick R; https://orcid.org/0000-0002-9663-9962, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Taalaibekova, Ajian, Raimberdiev, Madiiar, Champigneulle, Benoit, Sooronbaev, Talant; https://orcid.org/0000-0002-5609-0944, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, and Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022

Abstract

Background/aims: Amongst numerous travellers to high altitude (HA) are many with the highly prevalent COPD, who are at particular risk for altitude-related adverse health effects (ARAHE). We then investigated the hypoxia-altitude simulation test (HAST) to predict ARAHE in COPD patients travelling to altitude. Methods: This prospective diagnostic accuracy study included 75 COPD patients: 40 women, age 58±9 years, forced expiratory volume in 1 s (FEV$_{1}$) 40–80% pred, oxygen saturation measured by pulse oximetry (S$_{pO_{2}}$) ≥92% and arterial carbon dioxide tension (P$_{aCO_{2}}$) <6 kPa. Patients underwent baseline evaluation and HAST, breathing normobaric hypoxic air (inspiratory oxygen fraction (F$_{IO_{2}}$) of 15%) for 15 min, at low altitude (760 m). Cut-off values for a positive HAST were set according to British Thoracic Society (BTS) guidelines (arterial oxygen tension (P$_{aO_{2}}$) <6.6 kPa and/orS$_{pO_{2}}$<85%). The following day, patients travelled to HA (3100 m) for two overnight stays where ARAHE development including acute mountain sickness (AMS), Lake Louise Score ≥4 and/or AMS score ≥0.7, severe hypoxaemia (S$_{pO_{2}}$<80% for >30 min or 75% for >15 min) or intercurrent illness was observed. Results: ARAHE occurred in 50 (66%) patients and 23 out of 75 (31%) were positive on HAST according toS$_{pO_{2}}$, and 11 out of 64 (17%) according toP$_{aO_{2}}$. ForS$_{pO_{2}}$/P$_{aO_{2}}$we report a sensitivity of 46/25%, specificity of 84/95%, positive predictive value of 85/92% and negative predictive value of 44/37%. Conclusion: In COPD patients ascending to HA, ARAHE are common. Despite an acceptable positive predictive value of the HAST to predict ARAHE, its clinical use is limited by its insufficient sensitivity and overall accuracy. Counselling COPD patients before altitude travel remains challenging and best focuses on early recognition and treatment of ARAHE with oxygen and descent.

Published
2023

24. Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study

Author

Luyken, Matthias C, Appenzeller, Paula, Scheiwiller, Philipp M, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Muratbekova, Aybermet, Sheraliev, Ulan, Abdraeva, Ainura, Marazhapov, Nuriddin, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Luyken, Matthias C, Appenzeller, Paula, Scheiwiller, Philipp M, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Muratbekova, Aybermet, Sheraliev, Ulan, Abdraeva, Ainura, Marazhapov, Nuriddin, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, and Furian, Michael; https://orcid.org/0000-0002-8518-5029

Abstract

Introduction: This prospective cohort study assessed the effects of chronic hypoxaemia due to high-altitude residency on the cerebral tissue oxygenation (CTO) and cerebrovascular reactivity.Methods: Highlanders, born, raised, and currently living above 2,500 m, without cardiopulmonary disease, participated in a prospective cohort study from 2012 until 2017. The measurements were performed at 3,250 m. After 20 min of rest in supine position while breathing ambient air (FiO$_{2}$ 0.21) or oxygen (FiO$_{2}$ 1.0) in random order, guided hyperventilation followed under the corresponding gas mixture. Finger pulse oximetry (SpO$_{2}$) and cerebral near-infrared spectroscopy assessing CTO and change in cerebral haemoglobin concentration (cHb), a surrogate of cerebral blood volume changes and cerebrovascular reactivity, were applied. Arterial blood gases were obtained during ambient air breathing.Results: Fifty three highlanders, aged 50 ± 2 years, participated in 2017 and 2012. While breathing air in 2017 vs. 2012, PaO$_{2}$ was reduced, mean ± SE, 7.40 ± 0.13 vs. 7.84 ± 0.13 kPa; heart rate was increased 77 ± 1 vs. 70 ± 1 bpm (p < 0.05) but CTO remained unchanged, 67.2% ± 0.7% vs. 67.4% ± 0.7%. With oxygen, SpO$_{2}$ and CTO increased similarly in 2017 and 2012, by a mean (95% CI) of 8.3% (7.5–9.1) vs. 8.5% (7.7–9.3) in SpO$_{2}$, and 5.5% (4.1–7.0) vs. 4.5% (3.0–6.0) in CTO, respectively. Hyperventilation resulted in less reduction of cHb in 2017 vs. 2012, mean difference (95% CI) in change with air 2.0 U/L (0.3–3.6); with oxygen, 2.1 U/L (0.5–3.7).Conclusion: Within 5 years, CTO in highlanders was preserved despite a decreased PaO$_{2}$. As this was associated with a reduced response of cerebral blood volume to hypocapnia, adaptation of cerebrovascular reactivity might have occurred.

