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3. In Ovo-Based Antiviral Assay for Screening of Herbal Formulations Against Influenza Viruses

Author

Ghoke, Suresh Samadhan, Sood, Richa, Kumar, Naveen, Bhatia, Sandeep, Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Kumar, Naveen, editor, Tomar, Shailly, editor, and Ezzikouri, Sayeh, editor

Published
2024
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9. Proteomics Analysis of Duck Lung Tissues in Response to Highly Pathogenic Avian Influenza Virus.

Author

Vijayakumar, Periyasamy, Mishra, Anamika, Deka, Ram Pratim, Pinto, Sneha M., Subbannayya, Yashwanth, Sood, Richa, Prasad, Thottethodi Subrahmanya Keshava, and Raut, Ashwin Ashok

Subjects
INFLUENZA A virus, H5N1 subtype, AVIAN influenza A virus, JAK-STAT pathway, MALLARD, NF-kappa B
Abstract

Domestic ducks (Anas platyrhynchos domesticus) are resistant to most of the highly pathogenic avian influenza virus (HPAIV) infections. In this study, we characterized the lung proteome and phosphoproteome of ducks infected with the HPAI H5N1 virus (A/duck/India/02CA10/2011/Agartala) at 12 h, 48 h, and 5 days post-infection. A total of 2082 proteins were differentially expressed and 320 phosphorylation sites mapping to 199 phosphopeptides, corresponding to 129 proteins were identified. The functional annotation of the proteome data analysis revealed the activation of the RIG-I-like receptor and Jak-STAT signaling pathways, which led to the induction of interferon-stimulated gene (ISG) expression. The pathway analysis of the phosphoproteome datasets also confirmed the activation of RIG-I, Jak-STAT signaling, NF-kappa B signaling, and MAPK signaling pathways in the lung tissues. The induction of ISG proteins (STAT1, STAT3, STAT5B, STAT6, IFIT5, and PKR) established a protective anti-viral immune response in duck lung tissue. Further, the protein–protein interaction network analysis identified proteins like AKT1, STAT3, JAK2, RAC1, STAT1, PTPN11, RPS27A, NFKB1, and MAPK1 as the main hub proteins that might play important roles in disease progression in ducks. Together, the functional annotation of the proteome and phosphoproteome datasets revealed the molecular basis of the disease progression and disease resistance mechanism in ducks infected with the HPAI H5N1 virus. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs, biological pathways and genes involved in the molecular pathogenesis

Author

Mishra, Anamika, primary, Asaf, Muhasin, additional, Kumar, Amod, additional, Kulkarni, Diwakar Dattatreya, additional, Sood, Richa, additional, Bhatia, Sandeep, additional, Bhushan, Bharat, additional, and Raut, Ashwin Ashok, additional

Published
2022
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26. Gabapentin for smoking cessation

Author

Sood, Amit, Ebbert, Jon O., Wyatt, Kirk D., Croghan, Ivana T., Schroeder, Darrell R., Sood, Richa, and Hays, J. Taylor

Published
2010

31. Identification and molecular characterization of H9N2 viruses carrying multiple mammalian adaptation markers in resident birds in central-western wetlands in India

Author

Sood, Richa, primary, Kumar, Naveen, additional, Gokhe, Suresh S., additional, Pateriya, Atul Kumar, additional, Bhat, Sushant, additional, Bhatia, Sandeep, additional, Panickan, Sivasankar, additional, Mishra, Anamika, additional, Murugkar, H.V., additional, Dixit, Roma, additional, Shrivastava, Deepali, additional, Singh, Pushpendra, additional, Tripathi, Meghna, additional, and Singh, Vijendra Pal, additional

Published
2021
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35. Review on Synthesis and Applications of Zinc Oxide Nanoparticles

Author

MN, Darshita and Sood, Richa

Subjects
biomaterials
Abstract

Background:Boom in nanotechnology in current era has sketched unforeseen transformations in number of fields, such as medicine, health care, food, space, agriculture, etc. The synthesis of nanoparticles with different chemical compositions, sizes, shapes and controlled disparities is an important area of research in this field. Over the last decade, the biosynthesis of metal nanoparticles has received considerable attention due to their unusual and fascinating properties, with various applications, over their bulk counterparts.Hypothesis: The nanoparticle can have huge application in the field of food, pharmaceutical, and cosmetic industries and thus become a major area of research. Green synthesis of zinc oxide nanoparticles (ZnO NPs) using plant extracts offers an eco-friendly and promising substitute to the conventional methods of chemical synthesis. Conclusion: In the arena of nanoparticle phytosynthesis, novel materials have been produced that are eco-friendly, cost-effective and stable. In the current situation, nanotechnology inspires progress in all spheres of life, and therefore the phytosynthetic path of nanoparticle synthesis has emerged as a safe and best alternative to conventional methods. This review summarizes the recent work in the field of zinc nanoparticle phytosynthesis and critically discusses the mechanism proposed behind it.

