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12. The application of lactoferrin in infant formula: The past, present and future.

Author

Li, Wusun, Liu, Biao, Lin, Yingying, Xue, Peng, Lu, Yao, Song, Sijia, Li, Yixuan, Szeto, Ignatius Man-Yau, Ren, Fazheng, and Guo, Huiyuan

Subjects
INFANT formulas, IRON deficiency anemia, LACTOFERRIN, BONE health, INFANT nutrition, BONE growth
Abstract

Human milk is universally regarded as the gold standard to fulfill nutrition needs of infants. Lactoferrin (LF) is a major multiple bioactive glycoprotein in human milk but little is presented in infant formula. LF can resist digestion in the infant gastrointestinal tract and is absorbed into the bloodstream in an intact form to perform physiological functions. Evidence suggest that LF prevents pathogen infection, promotes immune system development, intestinal development, brain development and bone health, as well as ameliorates iron deficiency anemia. However, more clinical studies of LF need to be further elucidated to determine an appropriate dosage for application in infant formula. LF is sensitive to denaturation induced by processing of infant formula such as heat treatments and spay drying. Thus, further studies should be focus on maximizing the retention of LF activity in the infant formula process. This review summarizes the structural features of LF. Then the digestion, absorption and metabolism of LF in infants are discussed, followed by the function of LF for infants. Further, we summarize LF in infant formula and effects of processing of infant formula on bioactivities of LF, as well as future perspectives of LF research. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Changes in properties of human milk under different conditions of frozen storage

Author

Wang, Kaibo, primary, Zhao, Yanfeng, additional, Song, Sijia, additional, Lin, Yingying, additional, Luo, Yujia, additional, Zhang, Yafei, additional, Xue, Yi, additional, Li, Wusun, additional, Zhang, Yuning, additional, Lu, Yao, additional, Quan, Heng, additional, Zhang, Hao, additional, Liu, Huihui, additional, Gou, Qian, additional, and Guo, Huiyuan, additional

Published
2023
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15. Radiation-Hardened and Flexible Pb(Zr0.53Ti0.47)O3 Piezoelectric Sensor for Structural Health Monitoring

Author

Liu, Yajing, primary, Yun, Chao, additional, Wang, Yu, additional, Xu, Longjie, additional, Wang, Chongqi, additional, Li, Zhongxu, additional, Meng, Miao, additional, Song, Sijia, additional, Li, Kaifeng, additional, Li, Dong, additional, Chen, Feng, additional, Liu, Yang, additional, Ji, Yanda, additional, You, Tiangui, additional, Ning, Shuai, additional, Qiu, Lei, additional, Yang, Hao, additional, and Li, Weiwei, additional

Published
2023
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24. Preparation of bimodal mesoporous CoCe composite oxide for ethanol complete oxidation in air.

Author

Xie, Hongmei, Song, Sijia, Zeng, Jia, Zhang, Guizhi, and Chen, Shuang

Subjects
*ETHANOL, *REACTIVE oxygen species, *SOLID solutions, *POROSITY, *X-ray diffraction, *OXIDES, *OXIDATION
Abstract

The CeO2 and CeCoO composite oxide catalysts with bimodal mesopore structures were prepared by hard-template method and used for ethanol complete oxidation in air. The physicochemicalphysicochemical properties of the prepared catalysts were characterized by XRD, BET, TEM, XPS, H2-TPR, and O2-TPD. The Co species can be dissolved into CeO2 lattice to form Ce–O–Co solid solution, which promotes reactive oxygen species to be formed on the prepared CeCoO oxide catalysts surface. The bimodal mesopore structures can be obtained by the used hard-template method, and the pore structures of the prepared CeCoO oxide catalysts can be affected by the introduction of Co species. The synergistic effects from bimodal mesopore structures and reactive oxygen species can effectively boost ethanol complete oxidation to final product CO2. The CeCo2 catalyst with Ce/Co mole ratio of 2.0 exhibites superior ethanol complete oxidation activity and service stability, the ethanol oxidation conversion and final oxidation product CO2 selectivity reached 99.8 % and 99.2 % at 200 °C, respectively. This work indicates that the bimodal mesoporous CeCoO solid solution composite oxide catalyst is a promising candidate for OVOCs oxidation elimination from air. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Asiatic acid attenuates tubular injury in diabetic kidney disease by regulating mitochondrial dynamics via the Nrf-2 pathway

Author

Ji, Yali, primary, Zhang, Xuanxuan, additional, Chen, Jicong, additional, Song, Sijia, additional, Fang, Siyang, additional, Wang, Zihan, additional, Xu, Susu, additional, Xu, Yinying, additional, Liu, Jianjing, additional, Jiang, Cuihua, additional, Pan, Ke, additional, Zhang, Jian, additional, Wang, Lei, additional, and Yin, Zhiqi, additional

