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13 results on '"Song, Qinhui"'

2. Isoelectric Substitution Strategy to Construct a Partially Charged MOF for C2H2 Capture and Selective Dye Adsorption.

Author

Zhao, De, Song, Qinhui, Li, Yunbin, Li, Lu, Yuan, Furong, Yang, Yisi, Xiang, Shengchang, and Zhang, Zhangjing

Abstract

The charged metal–organic framework (MOF) (anionic and cationic MOF) material plays an important role in gas adsorption and separation and ecological environment management. Herein, we reported a partially charged Mg-based MOF (FJU-129) with dimethylamine counterions, which can efficiently separate C2H2 from CO2 and rapidly adsorb the cationic dye methylene blue (MB). FJU-129a showed a high uptake capacity of up to 133.8 cm3/g for C2H2 at 273 K, 1 bar, and low isosteric heat of adsorption of C2H2 (24.78 kJ/mol). The C2H2/CO2 separation is validated by a dynamic breakthrough experiment at 296 K, 1.5 bar, and the Grand Canonical Monte Carlo simulation revealed that the partially remaining charge on the magnesium sites has an electrostatic force on the −CC– bond of C2H2 molecules, and C–H···π interactions play an important role in the separation of C2H2/CO2 selective mixtures. In addition, owing to the pore size and electrostatic effect, FJU-129 selectively absorbs MB and excludes other cationic dyes and anionic dyes (MB, CV, RB, R6G, MO, and SD-III). [ABSTRACT FROM AUTHOR]

Published
2023
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8. RTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia.

Author

Jin, Yi, Wu, Jiaping, Song, Xiaoxiao, Song, Qinhui, Cully, Brittany L, Messmer-Blust, Angela, Xu, Ming, Foo, Shi-Yin, Rosenzweig, Anthony, Li, Jian, Jin, Yi, Wu, Jiaping, Song, Xiaoxiao, Song, Qinhui, Cully, Brittany L, Messmer-Blust, Angela, Xu, Ming, Foo, Shi-Yin, Rosenzweig, Anthony, and Li, Jian

Abstract

The amount of available hypoxia-inducible factor (HIF)-1α has been considered to be largely a consequence of post-translational modification by multiple ubiquitin-proteasome pathways. However, the role of transcriptional regulation of HIF-1α is less certain, and the mechanisms of transcriptional regulation of HIF-1α require further investigation. Here we report that related transcriptional enhancer factor-1 (RTEF-1), a member of the TEF transcriptional factor family, transcriptionally regulates the HIF-1α gene under normoxic and hypoxic conditions. The expression of HIF-1α mRNA was decreased in endothelial cells in which RTEF-1 was knocked down with siRNA. Sequential deletional analysis of the HIF-1α promoter revealed that the MCAT-like element in the HIF-1α promoter was essential for HIF-1α transcription. Binding of RTEF-1 to the MCAT-like element was confirmed by ChIP. Treatment of endothelial cells with a HIF-1 inhibitor resulted in retardation of RTEF-1-induced proliferation and tube formation. Moreover, increased HIF-1α expression was observed in transgenic mice expressing RTEF-1 under the VE-cadherin promoter (VE-Cad/RTEF-1). VE-Cad/RTEF-1 mice subjected to hindlimb ischemia demonstrated increased levels of HIF-1α, accelerated recovery of blood flow, and increased capillary density compared with littermate controls. These results identify RTEF-1 as a regulator of HIF-1α transcription, which results in up-regulation of HIF-1α and acceleration of recovery from ischemia.

Published
2011
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9. R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Author

Ruffner, Heinz, primary, Sprunger, Joëlle, additional, Charlat, Olga, additional, Leighton-Davies, Juliet, additional, Grosshans, Bianka, additional, Salathe, Adrian, additional, Zietzling, Svenja, additional, Beck, Valérie, additional, Therier, Maxime, additional, Isken, Andrea, additional, Xie, Yang, additional, Zhang, Yue, additional, Hao, Huaixiang, additional, Shi, Xiaoying, additional, Liu, Dong, additional, Song, Qinhui, additional, Clay, Ieuan, additional, Hintzen, Gabriele, additional, Tchorz, Jan, additional, Bouchez, Laure C., additional, Michaud, Gregory, additional, Finan, Peter, additional, Myer, Vic E., additional, Bouwmeester, Tewis, additional, Porter, Jeff, additional, Hild, Marc, additional, Bassilana, Fred, additional, Parker, Christian N., additional, and Cong, Feng, additional

Published
2012
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