Published
2021

42. Elicitation of Highly Pathogenic Avian Influenza H5N1 M2e and HA2-Specific Humoral and Cell-Mediated Immune Response in Chicken Following Immunization With Recombinant M2e–HA2 Fusion Protein

Author

Kalaiyarasu, Semmannan, primary, Bhatia, Sandeep, additional, Mishra, Niranjan, additional, Senthil Kumar, Dhanapal, additional, Kumar, Manoj, additional, Sood, Richa, additional, Rajukumar, Katherukamem, additional, Ponnusamy, Boopathi, additional, Desai, Dhruv, additional, and Singh, Vijendra Pal, additional

Published
2021
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44. Molecular characterization of recent HoBi‐like pestivirus isolates from cattle showing mucosal disease‐like signs in India reveals emergence of a novel genetic lineage

Author

Kalaiyarasu, Semmannan, primary, Mishra, Niranjan, additional, Jayalakshmi, Konappan, additional, Selvaraj, Palanisamy, additional, Sudhakar, Shashi Bhushan, additional, Jhade, Sandeep Kumar, additional, Sood, Richa, additional, Premalatha, Narayanasammi, additional, and Singh, Vijendra Pal, additional

Published
2021
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45. Regulatory Approval of Silver Nanoparticles

Author

Sood Richa and S. Chopra Dimple

Subjects
Chemistry, General Earth and Planetary Sciences, Nanotechnology, Silver nanoparticle, General Environmental Science
Published
2018

47. Randomized trials stopped early for benefit

Author

Montori, Victor M., Eggert, Christoph H., Darling, Elizabeth, Cook, Deborah J., Thompson, Carly A., Devereaux, P.J., Adhikari, Neill K.J., Briel, Matthias, Lacchetti, Christina, Burns, Karen E.A., Leung, Teresa W., Schunemann, Holger J., Meade, Maureen O., Bryant, Dianne M., Bucher, Heiner C., Erwin, Patricia J., Sood, Amit, Sood, Richa, Lo, Benjamin, Qi Zhou, Mills, Edward, and Guyatt, Gordon H.

Subjects
Health care industry, Company business management, Clinical trials -- Management, Health care industry -- Management
Abstract

The epidemiology and reporting quality of randomized clinical trials (RCTs) involving interventions stopped early for benefit is evaluated. RCTs stopped early for benefits are becoming more common, often fail to adequately report relevant information about the decision to stop early and give implausibly large treatment effects.

Published
2005

48. Molecular characterization of recent HoBi‐like pestivirus isolates from cattle showing mucosal disease‐like signs in India reveals emergence of a novel genetic lineage.

Author

Kalaiyarasu, Semmannan, Mishra, Niranjan, Jayalakshmi, Konappan, Selvaraj, Palanisamy, Sudhakar, Shashi Bhushan, Jhade, Sandeep Kumar, Sood, Richa, Premalatha, Narayanasammi, and Singh, Vijendra Pal

Subjects
CATTLE showing, COVID-19, HEALTH of cattle, PESTIVIRUS diseases, CATTLE crossbreeding, BOVINE viral diarrhea virus, GENETIC epidemiology, NUCLEOTIDE sequencing
Abstract

Natural infections with HoBi‐like pestivirus (HoBiPeV) have been detected in cattle in South America, Europe and Asia with a range of clinical manifestations including fatal mucosal disease (MD). In India, although HoBiPeV in cattle has been reported, there is no information on currently circulating HoBiPeV strains and associated severe clinical disease. Between September 2018 and December 2019, suspected cases of bovine viral diarrhoea with severe disease in cattle were noticed in farmers' small holdings in Tamil Nadu State. To determine the extent of pestivirus infection, blood, serum, nasal or oral swab samples of 46 cattle from 18 villages were tested. Based on the real‐time RT‐PCR, antigen ELISA and nucleotide sequencing results, pestivirus was detected in nine cattle from eight villages in two districts and all pestiviruses were identified as HoBiPeV. All nine HoBiPeV‐infected cattle displayed clinical signs resembling MD and HoBiPeV isolates (n = 9) obtained were characterized at genetic and antigenic level. Phylogenetic analyses based on 5′‐untranslated regions (5′‐UTR), Npro and combined 5′‐UTR‐Npro gene sequences revealed that eight HoBiPeV isolates clustered into a clade, distinct from all reported HoBiPeV clades (a–d), whereas one belonged to HoBiPeV‐d clade, thus providing evidence of emergence of a novel HoBiPeV clade (e). This was also supported by HoBiPeV‐e clade‐specific amino acid substitutions in Npro and the antigenic reactivity patterns. The study demonstrates the existence and independent evolution of five HoBiPeV clades (four main clades) globally and surprisingly three exclusive to India. Also we confirm first HoBiPeV occurrence in southern India with predominant prevalence of HoBiPeV‐e strains. Besides demonstrating increased HoBiPeV genetic diversity, here we show association of HoBiPeV with severe clinical disease involving fatalities highlighting impact of HoBiPeV on cattle health. The emergence of a novel HoBiPeV lineage provides new insights on global HoBiPeV epidemiology and genetic diversity reiterating the need for continuous monitoring of HoBiPeV in India. [ABSTRACT FROM AUTHOR]

Published
2022
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