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2. Corrigendum: Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Author

Tamara Zoran, Bettina Sartori, Laura Sappl, Maria Aigner, Ferran Sánchez-Reus, Antonio Rezusta, Anuradha Chowdhary, Saad J. Taj-Aldeen, Maiken C. Arendrup, Salvatore Oliveri, Dimitrios P. Kontoyiannis, Ana Alastruey-Izquierdo, Katrien Lagrou, Giuliana Lo Cascio, Jacques F. Meis, Walter Buzina, Claudio Farina, Miranda Drogari-Apiranthitou, Anna Grancini, Anna M. Tortorano, Birgit Willinger, Axel Hamprecht, Elizabeth Johnson, Lena Klingspor, Valentina Arsic-Arsenijevic, Oliver A. Cornely, Joseph Meletiadis, Wolfgang Prammer, Vivian Tullio, Jörg-Janne Vehreschild, Laura Trovato, Russell E. Lewis, Esther Segal, Peter-Michael Rath, Petr Hamal, Manuel Rodriguez-Iglesias, Emmanuel Roilides, Sevtap Arikan-Akdagli, Arunaloke Chakrabarti, Arnaldo L. Colombo, Mariana S. Fernández, M. Teresa Martin-Gomez, Hamid Badali, Georgios Petrikkos, Nikolai Klimko, Sebastian M. Heimann, Omrum Uzun, Maryam Roudbary, Sonia de la Fuente, Jos Houbraken, Brigitte Risslegger, Raquel Sabino, Cornelia Lass-Flörl, and Michaela Lackner

Subjects
cryptic species, Aspergillus section Terrei, susceptibility profiles, azoles, Cyp51A alterations, Microbiology, QR1-502
Published
2019
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3. A multicenter case-control study comparing sun exposure habits and use of photoprotection measures in patients diagnosed with different types of skin cancer

Author

Alba Navarro‐Bielsa, Tamara Gracia‐Cazaña, Manuel Almagro, Sonia De la Fuente‐Meira, Ángeles Florez, Oriol Yélamos, Trinidad Montero‐Vilchez, Carlos González‐Cruz, Adrián Diago, Isabel Abadías‐Granado, Victoria Fuentelsaz, María Colmenero, José Bañuls, Salvador Arias‐Santiago, Agustín Buendía‐Eisman, Manuel Almenara‐Blasco, Pedro Gil‐Pallares, and Yolanda Gilaberte

Subjects
Squamous cell carcinoma, Immunology, Basal cell carcinoma, Immunology and Allergy, Radiology, Nuclear Medicine and imaging, Dermatology, General Medicine, Melanoma, Photoprotection measures
Abstract

Background: While skin cancer awareness programs have significantly furthered public understanding about the harmful effects of the sun, there is a disparity between photoprotection knowledge and protection practices. Objective: To compare sun exposure habits and photoprotection measures in patients diagnosed with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma versus controls. Methods: Multicentre case–control observational study carried out by 13 Spanish dermatologists between April 2020 and August 2022. Patients diagnosed with BCC, SCC, or melanoma were considered cases. The control group consisted of individuals with no history of skin cancer. Results: Of the 254 cases (56.2% female; mean age, 62.67 ± 15.65), 119 (31.2%) had BCC, 62 (16.27%) SCC, and 73 (19.1%) melanoma. The control group consisted of 127 (33.33%) individuals. Avoiding sun exposure between 12:00 and 16:00 was the most commonly used photoprotection measure (habitually/always: 63.1%), followed by the use of sunscreen (habitually/always: 58.9%). Patients with melanoma were less likely to use clothing and shade to avoid sun exposure (p 50. No differences were observed in photoprotection measures between people with and without a previous history of skin cancer. Conclusions: We describe differences in photoprotection measures and sun exposure patterns among patients diagnosed with different skin tumor types. Whether these differences may influence the type of tumor each developed will require further investigation.

Published
2023

4. Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Problem or a Rare Phenomenon?