Published
2023

25. Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older—RCT

Author

Ceruti, Samuele, Ceruti, S ( Samuele ), Reiser, Aurelia E, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Buergin, Aline, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Appenzeller, Paula, Mayer, Laura, Muralt, Lara, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Abdyraeva, Ainura, Aidaralieva, Shoira, Muratbekova, Aibermet, Akylbekov, Azamat, Sheraliev, Ulan, Shabykeeva, Saltanat, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Ceruti, Samuele, Ceruti, S ( Samuele ), Reiser, Aurelia E, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Buergin, Aline, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Appenzeller, Paula, Mayer, Laura, Muralt, Lara, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Abdyraeva, Ainura, Aidaralieva, Shoira, Muratbekova, Aibermet, Akylbekov, Azamat, Sheraliev, Ulan, Shabykeeva, Saltanat, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, and Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387

Abstract

Objective: Altitude travel is increasingly popular also for middle-aged and older tourists and professionals. Due to the sensitivity of the central nervous system to hypoxia, altitude exposure may impair visuomotor performance although this has not been extensively studied. Therefore, we investigated whether a sojourn at moderately high altitude is associated with visuomotor performance impairments in healthy adults, 40y of age or older, and whether this adverse altitude-effect can be prevented by acetazolamide, a drug used to prevent acute mountain sickness. Methods: In this randomized placebo-controlled parallel-design trial, 59 healthy lowlanders, aged 40-75y, were assigned to acetazolamide (375 mg/day, n = 34) or placebo (n = 25), administered one day before ascent and while staying at high altitude (3100m). Visuomotor performance was assessed at 760m and 3100m after arrival and in the next morning (post-sleep) by a computer-assisted test (Motor-Task-Manager). It quantified deviation of a participant-controlled cursor affected by rotation during target tracking. Primary outcome was the directional error during post-sleep recall of adaptation to rotation estimated by multilevel linear regression modeling. Additionally, adaptation, immediate recall, and correct test execution were evaluated. Results: Compared to 760m, assessments at 3100m with placebo revealed a mean (95%CI) increase in directional error during adaptation and immediate recall by 1.9° (0.2 to 3.5, p = 0.024) and 1.1° (0.4 to 1.8, p = 0.002), respectively. Post-sleep recall remained unchanged (p = NS), however post-sleep correct test execution was 14% less likely (9 to 19, p<0.001). Acetazolamide improved directional error during post-sleep recall by 5.6° (2.6 to 8.6, p<0.001) and post-sleep probability of correct test execution by 36% (30 to 42, p<0.001) compared to placebo. Conclusion: In healthy individuals, 40y of age or older, altitude exposure impaired adaptation to and immediate recall and co

Published
2023

26. Counseling Patients with Chronic Obstructive Pulmonary Disease Traveling to High Altitude

Author

Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Sooronbaev, Talant M, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Sooronbaev, Talant M, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, and Furian, Michael; https://orcid.org/0000-0002-8518-5029

Published
2023

27. Validation of Noninvasive Assessment of Pulmonary Gas Exchange in Patients with Chronic Obstructive Pulmonary Disease during Initial Exposure to High Altitude

