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Abstract Plant diseases pose significant threats to agriculture, impacting both food safety and public health. Traditional plant disease detection systems are typically limited to recognizing disease categories included in the training dataset, rendering them ineffective against new disease types. Although out-of-distribution (OOD) detection methods have been proposed to address this issue, the impact of fine-tuning paradigms on these methods has been overlooked. This paper focuses on studying the impact of fine-tuning paradigms on the performance of detecting unknown plant diseases. Currently, fine-tuning on visual tasks is mainly divided into visual-based models and visual-language-based models. We first discuss the limitations of large-scale visual language models in this task: textual prompts are difficult to design. To avoid the side effects of textual prompts, we futher explore the effectiveness of purely visual pre-trained models for OOD detection in plant disease tasks. Specifically, we employed five publicly accessible datasets to establish benchmarks for open-set recognition, OOD detection, and few-shot learning in plant disease recognition. Additionally, we comprehensively compared various OOD detection methods, fine-tuning paradigms, and factors affecting OOD detection performance, such as sample quantity. The results show that visual prompt tuning outperforms fully fine-tuning and linear probe tuning in out-of-distribution detection performance, especially in the few-shot scenarios. Notably, the max-logit-based on visual prompt tuning achieves an AUROC score of 94.8 $$\%$$ % in the 8-shot setting, which is nearly comparable to the method of fully fine-tuning on the full dataset (95.2 $$\%$$ % ), which implies that an appropriate fine-tuning paradigm can directly improve OOD detection performance. Finally, we visualized the prediction distributions of different OOD detection methods and discussed the selection of thresholds. Overall, this work lays the foundation for unknown plant disease recognition, providing strong support for the security and reliability of plant disease recognition systems. We will release our code at https://github.com/JiuqingDong/PDOOD to further advance this field.

Although plant disease recognition has witnessed a significant improvement with deep learning in recent years, a common observation is that current deep learning methods with decent performance tend to suffer in real-world applications. We argue that this illusion essentially comes from the fact that current plant disease recognition datasets cater to deep learning methods and are far from real scenarios. Mitigating this illusion fundamentally requires an interdisciplinary perspective from both plant disease and deep learning, and a core question arises. What are the characteristics of a desired dataset? This paper aims to provide a perspective on this question. First, we present a taxonomy to describe potential plant disease datasets, which provides a bridge between the two research fields. We then give several directions for making future datasets, such as creating challenge-oriented datasets. We believe that our paper will contribute to creating datasets that can help achieve the ultimate objective of deploying deep learning in real-world plant disease recognition applications. To facilitate the community, our project is publicly available at https://github.com/xml94/PPDRD with the information of relevant public datasets.

Previous work on plant disease detection demonstrated that object detectors generally suffer from degraded training data, and annotations with noise may cause the training task to fail. Well-annotated datasets are therefore crucial to build a robust detector. However, a good label set generally requires much expert knowledge and meticulous work, which is expensive and time-consuming. This paper aims to learn robust feature representations with inaccurate bounding boxes, thereby reducing the model requirements for annotation quality. Specifically, we analyze the distribution of noisy annotations in the real world. A teacher-student learning paradigm is proposed to correct inaccurate bounding boxes. The teacher model is used to rectify the degraded bounding boxes, and the student model extracts more robust feature representations from the corrected bounding boxes. Furthermore, the method can be easily generalized to semi-supervised learning paradigms and auto-labeling techniques. Experimental results show that applying our method to the Faster-RCNN detector achieves a 26% performance improvement on the noisy dataset. Besides, our method achieves approximately 75% of the performance of a fully supervised object detector when 1% of the labels are available. Overall, this work provides a robust solution to real-world location noise. It alleviates the challenges posed by noisy data to precision agriculture, optimizes data labeling technology, and encourages practitioners to further investigate plant disease detection and intelligent agriculture at a lower cost. The code will be released at https://github.com/JiuqingDong/TS_OAMIL-for-Plant-disease-detection.

