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1. Erratum to 'Systematic versus on-demand early palliative care: A randomised clinical trial assessing quality of care and treatment aggressiveness near the end of life' [Eur J Cancer 69 (2016) 110-118]

Author

Antonella Galiano, Stefania Schiavon, Massimo Luzzani, Monia Dall'Agata, Vittorina Zagonel, Irene Guglieri, Camilla Di Nunzio, Alfina Bramanti, Alberto Farolfi, Barbara Bocci, Maria Teresa Cattaneo, Andrea Casadei Gardini, Davide Dalu, Angela Ragazzini, Pietro Sozzi, Monica Bosco, Alice Giacobino, Luigi Cavanna, C. Gandini, Cataldo Mastromauro, F. Negri, Carla Codecà, Cristina Pittureri, Silvia Ruscelli, Oriana Nanni, Cristina Autelitano, Marco Maltoni, Luisa Fioretto, Augusto Caraceni, Sonia Zoccali, Giovanni Luca Frassineti, Emanuela Scarpi, Claudia Biasini, Giovanna Luchena, Ferdinando Garetto, Carla Longhi, Alberto Gozza, Luigi Montanari, Silvia Quadrini, Roberto Bortolussi, Monica Giordano, Chiara Broglia, Paolo Pedrazzoli, Angela Buonadonna, Alessandro Comandone, Sara Pini, Marina Faedi, Sara Alquati, Rodolfo Scognamiglio, Teresa Gamucci, Sara Lonardi, Elena Amaducci, Manlio Monti, Elisabetta Sansoni, Daris Ferrari, Maria Simona Pino, Francesca Bergamo, Daniela Degiovanni, Martina Valgiusti, Maltoni M., Scarpi E., Dall'Agata M., Schiavon S., Biasini C., Codeca C., Broglia C.M., Sansoni E., Bortolussi R., Garetto F., Fioretto L., Cattaneo M.T., Giacobino A., Luzzani M., Luchena G., Alquati S., Quadrini S., Zagonel V., Cavanna L., Ferrari D., Pedrazzoli P., Frassineti G.L., Galiano A., Casadei Gardini A., Monti M., Nanni O., Farolfi A., Ruscelli S., Valgiusti M., Pini S., Faedi M., Ragazzini A., Pittureri C., Amaducci E., Guglieri I., Bergamo F., Lonardi S., Di Nunzio C., Bosco M., Bocci B., Bramanti A., Gandini C., Buonadonna A., Comandone A., Zoccali S., Pino M.S., Dalu D., Sozzi P., Gozza A., Giordano M., Longhi C., Autelitano C., Gamucci T., Mastromauro C., Scognamiglio R., Degiovanni D., Negri F., Caraceni A., and Montanari L.

Subjects
Cancer Research, medicine.medical_specialty, Palliative care, business.industry, Published Erratum, MEDLINE, Cancer, medicine.disease, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030502 gerontology, 030220 oncology & carcinogenesis, On demand, medicine, Physical therapy, NA, Quality of care, 0305 other medical science, Intensive care medicine, business
Abstract

