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1. Postural Control Measurements to Predict Future Motor Impairment in Preterm Infants: A Systematic Review

Author

Jennifer Bosserman, Sonia Kelkar, Kristen D. LeBlond, Jessica Cassidy, and Dana B. McCarty

Subjects
postural control, center of pressure, preterm infant, force plate, postural measurement, Medicine (General), R5-920
Abstract

Preterm infants are more likely to demonstrate developmental delays than fullterm infants. Postural measurement tools may be effective in measuring the center of pressure (COP) and asymmetry, as well as predicting future motor impairment. The objective of this systematic review was to evaluate existing evidence regarding use of pressure mats or force plates for measuring COP and asymmetry in preterm infants, to determine how measures differ between preterm and fullterm infants and if these tools appropriately predict future motor impairment. The consulted databases included PubMed, Embase, Scopus, and CINAHL. The quality of the literature and the risk of bias were assessed utilizing the ROB2: revised Cochrane risk-of bias tool. Nine manuscripts met the criteria for review. The postural control tools included were FSA UltraThin seat mat, Conformat Pressure-Sensitive mat, Play and Neuro-Developmental Assessment, and standard force plates. Studies demonstrated that all tools were capable of COP assessment in preterm infants and support the association between the observation of reduced postural complexity prior to the observation of midline head control as an indicator of future motor delay. Postural measurement tools provide quick and objective measures of postural control and asymmetry. Based on the degree of impairment, these tools may provide an alternative to standardized assessments that may be taxing to the preterm infant, inaccessible to therapists, or not sensitive enough to capture motor delays.

Published
2023
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2. Diabetes and Prostate Cancer Outcomes in Obese and Nonobese Men After Radical Prostatectomy

Author

Adva Eisenberg, Ilona Csizmadi, Martha K. Terris, Matthew R. Cooperberg, Sonia Kelkar, Stephen J. Freedland, Zachary Klaassen, Christopher J. Kane, Lauren E. Howard, Taofik Oyekunle, Christopher L. Amling, and William J. Aronson

Subjects
Oncology, Male, Urologic Diseases, Cancer Research, medicine.medical_specialty, Aging, medicine.medical_treatment, 030209 endocrinology & metabolism, Castration-Resistant, Article, Body Mass Index, Diabetes Complications, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Confidence Intervals, Medicine, Humans, Obesity, Veterans Affairs, Metabolic and endocrine, Proportional Hazards Models, Aged, Cancer, Nutrition, Prostatectomy, Analysis of Variance, business.industry, Incidence, Prostate Cancer, Hazard ratio, Diabetes, Prostatic Neoplasms, Prostate-Specific Antigen, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Cohort, Disease Progression, AcademicSubjects/MED00010, business, Body mass index
Abstract

Background The link between diabetes and prostate cancer progression is poorly understood and complicated by obesity. We investigated associations between diabetes and prostate cancer–specific mortality (PCSM), castrate-resistant prostate cancer (CRPC), and metastases in obese and nonobese men undergoing radical prostatectomy (RP). Methods We included 4688 men from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing RP from 1988 to 2017. Diabetes prior to RP, anthropometric, and clinical data were abstracted from 6 Veterans Affairs Medical Centers electronic medical records. Primary and secondary outcomes were PCSM and metastases and CRPC, respectively. Multivariable-adjusted hazard ratios (adj-HRs) and 95% confidence intervals (CIs) were estimated for diabetes and PCSM, CRPC, and metastases. Adjusted hazard ratios were also estimated in analyses stratified by obesity (body mass index: nonobese Results Diabetes was not associated with PCSM (adj-HR = 1.38, 95% CI = 0.86 to 2.24), CRPC (adj-HR = 1.05, 95% CI = 0.67 to 1.64), or metastases (adj-HR = 1.01, 95% CI = 0.70 to 1.46), among all men. Interaction terms for diabetes and obesity were statistically significant in multivariable models for PCSM, CRPC, and metastases (P ≤ .04). In stratified analyses, in obese men, diabetes was associated with PCSM (adj-HR = 3.06, 95% CI = 1.40 to 6.69), CRPC (adj-HR = 2.14, 95% CI = 1.11 to 4.15), and metastases (adj-HR = 1.57, 95% CI = 0.88 to 2.78), though not statistically significant for metastases. In nonobese men, inverse associations were suggested for diabetes and prostate cancer outcomes without reaching statistical significance. Conclusions Diabetes was associated with increased risks of prostate cancer progression and mortality among obese men but not among nonobese men, highlighting the importance of aggressively curtailing the increasing prevalence of obesity in prostate cancer survivors.

Published
2021

3. MP37-08 THE ASSOCIATION BETWEEN DIABETES AND PROSTATE CANCER-SPECIFIC MORTALITY IS DIFFERENT IN OBESE AND NON-OBESE MEN AFTER RADICAL PROSTATECTOMY: RESULTS FROM THE SEARCH DATABASE

Author

Sonia Kelkar, Taofik Oyekunle, Martha K. Terris, Lauren E. Howard, Matthew R. Cooperberg, Zachary Klaassen, Stephen J. Freedland, Christopher L. Amling, William J. Aronson, Ilona Csizmadi, Adva Eisenberg, and Christopher J. Kane

Subjects
Oncology, medicine.medical_specialty, business.industry, Prostatectomy, Urology, medicine.medical_treatment, Specific mortality, medicine.disease, Metastasis, Prostate cancer, Non obese, Internal medicine, Diabetes mellitus, medicine, business
Abstract

INTRODUCTION AND OBJECTIVE:We previously reported that in obese men, diabetes increased the risk of metastasis after radical prostatectomy (RP) whereas no such link was seen in non-obese men. Moreo...

Published
2020

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