Author

Tamara Zoran, Bettina Sartori, Laura Sappl, Maria Aigner, Ferran Sánchez-Reus, Antonio Rezusta, Anuradha Chowdhary, Saad J. Taj-Aldeen, Maiken C. Arendrup, Salvatore Oliveri, Dimitrios P. Kontoyiannis, Ana Alastruey-Izquierdo, Katrien Lagrou, Giuliana Lo Cascio, Jacques F. Meis, Walter Buzina, Claudio Farina, Miranda Drogari-Apiranthitou, Anna Grancini, Anna M. Tortorano, Birgit Willinger, Axel Hamprecht, Elizabeth Johnson, Lena Klingspor, Valentina Arsic-Arsenijevic, Oliver A. Cornely, Joseph Meletiadis, Wolfgang Prammer, Vivian Tullio, Jörg-Janne Vehreschild, Laura Trovato, Russell E. Lewis, Esther Segal, Peter-Michael Rath, Petr Hamal, Manuel Rodriguez-Iglesias, Emmanuel Roilides, Sevtap Arikan-Akdagli, Arunaloke Chakrabarti, Arnaldo L. Colombo, Mariana S. Fernández, M. Teresa Martin-Gomez, Hamid Badali, Georgios Petrikkos, Nikolai Klimko, Sebastian M. Heimann, Omrum Uzun, Maryam Roudbary, Sonia de la Fuente, Jos Houbraken, Brigitte Risslegger, Cornelia Lass-Flörl, and Michaela Lackner

Subjects
cryptic species, Aspergillus section Terrei, susceptibility profiles, azoles, Cyp51A alterations, Microbiology, QR1-502
Abstract

Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resistant strains remains to be studied.Methods: A global set (n = 498) of A. terreus and phenotypically related isolates was molecularly identified (beta-tubulin), tested for antifungal susceptibility against posaconazole, voriconazole, and itraconazole, and resistant phenotypes were correlated with point mutations in the cyp51A gene.Results: The majority of isolates was identified as A. terreus (86.8%), followed by A. citrinoterreus (8.4%), A. hortai (2.6%), A. alabamensis (1.6%), A. neoafricanus (0.2%), and A. floccosus (0.2%). One isolate failed to match a known Aspergillus sp., but was found most closely related to A. alabamensis. According to EUCAST clinical breakpoints azole resistance was detected in 5.4% of all tested isolates, 6.2% of A. terreus sensu stricto (s.s.) were posaconazole-resistant. Posaconazole resistance differed geographically and ranged from 0% in the Czech Republic, Greece, and Turkey to 13.7% in Germany. In contrast, azole resistance among cryptic species was rare 2 out of 66 isolates and was observed only in one A. citrinoterreus and one A. alabamensis isolate. The most affected amino acid position of the Cyp51A gene correlating with the posaconazole resistant phenotype was M217, which was found in the variation M217T and M217V.Conclusions:Aspergillus terreus was most prevalent, followed by A. citrinoterreus. Posaconazole was the most potent drug against A. terreus, but 5.4% of A. terreus sensu stricto showed resistance against this azole. In Austria, Germany, and the United Kingdom posaconazole-resistance in all A. terreus isolates was higher than 10%, resistance against voriconazole was rare and absent for itraconazole.

Published
2018
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5. Micosis fungoide papular en el anciano: a propósito de 2 casos

Author

Lucía Prieto-Torres, Andrea Montes-Torres, Victoria Lezcano-Biosca, and Sonia de la Fuente-Meira

Subjects
Aging, medicine.medical_specialty, Papular eruption, Mycosis fungoides, business.industry, Cutaneous T-cell lymphoma, Erythematous papule, Medicine (miscellaneous), medicine.disease, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Geriatrics and Gerontology, business
Abstract

Papular mycosis fungoides (MF) is an uncommon clinical variant of early MF without prognostic implications that follows an indolent course over years. It is characterized by the presence of multiple, small, pruritic, flat-topped, erythematous papules, often presenting as a nonspecific papular eruption which makes early diagnosis difficult. We describe two cases of elderly patients with papular MF, a probably underdiagnosed entity, which causes a significant deterioration in quality of life of patients who may benefit from specific treatments such as phototherapy.

Published
2021

7. Propiedades psicométricas de una encuesta de evaluación para el área docente de psiquiatría Psychometric properties of a teaching evaluation questionnaire for an Academic Psychiatric Area

Author

Pedro Saz, Antonio Campayo, Elena Lobo, Eduardo Aguilar, Sonia de la Fuente, and Antonio Lobo

Subjects
Educación Médica, Fiabilidad y Validez, Psicometría, Docencia, Education, Medical, Reliability and Validity, Psychometrics, Teaching, Education (General), L7-991, Medicine (General), R5-920
Abstract