Author

Champigneulle, Benoit; https://orcid.org/0000-0003-0922-5102, Reinhard, Lukas, Mademilov, Maamed, Marillier, Mathieu, Ulrich, Tanja, Carta, Arcangelo F; https://orcid.org/0000-0001-8019-7429, Scheiwiller, Philipp, Shabykeeva, Saltanat B, Sheraliev, Ulan U, Abdraeva, Ainura K, Magdieva, Kamila M, Mirzalieva, Gulzada, Taalaibekova, Aijan T, Ozonova, Aigul K, Erkinbaeva, Aidai O, Shakiev, Nurdin U, Azizbekov, Syimyk A, Ainslie, Philip N, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Verges, Samuel; https://orcid.org/0000-0002-0831-9222, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Champigneulle, Benoit; https://orcid.org/0000-0003-0922-5102, Reinhard, Lukas, Mademilov, Maamed, Marillier, Mathieu, Ulrich, Tanja, Carta, Arcangelo F; https://orcid.org/0000-0001-8019-7429, Scheiwiller, Philipp, Shabykeeva, Saltanat B, Sheraliev, Ulan U, Abdraeva, Ainura K, Magdieva, Kamila M, Mirzalieva, Gulzada, Taalaibekova, Aijan T, Ozonova, Aigul K, Erkinbaeva, Aidai O, Shakiev, Nurdin U, Azizbekov, Syimyk A, Ainslie, Philip N, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Verges, Samuel; https://orcid.org/0000-0002-0831-9222, and Furian, Michael; https://orcid.org/0000-0002-8518-5029

Abstract

Investigation of pulmonary gas exchange efficacy usually requires arterial blood gas analysis (aBGA) to determine arterial partial pressure of oxygen (mPaO2) and compute the Riley alveolar-to-arterial oxygen difference (A-aDO2); that is a demanding and invasive procedure. A noninvasive approach (AGM100), allowing the calculation of PaO2 (cPaO2) derived from pulse oximetry (SpO2), has been developed, but this has not been validated in a large cohort of chronic obstructive pulmonary disease (COPD) patients. Our aim was to conduct a validation study of the AG100 in hypoxemic moderate-to-severe COPD. Concurrent measurements of cPaO2 (AGM100) and mPaO2 (EPOC, portable aBGA device) were performed in 131 moderate-to-severe COPD patients (mean ±SD FEV1: 60 ± 10% of predicted value) and low-altitude residents, becoming hypoxemic (i.e., SpO2 < 94%) during a short stay at 3100 m (Too-Ashu, Kyrgyzstan). Agreements between cPaO2 (AGM100) and mPaO2 (EPOC) and between the O2-deficit (calculated as the difference between end-tidal pressure of O2 and cPaO2 by the AGM100) and Riley A-aDO2 were assessed. Mean bias (±SD) between cPaO2 and mPaO2 was 2.0 ± 4.6 mmHg (95% Confidence Interval (CI): 1.2 to 2.8 mmHg) with 95% limits of agreement (LoA): −7.1 to 11.1 mmHg. In multivariable analysis, larger body mass index (p = 0.046), an increase in SpO2 (p < 0.001), and an increase in PaCO2-PETCO2 difference (p < 0.001) were associated with imprecision (i.e., the discrepancy between cPaO2 and mPaO2). The positive predictive value of cPaO2 to detect severe hypoxemia (i.e., PaO2 ≤ 55 mmHg) was 0.94 (95% CI: 0.87 to 0.98) with a positive likelihood ratio of 3.77 (95% CI: 1.71 to 8.33). The mean bias between O2-deficit and A-aDO2 was 6.2 ± 5.5 mmHg (95% CI: 5.3 to 7.2 mmHg; 95%LoA: −4.5 to 17.0 mmHg). AGM100 provided an accurate estimate of PaO2 in hypoxemic patients with COPD, but the precision for individual values was modest. This device is promising for noninvasive assessment of pulmonary gas

Published
2023

28. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author

Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten

Published
2016
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29. Helsinki by nature: The Nature Step to Respiratory Health