Plant disease detection has made significant strides thanks to the emergence of deep learning. However, existing methods have been limited to closed-set and static learning settings, where models are trained using a specific dataset. This confinement restricts the model’s adaptability when encountering samples from unseen disease categories. Additionally, there is a challenge of knowledge degradation for these static learning settings, as the acquisition of new knowledge tends to overwrite the old when learning new categories. To overcome these limitations, this study introduces a novel paradigm for plant disease detection called open-world setting. Our approach can infer disease categories that have never been seen during the model training phase and gradually learn these unseen diseases through dynamic knowledge updates in the next training phase. Specifically, we utilize a well-trained unknown-aware region proposal network to generate pseudo-labels for unknown diseases during training and employ a class-agnostic classifier to enhance the recall rate for unknown diseases. Besides, we employ a sample replay strategy to maintain recognition ability for previously learned classes. Extensive experimental evaluation and ablation studies investigate the efficacy of our method in detecting old and unknown classes. Remarkably, our method demonstrates robust generalization ability even in cross-species disease detection experiments. Overall, this open-world and dynamically updated detection method shows promising potential to become the future paradigm for plant disease detection. We discuss open issues including classification and localization, and propose promising approaches to address them. We encourage further research in the community to tackle the crucial challenges in open-world plant disease detection. The code will be released at https://github.com/JiuqingDong/OWPDD.

Recent advancements in deep learning have brought significant improvements to plant disease recognition. However, achieving satisfactory performance often requires high-quality training datasets, which are challenging and expensive to collect. Consequently, the practical application of current deep learning–based methods in real-world scenarios is hindered by the scarcity of high-quality datasets. In this paper, we argue that embracing poor datasets is viable and aims to explicitly define the challenges associated with using these datasets. To delve into this topic, we analyze the characteristics of high-quality datasets, namely, large-scale images and desired annotation, and contrast them with the limited and imperfect nature of poor datasets. Challenges arise when the training datasets deviate from these characteristics. To provide a comprehensive understanding, we propose a novel and informative taxonomy that categorizes these challenges. Furthermore, we offer a brief overview of existing studies and approaches that address these challenges. We point out that our paper sheds light on the importance of embracing poor datasets, enhances the understanding of the associated challenges, and contributes to the ambitious objective of deploying deep learning in real-world applications. To facilitate the progress, we finally describe several outstanding questions and point out potential future directions. Although our primary focus is on plant disease recognition, we emphasize that the principles of embracing and analyzing poor datasets are applicable to a wider range of domains, including agriculture. Our project is public available at https://github.com/xml94/EmbracingLimitedImperfectTrainingDatasets.

Plant phenotyping is a critical field in agriculture, aiming to understand crop growth under specific conditions. Recent research uses images to describe plant characteristics by detecting visual information within organs such as leaves, flowers, stems, and fruits. However, processing data in real field conditions, with challenges such as image blurring and occlusion, requires improvement. This paper proposes a deep learning-based approach for leaf instance segmentation with a local refinement mechanism to enhance performance in cluttered backgrounds. The refinement mechanism employs Gaussian low-pass and High-boost filters to enhance target instances and can be applied to the training or testing dataset. An instance segmentation architecture generates segmented masks and detected areas, facilitating the derivation of phenotypic information, such as leaf count and size. Experimental results on a tomato leaf dataset demonstrate the system’s accuracy in segmenting target leaves despite complex backgrounds. The investigation of the refinement mechanism with different kernel sizes reveals that larger kernel sizes benefit the system’s ability to generate more leaf instances when using a High-boost filter, while prediction performance decays with larger Gaussian low-pass filter kernel sizes. This research addresses challenges in real greenhouse scenarios and enables automatic recognition of phenotypic data for smart agriculture. The proposed approach has the potential to enhance agricultural practices, ultimately leading to improved crop yields and productivity.