Introducción: La aplicación de los estándares internacionales de calidad en los estudios de Medicina es necesario en el contexto del actual proceso de Convergencia al Espacio Europeo de Educación Superior (CEEES) en Ciencias de la Salud; de ello se deriva la importancia de la mejora de la calidad docente. El empleo de cuestionarios es una de las herramientas más empleadas para evaluar la calidad de la docencia. El objetivo principal de esta publicación es presentar las propiedades psicométricas de fiabilidad y validez de una encuesta desarrollada para evaluar las asignaturas del Área de Psiquiatría de la Facultad de Medicina de Zaragoza. Material y Métodos: Durante el curso académico 2005-2006, en la asignatura "optativa" Psicosomática y Psiquiatría de Enlace Especial, se distribuyó a los alumnos asistentes a las dos últimas clases previas al examen, una encuesta confidencial diseñada por los autores. Se evaluaron las propiedades psicométricas de fiaibilidad test-retest, consistencia interna, validez de contenido y aproximación a la validez de constructo. Resultados: La encuesta ofreció un coeficiente de fiabilidad alfa de Cronbach de 0,865 (Meritorio-Excelente) y un índice medio de acuerdo KappaW test-retest=0,655 (I.C. al 99% 0,562-0,748). Así mismo se documenta una adecuada factibilidad e indicios de validez. Conclusiones: Los datos obtenidos documentan la factibilidad y fiabilidad de la nueva encuesta y sugieren que su validez de constructo es adecuada. Consecuentemente, puede resultar un instrumento útil en la toma de decisiones sobre modificaciones en la metodología docente del Área de Psiquiatría; además, generalizable a otras disciplinas de las ciencias biomédicas.Introduction: In the context of the process to establish the European Higher Education Area (EHEA), the implementation of international quality standards in Medical Education is essential; and the improvement of teaching effectiveness is therefore of great importance. Students' rating questionnaires are the teaching evaluation tool in most widespread use. The main objective of this study is to present psychometric properties, such as reliability and validity, of a questionnaire developed for the assessment of subjects in the Psychiatry Department of the Faculty of Medicine in Zaragoza. Methods: Students attending the last two Psychosomatics and Consultation-Liaison Psychiatry classes in 2005-2006, were invited to fill out a confidential questionnaire designed by the authors. Test retest reliability, internal consistency and content validity were tested, and an approximation to construct validity was also approached. Results: Cronbach’s a coefficient was 0.865 (good to excellent according to the standard) and test retest kappaW was 0.655 (C.I. 99% .562-.748). Feasibility was appropriate and data about correlation of measures of satisfaction and the outcome of teaching support the construct validity of the questionnaire. Conclusions: The feasibility and reliability of the new scale for medical students evaluation is documented, and preliminary data support its construct validity. It is suggested that the new tool may be useful in deciding about teaching methods in the Area of Psychiatry. Furthermore, its usefulness might be extended to other Biomedical Areas.

Published
2007

8. [Papular mycosis fungoides in elderly: Report of two cases]

Author

Andrea, Montes-Torres, Victoria, Lezcano-Biosca, Sonia, de la Fuente-Meira, and Lucía, Prieto-Torres

Subjects
Mycosis Fungoides, Skin Neoplasms, Quality of Life, Humans, Prognosis, Aged
Abstract

Papular mycosis fungoides (MF) is an uncommon clinical variant of early MF without prognostic implications that follows an indolent course over years. It is characterized by the presence of multiple, small, pruritic, flat-topped, erythematous papules, often presenting as a nonspecific papular eruption which makes early diagnosis difficult. We describe two cases of elderly patients with papular MF, a probably underdiagnosed entity, which causes a significant deterioration in quality of life of patients who may benefit from specific treatments such as phototherapy.

Published
2020

9. Lower Extremity Skin Ulcer Associated With Neurofibromatosis Type 1: A Case Report

Author

Tamara, Gracia-Cazaña, Sonia, de la Fuente, María A, Concellón, and Mariano, Ara-Martín

Subjects
Adult, Male, Neurofibromatosis 1, Treatment Outcome, Adrenal Cortex Hormones, Vascular Malformations, Leg Ulcer, Humans, Skin Diseases, Vascular, Anti-Bacterial Agents, Capillaries
Abstract

The association between neurofibromatosis type 1 (NF-1) and vasculopathy has been reported frequently, especially cerebral, intestinal, and peripheral vasculopathy. However, cutaneous vasculopathy is infrequent.The authors present the case of a 32-year-old man with a painful ulcer on his left thigh of 3 weeks' duration in the same location as a long-time capillary malformation associated with alopecia. The skin biopsy showed signs of perivascular fibromuscular dysplasia with proliferating myofibroblastic cells. The patient had been treated with various therapeutic options, such as topical antibiotics, oral and intralesional corticosteroids, and oral cyclosporine and intravenous prostanoids.Cutaneous vasculopathy related to the skin, such as livedo reticularis and ulcers of torpid evolution due to cutaneous vasculopathy are extremely rare. Thus, it is necessary to include skin ulcers as one of the phenotypic manifestations of NF-1.