Author

Haahtela, Tari, von Hertzen, Leena, Anto, Josep M., Bai, Chunxue, Baigenzhin, Abay, Bateman, Eric D., Behera, Digambar, Bennoor, Kazi, Camargos, Paulo, Chavannes, Niels, de Sousa, Jaime Correia, Cruz, Alvaro, Do Céu Teixeira, Maria, Erhola, Marina, Furman, Eeva, Gemicioğlu, Bilun, Gonzalez Diaz, Sandra, Hellings, Peter W., Jousilahti, Pekka, Khaltaev, Nikolai, Kolek, Vitezslav, Kuna, Piotr, La Grutta, Stefania, Lan, Le Thi Tuyet, Maglakelidze, Tamaz, Masjedi, Mohamed R., Mihaltan, Florin, Mohammad, Yousser, Nunes, Elizabete, Nyberg, Arvid, Quel, Jorge, Rosado-Pinto, Jose, Sagara, Hironori, Samolinski, Boleslaw, Schraufnagel, Dean, Sooronbaev, Talant, Tag Eldin, Mohamed, To, Teresa, Valiulis, Arunas, Varghese, Cherian, Vasankari, Tuula, Viegi, Giovanni, Winders, Tonya, Yañez, Anahi, Yorgancioğlu, Arzu, Yusuf, Osman, Bousquet, Jean, and Billo, Nils E.

Published
2019
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30. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group

Published
2019
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33. Counseling Patients with Chronic Obstructive Pulmonary Disease Traveling to High Altitude.

Author

Bloch, Konrad E., Sooronbaev, Talant M., Ulrich, Silvia, Lichtblau, Mona, and Furian, Michael

Subjects
*CHRONIC obstructive pulmonary disease, *ARRHYTHMIA, *SLEEP interruptions, *PULMONARY hypertension, *ALTITUDES, *PSYCHOLOGY of movement, *CARDIOLOGICAL manifestations of general diseases
Abstract

Bloch, Konrad E., Talant M. Sooronbaev, Silvia Ulrich, Mona Lichtblau, and Michael Furian. Clinician's corner: counseling patients with chronic obstructive pulmonary disease traveling to high altitude. High Alt Med Biol. 24:158–166, 2023.—Mountain travel is increasingly popular also among patients with chronic obstructive pulmonary disease (COPD), a highly prevalent condition often associated with cardiovascular and systemic manifestations. Recent studies have shown that nonhypercapnic and only mildly hypoxemic lowlanders with moderate to severe airflow obstruction owing to COPD experience dyspnea, exercise limitation, and sleep disturbances when traveling up to 3,100 m. Altitude-related adverse health effects (ARAHE) in patients with COPD include severe hypoxemia, which may be asymptomatic but expose patients to the risk of excessive systemic and pulmonary hypertension, cardiac arrhythmia, and even myocardial or cerebral ischemia. In addition, hypobaric hypoxia may impair postural control, psycho-motor, and cognitive performance in patients with COPD during altitude sojourns. Randomized, placebo-controlled trials have shown that preventive treatment with oxygen at night or with acetazolamide reduces the risk of ARAHE in patients with COPD while preventive dexamethasone treatment improves oxygenation and altitude-induced excessive sleep apnea, and lowers systemic and pulmonary artery pressure. This clinical review provides suggestions for pretravel assessment and preparations and measures during travel that may reduce the risk of ARAHE and contribute to pleasant mountain journeys of patients with COPD. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older—RCT

Author

Reiser, Aurelia E., primary, Furian, Michael, additional, Lichtblau, Mona, additional, Buergin, Aline, additional, Schneider, Simon R., additional, Appenzeller, Paula, additional, Mayer, Laura, additional, Muralt, Lara, additional, Mademilov, Maamed, additional, Abdyraeva, Ainura, additional, Aidaralieva, Shoira, additional, Muratbekova, Aibermet, additional, Akylbekov, Azamat, additional, Sheraliev, Ulan, additional, Shabykeeva, Saltanat, additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, and Bloch, Konrad E., additional

Published
2023
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36. Validation of Noninvasive Assessment of Pulmonary Gas Exchange in Patients with Chronic Obstructive Pulmonary Disease during Initial Exposure to High Altitude