Published
2023
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28. Radiation-Hardened and Flexible Pb(Zr0.53Ti0.47)O3Piezoelectric Sensor for Structural Health Monitoring

Author

Liu, Yajing, Yun, Chao, Wang, Yu, Xu, Longjie, Wang, Chongqi, Li, Zhongxu, Meng, Miao, Song, Sijia, Li, Kaifeng, Li, Dong, Chen, Feng, Liu, Yang, Ji, Yanda, You, Tiangui, Ning, Shuai, Qiu, Lei, Yang, Hao, and Li, Weiwei

Abstract

Piezoelectric sensors are excellent damage detectors that can be applied to structural health monitoring (SHM). SHM for complex structures of aerospace vehicles working in harsh conditions is frequently required, posing challenging requirements for a sensor’s flexibility, radiation hardness, and high-temperature tolerance. Here, we fabricate a flexible and lightweight Pb(Zr0.53Ti0.47)O3piezoelectric film on flexible KMg3(AlSi3O10)F2substrate via van der Waals (vdW) heteroepitaxy, endowing it with robust ferroelectric and piezoelectric properties under low energy-high flux protons (LE-HFPs) radiation (1015p/cm2). More importantly, the Pb(Zr0.53Ti0.47)O3film sensor maintains highly stable damage monitoring sensitivity on an aluminum plate under harsh conditions of LE-HFPs radiation (1015p/cm2, flat structure), high temperature (175 °C, flat structure), and mechanical fatigue (bending 105cycles under a radius of 5 mm, curved structure). All these superior qualities are suggested to result from the outstanding film crystal quality due to vdW epitaxy. The flexible and lightweight Pb(Zr0.53Ti0.47)O3film sensor demonstrated in this work provides an ideal candidate for real-timeSHM of aerospace vehicles with flat and complex curve-like structures working in harsh aerospace environments.

Published
2023
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44. Lidar-radar for underwater target detection using a modulated sub-nanosecond Q-switched laser

Author

Li, Guangying, primary, Zhou, Qiang, additional, Xu, Guoquan, additional, Wang, Xing, additional, Han, Wenjie, additional, Wang, Jiang, additional, Zhang, Guodong, additional, Zhang, Yifan, additional, Yuan, Zhi'an, additional, Song, Sijia, additional, Gu, Shangtai, additional, Chen, Fubin, additional, Xu, Ke, additional, Tian, Jinshou, additional, Wan, Jianwei, additional, Xie, Xiaoping, additional, and Cheng, Guanghua, additional

Published
2021
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45. Flexible ferroelectric Pb(Zr0.53Ti0.47)O3 epitaxial films with large radiation and high-temperature tolerance.

Author

Liu, Yajing, Song, Sijia, Gong, Pin, Xu, Longjie, Li, Kaifeng, Li, Dong, Wang, Hongguang, Fan, Jiyu, Qiu, Lei, Tang, Xiaobin, Li, Weiwei, and Yang, Hao

Subjects
*RADIATION tolerance, *NUCLEAR industry, *LEAD titanate, *FERROELECTRIC thin films, *ELECTRONIC equipment, *OUTER space, *RF values (Chromatography)
Abstract

Radiation and temperature hardness are important for electronic devices operating in harsh environments such as modern medical equipment, outer space, and nuclear energy industries. In this work, we report radiation and temperature-hardened flexible ferroelectric Pb(Zr0.53Ti0.47)O3 epitaxial films that were grown on flexible inorganic mica substrates via van der Waals heteroepitaxy and can be further used for building high-performance electronic devices. We systematically investigated the effect of 60Co-gamma radiation and temperature on the ferroelectric properties of Pb(Zr0.53Ti0.47)O3 films and their flexibility as well. Pb(Zr0.53Ti0.47)O3 films exhibit a radiation and temperature tolerance of up to 20 Mrad and 175 °C, respectively. In particular, the 20 Mrad-irradiated Pb(Zr0.53Ti0.47)O3 film has an excellent retention even after 105 s with extrapolate retention time longer than 10 years and polarization fatigue up to 1010 cycles as well as moderate flexibility and bending stability after bending 105 cycles. Furthermore, we identified that the degradation of macroscopic ferroelectric properties of irradiated Pb(Zr0.53Ti0.47)O3 films originates from the ferroelectric domain pinning effect induced by the ionization effect. Our work demonstrates that flexible ferroelectric Pb(Zr0.53Ti0.47)O3 films are promising for developing novel flexible electronic devices for applications in harsh environments. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population