Published
2019

10. Síndrome PAPASH con mutación en el gen MEFV

Author

Joana Cruañes Monferrer, Sonia de la Fuente Meira, Juan Monte Serrano, and Miguel Fernando García-Gil

Subjects
Gynecology, medicine.medical_specialty, business.industry, medicine, General Medicine, business
Published
2021

11. PAPASH syndrome with MEFV gene mutation

Author

Juan, Monte Serrano, Sonia, de la Fuente Meira, Joana, Cruañes Monferrer, and Miguel Fernando, García-Gil

Subjects
Gene Frequency, Mutation, Humans, Genetic Predisposition to Disease, Syndrome, Pyrin, Familial Mediterranean Fever
Published
2021

12. Unilateral linear facial depressions in an 11‐year‐old boy

Author

María E. Sánchez‐del Valle, Sonia de la Fuente‐Meira, and Tamara Gracia-Cazaña

Subjects
Male, Chin, medicine.medical_specialty, business.industry, Hamartoma, Dermatology, Skin Diseases, Surgery, Pediatrics, Perinatology and Child Health, medicine, Humans, Child, business, Neck
Published
2019

13. Evaluation of incubation time for dermatophytes cultures

Author

Antonio Rezusta, Ana Isabel López-Calleja, Maria Angeles Ruiz, Sonia de la Fuente, Yolanda Gilaberte, María José Revillo, Leticia Alcalá, and Matxalen Vidal-García

Subjects
0301 basic medicine, Fungal growth, Time Factors, Epidermophyton floccosum, 030106 microbiology, Mycology, Dermatology, Trichophyton rubrum, medicine.disease_cause, Incubation period, Microbiology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Tinea, Trichophyton, medicine, Incubation, biology, Arthrodermataceae, Epidermophyton, General Medicine, biology.organism_classification, Infectious Diseases, Dermatophyte, Visual observation
Abstract

In general, it is recommended to incubate dermatophytes cultures for a minimum of 4 weeks. Several aspects of routine fungal cultures should be evaluated in order to implement appropriate and necessary changes. The aim of this study was to determine the optimum incubation time for routine dermatophytes cultures, analysing the time to find first fungal growth by visual observation. We recorded the time when the initial growth was detected for all dermatophyte isolates during a 4-year period. A total of 5459 dermatophyte cultures were submitted to our laboratory. From the total cultures, only 16 (1.42%) isolates were recovered over/after 17 days of incubation and only three dermatophyte species were recovered over 17 days. Fourteen isolates belong to Trichophyton rubrum, one isolate to Trichophyton mentagrophytes complex and one isolate to Epidermophyton floccosum. We concluded that an incubation period of 17 days is enough to establish a microbiological diagnosis of dermatophytosis.

Published
2016

14. Placas induradas en la zona interglútea

Author

M. Elena del Valle Sánchez, M. Luisa Zubiri Ara, and Sonia de la Fuente Meira

Subjects
business.industry, Medicine, Dermatology, business
Published
2015

15. Postvaccination Bullous Pemphigoid in Infancy: Report of Three New Cases and Literature Review

Author

Sonia de la Fuente, MªAntonia González-Enseñat, Antonio Torrelo, Raúl De Lucas, Angela Hernández-Martín, Mariona Suñol, Isabel Colmenero, Asunción Vicente, and María Gonzalez-Beato

Subjects
Male, Pemphigoid, medicine.medical_specialty, Meningococcal Vaccines, Dermatology, Pemphigoid, Bullous, medicine, Humans, Hepatitis B Vaccines, skin and connective tissue diseases, Diphtheria-Tetanus-Pertussis Vaccine, Haemophilus Vaccines, integumentary system, Tetanus, business.industry, Diphtheria, Infant, Hepatitis B, medicine.disease, Poliomyelitis, Vaccination, Poliovirus Vaccine, Oral, Pediatrics, Perinatology and Child Health, Immunology, Etiology, Female, Bullous pemphigoid, business
Abstract

Bullous pemphigoid (BP) is an acquired autoimmune blistering disorder of unknown etiology uncommon in childhood. Unlike adult BP, infantile BP shows acral distribution and resolves rapidly with systemic steroids. We report three infants with infantile BP presenting shortly after vaccination for diphtheria, pertussis, tetanus, poliomyelitis, hepatitis B, Haemophilus influenzae B, and meningococcus C. Our cases further reinforce the causal association between childhood BP and vaccination.

