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Aims: To survey orthoptists’ confidence in communicating with patients with communication impairments and to investigate resources orthoptists are currently using to aid assessment and management and to explore future resources that may be beneficial. Methods and Procedures: Practicing orthoptists (n = 63; median age range: 31–35 years old) completed an online survey with quantitative and qualitative questions which investigated approaches to adult and paediatric patients with communication impairments and any communication tools used. Analysis of quantitative survey responses was conducted using IBM SPSS v27. Content analysis of qualitative responses was done. Outcomes and Results: Simple communication strategies (e.g., eye contact and body language, repeating/rephrasing sentences) were commonly used with both adult and paediatric patients while more complex strategies (e.g., electronic visual aids, writing key words/concepts) were rarely used. Usage of communication strategies was not affected by length of work experience, workplace clinical speciality or training during their clinical degree or after graduation (p < 0.05). Most participants (71.2%) reported being unaware of resources available for orthoptists to assist in the assessment and management of patients with communication impairments. Conclusions and Implications: Orthoptists have adopted some communication strategies to improve their interactions with patients with communication impairments, despite limited resources. With proper resources, such as training in supportive communication techniques, they can provide optimal patient care, making it essential to identify what kind of resources would be most appropriate.

COVID-19 has caused a wide range of psychological problems, such as panic disorders, anxiety, and depression. Knowing what others have researched on, what constructs they have focused on, will (a) summarize published information, (b) help identify research gaps, and (c) encourage future research that addresses these gaps. The aim of the study was to analyze the bibliometric indicators of scientific productivity of the impact of COVID-19 on constructs affecting undergraduate happiness. A bibliometric study was conducted. The PubMed database was used. Data summarized were: authors, year of publication, journal name, country, language of publication, and subtopic addressed. A total of 16 English-language studies were identified between April 2022 and December 2022. There were 12 countries that have published on the impact of COVID-19 on constructs affecting college students’ happiness. Most of the studies were developed in the United States (n = 4, 25%) and China (n = 2, 12.5%). Thirteen journals publishing these topics were detected. The subtopics considered were organized into nine categories (e.g., a: Psychological impact, b: Adverse childhood experiences, c: Stress, d: Personality traits, e: Perception of the educational environment, f: Spiritual health, g: Distress, h: Uncertainty and socioemotional learning, i: Satisfaction with life). This study suggests that the number of countries and scientific journals that have published on the impact of COVID-19 on constructs affecting college students’ happiness is small. In addition, the most discussed subtopics during the pandemic were related to constructs such as psychological impact and stress affecting college students’ happiness.

Se realiza una reflexión crítica sobre los resultados obtenidos tras la implementación de un proyecto de extensión desarrollado entre la Universidad Nacional de Luján y el Museo Municipal Casa del Florentino Ameghino de la ciudad de Luján. Ese proyecto tenía como objetivo general promover una comprensión crítica y reflexiva de la población local acerca de los elementos que componen el Patrimonio Cultural arqueológico y paleontológico de la cuenca superior y media del río Luján, como parte necesaria para su gestión sustentable. Se aportó a la clasificación y análisis del patrimonio cultural del acervo del Museo para su puesta en valor y se brindó contenido a las exposiciones, talleres y actividades de divulgación de la institución. Para ello, se tomó como eje a las colecciones, que articularon el intercambio de saberes entre diferentes actoras, actores y públicos. Se reflexiona, asimismo, sobre los desafíos pendientes para que los museos locales, en general, se transformen en instituciones autosustentables y generadoras de saberes superadores.

The study explored the impacts of patterns of language use (PLU) and socio-economic status (SES) on Casper, a constructed-response situational judgment test (SJT). 10,266 applicants from two U.S. medical schools were grouped into self-reported balanced bilinguals, unbalanced bilinguals, English monolinguals, and English as a Second Language (ESL) students. A multicomponent SES composite was used to assess the degree of socioeconomic disadvantage (DSD). Results from a hierarchical regression analysis showed that after accounting for demographic variables, both PLU and DED were significant factors on applicants' Casper performance. Bilingualism was associated with better Casper performance compared to English monolinguals and ESL students. No significant effect of speaking English as a native language was found on applicants' Casper performance. English monolinguals and ESL students performed equivalently on Casper. Finally, high DSD was associated with better Casper performance than low DSD, and the impact of DSD on Casper held the same across all four language groups. These findings provide evidence that socio-cultural factors, such as PLU and DSD have important impacts on SJT performance. Further research is needed to understand the role of differences in language construction across socio-cultural factors on constructed-response SJT performance.

The health of soil, a fundamental resource for life on Earth, is severely compromised by global environmental change. Evidence shows that the knowledge of Indigenous Peoples and local communities influences sustainable land management, hence the importance of understanding Indigenous soil classification. Using a participatory approach, we conducted semistructured interviews, focus groups, and collective mapping of soils in 4 Aymara communities of the Bolivian Altiplano. We found that families in the 4 communities organize their territory in homogenous zones, based upon characteristics perceivable by sight, touch, smell, and taste. The description and meaning of the zones refer to characteristics such as location, soil color, preferred land use, and topography. We argue that homogenous zones are kaleidoscopic and polysemic units of spatial organization of the Aymara territory. Each meaning conveyed is like a face of a kaleidoscope and refers to different features of the zone. They are polysemic because the descriptions of the zones refer to multiple elements of different kinds (eg color and fertility). Indigenous and local knowledge of soils has coevolved with thousands of years of Altiplano farming, leading to prescriptive and flexible homogenous zones of sustainable land management. These knowledge systems and the cultures they belong to constitute crucial elements for generating knowledge supporting transitions to sustainability.