Accurate identification of individual cattle is of paramount importance in precision livestock farming, enabling the monitoring of cattle behavior, disease prevention, and enhanced animal welfare. Unlike human faces, the faces of most Hanwoo cattle, a native breed of Korea, exhibit significant similarities and have the same body color, posing a substantial challenge in accurately distinguishing between individual cattle. In this study, we sought to extend the closed-set scope (only including identifying known individuals) to a more-adaptable open-set recognition scenario (identifying both known and unknown individuals) termed Cattle’s Face Open-Set Recognition (CFOSR). By integrating open-set techniques to enhance the closed-set accuracy, the proposed method simultaneously addresses the open-set scenario. In CFOSR, the objective is to develop a trained model capable of accurately identifying known individuals, while effectively handling unknown or novel individuals, even in cases where the model has been trained solely on known individuals. To address this challenge, we propose a novel approach that integrates Adversarial Reciprocal Points Learning (ARPL), a state-of-the-art open-set recognition method, with the effectiveness of Additive Margin Softmax loss (AM-Softmax). ARPL was leveraged to mitigate the overlap between spaces of known and unknown or unregistered cattle. At the same time, AM-Softmax was chosen over the conventional Cross-Entropy loss (CE) to classify known individuals. The empirical results obtained from a real-world dataset demonstrated the effectiveness of the ARPL and AM-Softmax techniques in achieving both intra-class compactness and inter-class separability. Notably, the results of the open-set recognition and closed-set recognition validated the superior performance of our proposed method compared to existing algorithms. To be more precise, our method achieved an AUROC of 91.84 and an OSCR of 87.85 in the context of open-set recognition on a complex dataset. Simultaneously, it demonstrated an accuracy of 94.46 for closed-set recognition. We believe that our study provides a novel vision to improve the classification accuracy of the closed set. Simultaneously, it holds the potential to significantly contribute to herd monitoring and inventory management, especially in scenarios involving the presence of unknown or novel cattle.

We propose an enhanced class-specific spatial normalization, a simple yet effective layer to generate a photorealistic image given a spatial-class map. Under the assumption that pixels belonging to the same class share the same distribution in the feature space, we intuitively split an image into classes according to the map. By learning the class-specific distributions, our generator can distinguish one class from other classes. Further, our spatial normalization combines the spatial-class map and the class-specific distributions, by which our generator can produce instances in the desired locations. We apply the proposed normalization not only in semantic image generation but also in object transfiguration. The experimental results demonstrate that the spatial-class map can be efficiently utilized with our proposed method, which results in competing performances with much fewer parameters.

Object detection models have become the current tool of choice for plant disease detection in precision agriculture. Most existing research improved the performance by ameliorating networks and optimizing the loss function. However, because of the vast influence of data annotation quality and the cost of annotation, the data-centric part of a project also needs more investigation. We should further consider the relationship between data annotation strategies, annotation quality, and the model’s performance. In this paper, a systematic strategy with four annotation strategies for plant disease detection is proposed: local, semi-global, global, and symptom-adaptive annotation. Labels with different annotation strategies will result in distinct models’ performance, and their contrasts are remarkable. An interpretability study of the annotation strategy is conducted by using class activation maps. In addition, we define five types of inconsistencies in the annotation process and investigate the severity of the impact of inconsistent labels on model’s performance. Finally, we discuss the problem of label inconsistency during data augmentation. Overall, this data-centric quantitative analysis helps us to understand the significance of annotation strategies, which provides practitioners a way to obtain higher performance and reduce annotation costs on plant disease detection. Our work encourages researchers to pay more attention to annotation consistency and the essential issues of annotation strategy. The code will be released at: https://github.com/JiuqingDong/PlantDiseaseDetection_Yolov5 .

Deep learning has witnessed a significant improvement in recent years to recognize plant diseases by observing their corresponding images. To have a decent performance, current deep learning models tend to require a large-scale dataset. However, collecting a dataset is expensive and time-consuming. Hence, the limited data is one of the main challenges to getting the desired recognition accuracy. Although transfer learning is heavily discussed and verified as an effective and efficient method to mitigate the challenge, most proposed methods focus on one or two specific datasets. In this paper, we propose a novel transfer learning strategy to have a high performance for versatile plant disease recognition, on multiple plant disease datasets. Our transfer learning strategy differs from the current popular one due to the following factors. First, PlantCLEF2022, a large-scale dataset related to plants with 2,885,052 images and 80,000 classes, is utilized to pre-train a model. Second, we adopt a vision transformer (ViT) model, instead of a convolution neural network. Third, the ViT model undergoes transfer learning twice to save computations. Fourth, the model is first pre-trained in ImageNet with a self-supervised loss function and with a supervised loss function in PlantCLEF2022. We apply our method to 12 plant disease datasets and the experimental results suggest that our method surpasses the popular one by a clear margin for different dataset settings. Specifically, our proposed method achieves a mean testing accuracy of 86.29over the 12 datasets in a 20-shot case, 12.76 higher than the current state-of-the-art method’s accuracy of 73.53. Furthermore, our method outperforms other methods in one plant growth stage prediction and the one weed recognition dataset. To encourage the community and related applications, we have made public our codes and pre-trained model1.