Published
2013

16. Pénfigo vegetante con afectación extraflexural

Author

Goretti Lacruz Ausín, Sonia de la Fuente Meira, Maria Antonia Concellón Doñate, and María Pilar Grasa Jordán

Subjects
business.industry, Medicine, Dermatology, business
Published
2013

17. Propiedades psicométricas de una encuesta de evaluación para el área docente de psiquiatría

Author

Pedro Saz, Antonio Campayo, Elena Lobo, Eduardo Aguilar, Sonia de la Fuente, and Antonio Lobo

Subjects
Educación Médica, Fiabilidad y Validez, Psicometría, Docencia, Education (General), L7-991, Medicine (General), R5-920
Abstract

Introducción: La aplicación de los estándares internacionales de calidad en los estudios de Medicina es necesario en el contexto del actual proceso de Convergencia al Espacio Europeo de Educación Superior (CEEES) en Ciencias de la Salud; de ello se deriva la importancia de la mejora de la calidad docente. El empleo de cuestionarios es una de las herramientas más empleadas para evaluar la calidad de la docencia. El objetivo principal de esta publicación es presentar las propiedades psicométricas de fiabilidad y validez de una encuesta desarrollada para evaluar las asignaturas del Área de Psiquiatría de la Facultad de Medicina de Zaragoza. Material y Métodos: Durante el curso académico 2005-2006, en la asignatura "optativa" Psicosomática y Psiquiatría de Enlace Especial, se distribuyó a los alumnos asistentes a las dos últimas clases previas al examen, una encuesta confidencial diseñada por los autores. Se evaluaron las propiedades psicométricas de fiaibilidad test-retest, consistencia interna, validez de contenido y aproximación a la validez de constructo. Resultados: La encuesta ofreció un coeficiente de fiabilidad alfa de Cronbach de 0,865 (Meritorio-Excelente) y un índice medio de acuerdo KappaW test-retest=0,655 (I.C. al 99% 0,562-0,748). Así mismo se documenta una adecuada factibilidad e indicios de validez. Conclusiones: Los datos obtenidos documentan la factibilidad y fiabilidad de la nueva encuesta y sugieren que su validez de constructo es adecuada. Consecuentemente, puede resultar un instrumento útil en la toma de decisiones sobre modificaciones en la metodología docente del Área de Psiquiatría; además, generalizable a otras disciplinas de las ciencias biomédicas.

19. Propiedades psicométricas de una encuesta de evaluación para el área docente de psiquiatría

Author

Elena Lobo, Antonio Lobo, Antonio Campayo, Sonia de la Fuente, Pedro Saz, and Eduardo J. Aguilar

Subjects
lcsh:R5-920, Fiabilidad y Validez, Docencia, General Engineering, Psicometría, Educación Médica, General Medicine, lcsh:L7-991, lcsh:Medicine (General), lcsh:Education (General), Education
Abstract

Introducción: La aplicación de los estándares internacionales de calidad en los estudios de Medicina es necesario en el contexto del actual proceso de Convergencia al Espacio Europeo de Educación Superior (CEEES) en Ciencias de la Salud; de ello se deriva la importancia de la mejora de la calidad docente. El empleo de cuestionarios es una de las herramientas más empleadas para evaluar la calidad de la docencia. El objetivo principal de esta publicación es presentar las propiedades psicométricas de fiabilidad y validez de una encuesta desarrollada para evaluar las asignaturas del Área de Psiquiatría de la Facultad de Medicina de Zaragoza. Material y Métodos: Durante el curso académico 2005-2006, en la asignatura "optativa" Psicosomática y Psiquiatría de Enlace Especial, se distribuyó a los alumnos asistentes a las dos últimas clases previas al examen, una encuesta confidencial diseñada por los autores. Se evaluaron las propiedades psicométricas de fiaibilidad test-retest, consistencia interna, validez de contenido y aproximación a la validez de constructo. Resultados: La encuesta ofreció un coeficiente de fiabilidad alfa de Cronbach de 0,865 (Meritorio-Excelente) y un índice medio de acuerdo KappaW test-retest=0,655 (I.C. al 99% 0,562-0,748). Así mismo se documenta una adecuada factibilidad e indicios de validez. Conclusiones: Los datos obtenidos documentan la factibilidad y fiabilidad de la nueva encuesta y sugieren que su validez de constructo es adecuada. Consecuentemente, puede resultar un instrumento útil en la toma de decisiones sobre modificaciones en la metodología docente del Área de Psiquiatría; además, generalizable a otras disciplinas de las ciencias biomédicas.

Published
2007

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