Author

Liu, Chao, Song, Sijia, Zhang, Junkai, Li, Xiao, and Gao, Huijie

Subjects
schizophrenia, Neuropsychiatric Disease and Treatment, gene polymorphism, oxidative stress, glutathione peroxidase, Original Research, glutathione S-transferase
Abstract

Chao Liu,1 Sijia Song,2 Junkai Zhang,1 Xiao Li,1 Huijie Gao1 1College of Pharmacy, Jining Medical University, Rizhao, Shandong, People’s Republic of China; 2Rizhao Mental Health Center, Rizhao, Shandong, People’s Republic of ChinaCorrespondence: Huijie GaoCollege of Pharmacy, Jining Medical University, 669 Xueyuan Road, Rizhao 276826, People’s Republic of ChinaTel +86 15954014646Email mianyigao@163.comPurpose: Several lines of evidence support the fact that the presence of oxidative stress plays an important role in the pathophysiological mechanisms of schizophrenia (SCZ). The glutathione peroxidases (GPXs) and glutathione S-transferases (GSTs) are the major antioxidant enzymes. Polymorphic variants of GPX and GST can affect the antioxidant activities of their encoded enzymes. This study explored the possible associations of the GSTA1 and GPX3 gene polymorphisms and schizophrenia in Chinese Han population.Methods: DNA from 648 healthy controls and 617 schizophrenic patients was genotyped for single-nucleotide polymorphisms (SNPs) rs3957357 in GSTA1 and rs736775 in GPX3 using a PCR-LDR genotyping assay. The χ2 test compared differences in genetic distributions between the two groups in a case–control study. The generalized multifactor dimensionality reduction (GMDR) was used to explore the interaction between the GSTA1 gene and the GPX3 gene on the risk of SCZ.Results: Significant differences in allelic and genotypic frequencies of GSTA1 rs3957357 were present between SCZ and control groups (GSTA1 rs3957357 χ2=6.172, P=0.046 by genotype, χ2=5.847, P=0.016, odds ratio=1.329, 95% confidence interval=1.055–1.674 by allele). No significant differences in allelic or genotypic frequencies of GPX3 rs736775 were detected between cases and controls (GPX3 rs736775: χ2=2.058, P=0.357 by genotype, χ2=1.853, P=0.173, odds ratio=1.131, 95% confidence interval=0.953–1.342 by allele). Moreover, the GMDR model showed that the interaction between GSTA1 rs3957357 and GPX3 rs736775 was associated significantly with SCZ risk, P=0.0107.Conclusion: Our results suggest that GSTA1 rs3957357 SNP has an effect on the risk of SCZ and the interaction between GSTA1 rs3957357and GPX3 rs736775 may affect the development of SCZ in Chinese Han population. However, these results should be validated by replication in different populations with large sample sizes.Keywords: oxidative stress, schizophrenia, glutathione peroxidase, glutathione S-transferase, gene polymorphism

Published
2020

49. DNA Supramolecular Hydrogel as a Biocompatible Artificial Vitreous Substitute.

Author

Jin, Yu, Li, Yujie, Song, Sijia, Ding, Yuqiao, Dong, Yuanchen, Lu, Yao, Liu, Dongsheng, and Zhang, Chun

Subjects
VITREOUS body, PARS plana, DNA, HUMAN body, HYDROGELS
Abstract

Pars plana vitrectomy plays an important role in treating serious ophthalmic diseases, which requires subsequent substitution of the natural vitreous. However, the current substitutes are known for the drawbacks in instability, toxicity, and injection‐induced fragmentation, so there is a very urgent need in novel artificial vitreous substitute for clinical practice. In this study, DNA supramolecular hydrogel is evaluated as a potential artificial vitreous substitute. It is observed that DNA supramolecular hydrogel exhibits relatively strong mechanical strength, shear‐thinning behavior, rapid recoverability, and other physical properties similar to the human vitreous body. The in vivo experiments further prove the injectability, excellent biocompatibility, and in vivo stability. With the support of the DNA supramolecular hydrogel, the morphology and basic functions of the operated eyes are well recovered without obvious inflammation, which demonstrate the DNA supramolecular hydrogel shows enormous potential as vitreous substitute. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Genetic variability and structure of an important wild steppe grass Psathyrostachys juncea (Triticeae: Poaceae) germplasm collection from north and central Asia

Author

Xiong, Yi, primary, Xiong, Yanli, additional, Yu, Qingqing, additional, Zhao, Junming, additional, Lei, Xiong, additional, Dong, Zhixiao, additional, Yang, Jian, additional, Song, Sijia, additional, Peng, Yan, additional, Liu, Wenhui, additional, Bai, Shiqie, additional, and Ma, Xiao, additional

Published
2020
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