Predicting plant growth is a fundamental challenge that can be employed to analyze plants and further make decisions to have healthy plants with high yields. Deep learning has recently been showing its potential to address this challenge in recent years, however, there are still two issues. First, image-based plant growth prediction is currently taken either from time series or image generation viewpoints, resulting in a flexible learning framework and clear predictions, respectively. Second, deep learning-based algorithms are notorious to require a large-scale dataset to obtain a competing performance but collecting enough data is time-consuming and expensive. To address the issues, we consider the plant growth prediction from both viewpoints with two new time-series data augmentation algorithms. To be more specific, we raise a new framework with a length-changeable time-series processing unit to generate images flexibly. A generative adversarial loss is utilized to optimize our model to obtain high-quality images. Furthermore, we first recognize three key points to perform time-series data augmentation and then put forward T-Mixup and T-Copy-Paste. T-Mixup fuses images from a different time pixel-wise while T-Copy-Paste makes new time-series images with a different background by reusing individual leaves extracted from the existing dataset. We perform our method in a public dataset and achieve superior results, such as the generated RGB images and instance masks securing an average PSNR of 27.53 and 27.62, respectively, compared to the previously best 26.55 and 26.92.

Cattle behavior recognition is essential for monitoring their health and welfare. Existing techniques for behavior recognition in closed barns typically rely on direct observation to detect changes using wearable devices or surveillance cameras. While promising progress has been made in this field, monitoring individual cattle, especially those with similar visual characteristics, remains challenging due to numerous factors such as occlusion, scale variations, and pose changes. Accurate and consistent individual identification over time is therefore essential to overcome these challenges. To address this issue, this paper introduces an approach for multiview monitoring of individual cattle behavior based on action recognition using video data. The proposed system takes an image sequence as input and utilizes a detector to identify hierarchical actions categorized as part and individual actions. These regions of interest are then inputted into a tracking and identification mechanism, enabling the system to continuously track each individual in the scene and assign them a unique identification number. By implementing this approach, cattle behavior is continuously monitored, and statistical analysis is conducted to assess changes in behavior in the time domain. The effectiveness of the proposed framework is demonstrated through quantitative and qualitative experimental results obtained from our Hanwoo cattle video database. Overall, this study tackles the challenges encountered in real farm indoor scenarios, capturing spatiotemporal information and enabling automatic recognition of cattle behavior for precision livestock farming.

Instance-level image translation aims to only translate instance of interest and can be operated more finely and flexibly than object-level and holistic-level image translation. However, current algorithms are not suitable to do it since they employ a holistic or object level’s discriminator that tends to change the whole image or all instances. To address the issue, we propose a simple yet effective local discriminator, in which the input image is split into two parts, region of interest (ROI) and background. Instance mask is employed to align the ROI and the background is design to be random in a prior distribution to mitigate a divergence between the ROI and the background. In this way, we obtain translated instance with decent margins without artifacts as current algorithms get. Moreover we propose a new architecture to simultaneously realize versatile instance-level image translation. Experimental results prove that our proposed algorithm outperforms the state-of-the-art in position accuracy and background retainment by a clear margin.