Author

Champigneulle, Benoit, primary, Reinhard, Lukas, additional, Mademilov, Maamed, additional, Marillier, Mathieu, additional, Ulrich, Tanja, additional, Carta, Arcangelo F., additional, Scheiwiller, Philipp, additional, Shabykeeva, Saltanat B., additional, Sheraliev, Ulan U., additional, Abdraeva, Ainura K., additional, Magdieva, Kamila M., additional, Mirzalieva, Gulzada, additional, Taalaibekova, Aijan T., additional, Ozonova, Aigul K., additional, Erkinbaeva, Aidai O., additional, Shakiev, Nurdin U., additional, Azizbekov, Syimyk A., additional, Ainslie, Philip N., additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, Bloch, Konrad E., additional, Verges, Samuel, additional, and Furian, Michael, additional

Published
2023
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37. Effect of altitude and acetazolamide on sleep and nocturnal breathing in healthy lowlanders 40 y of age or older. Data from a randomized trial

Author

Graf, Laura C, Furian, Michael, Bitos, Konstantinos, Mademilov, Maamed, Abdraeva, Ainura, Buenzli, Jana, Buenzli, Simone, Aidaralieva, Shaira, Sheraliev, Ulan, Mayer, Laura C, Schneider, Simon R, Sooronbaev, Talant M, Ulrich, Silvia, Bloch, Konrad E, and University of Zurich

Subjects
Physiology (medical), 10209 Clinic for Cardiology, 610 Medicine & health, Neurology (clinical), 10178 Clinic for Pneumology
Abstract

Study Objectives To assess altitude-induced sleep and nocturnal breathing disturbances in healthy lowlanders 40 y of age or older and the effects of preventive acetazolamide treatment. Methods Clinical examinations and polysomnography were performed at 760 m and in the first night after ascent to 3100 m in a subsample of participants of a larger trial evaluating altitude illness. Participants were randomized 1:1 to treatment with acetazolamide (375 mg/day) or placebo, starting 24 h before and while staying at 3100 m. The main outcomes were indices of sleep structure, oxygenation, and apnea/hypopnea index (AHI). Results Per protocol analysis included 86 participants (mean ± SE 53 ± 7 y old, 66% female). In 43 individuals randomized to placebo, mean nocturnal pulse oximetry (SpO2) was 94.0 ± 0.4% at 760 m and 86.7 ± 0.4% at 3100 m, with mean change (95%CI) −7.3% (−8.0 to −6.5); oxygen desaturation index (ODI) was 5.0 ± 2.3 at 760 m and 29.2 ± 2.3 at 3100 m, change 24.2/h (18.8 to 24.5); AHI was 11.3 ± 2.4/h at 760 m and 23.5 ± 2.4/h at 3100 m, change 12.2/h (7.3 to 17.0). In 43 individuals randomized to acetazolamide, altitude-induced changes were mitigated. Mean differences (Δ, 95%CI) in altitude-induced changes were: ΔSpO2 2.3% (1.3 to 3.4), ΔODI -15.0/h (−22.6 to −7.4), ΔAHI -11.4/h (−18.3 to −4.6). Total sleep time, sleep efficiency, and N3-sleep fraction decreased with an ascent to 3100 m under placebo by 40 min (17 to 60), 5% (2 to 8), and 6% (2 to 11), respectively. Acetazolamide did not significantly change these outcomes. Conclusions During a night at 3100 m, healthy lowlanders aged 40 y or older revealed hypoxemia, sleep apnea, and disturbed sleep. Preventive acetazolamide treatment improved oxygenation and nocturnal breathing but had no effect on sleep duration and structure. Trial registration The trial is registered at Clinical Trials, https://clinicaltrials.gov, NCT03561675

Published
2022

38. Visuomotor performance at high altitude in COPD patients. Randomized placebo-controlled trial of acetazolamide

Author

Scheiwiller, Philipp M, Furian, Michael, Buergin, Aline, Mayer, Laura C, Schneider, Simon R, Mademilov, Maamed, Lichtblau, Mona, Muralt, Lara, Sheraliev, Ulan, Sooronbaev, Talant M, Ulrich, Silvia, Bloch, Konrad E, University of Zurich, and Bloch, Konrad E

Subjects
2737 Physiology (medical), Physiology, Physiology (medical), 610 Medicine & health, 1314 Physiology, 10178 Clinic for Pneumology
Published
2022

39. Effect of acetazolamide on pulmonary vascular hemodynamics in patients with COPD going to altitude: a randomized, placebo-controlled, double-blind trial

