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Objectives: To determine the differences between pediatric patients with eating disorders (ED) and the control group in the amount of saliva and the concentration of total amylase and electrolytes in saliva, and to evaluate the correlation between the saliva changes and nutritional status. Material and methods: The study included 101 participants (14.34 ±1.99 years), out of which 50 participants with ED subgroups and 51 participants in the control group. Data were statistically analyzed (Mann-Whitney, Kruskal-Wallis, chi-square, Spearman rank correlation test, α=0.05). Results: No significant differences in salivary volume between the groups were found. A significant difference in the volume of saliva secreted in the 5th and 15th minute was found between the anorexia nervosa and bulimia nervosa subgroups. The examined anthropometric parameters were marginally or significantly positively associated with saliva volume at 5 and 15 minutes, noting a more significant correlation of the same at 15 than at 5 minutes. The patients with ED had a significantly higher concentration of inorganic phosphates in saliva while the concentrations of other electrolytes and total amylase in saliva did not differ significantly. Conclusions: Nutritional status affects salivation. There is a difference in saliva volume in pediatric patients with different ED disorders. Variations in saliva electrolytes in pediatric patients with ED are possible

The data about bond strength between digitally produced denture base resins and artificial teeth are scarce. Several studies investigated shear bond strength values of milled denture base resins and different types of artificial teeth. The purpose of the present study was to compare and evaluate the available evidence through a systematic review. A bibliographic search was conducted in PubMed, Scopus, and Web of Science to assess adequate studies published up to 1 June 2022. This review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The appropriate studies that determined the shear bond strength values between milled denture base resins and artificial teeth were selected. The initial search identified 103 studies, which were included in the PRISMA 2020 flow diagram for new systematic reviews. Three studies met the inclusion criteria, and all of them present a moderate risk of bias (score 6). Two studies found no statistical differences between heat-polymerized and CAD/CAM (milled) denture base materials when attached with different types of artificial teeth, while one study showed higher values of CAD/CAM (milled) denture base materials. Bonding agents ensure bonding strength at least similar to the conventional methods. In order to improve the quality of future studies, it would be advantageous to use a larger number of specimens with standardized dimensions and a blinded testing machine operator to decrease the risk of bias.

Objective: The objective of this pilot study was to examine the impact of occlusal splint treatment on mandibular border movements and the condyle position in subjects with bruxism. Material and methods: The study included 9 subjects diagnosed with bruxism (mean age 28.7) and 9 subjects in the control group (mean age 30.5). All subjects were adults, eugnathic, and with a dentoalveolar Angle Class I, without prosthetic restorations, previous or current orthodontic treatments, a systemic disease or previous surgical interventions in the temporomandibular joint. All experimental and con-trol group subjects were provided with a standardized relaxation occlusal splint, which they wore for 8 weeks. During this time, an initial and three additional measurements of incisal opening (IO), left condyle opening (OLC), right condyle opening (ORC), left laterotrusion (LLI) and right laterotrusion (LRI) (after 2, 4 and 8 weeks) were performed using an Arcus Digamma II (Kavo) ultrasound device for mandibular movements recording. Using the same instrument, the condylar position during protrusion, left and right laterotrusion, and in the centric relation position (CR) was analyzed initially and after 8 weeks using the maximum intercuspation as reference point. Continuous variables were described using basic statistical parameters, and the statistical significance of differences between the variables was checked by the t-test and χ2 test (p