The publisher regrets that the collaborators for this paper were not listed as such within the author details of the published paper. The collaborators were published in the Acknowledgements and are as follows: Alberto Farolfi, Silvia Ruscelli, Martina Valgiusti, Sara Pini, Marina Faedi, Department of Medical Oncology, IRST IRCCS, Meldola; Angela Ragazzini, Unit of Biostatistics and Clinical Trials, IRST IRCCS, Meldola; Cristina Pittureri and Elena Amaducci, Palliative Care and Hospice Unit, AUSL Romagna, Cesena; Irene Guglieri, Psychooncology Service, Veneto Institute of Oncology IOV – IRCCS, Padua; Francesca Bergamo, Sara Lonardi, Department of Clinical and Experimental Oncology, Medical Oncology 1, Veneto Institute of Oncology IOV – IRCCS, Padua; Camilla Di Nunzio, Medical Oncology Unit, Oncology–Hematology Department, Guglielmo da Saliceto Hospital, Piacenza; Monica Bosco, Palliative Care Unit, Oncology–Hematology Department, Guglielmo da Saliceto Hospital, Piacenza; Barbara Bocci, Medical Oncology Unit, San Paolo Hospital, Milan; Alfina Bramanti and Chiara Gandini, Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia; Angela Buonadonna, Medical Oncology Unit, Aviano National Cancer Institute, Aviano; Alessandro Comandone, Medical Oncology Unit, Presidio Humanitas Gradenigo, Turin; Sonia Zoccali, Coordinamento Cure Palliative (supported by F.I.L.E., Leniterapia Italian Foundatio), Florence; Maria Simona Pino, Medical Oncology Unit, Oncology Department, S. Maria Annunziata Hospital, Florence; Davide Dalu, Palliative Care Unit, Oncology Department, L. Sacco Hospital, Milan; Pietro Sozzi, Oncology Unit, Ospedale degli Infermi, Ponderano; Alberto Gozza, Medical Oncology, Department of Medicine, E.O. Galliera Hospitals, Genoa; Monica Giordano and Carla Longhi, Oncology Unit, Sant'Anna Hospital, Como; Cristina Autelitano, Palliative Care Unit, Arcispedale S. Maria Nuova – IRCCS, Reggio Emilia; Teresa Gamucci, Oncology Unit, SS Trinità Hospital Sora, ASL Frosinone, Frosinone; Cataldo Mastromauro, Oncology Unit, ULSS 12 Veneziana, Venice; Rodolfo Scognamiglio, Hospice Nazareth, Mestre; Daniela Degiovanni, Palliative Care Unit, Casale Monferrato, ASL Alessandria; Federica Negri, Medical Oncology Unit, Istituti Ospitalieri, Cremona; Augusto Caraceni, Palliative Care, Pain Therapy and Rehabilitation Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; and Luigi Montanari, Palliative Care Unit Ravenna, AUSL Romagna, Italy. The publisher would like to apologise for any inconvenience caused.

Published
2016

2. Systematic versus on-demand early palliative care: A randomised clinical trial assessing quality of care and treatment aggressiveness near the end of life

Author

Andrea Casadei Gardini, Francesca Bergamo, Sonia Zoccali, Teresa Gamucci, Manlio Monti, C. Gandini, Carla Longhi, Angela Buonadonna, Carla Codecà, Paolo Pedrazzoli, Monica Bosco, Oriana Nanni, Cristina Autelitano, Daniela Degiovanni, Augusto Caraceni, Ferdinando Garetto, Alfina Bramanti, Stefania Schiavon, Monica Giordano, Chiara Broglia, Elena Amaducci, Elisabetta Sansoni, Marina Faedi, Daris Ferrari, F. Negri, Emanuela Scarpi, Camilla Di Nunzio, Roberto Bortolussi, Rodolfo Scognamiglio, Angela Ragazzini, Giovanni Luca Frassineti, Davide Dalu, Martina Valgiusti, Antonella Galiano, Sara Pini, Alessandro Comandone, Irene Guglieri, Maria Simona Pino, Sara Alquati, Giovanna Luchena, Alice Giacobino, Claudia Biasini, Barbara Bocci, Maria Teresa Cattaneo, Alberto Farolfi, Pietro Sozzi, Luigi Cavanna, Silvia Quadrini, Sara Lonardi, Alberto Gozza, Luigi Montanari, Cristina Pittureri, Marco Maltoni, Luisa Fioretto, Silvia Ruscelli, Massimo Luzzani, Monia Dall'Agata, Vittorina Zagonel, Cataldo Mastromauro, Maltoni M., Scarpi E., Dall'Agata M., Schiavon S., Biasini C., Codeca C., Broglia C.M., Sansoni E., Bortolussi R., Garetto F., Fioretto L., Cattaneo M.T., Giacobino A., Luzzani M., Luchena G., Alquati S., Quadrini S., Zagonel V., Cavanna L., Ferrari D., Pedrazzoli P., Frassineti G.L., Galiano A., Casadei Gardini A., Monti M., Nanni O., Maltoni, Marco, Scarpi, Emanuela, Dall'Agata, Monia, Schiavon, Stefania, Biasini, Claudia, Codecà, Carla, Broglia, Chiara Maria, Sansoni, Elisabetta, Bortolussi, Roberto, Garetto, Ferdinando, Fioretto, Luisa, Cattaneo, Maria Teresa, Giacobino, Alice, Luzzani, Massimo, Luchena, Giovanna, Alquati, Sara, Quadrini, Silvia, Zagonel, Vittorina, Cavanna, Luigi, Ferrari, Dari, Pedrazzoli, Paolo, Frassineti, Giovanni Luca, Galiano, Antonella, Casadei Gardini, Andrea, Monti, Manlio, and Nanni, Oriana