Author

Lichtblau, Mona, primary, Saxer, Stéphanie, additional, Mayer, Laura, additional, Sheraliev, Ulan, additional, Mademilov, Maamed, additional, Furian, Michael, additional, Buergin, Aline, additional, Schweiwiller, Philipp M., additional, Schneider, Simon R., additional, Tanner, Felix C., additional, Sooronbaev, Talant, additional, Bloch, Konrad E, additional, and Ulrich, Silvia, additional

Published
2022
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40. The RECHARGE-IPCRG ‘Teach the Teacher’ programme: building capacity for pulmonary rehabilitation in low- and middle-income countries

Author

McDonnell, Juliet, primary, Orme, Mark, additional, Houchen–Wolloff, Linzy, additional, Baxter, Noel, additional, Barnard, Amanda, additional, Correia de Sousa, Jaime, additional, Tsiligianni, Ioanna, additional, Gardiner, Nikki, additional, Akylbekov, Azamat, additional, Mirzalieva, Gulzada, additional, Mademilov, Maamed, additional, Sooronbaev, Talant, additional, Kasiita, Richard, additional, Katagira, Winceslaus, additional, Kirenga, Bruce, additional, Wimalasekera, Savithri, additional, Amarasekara, Thamara, additional, Sooriyakanthan, Mathanki, additional, Karunatilake, Ravini, additional, Ishrat, Rubia, additional, Ahmed, Obaidullah, additional, Hanif, Humaira, additional, Dixit, Prajjwal, additional, Talwar, Deepak, additional, Sahasrabudhe, Shruti, additional, Bhakare, Meenakshi, additional, Salvi, Sundeep, additional, and Singh, Sally J, additional

Published
2022
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43. No time for change? Impact of contextual factors on the effect of training primary care healthcare workers in Kyrgyzstan and Vietnam on how to manage asthma in children - A FRESH AIR implementation study

Author

Kjærgaard, Jesper, Nissen, Thomas Nørrelykke, Isaeva, Elvira, Quynh, Nguyen Nhat, Reventlow, Susanne, Lund, Stine, Sooronbaev, Talant, Le An, Pham, Østergaard, Marianne Stubbe, Stout, Jim, Poulsen, Anja, Anastasaki, Marilena, Akylbekov, Azamat, Barton, Andy, Bertsias, Antonios, Binh, Pham Duong Uyen, van Boven, Job F.M., Brakema, Evelyn A., Burges, Dennis, Cartwright, Lucy, Chatzea, Vasiliki E., Chavannes, Niels H., Cragg, Liza, Dang, Tran Ngoc, Dautov, Ilyas, Emilov, Berik, Ferarrio, Irene, van Gemert, Frederik A., Hedrick, Ben, Hong, Le Huynh Thi Cam, Hopkinson, Nick, Jones, Rupert, de Jong, Corina, van Kampen, Sanne, Katagira, Winceslaus, Kirenga, Bruce, van der Kleij, Rianne Mjj, Kocks, Janwillem, Lan, Le Thi Tuyet, Linh, Tran Thanh Duv, Lionis, Christos, Loan, Kim Xuan, Luan, Nguyen Huy, Mademilov, Maamed, McEwen, Andy, Musinguzi, Patrick, Nantanda, Rebecca, Ndeezi, Grace, Papadakis, Sophia, and Pinnock, Hilary

Subjects
medicine.medical_specialty, Contextual factors, Health Personnel, Physical examination, 1110 Nursing, Health informatics, Pediatrics, Health administration, 1117 Public Health and Health Services, Time for consultation, 03 medical and health sciences, 0302 clinical medicine, Health care, Medicine, Humans, Training, 030212 general & internal medicine, Child, Kyrgyzstan, Asthma, Low- and middle-income countries, Under-five, medicine.diagnostic_test, Primary Health Care, business.industry, Health Policy, Public health, Nursing research, lcsh:Public aspects of medicine, Quality of care, FRESH AIR collaborators, lcsh:RA1-1270, medicine.disease, 3. Good health, Knowledge, 030228 respiratory system, Vietnam, Family medicine, Health Policy & Services, business, 0807 Library and Information Studies, Research Article
Abstract