Deep learning shows its advantages and potentials in plant disease recognition and has witnessed a profound development in recent years. To obtain a competing performance with a deep learning algorithm, enough amount of annotated data is requested but in the natural world, scarce or imbalanced data are common, and annotated data is expensive or hard to collect. Data augmentation, aiming to create variations for training data, has shown its power for this issue. But there are still two challenges: creating more desirable variations for scarce and imbalanced data, and designing a data augmentation to ease object detection and instance segmentation. First, current algorithms made variations only inside one specific class, but more desirable variations can further promote performance. To address this issue, we propose a novel data augmentation paradigm that can adapt variations from one class to another. In the novel paradigm, an image in the source domain is translated into the target domain, while the variations unrelated to the domain are maintained. For example, an image with a healthy tomato leaf is translated into a powdery mildew image but the variations of the healthy leaf are maintained and transferred into the powdery mildew class, such as types of tomato leaf, sizes, and viewpoints. Second, current data augmentation is suitable to promote the image classification model but may not be appropriate to alleviate object detection and instance segmentation model, mainly because the necessary annotations can not be obtained. In this study, we leverage a prior mask as input to tell the area we are interested in and reuse the original annotations. In this way, our proposed algorithm can be utilized to do the three tasks simultaneously. Further, We collect 1,258 images of tomato leaves with 1,429 instance segmentation annotations as there is more than one instance in one single image, including five diseases and healthy leaves. Extensive experimental results on the collected images validate that our new data augmentation algorithm makes useful variations and contributes to improving performance for diverse deep learning-based methods.

Recent advances in automatic recognition systems based on deep learning technology have shown the potential to provide environmental-friendly plant disease monitoring. These systems are able to reliably distinguish plant anomalies under varying environmental conditions as the basis for plant intervention using methods such as classification or detection. However, they often show a performance decay when applied under new field conditions and unseen data. Therefore, in this article, we propose an approach based on the concept of open-set domain adaptation to the task of plant disease recognition to allow existing systems to operate in new environments with unseen conditions and farms. Our system specifically copes diagnosis as an open set learning problem, and mainly operates in the target domain by exploiting a precise estimation of unknown data while maintaining the performance of the known classes. The main framework consists of two modules based on deep learning that perform bounding box detection and open set self and across domain adaptation. The detector is built based on our previous filter bank architecture for plant diseases recognition and enforces domain adaptation from the source to the target domain, by constraining data to be classified as one of the target classes or labeled as unknown otherwise. We perform an extensive evaluation on our tomato plant diseases dataset with three different domain farms, which indicates that our approach can efficiently cope with changes of new field environments during field-testing and observe consistent gains from explicit modeling of unseen data.

Recognizing plant diseases is a major challenge in agriculture, and recent works based on deep learning have shown high efficiency in addressing problems directly related to this area. Nonetheless, weak performance has been observed when a model trained on a particular dataset is evaluated in new greenhouse environments. Therefore, in this work, we take a step towards these issues and present a strategy to improve model accuracy by applying techniques that can help refine the model’s generalization capability to deal with complex changes in new greenhouse environments. We propose a paradigm called “control to target classes.” The core of our approach is to train and validate a deep learning-based detector using target and control classes on images collected in various greenhouses. Then, we apply the generated features for testing the inference of the system on data from new greenhouse conditions where the goal is to detect target classes exclusively. Therefore, by having explicit control over inter- and intra-class variations, our model can distinguish data variations that make the system more robust when applied to new scenarios. Experiments demonstrate the effectiveness and efficiency of the proposed approach on our extended tomato plant diseases dataset with 14 classes, from which 5 are target classes and the rest are control classes. Our detector achieves a recognition rate of target classes of 93.37% mean average precision on the inference dataset. Finally, we believe that our study offers valuable guidelines for researchers working in plant disease recognition with complex input data.

Finger vein is a new and secure biometric for personal authentication due to its line-structure network with abundant local and orientation features. However, these features cannot be well represented by the existing local descriptors. To effectively utilize these rich orientation features in finger vein images, this paper proposes a new local descriptor, namely, pyramid histogram of double competitive pattern (PHDCP). For a finger vein image, the PHDCP first obtains a bank of filtered images using Gabor filters with large kernel size and rich orientations, by which the local line features are captured. Then, the orientation orders with the largest and smallest responses, which are the most robust features, are selected to generate an encoded map. Finally, a column-partition-based pyramid histogram extraction method is presented to capture the hierarchical features from the encoded image. Numerical experiments are conducted on two public finger vein data sets, MMCBNU_6000 and UTFVP. The experimental results demonstrate that the proposed PHDCP performs much better than the existing local descriptors.