Subjects
Adult, Male, medicine.medical_specialty, Care aggressiveness near the end of life, Early palliative care, Use of health care services, Oncology, Cancer Research, Palliative care, Time Factors, Antineoplastic Agents, 03 medical and health sciences, 0302 clinical medicine, On demand, Secondary analysis, Metastatic pancreatic cancer, Medicine, Humans, 030212 general & internal medicine, Quality of care, Neoplasm Metastasis, Intensive care medicine, Hospice care, Aged, Quality of Health Care, Aged, 80 and over, Terminal Care, business.industry, Palliative Care, Cancer, Middle Aged, medicine.disease, Clinical trial, Pancreatic Neoplasms, Hospice Care, 030220 oncology & carcinogenesis, Emergency medicine, Quality of Life, Female, business, Delivery of Health Care
Abstract

Aim Early palliative care (EPC) in oncology has shown sparse evidence of a positive impact on patient outcomes, quality of care outcomesand costs. Patients and methods Data for this secondary analysis were taken from a trial of 207 outpatients with metastatic pancreatic cancer randomly assigned to receive standard cancer care plus on-demand EPC (standard arm) or standard cancer care plus systematic EPC (interventional arm). After 20 months’ follow-up, 149 (80%) had died. Outcome measures were frequency, type and timing of chemotherapy administration, use of resources, place of death and overall survival. Results Some indices of end-of-life (EoL) aggressiveness had a favourable impact from systematic EPC. Interventional arm patients showed higher use of hospice services: a significantly longer median and mean period of hospice care (P=0.025 for both indexes) and a significantly higher median and mean number of hospice admissions (both P&nbsp