Background Training is a common and cost-effective way of trying to improve quality of care in low- and middle-income countries but studies of contextual factors for the successful translation of increased knowledge into clinical change are lacking, especially in primary care. The purpose of this study was to assess the impact of contextual factors on the effect of training rural healthcare workers in Kyrgyzstan and Vietnam on their knowledge and clinical performance in managing pediatric patients with respiratory symptoms. Methods Primary care health workers in Kyrgyzstan and Vietnam underwent a one-day training session on asthma in children under five. The effect of training was measured on knowledge and clinical performance using a validated questionnaire, and by direct clinical observations. Results Eighty-one healthcare workers participated in the training. Their knowledge increased by 1.1 Cohen’s d (CI: 0.7 to 1.4) in Kyrgyzstan where baseline performance was lower and 1.5 Cohen’s d (CI: 0.5 to 2.5) in Vietnam. Consultations were performed by different types of health care workers in Kyrgyzstan and there was a 79.1% (CI 73.9 to 84.3%) increase in consultations where at least one core symptom of respiratory illness was asked. Only medical doctors participated in Vietnam, where the increase was 25.0% (CI 15.1 to 34.9%). Clinical examination improved significantly after training in Kyrgyzstan. In Vietnam, the number of actions performed generally declined. The most pronounced difference in contextual factors was consultation time, which was median 15 min in Kyrgyzstan and 2 min in Vietnam. Discussion and conclusion The effects on knowledge of training primary care health workers in lower middle-income countries in diagnosis and management of asthma in children under five only translated into changes in clinical performance where consultation time allowed for changes to clinical practice, emphasizing the importance of considering contextual factors in order to succeed in behavioral change after training.

Published
2020

44. Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults

Author

Furian, Michael; https://orcid.org/0000-0002-8518-5029, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Buergin, Aline, Scheiwiller, Philipp M, Mayer, Laura, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Emilov, Berik, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Bitos, Konstantinos, Muralt, Lara, Groth, Alexandra, Reiser, Aurelia E, Sevik, Ahmet, Sheraliev, Ulan, Marazhapov, Nuriddin H, Aydaralieva, Shoira, Muratbekova, Aybermet, Tabyshova, Aizhamal, Abdraeva, Ainura, Buenzli, Simone, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387, Furian, Michael; https://orcid.org/0000-0002-8518-5029, Mademilov, Maamed; https://orcid.org/0000-0001-8528-3115, Buergin, Aline, Scheiwiller, Philipp M, Mayer, Laura, Schneider, Simon R; https://orcid.org/0000-0003-3635-0515, Emilov, Berik, Lichtblau, Mona; https://orcid.org/0000-0003-4485-1758, Bitos, Konstantinos, Muralt, Lara, Groth, Alexandra, Reiser, Aurelia E, Sevik, Ahmet, Sheraliev, Ulan, Marazhapov, Nuriddin H, Aydaralieva, Shoira, Muratbekova, Aybermet, Tabyshova, Aizhamal, Abdraeva, Ainura, Buenzli, Simone, Sooronbaev, Talant M; https://orcid.org/0000-0002-5609-0944, Ulrich, Silvia; https://orcid.org/0000-0002-5250-5022, and Bloch, Konrad E; https://orcid.org/0000-0002-2377-7387

Abstract

Background We evaluated the efficacy of acetazolamide in preventing adverse altitude effects in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and in healthy lowlanders 40 years of age or older. Methods Trial 1 was a randomized, double-blind, parallel-design trial in which 176 patients with COPD were treated with acetazolamide capsules (375 mg/day) or placebo, starting 24 hours before staying for 2 days at 3100 m. The mean (±SD) age of participants was 57±9 years, and 34% were women. At 760 m, COPD patients had oxygen saturation measured by pulse oximetry of 92% or greater, arterial partial pressure of carbon dioxide less than 45 mm Hg, and mean forced expiratory volume in 1 second of 63±11% of predicted. The primary outcome in trial 1 was the incidence of the composite end point of altitude-related adverse health effects (ARAHE) at 3100 m. Criteria for ARAHE included acute mountain sickness (AMS) and symptoms or findings relevant to well-being and safety, such as severe hypoxemia, requiring intervention. Trial 2 comprised 345 healthy lowlanders. Their mean age was 53±7 years, and 69% were women. The participants in trial 2 underwent the same protocol as did the patients with COPD in trial 1. The primary outcome in trial 2 was the incidence of AMS assessed at 3100 m by the Lake Louise questionnaire score (the scale of self-assessed symptoms ranges from 0 to 15 points, indicating absent to severe, with 3 or more points including headache, indicating AMS). Results In trial 1 of patients with COPD, 68 of 90 (76%) receiving placebo and 42 of 86 (49%) receiving acetazolamide experienced ARAHE (hazard ratio, 0.54; 95% confidence interval [CI], 0.37 to 0.79; P<0.001). The number needed to treat (NNT) to prevent one case of ARAHE was 4 (95% CI, 3 to 8). In trial 2 of healthy individuals, 54 of 170 (32%) receiving placebo and 38 of 175 (22%) receiving acetazolamide experienced AMS (hazard ratio, 0.48; 95% CI, 0.29 to 0.80; chi-square statistic