Recent advances in Deep Neural Networks have allowed the development of efficient and automated diagnosis systems for plant anomalies recognition. Although existing methods have shown promising results, they present several limitations to provide an appropriate characterization of the problem, especially in real-field scenarios. To address this limitation, we propose an approach that besides being able to efficiently detect and localize plant anomalies, allows to generate more detailed information about their symptoms and interactions with the scene, by combining visual object recognition and language generation. It uses an image as input and generates a diagnosis result that shows the location of anomalies and sentences describing the symptoms as output. Our framework is divided into two main parts: First, a detector obtains a set of region features that contain the anomalies using a Region-based Deep Neural Network. Second, a language generator takes the features of the detector as input and generates descriptive sentences with details of the symptoms using Long-Short Term Memory (LSTM). Our loss metric allows the system to be trained end-to-end from the object detector to the language generator. Finally, the system outputs a set of bounding boxes along with the sentences that describe their symptoms using glocal criteria into two different ways: a set of specific descriptions of the anomalies detected in the plant and an abstract description that provides general information about the scene. We demonstrate the efficiency of our approach in the challenging tomato diseases and pests recognition task. We further show that our approach achieves a mean Average Precision (mAP) of 92.5% in our newly created Tomato Plant Anomalies Description Dataset. Our objective evaluation allows users to understand the relationships between pathologies and their evolution throughout their stage of infection, location in the plant, symptoms, etc. Our work introduces a cost-efficient tool that provides farmers with a technology that facilitates proper handling of crops.

A fundamental problem that confronts deep neural networks is the requirement of a large amount of data for a system to be efficient in complex applications. Promising results of this problem are made possible through the use of techniques such as data augmentation or transfer learning of pre-trained models in large datasets. But the problem still persists when the application provides limited or unbalanced data. In addition, the number of false positives resulting from training a deep model significantly cause a negative impact on the performance of the system. This study aims to address the problem of false positives and class unbalance by implementing a Refinement Filter Bank framework for Tomato Plant Diseases and Pests Recognition. The system consists of three main units: First, a Primary Diagnosis Unit (Bounding Box Generator) generates the bounding boxes that contain the location of the infected area and class. The promising boxes belonging to each class are then used as input to a Secondary Diagnosis Unit (CNN Filter Bank) for verification. In this second unit, misclassified samples are filtered through the training of independent CNN classifiers for each class. The result of the CNN Filter Bank is a decision of whether a target belongs to the category as it was detected (True) or not (False) otherwise. Finally, an integration unit combines the information from the primary and secondary units while keeping the True Positive samples and eliminating the False Positives that were misclassified in the first unit. By this implementation, the proposed approach is able to obtain a recognition rate of approximately 96%, which represents an improvement of 13% compared to our previous work in the complex task of tomato diseases and pest recognition. Furthermore, our system is able to deal with the false positives generated by the bounding box generator, and class unbalances that appear especially on datasets with limited data.

Finger vein recognition has been considered one of the most promising biometrics for personal authentication. However, the capacities and percentages of finger tissues (e.g., bone, muscle, ligament, water, fat, etc.) vary person by person. This usually causes poor quality of finger vein images, therefore degrading the performance of finger vein recognition systems (FVRSs). In this paper, the intrinsic factors of finger tissue causing poor quality of finger vein images are analyzed, and an intensity variation (IV) normalization method using guided filter based single scale retinex (GFSSR) is proposed for finger vein image enhancement. The experimental results on two public datasets demonstrate the effectiveness of the proposed method in enhancing the image quality and finger vein recognition accuracy.

Finger veins have been proved to be an effective biometric for personal identification in the recent years. However, finger vein images are easily affected by influences such as image translation, orientation, scale, scattering, finger structure, complicated background, uneven illumination, and collection posture. All these factors may contribute to inaccurate region of interest (ROI) definition, and so degrade the performance of finger vein identification system. To improve this problem, in this paper, we propose a finger vein ROI localization method that has high effectiveness and robustness against the above factors. The proposed method consists of a set of steps to localize ROIs accurately, namely segmentation, orientation correction, and ROI detection. Accurate finger region segmentation and correct calculated orientation can support each other to produce higher accuracy in localizing ROIs. Extensive experiments have been performed on the finger vein image database, MMCBNU_6000, to verify the robustness of the proposed method. The proposed method shows the segmentation accuracy of 100%. Furthermore, the average processing time of the proposed method is 22 ms for an acquired image, which satisfies the criterion of a real-time finger vein identification system.