Malware detectors based on machine learning are vulnerable to adversarial attacks. Generative Adversarial Networks (GAN) are architectures based on Neural Networks that may be used to produce successful adversarial samples. The interest towards this technology is quickly growing. This paper proposes a system that first generates feature vectors for making Android malware strongly evasive and then modifies the malicious program accordingly. The system has a twofold contribution: it could be used to build data-sets for validating detectors of GAN-based malware and to enlarge the training and testing data-sets to improve the robustness of malware classifiers.

Purpose Triple negative breast cancer (TNBC) is characterized by the presence of immune cells in the tumor microenvironment, however, the response to single-agent immune checkpoint inhibitor (ICI) therapy is modest. Preclinical models have demonstrated that intratumoral regulatory T cells (Tregs) dampen the antitumor response to ICI. We performed a single-arm phase II trial to evaluate the efficacy of a single low dose of cyclophosphamide (Cy) to deplete Tregs administered before initiating pembrolizumab.Patients and methods 40 patients with pretreated metastatic TNBC were enrolled. The primary endpoints were progression-free survival (PFS) and change in peripheral blood Tregs after Cy. Secondary endpoints included overall response rate (ORR), duration of response, overall survival, treatment-related adverse events (AEs), and correlative evaluations.Results Median PFS was 1.8 months, and the ORR was 21%. Tregs were not significantly decreased after Cy prior to ICI (−3.3%, p=0.19), and increased significantly after the first cycle of therapy (+21% between cycles 1 and 2, p=0.005). Immune-related AEs were similar to historical pembrolizumab monotherapy, and were associated with response to therapy (p=0.02). Patients with pretreatment tumors harboring increased expression of B cell metagene signatures and increased circulating B cell receptor repertoire diversity were associated with clinical response and immune-related toxicity (IRT).Conclusions Among patients with heavily pretreated TNBC, Cy prior to pembrolizumab did not significantly deplete Tregs, and in those with decreased numbers there was rapid recovery following therapy. Increased B cell gene expression in baseline samples was associated with clinical response and IRT.

BACKGROUND: Happiness is a positive component of mental well-being. In young university students, it is linked to ideals in many areas, such as physical health, mental health, harmonious inter-personal relationships, academic performance, and professional success. The aim of the study was to compare the happiness of university students from a state and private university according to professional areas and age range. MATERIALS AND METHODS: A descriptive cross-sectional study with selected 312 university students was conducted. The age range was from 17 to 32 years. The two professional areas surveyed were health sciences and engineering. Happiness was measured using a scale with 11 questions and four dimensions [1: Positive sense of life (three questions), 2: Satisfaction with life (three questions), 3: Personal fulfilment (two questions), and 4: Joy of living (three questions)]. The normality of the data was verified. Differences between sexes, areas, universities and ages were verified by t-test for independent samples. Differences between age ranges were verified by Anova. RESULTS: This study showed that there were no differences in happiness between EU and UP students when compared by gender, professional area, and age ranges. CONCLUSIONS: These results suggest that during the period of university studies, happiness values remain stable in both types of universities.

The present paper probes the use of French grammatical accents by English-speaking learners of French in a multilingual country: Cameroon. Its aim is twofold. First, it highlights the extent to which the various appropriative uses of French by French-speaking Cameroonians influence the form of the language spoken by their English-speaking counterparts. Then, it checks the effect of the language spoken by these learners on their written language. The data were collected among 160 Form 3 and Form 4 pupils from two high schools in the town of Maroua, Far North Region, Cameroon. Six tests and fifty tape recordings were carried out among the target population. Also, four French teachers were tape recorded during the exercise. The analysis of the errors made by the informants revealed significant patterns of acute and grave accents in the spoken language of respondents. These patterns of oral usage were found to strongly correlate with their written production. It therefore appears that Cameroon French displays some specific phonological characteristics, which severely spoils the acquisition of grammatical accents by English-speaking Cameroonians. These findings may revive the debate over whether French in former colonies should adapt to its contexts or keep its native purity.

Se analiza el contexto geoambiental durante los últimos 3000 años en la localidad arqueológica Paso Otero (cuenca media del río Quequén Grande, provincia de Buenos Aires) a partir de la descripción de perfiles estratigráficos, la utilización de barreno y la observación de fotografías aéreas. Se concluye que los depósitos reflejan la dinámica propia de un ambiente fluvial. Se generan expectativas acerca del potencial de ocupación de las unidades detectadas y se discuten los procesos de formación del registro en la localidad y en los sitios Paso Otero 1 y 3, en términos de resolución e integridad. Se espera que los resultados contribuyan a aumentar no sólo el conocimiento puntual de Paso Otero, sino también la reflexión respecto de las aplicaciones de la geoarqueología en general y en otros contextos fluviales de la región pampeana.The environmental context of the Paso Otero locality, Buenos Aires Province, during the past 3000 years is analyzed from stratigraphic profiles, the results of augers, and aerial photography. It is concluded that the deposits reflect a fluvial environment. Expectations for potential occupation are generated and formation processes are discussed for the Paso Otero 1 and 3 sites in terms of resolution and integrity. It is hoped that the results not only increase knowledge of Paso Otero, but also contribute to the use of geoarchaeology applications in general and their application in other fluvial contexts within the Pampean region.