Objective: The aim of this study was to investigate reproducibility of the position of centric relation in patients with disc displacement with reduction. Materials and methods: The test group included 30 subjects, diagnosed with disc displacement with reduction in right, left or both joints. The control group included 12 individuals with no signs and symptoms of temporomandibular disorders. Using chin point guidance with a jig, centric relation record was made three times by every participant, in a single session. Left and right condylar position for each centric relation record was determined and recorded using the electronic ultrasonic measuring device. The data were transferred to the computer, processed and analyzed. Condylar distances between centric relation records were measured (anteroposterior, vertical, transversal and linear values), and the data were statistically analyzed using the t and the F tests. Results: No statically significant difference was found between the test and the control groups. Two thirds of study participants demonstrated condylar position of the repeated centric relation recording within the area of 0.3 mm in diameter. For more than 90% of participants that area was within 0.4 mm. Conclusions: There is no difference in reproducibility of the centric relation between patients with disc displacement with reduction and healthy temporomandibular joint individuals (p>0.05). When doing centric relation record on a patient with disc displacement with reduction there is no need for previous splint therapy and standard precautions are acceptable. The obtained results must be interpreted within the experimental group, and not projected on the other groups of temporomandibular disorders.

Aim: The aim of this study was to determine the effect of occlusal interferences on the position of condyles. Materials and Methods: The study included 10 participants. All recordings of the condylar position were done using ultrasound jaw tracking device with six degrees of freedom. Paraocclusal tray was fixed in the lower jaw, and the artificial occlusal interference was made on the lower left second premolar with a composite resin, thickness of 1 mm. Condylar shift at the position of the occlusion with the artificial occlusal interference was measured using a jaw tracking device. Condylar positions were determined based on the Cartesian coordinate system. All deviations were measured according to a reference position which was the position of maximum intercuspation. Linear values of deviations between the reference position and the position of the occlusion with the occlusal interference were determined from the values of the Cartesian coordinate system. Results: Average superior condylar shift was 0.17 mm, SD 0.39. Average linear deviation between the position of maximum intercuspation and the position of the occlusion with the occlusal interference was 0.48 mm (SD 0.29, min 0.17 mm, max 1.19 mm). Conclusions: Occlusal interference leads to immediate change of the condylar position within the temporomandibular joint. Average values of determined superior condylar position confirm occurrence of lever within dental arches. The obtained results must be interpreted within the limitations of this study (immediate measurement of the condylar position). Further research is needed for the analysis of progression of the condylar position with occlusal interferences.

The purpose of this investigation was to study sagittal condylar inclination values within a uniform sample (Angle class I occlusion) using ‘articulator-related registration’ and Camper’s plane as a reference plane. The study was performed on a sample of 58 Angle class I subjects (mean age 25.1, SD 3.1). Measurements were performed with an ultrasonic jaw tracking device with six degrees of freedom. After a paraocclusal tray was fixed in the mouth, each subject had to make three protrusive movements and three right and left laterotrusive movements. From protrusive movements the software of the device automatically calculated the left and the right sagittal condylar inclination values used for setting of the articulator. The mean sagittal condylar inclination value was 41.0° (SD 10.5) for the right joint and 40.7° (SD 9.8) for the left joint. The maximum value was 65.0° for the right and 68.6° for the left joint, and the minimum value was 13.7° for the right and 21.7° for the left joint. The results of this study suggested the average articulator setting for sagittal condylar inclination for fully dentate adult subjects to be 40° in relation to Camper’s plane. This is especially important for the articulators that are set up in relation to Camper’s plane.

Every medication may lead to adverse effects, even when used in standard doses and mode of application. In the oral cavity, adverse effects may affect every part of oral mucosa and are the result of medications taken either locally or systemically. Oral adverse reactions to drugs are not typical and therefore sometimes not easy to recognize. On diagnosing adverse side effects in the oral cavity, experienced clinician will usually diagnose the condition on the basis of detailed medical history and clinical finding. However, the only objective evidence for the offending drug is ‘re-challenge’, i.e. exposure to the drug after its discontinuation. It carries a huge risk of anaphylactic reaction; therefore it has to be performed in a controlled hospital setting. Therapy is based on immediate exclusion of the offending drug and, if lesions are present in the oral cavity, topical or systemic corticosteroid therapy is prescribed. This article gives a review of patients with oral adverse drug reactions referred to the Department of Oral Medicine in Zagreb.