Recognizing the quality of fingerprints in advance can be beneficial for improving the performance of fingerprint recognition systems. The representative features to assess the quality of fingerprint images from different types of capture sensors are known to vary. In this paper, an effective quality estimation system that can be adapted for different types of capture sensors is designed by modifying and combining a set of features including orientation certainty, local orientation quality and consistency. The proposed system extracts basic features, and generates next level features which are applicable for various types of capture sensors. The system then uses the Support Vector Machine (SVM) classifier to determine whether or not an image should be accepted as input to the recognition system. The experimental results show that the proposed method can perform better than previous methods in terms of accuracy. In the meanwhile, the proposed method has an ability to eliminate residue images from the optical and capacitive sensors, and the coarse images from thermal sensors.

Plant Diseases and Pests are a major challenge in the agriculture sector. An accurate and a faster detection of diseases and pests in plants could help to develop an early treatment technique while substantially reducing economic losses. Recent developments in Deep Neural Networks have allowed researchers to drastically improve the accuracy of object detection and recognition systems. In this paper, we present a deep-learning-based approach to detect diseases and pests in tomato plants using images captured in-place by camera devices with various resolutions. Our goal is to find the more suitable deep-learning architecture for our task. Therefore, we consider three main families of detectors: Faster Region-based Convolutional Neural Network (Faster R-CNN), Region-based Fully Convolutional Network (R-FCN), and Single Shot Multibox Detector (SSD), which for the purpose of this work are called “deep learning meta-architectures”. We combine each of these meta-architectures with “deep feature extractors” such as VGG net and Residual Network (ResNet). We demonstrate the performance of deep meta-architectures and feature extractors, and additionally propose a method for local and global class annotation and data augmentation to increase the accuracy and reduce the number of false positives during training. We train and test our systems end-to-end on our large Tomato Diseases and Pests Dataset, which contains challenging images with diseases and pests, including several inter- and extra-class variations, such as infection status and location in the plant. Experimental results show that our proposed system can effectively recognize nine different types of diseases and pests, with the ability to deal with complex scenarios from a plant’s surrounding area.

In pedestrian detection methods, their high accuracy detection rates are always obtained at the cost of a large amount of false pedestrians. In order to overcome this problem, the authors propose an accurate pedestrian detection system based on two machine learning methods: cascade AdaBoost detector and random vector functional-link net. During the offline training phase, the parameters of a cascade AdaBoost detector and random vector functional-link net are trained by standard dataset. These candidates, extracted by the strategy of a multiscale sliding window, are normalized to be standard scale and verified by the cascade AdaBoost detector and random vector functional-link net on the online phase. Only those candidates with high confidence can pass the validation. The proposed system is more accurate than other single machine learning algorithms with fewer false pedestrians, which has been confirmed in simulation experiment on four datasets.