Published
2022

46. Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults

Author

Furian, Michael, Mademilov, Maamed, Buergin, Aline, Scheiwiller, Philipp M, Mayer, Laura, Schneider, Simon R, Emilov, Berik, Lichtblau, Mona, Bitos, Konstantinos, Muralt, Lara, Groth, Alexandra, Reiser, Aurelia E, Sevik, Ahmet, Sheraliev, Ulan, Marazhapov, Nuriddin H, Aydaralieva, Shoira, Muratbekova, Aybermet, Tabyshova, Aizhamal, Abdraeva, Ainura, Buenzli, Simone, Sooronbaev, Talant M, Ulrich, Silvia, Bloch, Konrad E, and University of Zurich

Subjects
610 Medicine & health, 10178 Clinic for Pneumology
Published
2022

47. Culturally adapted pulmonary rehabilitation for adults living with post-tuberculosis lung disease in Kyrgyzstan: protocol for a randomised controlled trial with blinded outcome measures

Author

Akylbekov, Azamat, primary, Orme, Mark W, additional, Jones, Amy V, additional, Mademilov, Maamed, additional, Muratbekova, Aibermet, additional, Aidaralieva, Shoira, additional, Mirzalieva, Gulzada, additional, Oleinik, Alena, additional, Magdieva, Kamila, additional, Taalaibekova, Aijan, additional, Rysbek kyzy, Aidai, additional, Yusuf, Zainab K, additional, Rupert, Jones, additional, Barton, Andy, additional, Miah, Ruhme B, additional, Manise, Adrian, additional, Matheson, Jesse A, additional, Malcolm, Dominic, additional, Free, Robert C, additional, Steiner, Michael C, additional, Sooronbaev, Talant, additional, and Singh, Sally J, additional

Published
2022
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48. What should pulmonary rehabilitation look like for people living with post-tuberculosis lung disease in the Bishkek and Chui region of the Kyrgyz Republic? A qualitative exploration

Author

Mademilov, Maamed, primary, Mirzalieva, Gulzada, additional, Yusuf, Zainab K, additional, Orme, Mark W, additional, Bourne, Claire, additional, Akylbekov, Azamat, additional, Jones, Amy V, additional, Miah, Ruhme B, additional, Jones, Rupert, additional, Barton, Andy, additional, Malcolm, Dominic, additional, Sooronbaev, Talant, additional, and Singh, Sally J, additional

Published
2022
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49. Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults

Author

Furian, Michael, primary, Mademilov, Maamed, additional, Buergin, Aline, additional, Scheiwiller, Philipp M., additional, Mayer, Laura, additional, Schneider, Simon, additional, Emilov, Berik, additional, Lichtblau, Mona, additional, Bitos, Konstantinos, additional, Muralt, Lara, additional, Groth, Alexandra, additional, Reiser, Aurelia E., additional, Sevik, Ahmet, additional, Sheraliev, Ulan, additional, Marazhapov, Nuriddin H., additional, Aydaralieva, Shoira, additional, Muratbekova, Aybermet, additional, Tabyshova, Aizhamal, additional, Abdraeva, Ainura, additional, Buenzli, Simone, additional, Sooronbaev, Talant M., additional, Ulrich, Silvia, additional, and Bloch, Konrad E., additional

Published
2022
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