Published
2016

3. Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial

Author

F. Negri, Emanuela Scarpi, Giovanna Luchena, Sara Alquati, Alessandro Comandone, Silvia Quadrini, Maria Simona Pino, Angela Buonadonna, Maria Grazia Rodriquenz, Ferdinando Garetto, Monica Giordano, Rodolfo Scognamiglio, Giovanni Luca Frassineti, Marina Faedi, Paolo Pedrazzoli, Roberta Gauna, Silvia Ruscelli, Massimo Costantini, Chiara Broglia, Filomena Narducci, Antonella Galiano, Sonia Zoccali, Chiara Cifatte, Daniela Degiovanni, Massimo Luzzani, Monia Dall'Agata, Alberto Farolfi, Raffaella Bertè, Vittorina Zagonel, Dino Amadori, Elena Amaducci, Elisabetta Sansoni, Pietro Sozzi, Maria Teresa Cattaneo, Daris Ferrari, Andrea Casadei Gardini, Francesca Crepaldi, Martina Valgiusti, Roberto Bortolussi, Cristina Pittureri, Rosa Porzio, Cataldo Mastromauro, Alfina Bramanti, Angela Ragazzini, Marco Maltoni, Luigi Montanari, Leonardo Trentin, Carla Codecà, Augusto Caraceni, Gino Crivellari, Oriana Nanni, Davide Dalu, Sara Pini, Claudia Biasini, Maltoni, Marco, Scarpi, Emanuela, Dall'Agata, Monia, Zagonel, Vittorina, Bertè, Raffaella, Ferrari, Dari, Broglia, Chiara Maria, Bortolussi, Roberto, Trentin, Leonardo, Valgiusti, Martina, Pini, Sara, Farolfi, Alberto, Casadei Gardini, Andrea, Nanni, Oriana, Amadori, Dino, Frassineti, Giovanni Luca, Sansoni, Elisabetta, Ragazzini, Angela, Ruscelli, Silvia, Crivellari, Gino, Galiano, Antonella, Rodriquenz, Maria Grazia, Biasini, Claudia, Porzio, Rosa, Pittureri, Cristina, Amaducci, Elena, Faedi, Marina, Codecà, Carla, Crepaldi, Francesca, Pedrazzoli, Paolo, Bramanti, Alfina, Buonadonna, Angela, Garetto, Ferdinando, Comandone, Alessandro, Giordano, Monica, Luchena, Giovanna, Luzzani, Massimo, Cifatte, Chiara, Pino, Maria Simona, Zoccali, Sonia, Cattaneo, Maria Teresa, Dalu, Davide, Sozzi, Pietro, Gauna, Roberta, Alquati, Sara, Costantini, Massimo, Quadrini, Silvia, Narducci, Filomena, Mastromauro, Cataldo, Scognamiglio, Rodolfo, Degiovanni, Daniela, Negri, Federica, Caraceni, Augusto, Montanari, Luigi, Maltoni M., Scarpi E., Dall'Agata M., Zagonel V., Berte R., Ferrari D., Broglia C.M., Bortolussi R., Trentin L., Valgiusti M., Pini S., Farolfi A., Casadei Gardini A., Nanni O., Amadori D., Frassineti G.L., Sansoni E., Ragazzini A., Ruscelli S., Crivellari G., Galiano A., Rodriquenz M.G., Biasini C., Porzio R., Pittureri C., Amaducci E., Faedi M., Codeca C., Crepaldi F., Pedrazzoli P., Bramanti A., Buonadonna A., Garetto F., Comandone A., Giordano M., Luchena G., Luzzani M., Cifatte C., Pino M.S., Zoccali S., Cattaneo M.T., Dalu D., Sozzi P., Gauna R., Alquati S., Costantini M., Quadrini S., Narducci F., Mastromauro C., Scognamiglio R., Degiovanni D., Negri F., Caraceni A., and Montanari L.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Cancer Research, Palliative care, Anxiety, 03 medical and health sciences, 0302 clinical medicine, Early palliative care, On demand, Internal medicine, Pancreatic cancer, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Patient Comfort, Aged, Quality of Health Care, Aged, 80 and over, Depression, business.industry, Palliative Care, Quality of care, Cancer, Oncology, Middle Aged, medicine.disease, Confidence interval, Pancreatic Neoplasms, Clinical trial, 030220 oncology & carcinogenesis, Physical therapy, Female, business, Cancer pain
Abstract

Background Early palliative care (EPC) in oncology has been shown to have a positive impact on clinical outcome, quality-of-care outcomes, and costs. However, the optimal way for activating EPC has yet to be defined. Methods This prospective, multicentre, randomised study was conducted on 207 outpatients with metastatic or locally advanced inoperable pancreatic cancer. Patients were randomised to receive ‘standard cancer care plus on-demand EPC’ (n=100) or ‘standard cancer care plus systematic EPC’ (n=107). Primary outcome was change in quality of life (QoL) evaluated through the Functional Assessment of Cancer Therapy – Hepatobiliary questionnaire between baseline (T0) and after 12 weeks (T1), in particular the integration of physical, functional, and Hepatic Cancer Subscale (HCS) combined in the Trial Outcome Index (TOI). Patient mood, survival, relatives' satisfaction with care, and indicators of aggressiveness of care were also evaluated. Findings The mean changes in TOI score and HCS score between T0 and T1 were −4.47 and −0.63, with a difference between groups of 3.83 (95% confidence interval [CI] 0.10–7.57) (p=0.041), and −2.23 and 0.28 (difference between groups of 2.51, 95% CI 0.40–4.61, p=0.013), in favour of interventional group. QoL scores at T1 of TOI scale and HCS were 84.4 versus 78.1 (p=0.022) and 52.0 versus 48.2 (p=0.008), respectively, for interventional and standard arm. Until February 2016, 143 (76.9%) of the 186 evaluable patients had died. There was no difference in overall survival between treatment arms. Interpretations Systematic EPC in advanced pancreatic cancer patients significantly improved QoL with respect to on-demand EPC.

Published
2016

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