Introduction: Bruton's tyrosine kinase (BTK) and interleukin (IL)-2 Inducible Tcell Kinase (ITK) inhibitors have anti-inflammatory properties. We investigated the therapeutic effect of ibrutinib, an orally bioavailable BTK/ITK inhibitor, in a mouse model of Graves' orbitopathy (GO). Methods: Genetic immunization was performed through intramuscular administration of the recombinant plasmid, pCMV6-hTSHR cDNA, to 8-weekold female BALB/c mice. Serum levels of T3, T4, and thyroid-stimulating hormone receptor (TSHR) antibodies (TRAbs) were quantified using enzymelinked immunosorbent assay. Histopathological changes in orbital tissues were examined using immunohistochemistry (IHC) staining for TSHR and various inflammatory markers. Following successful genetic immunization, ibrutinib was orally administered daily for 2 weeks in the GO model mice. After treatment, the mRNA and protein expression levels of BTK, ITK, IL-1b, and IL-6 in orbital tissues were evaluated using real-time PCR and Western blotting. Results: In total, 20 mice were sacrificed to confirm successful genetic immunization. The GO mouse group exhibited significantly increased serum T3, T4, and TRAb levels. IHC revealed increased expression of TSHR, IL-1b, IL-6, transforming growth factor-b1, interferon-g, CD40, CD4, BTK, and ITK in the GO mouse model. The orbital inflammation was significantly attenuated in ibrutinibtreated mice. The mRNA and protein expression levels of BTK, ITK, IL-1b, and IL-6 in orbital tissue were lower in ibrutinib-treated GO mouse group compared to the phosphate-buffered saline-treated GO mouse group. Conclusion: The GO mouse model demonstrated enhanced BTK and ITK expression. Ibrutinib, a BTK/ITK inhibitor, suppressed the inflammatory cytokine production. These findings highlight the potential involvement of BTK/ITK in the inflammatory pathogenesis of GO, suggesting its role as a novel therapeutic target. [ABSTRACT FROM AUTHOR]

Background/Aim: Interferon-induced transmembrane protein 1 (IFITM1) is known to be involved in breast cancer progression. We aimed to investigate its role in estrogen receptor (ER)-positive breast cancer cells with wildtype p53 and tamoxifen-resistant breast cancer cells. Materials and Methods: The ER-positive breast cancer cell lines, MCF7 with wild-type p53 and T47D with mutant p53, were used. We established an MCF-7-derived tamoxifen-resistant cell line (TamR) by long-term culture of MCF-7 cells with 4- hydroxytamoxifen. Results: IFITM1 inhibition in MCF-7 cells significantly decreased cell growth and migration. MCF-7 cells with suppression of IFITM1 using siRNA or ruxolitinib showed reduced cell viability after tamoxifen treatment compared with that in the control MCF-7 cells. Unexpectedly, mRNA and protein levels of IFITM1 were decreased in TamR cells compared with those in MCF-7 cells. TamR cells with suppression of IFITM1 using siRNA or ruxolitinib showed no change in cell viability after treatment with tamoxifen. P53 knockdown using siRNA reduced the mRNA levels of IRF9 and increased mRNA and protein levels of SOCS3 in MCF-7 cells, suggesting that loss or mutation of p53 can affect the induction of IFITM1 via the JAK/STAT signaling pathway in breast cancer. Furthermore, MCF-7 cells with p53 knockdown using siRNA showed no decrease in cell viability after tamoxifen treatment or IFITM1 inhibition, indicating that p53 status may be important for cell death after tamoxifen treatment or IFITM1 inhibition. Conclusion: IFITM1 inhibition may enhance the sensitivity to tamoxifen based on p53-dependent enhancement of IFN signaling in wild-type p53, ER-positive breast cancer cells. [ABSTRACT FROM AUTHOR]

Purpose: Orbital fibroblasts play key roles in the pathogenesis of Graves' orbitopathy (GO), and previous findings have shown that endoplasmic reticulum (ER) stress and autophagy also contribute to GO. In this study, we investigated the presently unclear roles of inositol-requiring enzyme 1 (IRE1) and related autophagy processes in the pro-fibrotic mechanism of GO. Materials and Methods: Orbital adipose/connective tissues were obtained from eight GO patients and six normal individuals during surgery. GO fibroblasts were transfected with IRE1 small-interfering RNA and treated with bafilomycin A1 (Baf-A1) to evaluate the inhibitory effects of ER stress and autophagy, and protein-expression levels were analyzed through western blotting after stimulation with transforming growth factor (TGF)-β. Results: TGF-β stimulation upregulated IRE1 in GO orbital fibroblasts, whereas silencing IRE1 suppressed fibrosis and autophagy responses. Similarly, Baf-A1, an inhibitor of late-phase autophagy, decreased the expression of pro-fibrotic proteins. Conclusion: IRE1 mediates autophagy and the pro-fibrotic mechanism of GO, which provides a more comprehensive interpretation of GO pathogenesis and suggests potential therapeutic targets. [ABSTRACT FROM AUTHOR]